product summary
Loading...
company name :
BioLegend
other brands :
Babco, Signet, Sternberger Monoclonals, Senetek, Covance
product type :
protein
product name :
Recombinant Mouse IL-6 (carrier-free)
catalog :
575708
quantity :
500 μg
price :
1875 USD
more info or order :
citations: 48
Reference
Istomine R, Al Aubodah T, Alvarez F, Smith J, WAGNER C, Piccirillo C. The eIF4EBP-eIF4E axis regulates CD4+ T cell differentiation through modulation of T cell activation and metabolism. iScience. 2023;26:106683 pubmed publisher
Aso K, Kono M, Kanda M, Kudo Y, Sakiyama K, Hisada R, et al. Itaconate ameliorates autoimmunity by modulating T cell imbalance via metabolic and epigenetic reprogramming. Nat Commun. 2023;14:984 pubmed publisher
Merchak A, Cahill H, Brown L, Brown R, Rivet Noor C, Beiter R, et al. The activity of the aryl hydrocarbon receptor in T cells tunes the gut microenvironment to sustain autoimmunity and neuroinflammation. PLoS Biol. 2023;21:e3002000 pubmed publisher
Karino K, Kono M, Takeyama S, Kudo Y, Kanda M, Abe N, et al. Inhibitor of NF-κB Kinase Subunit ε Contributes to Neuropsychiatric Manifestations in Lupus-Prone Mice Through Microglial Activation. Arthritis Rheumatol. 2023;75:411-423 pubmed publisher
Yu Y, Yang W, Yu T, Zhao X, Zhou Z, Yu Y, et al. Glucose promotes regulatory T cell differentiation to maintain intestinal homeostasis. iScience. 2022;25:105004 pubmed publisher
Smith K, Minns D, McHugh B, Holloway R, O CONNOR R, Williams A, et al. The antimicrobial peptide cathelicidin drives development of experimental autoimmune encephalomyelitis in mice by affecting Th17 differentiation. PLoS Biol. 2022;20:e3001554 pubmed publisher
Shen H, Huang F, Zhang X, Ojo O, Li Y, Trummell H, et al. Selective suppression of melanoma lacking IFN-γ pathway by JAK inhibition depends on T cells and host TNF signaling. Nat Commun. 2022;13:5013 pubmed publisher
Hsieh T, Sasaki D, Taira N, Chien H, Sarkar S, Seto Y, et al. JunB Is Critical for Survival of T Helper Cells. Front Immunol. 2022;13:901030 pubmed publisher
Li T, Bou Dargham M, Fultang N, Li X, Pear W, Sun H, et al. c-Rel-dependent monocytes are potent immune suppressor cells in cancer. J Leukoc Biol. 2022;112:845-859 pubmed publisher
Guo H, Ju Y, Choi M, Edman M, Louie S, Hamm Alvarez S, et al. Supra-lacrimal protein-based carriers for cyclosporine A reduce Th17-mediated autoimmunity in murine model of Sjögren's syndrome. Biomaterials. 2022;283:121441 pubmed publisher
Chen Y, Liu R, Cui Y, Hettinghouse A, Fu W, Zhang L, et al. Penfluridol targets acid sphingomyelinase to inhibit TNF signaling and is therapeutic against inflammatory autoimmune diseases. Arthritis Res Ther. 2022;24:27 pubmed publisher
Teh M, Frost J, Armitage A, Drakesmith H. Analysis of Iron and Iron-Interacting Protein Dynamics During T-Cell Activation. Front Immunol. 2021;12:714613 pubmed publisher
Hanley K, Liang Y, Wang G, Lin X, Yang M, Karin M, et al. Concurrent Disruption of the Ras/MAPK and NF-κB Pathways Induces Circadian Deregulation and Hepatocarcinogenesis. Mol Cancer Res. 2022;20:337-349 pubmed publisher
Miki S, Suzuki J, Takashima M, Ishida M, Kokubo H, Yoshizumi M. S-1-Propenylcysteine promotes IL-10-induced M2c macrophage polarization through prolonged activation of IL-10R/STAT3 signaling. Sci Rep. 2021;11:22469 pubmed publisher
Chao J, Korzinkin M, Zhavoronkov A, Ozerov I, Walker M, Higgins K, et al. Effector T cell responses unleashed by regulatory T cell ablation exacerbate oral squamous cell carcinoma. Cell Rep Med. 2021;2:100399 pubmed publisher
Xu K, Li M. Delivery of membrane impermeable molecules to primary mouse T lymphocytes. STAR Protoc. 2021;2:100757 pubmed publisher
Hao L, Mao Y, Park J, Bae E, Park B. Repurposing the anthelmintic praziquantel to treat psoriasis. Br J Pharmacol. 2021;178:4726-4740 pubmed publisher
