product summary
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company name :
BioLegend
other brands :
Babco, Signet, Sternberger Monoclonals, Senetek, Covance
product type :
antibody
product name :
PE anti-human IL-2
catalog :
500307
quantity :
100 tests
price :
242 USD
clonality :
monoclonal
host :
rat
conjugate :
PE
clone name :
MQ1-17H12
reactivity :
human
application :
immunocytochemistry, flow cytometry
more info or order :
citations: 36
Published Application/Species/Sample/DilutionReference
  • flow cytometry; human; loading ...; fig 5a
Xie L, Zhou F, Liu X, Fang Y, Yu Z, Song N, et al. Serum microRNA181a: Correlates with the intracellular cytokine levels and a potential biomarker for acute graft-versus-host disease. Cytokine. 2016;85:37-44 pubmed publisher
Eser T, Baranov O, Huth M, Ahmed M, De xe1 k F, Held K, et al. Nucleocapsid-specific T cell responses associate with control of SARS-CoV-2 in the upper airways before seroconversion. Nat Commun. 2023;14:2952 pubmed publisher
Statzu M, Jin W, Fray E, Wong A, Kumar M, Ferrer E, et al. CD8+ lymphocytes do not impact SIV reservoir establishment under ART. Nat Microbiol. 2023;8:299-308 pubmed publisher
Gartshteyn Y, Askanase A, Song R, Bukhari S, Dragovich M, Adam K, et al. SLAMF6 compartmentalization enhances T cell functions. Life Sci Alliance. 2023;6: pubmed publisher
Olafsdottir T, Bjarnadóttir K, Norddahl G, Halldorsson G, Melsted P, Gunnarsdottir K, et al. HLA alleles, disease severity, and age associate with T-cell responses following infection with SARS-CoV-2. Commun Biol. 2022;5:914 pubmed publisher
Gao X, He J, Sun X, Li F. Dynamically modeling the effective range of IL-2 dosage in the treatment of systemic lupus erythematosus. iScience. 2022;25:104911 pubmed publisher
van der Ploeg K, Kirosingh A, Mori D, Chakraborty S, Hu Z, Sievers B, et al. TNF-α+ CD4+ T cells dominate the SARS-CoV-2 specific T cell response in COVID-19 outpatients and are associated with durable antibodies. Cell Rep Med. 2022;3:100640 pubmed publisher
Balle C, Armistead B, Kiravu A, Song X, Happel A, Hoffmann A, et al. Factors influencing maternal microchimerism throughout infancy and its impact on infant T cell immunity. J Clin Invest. 2022;132: pubmed publisher
Paniskaki K, Anft M, Thieme C, Skrzypczyk S, Konik M, Dolff S, et al. Severe Acute Respiratory Syndrome Coronavirus 2 Cross-Reactive B and T Cell Responses in Kidney Transplant Patients. Transplant Proc. 2022;54:1455-1464 pubmed publisher
Yen M, Ren J, Liu Q, Glassman C, Sheahan T, Picton L, et al. Facile discovery of surrogate cytokine agonists. Cell. 2022;185:1414-1430.e19 pubmed publisher
Pymm P, Tenzer S, Wee E, Weimershaus M, Burgevin A, Kollnberger S, et al. Epitope length variants balance protective immune responses and viral escape in HIV-1 infection. Cell Rep. 2022;38:110449 pubmed publisher
Sung B, Lin Y, Kong Q, Shah P, Glick Bieler J, Palmer S, et al. Wnt activation promotes memory T cell polyfunctionality via epigenetic regulator PRMT1. J Clin Invest. 2022;132: pubmed publisher
Mansilla Soto J, Eyquem J, Haubner S, Hamieh M, Feucht J, Paillon N, et al. HLA-independent T cell receptors for targeting tumors with low antigen density. Nat Med. 2022;28:345-352 pubmed publisher
