product summary
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company name :
BioLegend
other brands :
Babco, Signet, Sternberger Monoclonals, Senetek, Covance
product type :
antibody
product name :
Brilliant Violet 421™ anti-mouse IL-17A
catalog :
506926
quantity :
50 μg
price :
248 USD
clonality :
monoclonal
host :
rat
conjugate :
BV421
clone name :
TC11-18H10.1
reactivity :
mouse
application :
immunocytochemistry, flow cytometry
more info or order :
citations: 38
Published Application/Species/Sample/DilutionReference
  • flow cytometry; mouse; 1:100; loading ...; fig s9e
Bielecki P, Riesenfeld S, Hütter J, Torlai Triglia E, Kowalczyk M, Ricardo Gonzalez R, et al. Skin-resident innate lymphoid cells converge on a pathogenic effector state. Nature. 2021;592:128-132 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 3a
Cohen J, Edwards T, Liu A, Hirai T, Jones M, Wu J, et al. Cutaneous TRPV1+ Neurons Trigger Protective Innate Type 17 Anticipatory Immunity. Cell. 2019;178:919-932.e14 pubmed publisher
Dijkman K, Lindenstr xf8 m T, Rosenkrands I, S xf8 e R, Woodworth J, Lindestam Arlehamn C, et al. A protective, single-visit TB vaccination regimen by co-administration of a subunit vaccine with BCG. NPJ Vaccines. 2023;8:66 pubmed publisher
Latour Y, Allaman M, Barry D, Smith T, Williams K, McNamara K, et al. Epithelial talin-1 protects mice from citrobacter rodentium-induced colitis by restricting bacterial crypt intrusion and enhancing t cell immunity. Gut Microbes. 2023;15:2192623 pubmed publisher
Xu H, Zhao Y, Zhao Q, Shi M, Zhang Z, Ding W, et al. Tuberous Sclerosis Complex 1 Deficiency in Macrophages Promotes Unclassical Inflammatory Response to Lipopolysaccharide In Vitro and Dextran Sodium Sulfate-Induced Colitis in Mice. Aging Dis. 2022;13:1875-1890 pubmed publisher
Klaus T, Wilson A, Vicari E, Hadaschik E, Klein M, Helbich S, et al. Impaired Treg-DC interactions contribute to autoimmunity in leukocyte adhesion deficiency type 1. JCI Insight. 2022;7: pubmed publisher
Bout xe9 M, Ait Yahia S, Fan Y, Alvarez Simón D, Vorng H, Balsamelli J, et al. NOD2 Signaling Circuitry during Allergen Sensitization Does Not Worsen Experimental Neutrophilic Asthma but Promotes a Th2/Th17 Profile in Asthma Patients but Not Healthy Subjects. Int J Mol Sci. 2022;23: pubmed publisher
McCauley K, Rackaityte E, LaMere B, Fadrosh D, Fujimura K, Panzer A, et al. Heritable vaginal bacteria influence immune tolerance and relate to early-life markers of allergic sensitization in infancy. Cell Rep Med. 2022;3:100713 pubmed publisher
Palathingal Bava E, George J, Tarique M, Iyer S, Sahay P, Gomez Aguilar B, et al. Pirfenidone increases IL-10 and improves acute pancreatitis in multiple clinically relevant murine models. JCI Insight. 2022;7: pubmed publisher
Gupta S, Li D, Ostrov D, Nguyen C. Blocking IAg7 class II major histocompatibility complex by drug-like small molecules alleviated Sjögren's syndrome in NOD mice. Life Sci. 2022;288:120182 pubmed publisher
Shen X, Zhang H, Xie H, Chen L, Li S, Zheng J, et al. Reduced CCR6+IL-17A+Treg Cells in Blood and CCR6-Dependent Accumulation of IL-17A+Treg Cells in Lungs of Patients With Allergic Asthma. Front Immunol. 2021;12:710750 pubmed publisher
Yang L, Li N, Yang D, Chen A, Tang J, Jing Y, et al. CCL2 regulation of MST1-mTOR-STAT1 signaling axis controls BCR signaling and B-cell differentiation. Cell Death Differ. 2021;: pubmed publisher