Yang F, He Z, Duan H, Zhang D, Li J, Yang H, et al. Synergistic immunotherapy of glioblastoma by dual targeting of IL-6 and CD40. Nat Commun. 2021;12:3424 pubmed publisher
Swan G, Geng J, Park E, Ding Q, Zhou J, Walcott C, et al. A Requirement of Protein Geranylgeranylation for Chemokine Receptor Signaling and Th17 Cell Function in an Animal Model of Multiple Sclerosis. Front Immunol. 2021;12:641188 pubmed publisher
Minns D, Smith K, Alessandrini V, Hardisty G, Melrose L, Jackson Jones L, et al. The neutrophil antimicrobial peptide cathelicidin promotes Th17 differentiation. Nat Commun. 2021;12:1285 pubmed publisher
Foley K, Chen Y, Barra N, Heal M, Kwok K, Tamrakar A, et al. Inflammation promotes adipocyte lipolysis via IRE1 kinase. J Biol Chem. 2021;296:100440 pubmed publisher
Kurashima Y, Kigoshi T, Murasaki S, Arai F, Shimada K, Seki N, et al. Pancreatic glycoprotein 2 is a first line of defense for mucosal protection in intestinal inflammation. Nat Commun. 2021;12:1067 pubmed publisher
Cartwright A, Suo S, Badrinath S, Kumar S, Melms J, Luoma A, et al. Immunosuppressive Myeloid Cells Induce Nitric Oxide-Dependent DNA Damage and p53 Pathway Activation in CD8+ T Cells. Cancer Immunol Res. 2021;9:470-485 pubmed publisher
Wu B, Zhang S, Guo Z, Bi Y, Zhou M, Li P, et al. The TGF-β superfamily cytokine Activin-A is induced during autoimmune neuroinflammation and drives pathogenic Th17 cell differentiation. Immunity. 2021;54:308-323.e6 pubmed publisher
Al Dow M, Silveira M, Poliquin A, Tribouillard L, Fournier E, Trébaol E, et al. Control of adipogenic commitment by a STAT3-VSTM2A axis. Am J Physiol Endocrinol Metab. 2021;320:E259-E269 pubmed publisher
Pariser D, Hilt Z, Ture S, Blick Nitko S, Looney M, Cleary S, et al. Lung megakaryocytes are immune modulatory cells. J Clin Invest. 2021;131: pubmed publisher
Hsieh W, Svensson M, Zoccheddu M, Tremblay M, Sakaguchi S, Stanford S, et al. PTPN2 links colonic and joint inflammation in experimental autoimmune arthritis. JCI Insight. 2020;5: pubmed publisher
Ramstead A, Wallace J, Lee S, Bauer K, Tang W, Ekiz H, et al. Mitochondrial Pyruvate Carrier 1 Promotes Peripheral T Cell Homeostasis through Metabolic Regulation of Thymic Development. Cell Rep. 2020;30:2889-2899.e6 pubmed publisher
Sorg I, Schmutz C, Lu Y, Fromm K, Siewert L, B xf6 gli A, et al. A Bartonella Effector Acts as Signaling Hub for Intrinsic STAT3 Activation to Trigger Anti-inflammatory Responses. Cell Host Microbe. 2020;27:476-485.e7 pubmed publisher
Shin B, Benavides G, Geng J, Koralov S, Hu H, Darley Usmar V, et al. Mitochondrial Oxidative Phosphorylation Regulates the Fate Decision between Pathogenic Th17 and Regulatory T Cells. Cell Rep. 2020;30:1898-1909.e4 pubmed publisher
Tonsawan P, Dylewski J, Lewis L, Blaine J. Knockout of the neonatal Fc receptor in cultured podocytes alters IL-6 signaling and the actin cytoskeleton. Am J Physiol Cell Physiol. 2019;317:C1048-C1060 pubmed publisher
Li W, Qu G, Choi S, Cornaby C, Titov A, Kanda N, et al. Targeting T Cell Activation and Lupus Autoimmune Phenotypes by Inhibiting Glucose Transporters. Front Immunol. 2019;10:833 pubmed publisher
Paris J, Morgan M, Campos J, Spencer G, Shmakova A, Ivanova I, et al. Targeting the RNA m6A Reader YTHDF2 Selectively Compromises Cancer Stem Cells in Acute Myeloid Leukemia. Cell Stem Cell. 2019;: pubmed publisher
Xu Y, Melo Cardenas J, Zhang Y, Gau I, Wei J, Montauti E, et al. The E3 ligase Hrd1 stabilizes Tregs by antagonizing inflammatory cytokine-induced ER stress response. JCI Insight. 2019;4: pubmed publisher
Martínez López M, Iborra S, Conde Garrosa R, Mastrangelo A, Danne C, Mann E, et al. Microbiota Sensing by Mincle-Syk Axis in Dendritic Cells Regulates Interleukin-17 and -22 Production and Promotes Intestinal Barrier Integrity. Immunity. 2019;50:446-461.e9 pubmed publisher
