Alexa Fluor® 647 anti-human MRP1 (ABCC1) | BioLegend 370304 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

BioLegend

other brands :

Babco, Signet, Sternberger Monoclonals, Senetek, Covance

product type :

antibody

product name :

Alexa Fluor® 647 anti-human MRP1 (ABCC1)

catalog :

370304

quantity :

100 tests

price :

295 USD

clonality :

monoclonal

host :

mouse

conjugate :

AF647

clone name :

QCRL-3

reactivity :

human

application :

flow cytometry

citations: 1

Reference
Aguilar Briseño J, Upasani V, Ellen B, Moser J, Pauzuolis M, Ruiz Silva M, et al. TLR2 on blood monocytes senses dengue virus infection and its expression correlates with disease pathogenesis. Nat Commun. 2020;11:3177 pubmed publisher

product information

Antigen :

MRP1

Apps. Abbrev. :

Intracellular Staining for Flow Cytometry

Cat # :

370304

Clone :

QCRL-3

Item :

Alexa Fluor® 647 anti-human MRP1 (ABCC1)

Isotype :

Mouse IgG2a, κ

Other Names :

ABC29, ABCC, GS-X, MRP, Multidrug resistance-associated protein 1, LTC4 transporter, leukotriene C(4) transporter

Size :

100 tests

Price (USD) :

295 USD

Reactivity :

Human

Clonality :

Monoclonal

Host :

Mouse

Conjugate/Tag/Label :

A647

Immunogen :

QCRL-3 was raised against membranes prepared from the human small cell lung cancer cell line, H69AR, which highly over expresses MRP1.

Application Notes :

QCRL-3 detects a discontinuous conformation-dependent epitope wholly contained in NBD1 of MRP1. The epitope for QCRL-3 has been mapped to aa 647-932. QCRL-3 is reported to be an effective and specific inhibitor of MRP1 activity when used in transport assays with inside-out membrane vesicles. QCRL-1, QCRL-2, QCRL-3, and QCRL-4 each bind distinct non-overlapping epitopes. NOTE : For flow cytometric staining with this clone, True-Nuclear Transcription Factor Buffer Set (Cat. No. 424401 ) offers improved staining and is highly recommended.