product summary
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company name :
BioLegend
other brands :
Babco, Signet, Sternberger Monoclonals, Senetek, Covance
product type :
antibody
product name :
PE anti-human CD126 (IL-6Rα)
catalog :
352803
quantity :
25 tests
price :
129 USD
clonality :
monoclonal
host :
mouse
conjugate :
PE
clone name :
UV4
reactivity :
human
application :
flow cytometry
more info or order :
citations: 12
Published Application/Species/Sample/DilutionReference
  • flow cytometry; human; 1:50
Perrigue P, Silva M, Warden C, Feng N, Reid M, Mota D, et al. The histone demethylase jumonji coordinates cellular senescence including secretion of neural stem cell-attracting cytokines. Mol Cancer Res. 2015;13:636-50 pubmed publisher
Nunes Santos C, Kuehn H, Boast B, Hwang S, Kuhns D, Stoddard J, et al. Inherited ARPC5 mutations cause an actinopathy impairing cell motility and disrupting cytokine signaling. Nat Commun. 2023;14:3708 pubmed publisher
Salameh J, Kumar S, Rivera Cruz C, FIGUEIREDO M. A Second-Generation Nanoluc-IL27 Fusion Cytokine for Targeted-Gene-Therapy Applications. Bioengineering (Basel). 2022;9: pubmed publisher
Csomós I, Nagy P, Filep C, Rebenku I, Nizsalóczki E, Kovacs T, et al. Opposing Effects of Chelidonine on Tyrosine and Serine Phosphorylation of STAT3 in Human Uveal Melanoma Cells. Int J Mol Sci. 2021;22: pubmed publisher
Alasady M, Terry A, Pierce A, Cavalier M, Blaha C, Adipietro K, et al. The calcium-binding protein S100B reduces IL6 production in malignant melanoma via inhibition of RSK cellular signaling. PLoS ONE. 2021;16:e0256238 pubmed publisher
Van Zeebroeck L, Arroyo Hornero R, Côrte Real B, Hamad I, Meissner T, Kleinewietfeld M. Fast and Efficient Genome Editing of Human FOXP3+ Regulatory T Cells. Front Immunol. 2021;12:655122 pubmed publisher
Wu J, Weisshaar N, Hotz Wagenblatt A, Madi A, Ma S, Mieg A, et al. Skeletal muscle antagonizes antiviral CD8+ T cell exhaustion. Sci Adv. 2020;6:eaba3458 pubmed publisher
Zhang G, Iwase H, Wang L, Yamamoto T, Jagdale A, Ayares D, et al. Is interleukin-6 receptor blockade (tocilizumab) beneficial or detrimental to pig-to-baboon organ xenotransplantation?. Am J Transplant. 2020;20:999-1013 pubmed publisher
Saga R, Hasegawa K, Murata K, Chiba M, Nakamura T, Okumura K, et al. Regulation of radiosensitivity by 4-methylumbelliferone via the suppression of interleukin-1 in fibrosarcoma cells. Oncol Lett. 2019;17:3555-3561 pubmed publisher
Eriksson E, Milenova I, Wenthe J, Moreno R, Alemany R, Loskog A. IL-6 Signaling Blockade during CD40-Mediated Immune Activation Favors Antitumor Factors by Reducing TGF-β, Collagen Type I, and PD-L1/PD-1. J Immunol. 2019;: pubmed publisher
Eriksson E, Moreno R, Milenova I, Liljenfeldt L, Dieterich L, Christiansson L, et al. Activation of myeloid and endothelial cells by CD40L gene therapy supports T-cell expansion and migration into the tumor microenvironment. Gene Ther. 2017;24:92-103 pubmed publisher
Ferreira R, Freitag D, Cutler A, Howson J, Rainbow D, Smyth D, et al. Functional IL6R 358Ala allele impairs classical IL-6 receptor signaling and influences risk of diverse inflammatory diseases. PLoS Genet. 2013;9:e1003444 pubmed publisher
product information
Antigen :
CD126
Apps. Abbrev. :
FC
Cat # :
352803
Clone :
UV4
Item :
PE anti-human CD126 (IL-6Rα)
Isotype :
Mouse IgG1, κ
Other Names :
IL-6R1, gp80, IL-6 receptor alpha, IL-6R
Size :
25 tests
Price (USD) :
129 USD
Reactivity :
Human
Clonality :
Monoclonal
Host :
Mouse
Conjugate/Tag/Label :
PE
Immunogen :
Human myeloma cell line U266
Application Notes :
Additional reported applications (for the relevant formats) include: blocking of IL-6 binding to IL-6R.;
more info or order :
company information
BioLegend
8999 BioLegend Way
San Diego, CA 92121
customerserv@biolegend.com
https://www.biolegend.com
headquarters: USA