product summary
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company name :
BioLegend
other brands :
Babco, Signet, Sternberger Monoclonals, Senetek, Covance
product type :
antibody
product name :
PE/Dazzle™ 594 anti-mouse IL-17A
catalog :
506938
quantity :
100 μg
price :
347 USD
clonality :
monoclonal
host :
rat
conjugate :
PE
clone name :
TC11-18H10.1
reactivity :
mouse
application :
immunocytochemistry, flow cytometry
more info or order :
citations: 25
Published Application/Species/Sample/DilutionReference
  • flow cytometry; mouse; 1:100; loading ...; fig s1e
Smith K, Minns D, McHugh B, Holloway R, O CONNOR R, Williams A, et al. The antimicrobial peptide cathelicidin drives development of experimental autoimmune encephalomyelitis in mice by affecting Th17 differentiation. PLoS Biol. 2022;20:e3001554 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 1c, 4d
Aarts J, van Caam A, Chen X, Marijnissen R, Helsen M, Walgreen B, et al. Local inhibition of TGF-β1 signaling improves Th17/Treg balance but not joint pathology during experimental arthritis. Sci Rep. 2022;12:3182 pubmed publisher
  • flow cytometry; mouse; fig 2b
Tanaka Y, Onozato M, Mikami T, Kohwi Shigematsu T, Fukushima T, Kondo M. Increased Indoleamine 2,3-Dioxygenase Levels at the Onset of Sjögren's Syndrome in SATB1-Conditional Knockout Mice. Int J Mol Sci. 2021;22: pubmed publisher
  • flow cytometry; mouse; 1:100; loading ...; fig 1a
Minns D, Smith K, Alessandrini V, Hardisty G, Melrose L, Jackson Jones L, et al. The neutrophil antimicrobial peptide cathelicidin promotes Th17 differentiation. Nat Commun. 2021;12:1285 pubmed publisher
  • flow cytometry; mouse; 2 ug/ml; loading ...; fig s2f
Gil Cruz C, Perez Shibayama C, De Martin A, Ronchi F, Van der Borght K, Niederer R, et al. Microbiota-derived peptide mimics drive lethal inflammatory cardiomyopathy. Science. 2019;366:881-886 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 4f
Karmaus P, Chen X, Lim S, Herrada A, Nguyen T, Xu B, et al. Metabolic heterogeneity underlies reciprocal fates of TH17 cell stemness and plasticity. Nature. 2019;565:101-105 pubmed publisher
  • flow cytometry; mouse; loading ...; fig s4c
Metghalchi S, Vandestienne M, Haddad Y, Esposito B, Dairou J, Tedgui A, et al. Indoleamine 2 3-dioxygenase knockout limits angiotensin II-induced aneurysm in low density lipoprotein receptor-deficient mice fed with high fat diet. PLoS ONE. 2018;13:e0193737 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 3a
Contreras F, Prado C, Gonzalez H, Franz D, Osorio Barrios F, Osorio F, et al. Dopamine Receptor D3 Signaling on CD4+ T Cells Favors Th1- and Th17-Mediated Immunity. J Immunol. 2016;196:4143-9 pubmed publisher
  • flow cytometry; mouse; fig 4
Charlton J, Tsoukatou D, Mamalaki C, Chatzidakis I. Programmed death 1 regulates memory phenotype CD4 T cell accumulation, inhibits expansion of the effector memory phenotype subset and modulates production of effector cytokines. PLoS ONE. 2015;10:e0119200 pubmed publisher
  • flow cytometry; mouse; fig s1
Kim Y, Lim H, Jung H, Wetsel R, Chung Y. Regulation of autoimmune germinal center reactions in lupus-prone BXD2 mice by follicular helper T cells. PLoS ONE. 2015;10:e0120294 pubmed publisher
  • flow cytometry; mouse; fig 7
Cao A, Yao S, Gong B, Nurieva R, Elson C, Cong Y. Interleukin (IL)-21 promotes intestinal IgA response to microbiota. Mucosal Immunol. 2015;8:1072-82 pubmed publisher
  • flow cytometry; mouse
Kuwahara M, Suzuki J, Tofukuji S, Yamada T, Kanoh M, Matsumoto A, et al. The Menin-Bach2 axis is critical for regulating CD4 T-cell senescence and cytokine homeostasis. Nat Commun. 2014;5:3555 pubmed publisher
Schepers M, Paes D, Tiane A, Rombaut B, Piccart E, van Veggel L, et al. Selective PDE4 subtype inhibition provides new opportunities to intervene in neuroinflammatory versus myelin damaging hallmarks of multiple sclerosis. Brain Behav Immun. 2022;109:1-22 pubmed publisher
