Alexa Fluor® 647 anti-human CD41/CD61 | BioLegend 362806 product information

product summary

company name :

BioLegend

other brands :

Babco, Signet, Sternberger Monoclonals, Senetek, Covance

product type :

antibody

product name :

Alexa Fluor® 647 anti-human CD41/CD61

catalog :

362806

quantity :

100 tests

price :

370 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

PAC-1

reactivity :

human

application :

flow cytometry

more info or order :

BioLegend product webpage

citations: 8

Reference
Ma X, Liang J, Zhu G, Bhoria P, Shoara A, MacKeigan D, et al. SARS-CoV-2 RBD and Its Variants Can Induce Platelet Activation and Clearance: Implications for Antibody Therapy and Vaccinations against COVID-19. Research (Wash D C). 2023;6:0124 pubmed publisher
Van Bael J, Vandenbulcke A, Ahmed Belkacem A, Guichou J, Pawlotsky J, Samyn J, et al. Small-Molecule Cyclophilin Inhibitors Potently Reduce Platelet Procoagulant Activity. Int J Mol Sci. 2023;24: pubmed publisher
Yasseen B, Elkhodiry A, El Messiery R, El Sayed H, Elbenhawi M, Kamel A, et al. Platelets' morphology, metabolic profile, exocytosis, and heterotypic aggregation with leukocytes in relation to severity and mortality of COVID-19-patients. Front Immunol. 2022;13:1022401 pubmed publisher
Bahmani B, Gong H, Luk B, Haushalter K, DeTeresa E, Previti M, et al. Intratumoral immunotherapy using platelet-cloaked nanoparticles enhances antitumor immunity in solid tumors. Nat Commun. 2021;12:1999 pubmed publisher
Nicolai L, Leunig A, Brambs S, Kaiser R, Weinberger T, Weigand M, et al. Immunothrombotic Dysregulation in COVID-19 Pneumonia Is Associated With Respiratory Failure and Coagulopathy. Circulation. 2020;142:1176-1189 pubmed publisher
Chauhan A, Sheriff L, Hussain M, Webb G, Patten D, Shepherd E, et al. The platelet receptor CLEC-2 blocks neutrophil mediated hepatic recovery in acetaminophen induced acute liver failure. Nat Commun. 2020;11:1939 pubmed publisher
Chen Z, Lu J, Zhang C, Hsia I, Yu X, Marecki L, et al. Microclot array elastometry for integrated measurement of thrombus formation and clot biomechanics under fluid shear. Nat Commun. 2019;10:2051 pubmed publisher
Gillespie S, Holloway P, Becker F, Rauzi F, Vital S, Taylor K, et al. The isothiocyanate sulforaphane modulates platelet function and protects against cerebral thrombotic dysfunction. Br J Pharmacol. 2018;175:3333-3346 pubmed publisher

product information

Antigen :

CD41/CD61

Apps. Abbrev. :

Cat # :

362806

Clone :

PAC-1

Item :

Alexa Fluor® 647 anti-human CD41/CD61

Isotype :

Mouse IgM, κ

Other Names :

gpIIb/IIIa complex, integrin αIIbβ3

Size :

100 tests

Price (USD) :

370 USD

Reactivity :

Human

Clonality :

Monoclonal

Host :

Mouse

Conjugate/Tag/Label :

A647

Immunogen :

Human platelets

Application Notes :

Additional reported applications (for the relevant formats of this clone) include: immunoprecipitation^1,2, Western blotting^2 and in vitro blocking of platelet aggregation^2.; The PAC-1 antibody reacts with activation-induced conformational epitope of the integrin aIIbß3. PAC-1 binding to fibrinogen is pH and Ca^2+ dependent, and will not bind to platelets that have been fixed. We recommend staining in buffers free of Ethylenediaminetetraacetic acid (EDTA) at a pH of 6.5 or higher. Sodium citrate may be used as an anticoagulant for blood collection^3.;

more info or order :

BioLegend product webpage