product summary
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company name :
BioLegend
other brands :
Babco, Signet, Sternberger Monoclonals, Senetek, Covance
product type :
antibody
product name :
Purified anti-human CD45
catalog :
368502
quantity :
100 μg
price :
101 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
2D1
reactivity :
human, mouse
application :
flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
citations: 25
Published Application/Species/Sample/DilutionReference
  • flow cytometry; human; loading ...; fig 2b, 3c
Laffey K, Stiles R, Ludescher M, Davis T, Khwaja S, Bram R, et al. Early expression of mature αβ TCR in CD4-CD8- T cell progenitors enables MHC to drive development of T-ALL bearing NOTCH mutations. Proc Natl Acad Sci U S A. 2022;119:e2118529119 pubmed publisher
  • flow cytometry; human; fig s1
Poletto E, Colella P, Pimentel Vera L, Khan S, Tomatsu S, Baldo G, et al. Improved engraftment and therapeutic efficacy by human genome-edited hematopoietic stem cells with Busulfan-based myeloablation. Mol Ther Methods Clin Dev. 2022;25:392-409 pubmed publisher
  • flow cytometry; human; loading ...; fig s1a
Pan C, Wu Q, Wang S, Mei Z, Zhang L, Gao X, et al. Combination with Toll-like receptor 4 (TLR4) agonist reverses GITR agonism mediated M2 polarization of macrophage in Hepatocellular carcinoma. Oncoimmunology. 2022;11:2073010 pubmed publisher
  • flow cytometry; human; 1:100; loading ...; fig 1a
Shen X, Geng R, Li Q, Chen Y, Li S, Wang Q, et al. ACE2-independent infection of T lymphocytes by SARS-CoV-2. Signal Transduct Target Ther. 2022;7:83 pubmed publisher
  • flow cytometry; human; 0.125 ug/ml; fig s1a
Sasamoto Y, Lee C, Yoshihara M, Martin G, Ksander B, Frank M, et al. High expression of SARS-CoV2 viral entry-related proteins in human limbal stem cells. Ocul Surf. 2022;23:197-200 pubmed publisher
  • flow cytometry; human; loading ...
Yue X, Petersen F, Shu Y, Kasper B, Magatsin J, Ahmadi M, et al. Transfer of PBMC From SSc Patients Induces Autoantibodies and Systemic Inflammation in Rag2-/-/IL2rg-/- Mice. Front Immunol. 2021;12:677970 pubmed publisher
  • flow cytometry; human; 3:100; loading ...; fig 1a
Chioh F, Fong S, Young B, Wu K, Siau A, Krishnan S, et al. Convalescent COVID-19 patients are susceptible to endothelial dysfunction due to persistent immune activation. elife. 2021;10: pubmed publisher
  • flow cytometry; mouse; 1:500; loading ...; fig s1b
Gang E, Kim H, Hsieh Y, Ruan Y, Ogana H, Lee S, et al. Integrin α6 mediates the drug resistance of acute lymphoblastic B-cell leukemia. Blood. 2020;136:210-223 pubmed publisher
  • flow cytometry; human; loading ...; fig s6c
Stewart B, Ferdinand J, Young M, Mitchell T, Loudon K, Riding A, et al. Spatiotemporal immune zonation of the human kidney. Science. 2019;365:1461-1466 pubmed publisher
  • immunohistochemistry - frozen section; human; fig 4g
Ring N, Herndler Brandstetter D, Weiskopf K, Shan L, Volkmer J, George B, et al. Anti-SIRPα antibody immunotherapy enhances neutrophil and macrophage antitumor activity. Proc Natl Acad Sci U S A. 2017;114:E10578-E10585 pubmed publisher
  • immunohistochemistry - paraffin section; human; fig 6b
Nielsen C, van Putten S, Lund I, Melander M, Nørregaard K, Jürgensen H, et al. The collagen receptor uPARAP/Endo180 as a novel target for antibody-drug conjugate mediated treatment of mesenchymal and leukemic cancers. Oncotarget. 2017;8:44605-44624 pubmed publisher