Jowett G, Read E, Roberts L, Coman D, Vil xe0 Gonz xe1 lez M, Zabinski T, et al. Organoids capture tissue-specific innate lymphoid cell development in mice and humans. Cell Rep. 2022;40:111281 pubmed publisher
Imani J, Liu K, Cui Y, Assaker J, Han J, Ghosh A, et al. Blocking hyaluronan synthesis alleviates acute lung allograft rejection. JCI Insight. 2021;6: pubmed publisher
Bogie J, Grajchen E, Wouters E, Broux B, Stinissen P, Van Wijmeersch B, et al. CNS delivery of anti-CD52 antibodies modestly reduces disease severity in an animal model for multiple sclerosis. Ther Adv Chronic Dis. 2020;11:2040622320947378 pubmed publisher
Ge C, Monk I, Pizzolla A, Wang N, Bedford J, Stinear T, et al. Bystander Activation of Pulmonary Trm Cells Attenuates the Severity of Bacterial Pneumonia by Enhancing Neutrophil Recruitment. Cell Rep. 2019;29:4236-4244.e3 pubmed publisher
Murakami R, Denda Nagai K, Hashimoto S, Nagai S, Hattori M, Irimura T. A unique dermal dendritic cell subset that skews the immune response toward Th2. PLoS ONE. 2013;8:e73270 pubmed publisher
Ma Y, Zhang X, Bao H, Mi S, Cai W, Yan H, et al. Toll-like receptor (TLR) 2 and TLR4 differentially regulate doxorubicin induced cardiomyopathy in mice. PLoS ONE. 2012;7:e40763 pubmed publisher
Cooney L, Towery K, Endres J, Fox D. Sensitivity and resistance to regulation by IL-4 during Th17 maturation. J Immunol. 2011;187:4440-50 pubmed publisher
Cui Y, Shao H, Sun D, Kaplan H. Regulation of interphotoreceptor retinoid-binding protein (IRBP)-specific Th1 and Th17 cells in anterior chamber-associated immune deviation (ACAID). Invest Ophthalmol Vis Sci. 2009;50:5811-7 pubmed publisher
Wang C, Kang S, Lee J, Sun Z, Kim C. The roles of CCR6 in migration of Th17 cells and regulation of effector T-cell balance in the gut. Mucosal Immunol. 2009;2:173-83 pubmed publisher
Smith E, Stark M, Zarbock A, Burcin T, Bruce A, Vaswani D, et al. IL-17A inhibits the expansion of IL-17A-producing T cells in mice through "short-loop" inhibition via IL-17 receptor. J Immunol. 2008;181:1357-64 pubmed
Kivisakk P, Imitola J, Rasmussen S, Elyaman W, Zhu B, Ransohoff R, et al. Localizing central nervous system immune surveillance: meningeal antigen-presenting cells activate T cells during experimental autoimmune encephalomyelitis. Ann Neurol. 2009;65:457-69 pubmed publisher
Neufert C, Becker C, Wirtz S, Fantini M, Weigmann B, Galle P, et al. IL-27 controls the development of inducible regulatory T cells and Th17 cells via differential effects on STAT1. Eur J Immunol. 2007;37:1809-16 pubmed
product information
Antigen :
IL-17A
Apps. Abbrev. :
ICFC
Cat # :
506938
Clone :
TC11-18H10.1
Item :
PE/Dazzle™ 594 anti-mouse IL-17A
Isotype :
Rat IgG1, κ
Other Names :
Interleukin-17, Cytotoxic T lymphocyte-associated antigen 8 (CTLA-8)
Size :
100 μg
Price (USD) :
347 USD
Reactivity :
Mouse
Clonality :
Monoclonal
Host :
Rat
Conjugate/Tag/Label :
PE_DZL594
Immunogen :
E. coli expressed, recombinant mouse IL-17A
Application Notes :
ELISA Capture^3,4 and ELISPOT Capture^5: The purified TC11-18H10.1 antibody is useful as the capture antibody in a sandwich ELISA, when used in conjunction with the biotinylated TC11-8H4 antibody (Cat. No. 507002) as the detecting antibody and recombinant mouse IL-17 (Cat. No. 576009) as the standard.Flow Cytometry^2-4,7,8,11,12: The TC11-18H10.1 antibody is useful for intracellular immunofluorescent staining and flow cytometric analysis to identify IL-17-producing cells within mixed cell populations.Neutralization^6,9: The LEAF™ purified antibody (Endotoxin <0.1 EU/µg, Azide-Free, 0.2 µm filtered) is recommended for neutralization of mouse IL-17 bioactivity in vivo and in vitro (Cat. No. 506906).;
more info or order :
company information
BioLegend
8999 BioLegend Way
San Diego, CA 92121
customerserv@biolegend.com
https://www.biolegend.com
headquarters: USA