Sanchez Felipe L, Vercruysse T, Sharma S, Ma J, Lemmens V, Van Looveren D, et al. A single-dose live-attenuated YF17D-vectored SARS-CoV-2 vaccine candidate. Nature. 2021;590:320-325 pubmed publisher
Du Z, Chen A, Huang L, Dai X, Chen Q, Yang D, et al. STAT3 couples with 14-3-3σ to regulate BCR signaling, B-cell differentiation, and IgE production. J Allergy Clin Immunol. 2021;147:1907-1923.e6 pubmed publisher
Zeng F, Chen H, Chen L, Mao J, Cai S, Xiao Y, et al. An Autocrine Circuit of IL-33 in Keratinocytes Is Involved in the Progression of Psoriasis. J Invest Dermatol. 2021;141:596-606.e7 pubmed publisher
Chong W, Mattapallil M, Raychaudhuri K, Bing S, Wu S, Zhong Y, et al. The Cytokine IL-17A Limits Th17 Pathogenicity via a Negative Feedback Loop Driven by Autocrine Induction of IL-24. Immunity. 2020;53:384-397.e5 pubmed publisher
Jing Y, Dai X, Yang L, Kang D, Jiang P, Li N, et al. STING couples with PI3K to regulate actin reorganization during BCR activation. Sci Adv. 2020;6:eaax9455 pubmed publisher
Sharma N, Gupta V, Garrido V, Hadad R, Durden B, Kesh K, et al. Targeting tumor-intrinsic hexosamine biosynthesis sensitizes pancreatic cancer to anti-PD1 therapy. J Clin Invest. 2020;130:451-465 pubmed publisher
Sendler M, van den Brandt C, Glaubitz J, Wilden A, Golchert J, Weiss F, et al. NLRP3 Inflammasome Regulates Development of Systemic Inflammatory Response and Compensatory Anti-Inflammatory Response Syndromes in Mice With Acute Pancreatitis. Gastroenterology. 2020;158:253-269.e14 pubmed publisher
Findlay E, Currie A, Zhang A, Ovciarikova J, Young L, Stevens H, et al. Exposure to the antimicrobial peptide LL-37 produces dendritic cells optimized for immunotherapy. Oncoimmunology. 2019;8:1608106 pubmed publisher
Ning X, Wang Y, Jing M, Sha M, Lv M, Gao P, et al. Apoptotic Caspases Suppress Type I Interferon Production via the Cleavage of cGAS, MAVS, and IRF3. Mol Cell. 2019;74:19-31.e7 pubmed publisher
Nagai Y, Ji M, Zhu F, Xiao Y, Tanaka Y, Kambayashi T, et al. PRMT5 Associates With the FOXP3 Homomer and When Disabled Enhances Targeted p185erbB2/neu Tumor Immunotherapy. Front Immunol. 2019;10:174 pubmed publisher
Kim M, Galan C, Hill A, Wu W, Fehlner Peach H, Song H, et al. Critical Role for the Microbiota in CX3CR1+ Intestinal Mononuclear Phagocyte Regulation of Intestinal T Cell Responses. Immunity. 2018;49:151-163.e5 pubmed publisher
Hirota K, Hashimoto M, Ito Y, Matsuura M, Ito H, Tanaka M, et al. Autoimmune Th17 Cells Induced Synovial Stromal and Innate Lymphoid Cell Secretion of the Cytokine GM-CSF to Initiate and Augment Autoimmune Arthritis. Immunity. 2018;48:1220-1232.e5 pubmed publisher
Haertel E, Joshi N, Hiebert P, Kopf M, Werner S. Regulatory T cells are required for normal and activin-promoted wound repair in mice. Eur J Immunol. 2018;48:1001-1013 pubmed publisher
Alves C, Ober Blöbaum J, Brouwers Haspels I, Asmawidjaja P, Mus A, Razawy W, et al. Dendritic Cell-Specific Deletion of β-Catenin Results in Fewer Regulatory T-Cells without Exacerbating Autoimmune Collagen-Induced Arthritis. PLoS ONE. 2015;10:e0142972 pubmed publisher
Cabrera Perez J, Condotta S, James B, Kashem S, Brincks E, Rai D, et al. Alterations in antigen-specific naive CD4 T cell precursors after sepsis impairs their responsiveness to pathogen challenge. J Immunol. 2015;194:1609-20 pubmed publisher
Murakami R, Denda Nagai K, Hashimoto S, Nagai S, Hattori M, Irimura T. A unique dermal dendritic cell subset that skews the immune response toward Th2. PLoS ONE. 2013;8:e73270 pubmed publisher
