product summary
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company name :
BioLegend
other brands :
Babco, Signet, Sternberger Monoclonals, Senetek, Covance
product type :
antibody
product name :
APC anti-human CD126 (IL-6Rα)
catalog :
352806
quantity :
100 tests
price :
338 USD
clonality :
monoclonal
host :
mouse
conjugate :
APC
clone name :
UV4
reactivity :
human
application :
flow cytometry
more info or order :
citations: 7
Reference
Ferreira L, Ashander L, Appukuttan B, Ma Y, Williams K, Best G, et al. Human retinal endothelial cells express functional interleukin-6 receptor. J Ophthalmic Inflamm Infect. 2023;13:21 pubmed publisher
Domenger A, Choisy C, Baron L, Mayau V, Perthame E, Deriano L, et al. The Sec61 translocon is a therapeutic vulnerability in multiple myeloma. EMBO Mol Med. 2022;14:e14740 pubmed publisher
Reyes M, Filbin M, Bhattacharyya R, Sonny A, Mehta A, Billman K, et al. Plasma from patients with bacterial sepsis or severe COVID-19 induces suppressive myeloid cell production from hematopoietic progenitors in vitro. Sci Transl Med. 2021;13: pubmed publisher
Theurich S, Tsaousidou E, Hanssen R, Lempradl A, Mauer J, Timper K, et al. IL-6/Stat3-Dependent Induction of a Distinct, Obesity-Associated NK Cell Subpopulation Deteriorates Energy and Glucose Homeostasis. Cell Metab. 2017;26:171-184.e6 pubmed publisher
Wolf J, Waetzig G, Chalaris A, Reinheimer T, Wege H, Rose John S, et al. Different Soluble Forms of the Interleukin-6 Family Signal Transducer gp130 Fine-tune the Blockade of Interleukin-6 Trans-signaling. J Biol Chem. 2016;291:16186-96 pubmed publisher
Eichten A, Su J, Adler A, Zhang L, Ioffe E, Parveen A, et al. Resistance to Anti-VEGF Therapy Mediated by Autocrine IL6/STAT3 Signaling and Overcome by IL6 Blockade. Cancer Res. 2016;76:2327-39 pubmed publisher
Krow Lucal E, Kim C, Burt T, McCune J. Distinct functional programming of human fetal and adult monocytes. Blood. 2014;123:1897-904 pubmed publisher
product information
Antigen :
CD126
Apps. Abbrev. :
FC
Cat # :
352806
Clone :
UV4
Item :
APC anti-human CD126 (IL-6Rα)
Isotype :
Mouse IgG1, κ
Other Names :
IL-6R1, gp80, IL-6 receptor alpha, IL-6R
Size :
100 tests
Price (USD) :
338 USD
Reactivity :
Human
Clonality :
Monoclonal
Host :
Mouse
Conjugate/Tag/Label :
APC
Immunogen :
Human myeloma cell line U266
Application Notes :
Additional reported applications (for the relevant formats) include: blocking of IL-6 binding to IL-6R.;
more info or order :
company information
BioLegend
8999 BioLegend Way
San Diego, CA 92121
customerserv@biolegend.com
https://www.biolegend.com
headquarters: USA