PerCP/Cyanine5.5 anti-mouse IL-2 | BioLegend 503822 product information

product summary

company name :

BioLegend

other brands :

Babco, Signet, Sternberger Monoclonals, Senetek, Covance

product type :

antibody

product name :

PerCP/Cyanine5.5 anti-mouse IL-2

catalog :

503822

quantity :

100 μg

price :

323 USD

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

JES6-5H4

reactivity :

mouse

application :

immunocytochemistry

more info or order :

BioLegend product webpage

citations: 15

Reference
Lu C, Zhang Y, Liu X, Hou F, Cai R, Yu Z, et al. Heterologous boost with mRNA vaccines against SARS-CoV-2 Delta/Omicron variants following an inactivated whole-virus vaccine. Antiviral Res. 2023;212:105556 pubmed publisher
Kim D, Jeong J, Lee D, Hyeon D, Park G, Jeon S, et al. PD-L1-directed PlGF/VEGF blockade synergizes with chemotherapy by targeting CD141+ cancer-associated fibroblasts in pancreatic cancer. Nat Commun. 2022;13:6292 pubmed publisher
Yuan Y, Zhang X, Chen R, Li Y, Wu B, Li R, et al. A bivalent nanoparticle vaccine exhibits potent cross-protection against the variants of SARS-CoV-2. Cell Rep. 2021;:110256 pubmed publisher
Liu Y, Debo B, Li M, Shi Z, Sheng W, Shi Y. LSD1 inhibition sustains T cell invigoration with a durable response to PD-1 blockade. Nat Commun. 2021;12:6831 pubmed publisher
Nagarajan D, Pearson J, Brentville V, Metheringham R, Pockley A, Durrant L, et al. ImmunoBody®-HAGE derived vaccine induces immunity to HAGE and delays the growth and metastasis of HAGE-expressing tumours in vivo. Immunol Cell Biol. 2021;: pubmed publisher
Guo Y, Xie Y, Gao M, Zhao Y, Franco F, Wenes M, et al. Metabolic reprogramming of terminally exhausted CD8+ T cells by IL-10 enhances anti-tumor immunity. Nat Immunol. 2021;22:746-756 pubmed publisher
Hodgins B, Pillet S, Landry N, Ward B. Prime-pull vaccination with a plant-derived virus-like particle influenza vaccine elicits a broad immune response and protects aged mice from death and frailty after challenge. Immun Ageing. 2019;16:27 pubmed publisher
Zhou J, Peng H, Li K, Qu K, Wang B, Wu Y, et al. Liver-Resident NK Cells Control Antiviral Activity of Hepatic T Cells via the PD-1-PD-L1 Axis. Immunity. 2019;50:403-417.e4 pubmed publisher
Chiou N, Kageyama R, Ansel K. Selective Export into Extracellular Vesicles and Function of tRNA Fragments during T Cell Activation. Cell Rep. 2018;25:3356-3370.e4 pubmed publisher
Tsai S, Clemente Casares X, Zhou A, Lei H, Ahn J, Chan Y, et al. Insulin Receptor-Mediated Stimulation Boosts T Cell Immunity during Inflammation and Infection. Cell Metab. 2018;28:922-934.e4 pubmed publisher
Yamamoto M, Seki Y, Iwai K, Ko I, Martin A, Tsuji N, et al. Ontogeny and localization of the cells produce IL-2 in healthy animals. Cytokine. 2013;61:831-41 pubmed publisher
Aldhamen Y, Seregin S, Schuldt N, Rastall D, Liu C, Godbehere S, et al. Vaccines expressing the innate immune modulator EAT-2 elicit potent effector memory T lymphocyte responses despite pre-existing vaccine immunity. J Immunol. 2012;189:1349-59 pubmed publisher
Fourcade J, Sun Z, Pagliano O, Guillaume P, Luescher I, Sander C, et al. CD8(+) T cells specific for tumor antigens can be rendered dysfunctional by the tumor microenvironment through upregulation of the inhibitory receptors BTLA and PD-1. Cancer Res. 2012;72:887-96 pubmed publisher
Aldhamen Y, Appledorn D, Seregin S, Liu C, Schuldt N, Godbehere S, et al. Expression of the SLAM family of receptors adapter EAT-2 as a novel strategy for enhancing beneficial immune responses to vaccine antigens. J Immunol. 2011;186:722-32 pubmed publisher
Fourcade J, Sun Z, Benallaoua M, Guillaume P, Luescher I, Sander C, et al. Upregulation of Tim-3 and PD-1 expression is associated with tumor antigen-specific CD8+ T cell dysfunction in melanoma patients. J Exp Med. 2010;207:2175-86 pubmed publisher

product information

Antigen :

IL-2

Apps. Abbrev. :

ICFC

Cat # :

503822

Clone :

JES6-5H4

Item :

PerCP/Cyanine5.5 anti-mouse IL-2

Isotype :

Rat IgG2b, κ

Other Names :

Interleukin-2, T cell growth factor (TCGF), Eosinophil differentiation factor (EDF), Killer cell helper factor (KHF), Macrophage-activating factor for cytotoxicity I (MAF-C I), Thymocyte differentiation factor (TDF)

Size :

100 μg

Price (USD) :

323 USD

Reactivity :

Mouse

Clonality :

Monoclonal

Host :

Rat

Conjugate/Tag/Label :

PERCP_CYANINE5.5

Immunogen :

E. coli -expressed, recombinant mouse IL-2

Application Notes :

ELISA Detection^1-3 or ELISPOT Detection^4-6: The biotinylated JES6-5H4 antibody is useful as a detection antibody for a sandwich ELISA or ELISPOT assay, when used in conjunction with the purified JES6-1A12 antibody (Cat. Nos. 503701 & 503702) as capture antibody and recombinant mouse IL-2 (Cat. No. 575409) as the standard.Flow Cytometry^8-10: The fluorochrome-labeled JES6-5H4 antibody is useful for intracellular immunofluorescent staining and flow cytometric analysis to identify IL-2 -producing cells within mixed cell populations.Neutralization^1,7: The Ultra-LEAF™ purified antibody (Endotoxin in vivo and in vitro (Cat. No. 503845-503850)) is recommended for neutralization.Additional reported applications (for the relevant formats) include: immunoprecipitation^1, immunohistochemical staining of paraformaldehyde-fixed, saponin-treated frozen tissue sections^2, in vivo capture^7, and immunocytochemistry.Note: For testing mouse IL-2 in serum, plasma or supernatant, BioLegend's ELISA MAX™ Sets (Cat. No. 431001 & 431004) are specially developed and recommended.;

more info or order :

BioLegend product webpage