product summary
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company name :
BioLegend
other brands :
Babco, Signet, Sternberger Monoclonals, Senetek, Covance
product type :
antibody
product name :
Alexa Fluor® 647 anti-Bcl-2
catalog :
633509
quantity :
25 μg
price :
129 USD
clonality :
monoclonal
host :
mouse
conjugate :
AF647
clone name :
BCL/10C4
reactivity :
human, mouse, rat
application :
western blot, immunocytochemistry, flow cytometry
more info or order :
citations: 32
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; loading ...; fig 1c
Amen A, Loughran R, Huang C, Lew R, Ravi A, Guan Y, et al. Endogenous spacing enables co-processing of microRNAs and efficient combinatorial RNAi. Cell Rep Methods. 2022;2:100239 pubmed publisher
  • flow cytometry; mouse; loading ...; fig s3o, 2j
Leone R, Zhao L, Englert J, Sun I, Oh M, Sun I, et al. Glutamine blockade induces divergent metabolic programs to overcome tumor immune evasion. Science. 2019;366:1013-1021 pubmed publisher
Lin Y, Duong H, Limary A, Kim E, Hsu P, Patel S, et al. Small intestine and colon tissue-resident memory CD8+ T cells exhibit molecular heterogeneity and differential dependence on Eomes. Immunity. 2023;56:207-223.e8 pubmed publisher
VanDyke D, Iglesias M, Tomala J, Young A, Smith J, Perry J, et al. Engineered human cytokine/antibody fusion proteins expand regulatory T cells and confer autoimmune disease protection. Cell Rep. 2022;41:111478 pubmed publisher
Shallberg L, Phan A, Christian D, Perry J, Haskins B, Beiting D, et al. Impact of secondary TCR engagement on the heterogeneity of pathogen-specific CD8+ T cell response during acute and chronic toxoplasmosis. PLoS Pathog. 2022;18:e1010296 pubmed publisher
Severance A, Kinder J, Xin L, Burg A, Shao T, Pham G, et al. Maternal-fetal conflict averted by progesterone- induced FOXP3+ regulatory T cells. iScience. 2022;25:104400 pubmed publisher
Grebinoski S, Zhang Q, Cillo A, Manne S, Xiao H, Brunazzi E, et al. Autoreactive CD8+ T cells are restrained by an exhaustion-like program that is maintained by LAG3. Nat Immunol. 2022;23:868-877 pubmed publisher
Hailemichael Y, Johnson D, Abdel Wahab N, Foo W, Bentebibel S, Daher M, et al. Interleukin-6 blockade abrogates immunotherapy toxicity and promotes tumor immunity. Cancer Cell. 2022;40:509-523.e6 pubmed publisher
Wiede F, Lu K, Du X, Zeissig M, Xu R, Goh P, et al. PTP1B Is an Intracellular Checkpoint that Limits T-cell and CAR T-cell Antitumor Immunity. Cancer Discov. 2022;12:752-773 pubmed publisher
Di Pilato M, Kfuri Rubens R, Pruessmann J, Ozga A, Messemaker M, Cadilha B, et al. CXCR6 positions cytotoxic T cells to receive critical survival signals in the tumor microenvironment. Cell. 2021;: pubmed publisher
Zhang H, Dai D, Hu Q, Yang F, Xue Y, Li F, et al. Bach2 attenuates IL-2R signaling to control Treg homeostasis and Tfr development. Cell Rep. 2021;35:109096 pubmed publisher
Huang H, Zhou P, Wei J, Long L, Shi H, Dhungana Y, et al. In vivo CRISPR screening reveals nutrient signaling processes underpinning CD8+ T cell fate decisions. Cell. 2021;184:1245-1261.e21 pubmed publisher
Su W, Chapman N, Wei J, Zeng H, Dhungana Y, Shi H, et al. Protein Prenylation Drives Discrete Signaling Programs for the Differentiation and Maintenance of Effector Treg Cells. Cell Metab. 2020;32:996-1011.e7 pubmed publisher
Sun Y, Preiss N, Valenteros K, Kamal Y, Usherwood Y, Frost H, et al. Zbtb20 Restrains CD8 T Cell Immunometabolism and Restricts Memory Differentiation and Antitumor Immunity. J Immunol. 2020;205:2649-2666 pubmed publisher
Toubal A, Kiaf B, Beaudoin L, Cagninacci L, Rhimi M, Fruchet B, et al. Mucosal-associated invariant T cells promote inflammation and intestinal dysbiosis leading to metabolic dysfunction during obesity. Nat Commun. 2020;11:3755 pubmed publisher
Yang H, Wang C, Lai Z, Yang S, Zheng Z, Shi J, et al. Decidual stromal cells maintain decidual macrophage homeostasis by secreting IL-24 in early pregnancy. Am J Reprod Immunol. 2020;84:e13261 pubmed publisher
Jin J, Jung I, Moon S, Jeon S, Jeong S, Sonn S, et al. CD137 Signaling Regulates Acute Colitis via RALDH2-Expressing CD11b-CD103+ DCs. Cell Rep. 2020;30:4124-4136.e5 pubmed publisher
