product summary
Loading...
company name :
BioLegend
other brands :
Babco, Signet, Sternberger Monoclonals, Senetek, Covance
product type :
antibody
product name :
Alexa Fluor® 647 anti-T-bet
catalog :
644803
quantity :
25 μg
price :
176 USD
clonality :
monoclonal
host :
mouse
conjugate :
AF647
clone name :
4B10
reactivity :
human, mouse
application :
immunocytochemistry, flow cytometry
more info or order :
citations: 45
Published Application/Species/Sample/DilutionReference
  • flow cytometry; mouse; loading ...; fig s2b
Shi Z, Takeuchi T, Nakanishi Y, Kato T, Beck K, Nagata R, et al. A Japanese Herbal Formula, Daikenchuto, Alleviates Experimental Colitis by Reshaping Microbial Profiles and Enhancing Group 3 Innate Lymphoid Cells. Front Immunol. 2022;13:903459 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 7b, s1a
Piao W, Li L, Saxena V, Iyyathurai J, Lakhan R, Zhang Y, et al. PD-L1 signaling selectively regulates T cell lymphatic transendothelial migration. Nat Commun. 2022;13:2176 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 1e
Kumar A, Chamoto K, Chowdhury P, Honjo T. Tumors attenuating the mitochondrial activity in T cells escape from PD-1 blockade therapy. elife. 2020;9: pubmed publisher
  • flow cytometry; mouse; loading ...; fig e8b
Alspach E, Lussier D, Miceli A, Kizhvatov I, DuPage M, Luoma A, et al. MHC-II neoantigens shape tumour immunity and response to immunotherapy. Nature. 2019;574:696-701 pubmed publisher
  • flow cytometry; mouse; 1:200; loading ...; fig 4c, 4e, s6c
Ansaldo E, Slayden L, Ching K, Koch M, Wolf N, Plichta D, et al. Akkermansia muciniphila induces intestinal adaptive immune responses during homeostasis. Science. 2019;364:1179-1184 pubmed publisher
  • flow cytometry; mouse; loading ...
Di Pilato M, Kim E, Cadilha B, Prüßmann J, Nasrallah M, Seruggia D, et al. Targeting the CBM complex causes Treg cells to prime tumours for immune checkpoint therapy. Nature. 2019;570:112-116 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 1c
Kotov J, Kotov D, Linehan J, Bardwell V, Gearhart M, Jenkins M. BCL6 corepressor contributes to Th17 cell formation by inhibiting Th17 fate suppressors. J Exp Med. 2019;216:1450-1464 pubmed publisher
  • flow cytometry; human; loading ...; fig 3c
Alam M, Yang D, Trivett A, Meyer T, Oppenheim J. HMGN1 and R848 Synergistically Activate Dendritic Cells Using Multiple Signaling Pathways. Front Immunol. 2018;9:2982 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 3d, 3f
Sato Y, Bolzenius J, Eteleeb A, Su X, Maher C, Sehn J, et al. CD4+ T cells induce rejection of urothelial tumors after immune checkpoint blockade. JCI Insight. 2018;3: pubmed publisher
  • flow cytometry; mouse; loading ...; fig 1d
Singh M, Ni M, Sullivan J, Hamerman J, Campbell D. B cell adaptor for PI3-kinase (BCAP) modulates CD8+ effector and memory T cell differentiation. J Exp Med. 2018;215:2429-2443 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 3a
Cummings M, Arumanayagam A, Zhao P, Kannanganat S, Stuve O, Karandikar N, et al. Presenilin1 regulates Th1 and Th17 effector responses but is not required for experimental autoimmune encephalomyelitis. PLoS ONE. 2018;13:e0200752 pubmed publisher
  • flow cytometry; human; loading ...; fig 3d
Hartana C, Ahlén Bergman E, Broome A, Berglund S, Johansson M, Alamdari F, et al. Tissue-resident memory T cells are epigenetically cytotoxic with signs of exhaustion in human urinary bladder cancer. Clin Exp Immunol. 2018;194:39-53 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 3c
Arnold I, Artola Borán M, Tallón de Lara P, Kyburz A, Taube C, OTTEMANN K, et al. Eosinophils suppress Th1 responses and restrict bacterially induced gastrointestinal inflammation. J Exp Med. 2018;215:2055-2072 pubmed publisher
  • flow cytometry; human; loading ...; fig 6l
