This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
BioLegend
other brands :
Babco, Signet, Sternberger Monoclonals, Senetek, Covance
product type :
antibody
product name :
Purified anti-XBP-1s
catalog :
619502
quantity :
200 μl
price :
225 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
clone name :
Poly6195
reactivity :
human, mouse, rat
application :
western blot, chromatin immunoprecipitation, immunohistochemistry - frozen section
citations: 35
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; 1:500; loading ...; fig 5c
Zhu H, Bhatt B, Sivaprakasam S, Cai Y, Liu S, Kodeboyina S, et al. Ufbp1 promotes plasma cell development and ER expansion by modulating distinct branches of UPR. Nat Commun. 2019;10:1084 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:100; loading ...; fig s4b
Wheeler M, Jaronen M, Covacu R, Zandee S, Scalisi G, Rothhammer V, et al. Environmental Control of Astrocyte Pathogenic Activities in CNS Inflammation. Cell. 2019;176:581-596.e18 pubmed publisher
  • western blot; mouse; loading ...; fig 4h
Chapple R, Hu T, Tseng Y, Liu L, Kitano A, Luu V, et al. ERα promotes murine hematopoietic regeneration through the Ire1α-mediated unfolded protein response. elife. 2018;7: pubmed publisher
  • western blot; human; fig 2
Gupta A, Hossain M, Miller N, Kerin M, Callagy G, Gupta S. NCOA3 coactivator is a transcriptional target of XBP1 and regulates PERK-eIF2α-ATF4 signalling in breast cancer. Oncogene. 2016;35:5860-5871 pubmed publisher
  • western blot; human; fig 5
Gupta A, Hossain M, Read D, Hetz C, Samali A, Gupta S. PERK regulated miR-424(322)-503 cluster fine-tunes activation of IRE1 and ATF6 during Unfolded Protein Response. Sci Rep. 2015;5:18304 pubmed publisher
  • western blot; human
Deegan S, Koryga I, Glynn S, Gupta S, Gorman A, Samali A. A close connection between the PERK and IRE arms of the UPR and the transcriptional regulation of autophagy. Biochem Biophys Res Commun. 2015;456:305-11 pubmed publisher
  • western blot; human
Rajapaksa G, Nikolos F, Bado I, Clarke R, Gustafsson J, Thomas C. ERβ decreases breast cancer cell survival by regulating the IRE1/XBP-1 pathway. Oncogene. 2015;34:4130-41 pubmed publisher
Shi Z, Yu X, Yuan M, Lv W, Feng T, Bai R, et al. Activation of the PERK-ATF4 pathway promotes chemo-resistance in colon cancer cells. Sci Rep. 2019;9:3210 pubmed publisher
Chae U, Lee H, Kim B, Jung H, Kim B, Lee A, et al. A negative feedback loop between XBP1 and Fbw7 regulates cancer development. Oncogenesis. 2019;8:12 pubmed publisher
Xu S, Di Z, He Y, Wang R, Ma Y, Sun R, et al. Mesencephalic astrocyte-derived neurotrophic factor (MANF) protects against Aβ toxicity via attenuating Aβ-induced endoplasmic reticulum stress. J Neuroinflammation. 2019;16:35 pubmed publisher
Cai Y, Zhu G, Liu S, Pan Z, Quintero M, Poole C, et al. Indispensable role of the Ubiquitin-fold modifier 1-specific E3 ligase in maintaining intestinal homeostasis and controlling gut inflammation. Cell Discov. 2019;5:7 pubmed publisher
Blackwood E, Azizi K, Thuerauf D, Paxman R, Plate L, Kelly J, et al. Pharmacologic ATF6 activation confers global protection in widespread disease models by reprograming cellular proteostasis. Nat Commun. 2019;10:187 pubmed publisher
Kim S, Woo C. Laminar Flow Inhibits ER Stress-Induced Endothelial Apoptosis through PI3K/Akt-Dependent Signaling Pathway. Mol Cells. 2018;41:964-970 pubmed publisher
Unlu I, Lu Y, Wang X. The cyclic phosphodiesterase CNP and RNA cyclase RtcA fine-tune noncanonical XBP1 splicing during ER stress. J Biol Chem. 2018;293:19365-19376 pubmed publisher
Estornes Y, Dondelinger Y, Weber K, Bruggeman I, Peall A, MacFarlane M, et al. N-glycosylation of mouse TRAIL-R restrains TRAIL-induced apoptosis. Cell Death Dis. 2018;9:494 pubmed publisher
Hossain M, Barua D, Arabkari V, Islam N, Gupta A, Gupta S. Hyperactivation of nuclear receptor coactivators induces PERK-dependent cell death. Oncotarget. 2018;9:11707-11721 pubmed publisher
Tsuchiya Y, Saito M, Kadokura H, Miyazaki J, Tashiro F, Imagawa Y, et al. IRE1-XBP1 pathway regulates oxidative proinsulin folding in pancreatic β cells. J Cell Biol. 2018;217:1287-1301 pubmed publisher
Zhao N, Cao J, Xu L, Tang Q, Dobrolecki L, Lv X, et al. Pharmacological targeting of MYC-regulated IRE1/XBP1 pathway suppresses MYC-driven breast cancer. J Clin Invest. 2018;128:1283-1299 pubmed publisher