Meyer L, Huang B, Delgado Martín C, Roy R, Hechmer A, Wandler A, et al. Glucocorticoids paradoxically facilitate steroid resistance in T cell acute lymphoblastic leukemias and thymocytes. J Clin Invest. 2020;130:863-876 pubmed publisher
Zhu X, Zhang W, Guo J, Zhang X, Li L, Wang T, et al. Noc4L-Mediated Ribosome Biogenesis Controls Activation of Regulatory and Conventional T Cells. Cell Rep. 2019;27:1205-1220.e4 pubmed publisher
Bauche D, Joyce Shaikh B, Jain R, Grein J, Ku K, Blumenschein W, et al. LAG3+ Regulatory T Cells Restrain Interleukin-23-Producing CX3CR1+ Gut-Resident Macrophages during Group 3 Innate Lymphoid Cell-Driven Colitis. Immunity. 2018;49:342-352.e5 pubmed publisher
Sun I, Oh M, Zhao L, Patel C, Arwood M, Xu W, et al. mTOR Complex 1 Signaling Regulates the Generation and Function of Central and Effector Foxp3+ Regulatory T Cells. J Immunol. 2018;201:481-492 pubmed publisher
Herndler Brandstetter D, Ishigame H, Shinnakasu R, Plajer V, Stecher C, Zhao J, et al. KLRG1+ Effector CD8+ T Cells Lose KLRG1, Differentiate into All Memory T Cell Lineages, and Convey Enhanced Protective Immunity. Immunity. 2018;48:716-729.e8 pubmed publisher
Tang J, Sun M, Shi G, Xu Y, Han Y, Li X, et al. Toll-Like Receptor 8 Agonist Strengthens the Protective Efficacy of ESAT-6 Immunization to Mycobacterium tuberculosis Infection. Front Immunol. 2017;8:1972 pubmed publisher
Li Z, Zhang S, Wan Y, Cai M, Wang W, Zhu Y, et al. MicroRNA-146a Overexpression Impairs the Positive Selection during T Cell Development. Front Immunol. 2017;8:2006 pubmed publisher
Jain R, Sheridan J, Policheni A, Heinlein M, Gandolfo L, Dewson G, et al. A critical epithelial survival axis regulated by MCL-1 maintains thymic function in mice. Blood. 2017;130:2504-2515 pubmed publisher
Widjaja C, Olvera J, Metz P, Phan A, Savas J, de Bruin G, et al. Proteasome activity regulates CD8+ T lymphocyte metabolism and fate specification. J Clin Invest. 2017;127:3609-3623 pubmed publisher
Klann J, Remedios K, Kim S, Metz P, Lopez J, Mack L, et al. Talin Plays a Critical Role in the Maintenance of the Regulatory T Cell Pool. J Immunol. 2017;198:4639-4651 pubmed publisher
Wang H, Li M, Hung C, Sinha M, Lee L, Wiesner D, et al. MyD88 Shapes Vaccine Immunity by Extrinsically Regulating Survival of CD4+ T Cells during the Contraction Phase. PLoS Pathog. 2016;12:e1005787 pubmed publisher
Nakamura M, Shibata K, Hatano S, Sato T, Ohkawa Y, Yamada H, et al. A genome-wide analysis identifies a notch-RBP-Jκ-IL-7Rα axis that controls IL-17-producing γδ T cell homeostasis in mice. J Immunol. 2015;194:243-51 pubmed publisher
Beus J, Hashmi S, Selvaraj S, Duan D, Stempora L, Monday S, et al. Heterologous immunity triggered by a single, latent virus in Mus musculus: combined costimulation- and adhesion- blockade decrease rejection. PLoS ONE. 2013;8:e71221 pubmed publisher
Doi K, Fujimoto T, Okamura T, Ogawa M, Tanaka Y, Mototani Y, et al. ZFAT plays critical roles in peripheral T cell homeostasis and its T cell receptor-mediated response. Biochem Biophys Res Commun. 2012;425:107-12 pubmed publisher
Zuber J, Rappaport A, Luo W, Wang E, Chen C, Vaseva A, et al. An integrated approach to dissecting oncogene addiction implicates a Myb-coordinated self-renewal program as essential for leukemia maintenance. Genes Dev. 2011;25:1628-40 pubmed publisher
product information
Antigen :
Bcl-2
Apps. Abbrev. :
ICFC
Cat # :
633509
Clone :
BCL/10C4
Item :
Alexa Fluor® 647 anti-Bcl-2
Isotype :
Mouse IgG1, κ
Other Names :
B-cell leukemia 2
Size :
25 μg
Price (USD) :
129 USD
Reactivity :
Mouse, Rat
Clonality :
Monoclonal
Host :
Mouse
Conjugate/Tag/Label :
A647
Immunogen :
N-terminal, Amino acid residues 61-76 of mouse Bcl-2
Application Notes :
Additional reported applications (for the relevant formats) include: immunohistochemical staining of frozen tissue^4, immunocytochemical staining^5, and immunoprecipitation^5.;
more info or order :
company information
BioLegend
8999 BioLegend Way
San Diego, CA 92121
customerserv@biolegend.com
https://www.biolegend.com
headquarters: USA