Seboko A, Conradie M, Kruger M, Ferris W, Conradie M, van de Vyver M. Systemic Factors During Metabolic Disease Progression Contribute to the Functional Decline of Adipose Tissue-Derived Mesenchymal Stem Cells in Reproductive Aged Females. Front Physiol. 2018;9:1812 pubmed publisher
Ren W, Liao Y, Ding X, Jiang Y, Yan J, Xia Y, et al. Slc6a13 deficiency promotes Th17 responses during intestinal bacterial infection. Mucosal Immunol. 2019;12:531-544 pubmed publisher
Bachran C, Schröder M, Conrad L, Cragnolini J, Tafesse F, Helming L, et al. The activity of myeloid cell-specific VHH immunotoxins is target-, epitope-, subset- and organ dependent. Sci Rep. 2017;7:17916 pubmed publisher
Chen X, Deng H, Churchill M, Luchsinger L, Du X, Chu T, et al. Bone Marrow Myeloid Cells Regulate Myeloid-Biased Hematopoietic Stem Cells via a Histamine-Dependent Feedback Loop. Cell Stem Cell. 2017;21:747-760.e7 pubmed publisher
Xu L, Huang Q, Wang H, Hao Y, Bai Q, Hu J, et al. The Kinase mTORC1 Promotes the Generation and Suppressive Function of Follicular Regulatory T Cells. Immunity. 2017;47:538-551.e5 pubmed publisher
Gumusoglu S, Fine R, Murray S, Bittle J, Stevens H. The role of IL-6 in neurodevelopment after prenatal stress. Brain Behav Immun. 2017;65:274-283 pubmed publisher
Singh R, Miao T, Symonds A, Omodho B, Li S, Wang P. Egr2 and 3 Inhibit T-bet-Mediated IFN-? Production in T Cells. J Immunol. 2017;198:4394-4402 pubmed publisher
Khosravi F, Loeian S, Panchapakesan B. Ultrasensitive Label-Free Sensing of IL-6 Based on PASE Functionalized Carbon Nanotube Micro-Arrays with RNA-Aptamers as Molecular Recognition Elements. Biosensors (Basel). 2017;7: pubmed publisher
Lin C, Bradstreet T, Schwarzkopf E, Jarjour N, Chou C, Archambault A, et al. IL-1-induced Bhlhe40 identifies pathogenic T helper cells in a model of autoimmune neuroinflammation. J Exp Med. 2016;213:251-71 pubmed publisher
Bremser A, Brack M, Izcue A. Higher Sensitivity of Foxp3+ Treg Compared to Foxp3- Conventional T Cells to TCR-Independent Signals for CD69 Induction. PLoS ONE. 2015;10:e0137393 pubmed publisher
Allen M, Fan Y, Monk J, Hou T, Barhoumi R, McMurray D, et al. n-3 PUFAs reduce T-helper 17 cell differentiation by decreasing responsiveness to interleukin-6 in isolated mouse splenic CD4? T cells. J Nutr. 2014;144:1306-13 pubmed publisher
Suzuki T, Yoshinaga N, Tanabe S. Interleukin-6 (IL-6) regulates claudin-2 expression and tight junction permeability in intestinal epithelium. J Biol Chem. 2011;286:31263-71 pubmed publisher
Wang Q, Li H, Yao Y, Xia D, Zhou J. The overexpression of heparin-binding epidermal growth factor is responsible for Th17-induced airway remodeling in an experimental asthma model. J Immunol. 2010;185:834-41 pubmed publisher
product information
Antigen :
IL-6
Apps. Abbrev. :
BA
Cat # :
575708
Item :
Recombinant Mouse IL-6 (carrier-free)
Other Names :
Interleukin-6, Interferon-β2, B cell stimulating factor-2 (BSF-2), Cytotoxic T cell differentiation factor (CDF), Hepatocyte stimulating factor (HSF), Hybridoma/plasmacytoma growth factor (HPGF)
Size :
500 μg
Price (USD) :
1875 USD
Reactivity :
Mouse
Host :
ADD EXPRESSION SYSTEM HERE
Conjugate/Tag/Label :
RECOM
Application Notes :
BioLegend carrier-free recombinant proteins provided in liquid format are shipped on blue-ice. Our comparison testing data indicates that when handled and stored as recommended, the liquid format has equal or better stability and shelf-life compared to commercially available lyophilized proteins after reconstitution. Our liquid proteins are verified in-house to maintain activity after shipping on blue ice and are backed by our 100% satisfaction guarantee. If you have any concerns, contact us at tech@biolegend.com.;
more info or order :
company information
BioLegend
8999 BioLegend Way
San Diego, CA 92121
customerserv@biolegend.com
https://www.biolegend.com
headquarters: USA