Costa Martins A, Mane K, Lindsey B, Ogava R, Castro Í, Jagne Y, et al. Prior upregulation of interferon pathways in the nasopharynx impacts viral shedding following live attenuated influenza vaccine challenge in children. Cell Rep Med. 2021;2:100465 pubmed publisher
Shen C, Zhang Z, Tian Y, Li F, Zhou L, Jiang W, et al. Sulforaphane enhances the antitumor response of chimeric antigen receptor T cells by regulating PD-1/PD-L1 pathway. BMC Med. 2021;19:283 pubmed publisher
Nel I, Beaudoin L, Gouda Z, Rousseau C, Soulard P, Rouland M, et al. MAIT cell alterations in adults with recent-onset and long-term type 1 diabetes. Diabetologia. 2021;64:2306-2321 pubmed publisher
Ajith A, Mulloy L, Musa M, Bravo Egana V, Horuzsko D, Gani I, et al. Humanized Mouse Model as a Novel Approach in the Assessment of Human Allogeneic Responses in Organ Transplantation. Front Immunol. 2021;12:687715 pubmed publisher
Dykema A, Zhang B, Woldemeskel B, Garliss C, Cheung L, Choudhury D, et al. Functional characterization of CD4+ T cell receptors crossreactive for SARS-CoV-2 and endemic coronaviruses. J Clin Invest. 2021;131: pubmed publisher
Dhariwala M, Karthikeyan D, Vasquez K, Farhat S, Weckel A, Taravati K, et al. Developing Human Skin Contains Lymphocytes Demonstrating a Memory Signature. Cell Rep Med. 2020;1:100132 pubmed publisher
Woldemeskel B, Kwaa A, Garliss C, Laeyendecker O, Ray S, Blankson J. Healthy donor T cell responses to common cold coronaviruses and SARS-CoV-2. J Clin Invest. 2020;130:6631-6638 pubmed publisher
Thieme C, Anft M, Paniskaki K, Blazquez Navarro A, Doevelaar A, Seibert F, et al. Robust T Cell Response Toward Spike, Membrane, and Nucleocapsid SARS-CoV-2 Proteins Is Not Associated with Recovery in Critical COVID-19 Patients. Cell Rep Med. 2020;1:100092 pubmed publisher
Bartolom xe9 Casado R, Landsverk O, Chauhan S, S xe6 tre F, Hagen K, Yaqub S, et al. CD4+ T cells persist for years in the human small intestine and display a TH1 cytokine profile. Mucosal Immunol. 2021;14:402-410 pubmed publisher
Luo X, Cui H, Cai L, Zhu W, Yang W, PATRICK M, et al. Selection of a Clinical Lead TCR Targeting Alpha-Fetoprotein-Positive Liver Cancer Based on a Balance of Risk and Benefit. Front Immunol. 2020;11:623 pubmed publisher
Fan Z, Tian Y, Chen Z, Liu L, Zhou Q, He J, et al. Blocking interaction between SHP2 and PD-1 denotes a novel opportunity for developing PD-1 inhibitors. EMBO Mol Med. 2020;12:e11571 pubmed publisher
Kobayashi Y, Yamada D, Kawai T, Sato Y, Teshima T, Yamada Y, et al. Different immunological effects of the molecular targeted agents sunitinib, everolimus and temsirolimus in patients with renal cell carcinoma. Int J Oncol. 2020;56:999-1013 pubmed publisher
Lindesmith L, Brewer Jensen P, Mallory M, Jensen K, Yount B, Costantini V, et al. Virus-Host Interactions Between Nonsecretors and Human Norovirus. Cell Mol Gastroenterol Hepatol. 2020;10:245-267 pubmed publisher
Harper J, Gordon S, Chan C, Wang H, Lindemuth E, Galardi C, et al. CTLA-4 and PD-1 dual blockade induces SIV reactivation without control of rebound after antiretroviral therapy interruption. Nat Med. 2020;26:519-528 pubmed publisher
Pal R, Schaubhut J, Clark D, Brown L, Stewart J. Single-Cell Analysis of Cytokine mRNA and Protein Expression by Flow Cytometry. Curr Protoc Cytom. 2020;92:e69 pubmed publisher
