product summary
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company name :
BioLegend
other brands :
Babco, Signet, Sternberger Monoclonals, Senetek, Covance
product type :
antibody
product name :
Purified anti-human/mouse/rat MR1
catalog :
361102
quantity :
100 μg
price :
293 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
26.5
reactivity :
human, mouse, rat
application :
ELISA, neutralization, immunoprecipitation, flow cytometry, blocking or activating experiments
more info or order :
citations: 16
Published Application/Species/Sample/DilutionReference
  • blocking or activating experiments; human; loading ...; fig 1f
Dias J, Leeansyah E, Sandberg J. Multiple layers of heterogeneity and subset diversity in human MAIT cell responses to distinct microorganisms and to innate cytokines. Proc Natl Acad Sci U S A. 2017;114:E5434-E5443 pubmed publisher
Wyatt Johnson S, Kersey H, Codocedo J, Newell K, Landreth G, Lamb B, et al. Control of the temporal development of Alzheimer's disease pathology by the MR1/MAIT cell axis. J Neuroinflammation. 2023;20:78 pubmed publisher
Vorkas C, Krishna C, Li K, AUBE J, Fitzgerald D, Mazutis L, et al. Single-Cell Transcriptional Profiling Reveals Signatures of Helper, Effector, and Regulatory MAIT Cells during Homeostasis and Activation. J Immunol. 2022;208:1042-1056 pubmed publisher
Marquardt I, Jakob J, Scheibel J, Hofmann J, Klawonn F, Neumann Schaal M, et al. Clostridioides difficile Toxin CDT Induces Cytotoxic Responses in Human Mucosal-Associated Invariant T (MAIT) Cells. Front Microbiol. 2021;12:752549 pubmed publisher
Gherardin N, Waldeck K, Caneborg A, Martelotto L, Balachander S, Zethoven M, et al. γδ T Cells in Merkel Cell Carcinomas Have a Proinflammatory Profile Prognostic of Patient Survival. Cancer Immunol Res. 2021;9:612-623 pubmed publisher
Flament H, Rouland M, Beaudoin L, Toubal A, Bertrand L, Lebourgeois S, et al. Outcome of SARS-CoV-2 infection is linked to MAIT cell activation and cytotoxicity. Nat Immunol. 2021;22:322-335 pubmed publisher
Sattler A, Thiel L, Ruhm A, Bergmann Y, Dornieden T, Choi M, et al. Mucosal associated invariant T cells are differentially impaired in tolerant and immunosuppressed liver transplant recipients. Am J Transplant. 2021;21:87-102 pubmed publisher
Kurniawan H, Franchina D, Guerra L, Bonetti L, Baguet L, Grusdat M, et al. Glutathione Restricts Serine Metabolism to Preserve Regulatory T Cell Function. Cell Metab. 2020;31:920-936.e7 pubmed publisher
Berkson J, Slichter C, Deberg H, Delaney M, Woodward Davis A, Maurice N, et al. Inflammatory Cytokines Induce Sustained CTLA-4 Cell Surface Expression on Human MAIT Cells. Immunohorizons. 2020;4:14-22 pubmed publisher
Lamichhane R, Galvin H, Hannaway R, de la Harpe S, Munro F, Tyndall J, et al. Type I interferons are important co-stimulatory signals during T cell receptor mediated human MAIT cell activation. Eur J Immunol. 2020;50:178-191 pubmed publisher
Lightman S, Utley A, Lee K. Survival of Long-Lived Plasma Cells (LLPC): Piecing Together the Puzzle. Front Immunol. 2019;10:965 pubmed publisher
Dias J, Boulouis C, Gorin J, van den Biggelaar R, Lal K, Gibbs A, et al. The CD4-CD8- MAIT cell subpopulation is a functionally distinct subset developmentally related to the main CD8+ MAIT cell pool. Proc Natl Acad Sci U S A. 2018;115:E11513-E11522 pubmed publisher
Paquin Proulx D, Avelino Silva V, Santos B, Silveira Barsotti N, Siroma F, Fernandes Ramos J, et al. MAIT cells are activated in acute Dengue virus infection and after in vitro Zika virus infection. PLoS Negl Trop Dis. 2018;12:e0006154 pubmed publisher
Howson L, Napolitani G, Shepherd D, Ghadbane H, Kurupati P, Preciado Llanes L, et al. MAIT cell clonal expansion and TCR repertoire shaping in human volunteers challenged with Salmonella Paratyphi A. Nat Commun. 2018;9:253 pubmed publisher
Shaler C, Choi J, Rudak P, Memarnejadian A, Szabo P, Tun Abraham M, et al. MAIT cells launch a rapid, robust and distinct hyperinflammatory response to bacterial superantigens and quickly acquire an anergic phenotype that impedes their cognate antimicrobial function: Defining a novel mechanism of superantigen-induced immuno. PLoS Biol. 2017;15:e2001930 pubmed publisher
van Wilgenburg B, Scherwitzl I, Hutchinson E, Leng T, Kurioka A, Kulicke C, et al. MAIT cells are activated during human viral infections. Nat Commun. 2016;7:11653 pubmed publisher
product information
Antigen :
MR1
Apps. Abbrev. :
FC, ELISA, IP, Block
Cat # :
361102
Clone :
26.5
Item :
Purified anti-human/mouse/rat MR1
Isotype :
Mouse IgG2a, κ
Other Names :
Major Histocompatibility Complex Class I-related, HLALS
Size :
100 μg
Price (USD) :
293 USD
Reactivity :
Human, Mouse, Rat
Clonality :
Monoclonal
Host :
Mouse
Conjugate/Tag/Label :
PURE
Immunogen :
Soluble complexes of MR1 ectodomain and B2M.
Application Notes :
Additional reported applications for the relevant formats include: blocking MR1-dependent activation of MAIT hybridomas, clones, or MAIT TCR-transduced cell lines^1-6, detection of folded MR1 conformers^3,7, and immunoprecipitation of MR1 from cell lysates^7.;
more info or order :
company information
BioLegend
8999 BioLegend Way
San Diego, CA 92121
customerserv@biolegend.com
https://www.biolegend.com
headquarters: USA