Xie H, Tang C, Song J, Mancuso A, Del Valle J, Cao J, et al. IRE1α RNase-dependent lipid homeostasis promotes survival in Myc-transformed cancers. J Clin Invest. 2018;128:1300-1316 pubmed publisher
Guo J, Cui Y, Liu Q, Yang Y, Li Y, Weng L, et al. Piperine ameliorates SCA17 neuropathology by reducing ER stress. Mol Neurodegener. 2018;13:4 pubmed publisher
Ren Z, Wang X, Yang F, Xu M, Frank J, Wang H, et al. Ethanol-induced damage to the developing spinal cord: The involvement of CCR2 signaling. Biochim Biophys Acta Mol Basis Dis. 2017;1863:2746-2761 pubmed publisher
Zhu B, Zhang Q, Pan Y, Mace E, York B, Antoulas A, et al. A Cell-Autonomous Mammalian 12 hr Clock Coordinates Metabolic and Stress Rhythms. Cell Metab. 2017;25:1305-1319.e9 pubmed publisher
Besse W, Dong K, Choi J, Punia S, Fedeles S, Choi M, et al. Isolated polycystic liver disease genes define effectors of polycystin-1 function. J Clin Invest. 2017;127:1772-1785 pubmed publisher
Cho Y, Kim T, Hun Kim D, Hee Kim D, Jeong S, Kwon O. miR-148a is a downstream effector of X-box-binding protein 1 that silences Wnt10b during adipogenesis of 3T3-L1 cells. Exp Mol Med. 2016;48:e226 pubmed publisher
Hassan H, Tian X, Inoue K, Chai N, Liu C, Soda K, et al. Essential Role of X-Box Binding Protein-1 during Endoplasmic Reticulum Stress in Podocytes. J Am Soc Nephrol. 2016;27:1055-65 pubmed publisher
Iwao C, Shidoji Y. Polyunsaturated Branched-Chain Fatty Acid Geranylgeranoic Acid Induces Unfolded Protein Response in Human Hepatoma Cells. PLoS ONE. 2015;10:e0132761 pubmed publisher
Bright M, Itzhak D, Wardell C, Morgan G, Davies F. Cleavage of BLOC1S1 mRNA by IRE1 Is Sequence Specific, Temporally Separate from XBP1 Splicing, and Dispensable for Cell Viability under Acute Endoplasmic Reticulum Stress. Mol Cell Biol. 2015;35:2186-202 pubmed publisher
Sheng X, Arnoldussen Y, Storm M, Tesikova M, Nenseth H, Zhao S, et al. Divergent androgen regulation of unfolded protein response pathways drives prostate cancer. EMBO Mol Med. 2015;7:788-801 pubmed publisher
Vial G, Chauvin M, Bendridi N, Durand A, Meugnier E, Madec A, et al. Imeglimin normalizes glucose tolerance and insulin sensitivity and improves mitochondrial function in liver of a high-fat, high-sucrose diet mice model. Diabetes. 2015;64:2254-64 pubmed publisher
Yang W, Shen Y, Chen Y, Chen L, Wang L, Wang H, et al. Mesencephalic astrocyte-derived neurotrophic factor prevents neuron loss via inhibiting ischemia-induced apoptosis. J Neurol Sci. 2014;344:129-38 pubmed publisher
Chang P, Hung C, Wang S, Tsai P, Shih Y, Chen L, et al. Identification and characterization of two novel spliced genes located in the orf47-orf46-orf45 gene locus of Kaposi's sarcoma-associated herpesvirus. J Virol. 2014;88:10092-109 pubmed publisher
Kawabata S, Gills J, Mercado Matos J, LoPiccolo J, Wilson W, Hollander M, et al. Synergistic effects of nelfinavir and bortezomib on proteotoxic death of NSCLC and multiple myeloma cells. Cell Death Dis. 2012;3:e353 pubmed publisher
Pattison J, Sanbe A, Maloyan A, Osinska H, Klevitsky R, Robbins J. Cardiomyocyte expression of a polyglutamine preamyloid oligomer causes heart failure. Circulation. 2008;117:2743-51 pubmed publisher
Kim K, Pae H, Zheng M, Park R, Kim Y, Chung H. Carbon monoxide induces heme oxygenase-1 via activation of protein kinase R-like endoplasmic reticulum kinase and inhibits endothelial cell apoptosis triggered by endoplasmic reticulum stress. Circ Res. 2007;101:919-27 pubmed
Thuerauf D, Marcinko M, Gude N, Rubio M, Sussman M, Glembotski C. Activation of the unfolded protein response in infarcted mouse heart and hypoxic cultured cardiac myocytes. Circ Res. 2006;99:275-82 pubmed
product information
Antigen :
Xbp-1 (COOH terminus)
Apps. Abbrev. :
Western Blotting, ChIP
Cat # :
619502
Clone :
Poly6195
Item :
Purified anti-XBP-1s
Isotype :
Rabbit Polyclonal IgG
Other Names :
X-box binding protein 1
Size :
200 μl
Price (USD) :
225 USD
Reactivity :
Human, Rat, and weak reactive with Mouse; recognizes the 54 kD form
Clonality :
Polyclonal
Host :
Rabbit
Conjugate/Tag/Label :
PURE
Immunogen :
Peptide
Application Notes :
Additional reported applications (for the relevant formats) include: chromatin immunoprecipitation 8 . . This product may contain other non-IgG subtypes.
company information
BioLegend
9727 Pacific Heights Blvd.
San Diego, CA 92121
customerserv@biolegend.com
https://www.biolegend.com
headquarters: USA