Cobb D, de Rossi J, Liu L, An E, Lee D. Targeting of the alphav beta3 integrin complex by CAR-T cells leads to rapid regression of diffuse intrinsic pontine glioma and glioblastoma. J Immunother Cancer. 2022;10: pubmed publisher
Valet C, Magnen M, Qiu L, Cleary S, Wang K, Ranucci S, et al. Sepsis promotes splenic production of a protective platelet pool with high CD40 ligand expression. J Clin Invest. 2022;132: pubmed publisher
Xie S, Shan X, Yau V, Zhang J, Zhang X, Yan Y, et al. Hyperion imaging system reveals heterogeneous tumor microenvironment of oral squamous cell carcinoma patients at T1N0M0 stage. Ann Transl Med. 2020;8:1513 pubmed publisher
Korn M, Schmitt H, Angermüller S, Chambers D, Seeling M, Lux U, et al. Siglec-15 on Osteoclasts Is Crucial for Bone Erosion in Serum-Transfer Arthritis. J Immunol. 2020;205:2595-2605 pubmed publisher
Mann E, Menon M, Knight S, Konkel J, Jagger C, Shaw T, et al. Longitudinal immune profiling reveals key myeloid signatures associated with COVID-19. Sci Immunol. 2020;5: pubmed publisher
Wang J, Wuethrich A, Sina A, Lane R, Lin L, Wang Y, et al. Tracking extracellular vesicle phenotypic changes enables treatment monitoring in melanoma. Sci Adv. 2020;6:eaax3223 pubmed publisher
Wäldchen F, Schlegel J, Götz R, Luciano M, SCHNERMANN M, Doose S, et al. Whole-cell imaging of plasma membrane receptors by 3D lattice light-sheet dSTORM. Nat Commun. 2020;11:887 pubmed publisher
Weisberg S, Carpenter D, Chait M, Dogra P, Gartrell Corrado R, Chen A, et al. Tissue-Resident Memory T Cells Mediate Immune Homeostasis in the Human Pancreas through the PD-1/PD-L1 Pathway. Cell Rep. 2019;29:3916-3932.e5 pubmed publisher
Walker D, Lue L, Beach T, Tooyama I. Microglial Phenotyping in Neurodegenerative Disease Brains: Identification of Reactive Microglia with an Antibody to Variant of CD105/Endoglin. Cells. 2019;8: pubmed publisher
Balakrishnan A, Koppaka D, Anand A, Deb B, Grenci G, Viasnoff V, et al. Circulating Tumor Cell cluster phenotype allows monitoring response to treatment and predicts survival. Sci Rep. 2019;9:7933 pubmed publisher
Yoshihara S, Li Y, Xia J, Danzl N, Sykes M, Yang Y. Posttransplant Hemophagocytic Lymphohistiocytosis Driven by Myeloid Cytokines and Vicious Cycles of T-Cell and Macrophage Activation in Humanized Mice. Front Immunol. 2019;10:186 pubmed publisher
Zhao L, He R, Long H, Guo B, Jia Q, Qin D, et al. Late-stage tumors induce anemia and immunosuppressive extramedullary erythroid progenitor cells. Nat Med. 2018;24:1536-1544 pubmed publisher
Ran L, Zeng Y, Wang S, Zhang D, Hong M, Li S, et al. Effect of co‑culture with amniotic epithelial cells on the biological characteristics of amniotic mesenchymal stem cells. Mol Med Rep. 2018;18:723-732 pubmed publisher
Donnelly C, Dykstra B, Mondal N, Huang J, Kaskow B, Griffin R, et al. Optimizing human Treg immunotherapy by Treg subset selection and E-selectin ligand expression. Sci Rep. 2018;8:420 pubmed publisher
product information
Antigen :
CD45
Apps. Abbrev. :
FC, IHC-P
Cat # :
368502
Clone :
2D1
Item :
Purified anti-human CD45
Isotype :
Mouse IgG1, κ
Other Names :
Leukocyte Common Antigen (LCA), T200
Size :
100 μg
Price (USD) :
101 USD
Reactivity :
Human
Clonality :
Monoclonal
Host :
Mouse
Conjugate/Tag/Label :
PURE
Immunogen :
Human PBMC
Application Notes :
It was found that the HI30 clone and the 2D1 clone can cross block each other's binding.;
more info or order :
company information
BioLegend
8999 BioLegend Way
San Diego, CA 92121
customerserv@biolegend.com
https://www.biolegend.com
headquarters: USA