Purified anti-mouse IL-2 | BioLegend 503701 product information

product summary

company name :

BioLegend

other brands :

Babco, Signet, Sternberger Monoclonals, Senetek, Covance

product type :

antibody

product name :

Purified anti-mouse IL-2

catalog :

503701

quantity :

50 μg

price :

83 USD

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

JES6-1A12

reactivity :

mouse

application :

western blot, ELISA, immunoprecipitation

more info or order :

BioLegend product webpage

citations: 11

Reference
Read K, Jones D, Pokhrel S, Hales E, Varkey A, Tuazon J, et al. Aiolos represses CD4+ T cell cytotoxic programming via reciprocal regulation of TFH transcription factors and IL-2 sensitivity. Nat Commun. 2023;14:1652 pubmed publisher
Sato A, Azuma M, Nagai H, Imai W, Kawaguchi K, Morita M, et al. OX40 Ligand-Mannose-Binding Lectin Fusion Protein Induces Potent OX40 Cosignaling in CD4+ T Cells. Biol Pharm Bull. 2022;45:1798-1804 pubmed publisher
Lin Y, Papp G, Miskey C, Fiedler A, Goretzki A, Wolfheimer S, et al. The Flagellin:Allergen Fusion Protein rFlaA:Betv1 Induces a MyD88- and MAPK-Dependent Activation of Glucose Metabolism in Macrophages. Cells. 2021;10: pubmed publisher
Zhao L, Liu P, Xie W, Zhang S, Thieme S, Zitvogel L, et al. A genotype-phenotype screening system using conditionally immortalized immature dendritic cells. STAR Protoc. 2021;2:100732 pubmed publisher
Galaski J, Shhadeh A, Uma xf1 a A, Yoo C, Arpinati L, Isaacson B, et al. Fusobacterium nucleatum CbpF Mediates Inhibition of T Cell Function Through CEACAM1 Activation. Front Cell Infect Microbiol. 2021;11:692544 pubmed publisher
Phan T, Schink L, Mann J, Merk V, Zwicky P, Mundt S, et al. Keratinocytes control skin immune homeostasis through de novo-synthesized glucocorticoids. Sci Adv. 2021;7: pubmed publisher
Newland S, Mohanta S, Clement M, Taleb S, Walker J, Nus M, et al. Type-2 innate lymphoid cells control the development of atherosclerosis in mice. Nat Commun. 2017;8:15781 pubmed publisher
Parrish H, Glassman C, Keenen M, Deshpande N, Bronnimann M, Kuhns M. A Transmembrane Domain GGxxG Motif in CD4 Contributes to Its Lck-Independent Function but Does Not Mediate CD4 Dimerization. PLoS ONE. 2015;10:e0132333 pubmed publisher
Nishio J, Feuerer M, Wong J, Mathis D, Benoist C. Anti-CD3 therapy permits regulatory T cells to surmount T cell receptor-specified peripheral niche constraints. J Exp Med. 2010;207:1879-89 pubmed publisher
Dal Secco V, Riccioli A, Padula F, Ziparo E, Filippini A. Mouse Sertoli cells display phenotypical and functional traits of antigen-presenting cells in response to interferon gamma. Biol Reprod. 2008;78:234-42 pubmed
Devine L, Thakral D, Nag S, Dobbins J, Hodsdon M, Kavathas P. Mapping the binding site on CD8 beta for MHC class I reveals mutants with enhanced binding. J Immunol. 2006;177:3930-8 pubmed

product information

Antigen :

IL-2

Apps. Abbrev. :

ELISA Capture, IP, WB

Cat # :

503701

Clone :

JES6-1A12

Item :

Purified anti-mouse IL-2

Isotype :

Rat IgG2a, κ

Other Names :

Interleukin-2, T cell growth factor (TCGF), Eosinophil differentiation factor (EDF), Killer cell helper factor (KHF), Macrophage-activating factor for cytotoxicity I (MAF-C I), Thymocyte differentiation factor (TDF)

Size :

50 μg

Price (USD) :

83 USD

Reactivity :

Mouse

Clonality :

Monoclonal

Host :

Rat

Conjugate/Tag/Label :

PURE

Immunogen :

E. coli -expressed, recombinant mouse IL-2

Application Notes :

ELISA Capture^1-3 or ELISPOT Capture^4-6: The purified JES6-1A12 antibody is useful as the capture antibody in a sandwich ELISA or ELISPOT assay, when used in conjunction with the biotinylated JES6-5H4 antibody (Cat. No. 503804) as the detecting antibody and recombinant mouse IL-2 (Cat. No.575409) as the standard. The LEAF™ purified antibody is suggested for ELISPOT capture (Cat. No. 503704).Neutralization: The JES6-1A12 antibody can neutralize the bioactivity of natural or recombinant IL-2. For in vivo studies or highly sensitive assays, we recommend Ultra-LEAF™ purified antibody (Cat. No. 503706) with a lower endotoxin limit than standard LEAF™ purified antibodies (Endotoxin <0.01 EU/µg).;

more info or order :

BioLegend product webpage