Jung I, Kim Y, Yu H, Lee M, Kim S, Lee J. CRISPR/Cas9-Mediated Knockout of DGK Improves Antitumor Activities of Human T Cells. Cancer Res. 2018;78:4692-4703 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 6b
Tinoco R, Carrette F, Henriquez M, Fujita Y, Bradley L. Fucosyltransferase Induction during Influenza Virus Infection Is Required for the Generation of Functional Memory CD4+ T Cells. J Immunol. 2018;200:2690-2702 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 6a
Kotov D, Kotov J, Goldberg M, Jenkins M. Many Th Cell Subsets Have Fas Ligand-Dependent Cytotoxic Potential. J Immunol. 2018;200:2004-2012 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 3b
Burrack A, Malhotra D, Dileepan T, Osum K, Swanson L, Fife B, et al. Cutting Edge: Allograft Rejection Is Associated with Weak T Cell Responses to Many Different Graft Leukocyte-Derived Peptides. J Immunol. 2018;200:477-482 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 5b
Maseda D, Johnson E, Nyhoff L, Baron B, Kojima F, Wilhelm A, et al. mPGES1-Dependent Prostaglandin E2 (PGE2) Controls Antigen-Specific Th17 and Th1 Responses by Regulating T Autocrine and Paracrine PGE2 Production. J Immunol. 2018;200:725-736 pubmed publisher
  • flow cytometry; mouse; 1:50; loading ...; fig s5f
Hasan Z, Koizumi S, Sasaki D, Yamada H, Arakaki N, Fujihara Y, et al. JunB is essential for IL-23-dependent pathogenicity of Th17 cells. Nat Commun. 2017;8:15628 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 2b
Lino C, Barros Martins J, Oberdörfer L, Walzer T, Prinz I. Eomes expression reports the progressive differentiation of IFN-?-producing Th1-like ?? T cells. Eur J Immunol. 2017;47:970-981 pubmed publisher
  • flow cytometry; human; loading ...; fig s2a
Martin Gayo E, Cronin J, Hickman T, Ouyang Z, Lindqvist M, Kolb K, et al. Circulating CXCR5+CXCR3+PD-1lo Tfh-like cells in HIV-1 controllers with neutralizing antibody breadth. JCI Insight. 2017;2:e89574 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 2d
Beyaz S, Kim J, Pinello L, Xifaras M, Hu Y, Huang J, et al. The histone demethylase UTX regulates the lineage-specific epigenetic program of invariant natural killer T cells. Nat Immunol. 2017;18:184-195 pubmed publisher
Christian D, Adams T, Shallberg L, Phan A, Smith T, Abraha M, et al. cDC1 coordinate innate and adaptive responses in the omentum required for T cell priming and memory. Sci Immunol. 2022;7:eabq7432 pubmed publisher
Snyder L, Belmares Ortega J, Doherty C, Denkers E. Impact of MyD88, Microbiota, and Location on Type 1 and Type 3 Innate Lymphoid Cells during Toxoplasma gondii Infection. Immunohorizons. 2022;6:660-670 pubmed publisher
Wang R, Chen J, Wang W, Zhao Z, Wang H, Liu S, et al. CD40L-armed oncolytic herpes simplex virus suppresses pancreatic ductal adenocarcinoma by facilitating the tumor microenvironment favorable to cytotoxic T cell response in the syngeneic mouse model. J Immunother Cancer. 2022;10: pubmed publisher
Shiozawa S, Tsumiyama K, Miyazaki Y, Uto K, Sakurai K, Nakashima T, et al. DOCK8-expressing T follicular helper cells newly generated beyond self-organized criticality cause systemic lupus erythematosus. iScience. 2022;25:103537 pubmed publisher
Cossarizza A, Chang H, Radbruch A, Abrignani S, Addo R, Akdis M, et al. Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition). Eur J Immunol. 2021;51:2708-3145 pubmed publisher
Mukherjee A, Roy S, Patidar A, Bodhale N, Dandapat J, Saha B, et al. TLR2 dimer-specific ligands selectively activate protein kinase C isoforms in Leishmania infection. Immunology. 2021;164:318-331 pubmed publisher
Zutshi S, Sarode A, Ghosh S, Jha M, Sudan R, Kumar S, et al. LmjF.36.3850, a novel hypothetical Leishmania major protein, contributes to the infection. Immunology. 2021;163:460-477 pubmed publisher
Doss P, Umair M, Baillargeon J, Fazazi R, Fudge N, Akbar I, et al. Male sex chromosomal complement exacerbates the pathogenicity of Th17 cells in a chronic model of central nervous system autoimmunity. Cell Rep. 2021;34:108833 pubmed publisher