Kawabe T, Sun S, Fujita T, Yamaki S, Asao A, Takahashi T, et al. Homeostatic proliferation of naive CD4+ T cells in mesenteric lymph nodes generates gut-tropic Th17 cells. J Immunol. 2013;190:5788-98 pubmed publisher
Bergink V, Burgerhout K, Weigelt K, Pop V, de Wit H, Drexhage R, et al. Immune system dysregulation in first-onset postpartum psychosis. Biol Psychiatry. 2013;73:1000-7 pubmed publisher
Leeansyah E, Ganesh A, Quigley M, Sonnerborg A, Andersson J, Hunt P, et al. Activation, exhaustion, and persistent decline of the antimicrobial MR1-restricted MAIT-cell population in chronic HIV-1 infection. Blood. 2013;121:1124-35 pubmed publisher
Ma Y, Zhang X, Bao H, Mi S, Cai W, Yan H, et al. Toll-like receptor (TLR) 2 and TLR4 differentially regulate doxorubicin induced cardiomyopathy in mice. PLoS ONE. 2012;7:e40763 pubmed publisher
Cooney L, Towery K, Endres J, Fox D. Sensitivity and resistance to regulation by IL-4 during Th17 maturation. J Immunol. 2011;187:4440-50 pubmed publisher
Cui Y, Shao H, Sun D, Kaplan H. Regulation of interphotoreceptor retinoid-binding protein (IRBP)-specific Th1 and Th17 cells in anterior chamber-associated immune deviation (ACAID). Invest Ophthalmol Vis Sci. 2009;50:5811-7 pubmed publisher
Wang C, Kang S, Lee J, Sun Z, Kim C. The roles of CCR6 in migration of Th17 cells and regulation of effector T-cell balance in the gut. Mucosal Immunol. 2009;2:173-83 pubmed publisher
Smith E, Stark M, Zarbock A, Burcin T, Bruce A, Vaswani D, et al. IL-17A inhibits the expansion of IL-17A-producing T cells in mice through "short-loop" inhibition via IL-17 receptor. J Immunol. 2008;181:1357-64 pubmed
Kivisakk P, Imitola J, Rasmussen S, Elyaman W, Zhu B, Ransohoff R, et al. Localizing central nervous system immune surveillance: meningeal antigen-presenting cells activate T cells during experimental autoimmune encephalomyelitis. Ann Neurol. 2009;65:457-69 pubmed publisher
Neufert C, Becker C, Wirtz S, Fantini M, Weigmann B, Galle P, et al. IL-27 controls the development of inducible regulatory T cells and Th17 cells via differential effects on STAT1. Eur J Immunol. 2007;37:1809-16 pubmed
product information
Antigen :
IL-17A
Apps. Abbrev. :
ICFC
Cat # :
506926
Clone :
TC11-18H10.1
Item :
Brilliant Violet 421™ anti-mouse IL-17A
Isotype :
Rat IgG1, κ
Other Names :
Interleukin-17, Cytotoxic T lymphocyte-associated antigen 8 (CTLA-8)
Size :
50 μg
Price (USD) :
248 USD
Reactivity :
Mouse
Clonality :
Monoclonal
Host :
Rat
Conjugate/Tag/Label :
BV421
Immunogen :
E. coli expressed, recombinant mouse IL-17A
Application Notes :
ELISA Capture^3,4 and ELISPOT Capture^5: The purified TC11-18H10.1 antibody is useful as the capture antibody in a sandwich ELISA, when used in conjunction with the biotinylated TC11-8H4 antibody (Cat. No. 507002) as the detecting antibody and recombinant mouse IL-17 (Cat. No. 576009) as the standard.Flow Cytometry^2-4,7,8,11,12: The TC11-18H10.1 antibody is useful for intracellular immunofluorescent staining and flow cytometric analysis to identify IL-17-producing cells within mixed cell populations.Neutralization^6,9: The LEAF™ purified antibody (Endotoxin <0.1 EU/µg, Azide-Free, 0.2 µm filtered) is recommended for neutralization of mouse IL-17 bioactivity in vivo and in vitro (Cat. No. 506906).;
more info or order :
company information
BioLegend
8999 BioLegend Way
San Diego, CA 92121
customerserv@biolegend.com
https://www.biolegend.com
headquarters: USA