Weisberg S, Carpenter D, Chait M, Dogra P, Gartrell Corrado R, Chen A, et al. Tissue-Resident Memory T Cells Mediate Immune Homeostasis in the Human Pancreas through the PD-1/PD-L1 Pathway. Cell Rep. 2019;29:3916-3932.e5 pubmed publisher
Mastelic Gavillet B, Navarro Rodrigo B, Décombaz L, Wang H, Ercolano G, Ahmed R, et al. Adenosine mediates functional and metabolic suppression of peripheral and tumor-infiltrating CD8+ T cells. J Immunother Cancer. 2019;7:257 pubmed publisher
Cella M, Gamini R, Sécca C, Collins P, Zhao S, Peng V, et al. Subsets of ILC3-ILC1-like cells generate a diversity spectrum of innate lymphoid cells in human mucosal tissues. Nat Immunol. 2019;: pubmed publisher
Salvany Celades M, van der Zwan A, Benner M, Setrajcic Dragos V, Bougleux Gomes H, Iyer V, et al. Three Types of Functional Regulatory T Cells Control T Cell Responses at the Human Maternal-Fetal Interface. Cell Rep. 2019;27:2537-2547.e5 pubmed publisher
Boutboul D, Kuehn H, Van de Wyngaert Z, Niemela J, Callebaut I, Stoddard J, et al. Dominant-negative IKZF1 mutations cause a T, B, and myeloid cell combined immunodeficiency. J Clin Invest. 2018;128:3071-3087 pubmed publisher
Wu Z, Frascaroli G, Bayer C, Schmal T, Mertens T. Interleukin-2 from Adaptive T Cells Enhances Natural Killer Cell Activity against Human Cytomegalovirus-Infected Macrophages. J Virol. 2015;89:6435-41 pubmed publisher
Sashihara J, Hoshino Y, Bowman J, Krogmann T, Burbelo P, Coffield V, et al. Soluble rhesus lymphocryptovirus gp350 protects against infection and reduces viral loads in animals that become infected with virus after challenge. PLoS Pathog. 2011;7:e1002308 pubmed publisher
Mikkelsen S, Reckling S, Egan E, Dean G. In vivo depletion of CD4(+)CD25(hi) regulatory T cells is associated with improved antiviral responses in cats chronically infected with feline immunodeficiency virus. Virology. 2010;403:163-72 pubmed publisher
product information
Antigen :
IL-2
Apps. Abbrev. :
ICFC
Cat # :
500307
Clone :
MQ1-17H12
Item :
PE anti-human IL-2
Isotype :
Rat IgG2a, κ
Other Names :
Interleukin-2, T cell growth factor (TCGF), Eosinophil differentiation factor (EDF), Killer cell helper factor (KHF), Macrophage-activating factor for cytotoxicity I (MAF-C I), Thymocyte differentiation factor (TDF)
Size :
100 tests
Price (USD) :
242 USD
Reactivity :
Human
Clonality :
Monoclonal
Host :
Rat
Conjugate/Tag/Label :
PE
Immunogen :
E. coli - expressed recombinant human IL-2
Application Notes :
ELISA or ELISPOT Capture^2,3: The purified MQ1-17H12 antibody is useful as the capture antibody in a sandwich ELISA or ELISPOT assay, when used in conjunction with the Biotin anti-human IL-2 antibody (Cat. No. 517605) as the detecting antibody. The Ultra-LEAF™ purified antibody is suggested for ELISPOT capture. For ELISPOT capture applications, a concentration range of 4.0 - 8.0 µg/mL is recommended.Additional reported applications (for the relevant formats) include: immunoprecipitation^2, immunohistochemical staining of paraformaldehyde-fixed, saponin-treated frozen tissue sections^1,4-6,8, neutralization^13, and immunocytochemistry.Note: For testing human IL-2 in serum or plasma, BioLegend's LEGEND MAX™ Kit (Cat. No. 431807) is specially developed and recommended.Clone MQ1-17H12 cross-reacts to Cat^15;
more info or order :
company information
BioLegend
8999 BioLegend Way
San Diego, CA 92121
customerserv@biolegend.com
https://www.biolegend.com
headquarters: USA