Vogel A, Kanevsky I, Che Y, Swanson K, Muik A, Vormehr M, et al. BNT162b vaccines protect rhesus macaques from SARS-CoV-2. Nature. 2021;592:283-289 pubmed publisher
Martínez Fábregas J, Wang L, Pohler E, Cozzani A, Wilmes S, Kazemian M, et al. CDK8 Fine-Tunes IL-6 Transcriptional Activities by Limiting STAT3 Resident Time at the Gene Loci. Cell Rep. 2020;33:108545 pubmed publisher
Tuganbaev T, Mor U, Bashiardes S, Liwinski T, Nobs S, Leshem A, et al. Diet Diurnally Regulates Small Intestinal Microbiome-Epithelial-Immune Homeostasis and Enteritis. Cell. 2020;: pubmed publisher
Yan J, Pandey S, Barnes B, Turner J, Abraham C. T Cell-Intrinsic IRF5 Regulates T Cell Signaling, Migration, and Differentiation and Promotes Intestinal Inflammation. Cell Rep. 2020;31:107820 pubmed publisher
Katsuyama E, Suárez Fueyo A, Bradley S, Mizui M, Marin A, Mulki L, et al. The CD38/NAD/SIRTUIN1/EZH2 Axis Mitigates Cytotoxic CD8 T Cell Function and Identifies Patients with SLE Prone to Infections. Cell Rep. 2020;30:112-123.e4 pubmed publisher
Camell C, Günther P, Lee A, Goldberg E, Spadaro O, Youm Y, et al. Aging Induces an Nlrp3 Inflammasome-Dependent Expansion of Adipose B Cells That Impairs Metabolic Homeostasis. Cell Metab. 2019;30:1024-1039.e6 pubmed publisher
Koyama M, Mukhopadhyay P, Schuster I, Henden A, Hülsdünker J, Varelias A, et al. MHC Class II Antigen Presentation by the Intestinal Epithelium Initiates Graft-versus-Host Disease and Is Influenced by the Microbiota. Immunity. 2019;51:885-898.e7 pubmed publisher
Chow M, Ozga A, Servis R, Frederick D, Lo J, Fisher D, et al. Intratumoral Activity of the CXCR3 Chemokine System Is Required for the Efficacy of Anti-PD-1 Therapy. Immunity. 2019;: pubmed publisher
Wang D, Diao H, Getzler A, Rogal W, Frederick M, Milner J, et al. The Transcription Factor Runx3 Establishes Chromatin Accessibility of cis-Regulatory Landscapes that Drive Memory Cytotoxic T Lymphocyte Formation. Immunity. 2018;48:659-674.e6 pubmed publisher
Chmielewski M, Abken H. CAR T Cells Releasing IL-18 Convert to T-Bethigh FoxO1low Effectors that Exhibit Augmented Activity against Advanced Solid Tumors. Cell Rep. 2017;21:3205-3219 pubmed publisher
Maschmeyer P, Petkau G, Siracusa F, Zimmermann J, Zügel F, Kühl A, et al. Selective targeting of pro-inflammatory Th1 cells by microRNA-148a-specific antagomirs in vivo. J Autoimmun. 2018;89:41-52 pubmed publisher
Feng J, Yang P, Mack M, Dryn D, Luo J, Gong X, et al. Sensory TRP channels contribute differentially to skin inflammation and persistent itch. Nat Commun. 2017;8:980 pubmed publisher
Soderquest K, Hertweck A, Giambartolomei C, Henderson S, Mohamed R, Goldberg R, et al. Genetic variants alter T-bet binding and gene expression in mucosal inflammatory disease. PLoS Genet. 2017;13:e1006587 pubmed publisher
Wieten R, Jonker E, van Leeuwen E, Remmerswaal E, ten Berge I, de Visser A, et al. A Single 17D Yellow Fever Vaccination Provides Lifelong Immunity; Characterization of Yellow-Fever-Specific Neutralizing Antibody and T-Cell Responses after Vaccination. PLoS ONE. 2016;11:e0149871 pubmed publisher
Hsieh C, Chen C, Tsai C, Huang W, Tseng P, Lin Y, et al. Inhibiting glycogen synthase kinase-3 decreases 12-O-tetradecanoylphorbol-13-acetate-induced interferon-?-mediated skin inflammation. J Pharmacol Exp Ther. 2012;343:125-33 pubmed publisher
product information
Antigen :
T-bet
Apps. Abbrev. :
ICFC
Cat # :
644803
Clone :
4B10
Item :
Alexa Fluor® 647 anti-T-bet
Isotype :
Mouse IgG1, κ
Other Names :
T-box expressed in T cells, T box 21, TBLYM
Size :
25 μg
Price (USD) :
176 USD
Reactivity :
Human, Mouse
Clonality :
Monoclonal
Host :
Mouse
Conjugate/Tag/Label :
A647
more info or order :
company information
BioLegend
8999 BioLegend Way
San Diego, CA 92121
customerserv@biolegend.com
https://www.biolegend.com
headquarters: USA