PerCP/Cyanine5.5 anti-human TCR Vα7.2 | BioLegend 351709 product information

product summary

company name :

BioLegend

other brands :

Babco, Signet, Sternberger Monoclonals, Senetek, Covance

product type :

antibody

product name :

PerCP/Cyanine5.5 anti-human TCR Vα7.2

catalog :

351709

quantity :

25 tests

price :

176 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

3C10

reactivity :

human

application :

flow cytometry

more info or order :

BioLegend product webpage

citations: 7

Reference
Ogishi M, Yang R, Rodriguez R, Golec D, Martin E, Philippot Q, et al. Inherited human ITK deficiency impairs IFN-γ immunity and underlies tuberculosis. J Exp Med. 2023;220: pubmed publisher
Hackstein C, Costigan D, Drexhage L, Pearson C, Bullers S, Ilott N, et al. A conserved population of MHC II-restricted, innate-like, commensal-reactive T cells in the gut of humans and mice. Nat Commun. 2022;13:7472 pubmed publisher
Ogishi M, Arias A, Yang R, Han J, Zhang P, Rinchai D, et al. Impaired IL-23-dependent induction of IFN-γ underlies mycobacterial disease in patients with inherited TYK2 deficiency. J Exp Med. 2022;219: pubmed publisher
Hagel J, Bennett K, Buffa F, Klenerman P, Willberg C, Powell K. Defining T Cell Subsets in Human Tonsils Using ChipCytometry. J Immunol. 2021;206:3073-3082 pubmed publisher
Leng T, Akther H, Hackstein C, Powell K, King T, Friedrich M, et al. TCR and Inflammatory Signals Tune Human MAIT Cells to Exert Specific Tissue Repair and Effector Functions. Cell Rep. 2019;28:3077-3091.e5 pubmed publisher
Howson L, Napolitani G, Shepherd D, Ghadbane H, Kurupati P, Preciado Llanes L, et al. MAIT cell clonal expansion and TCR repertoire shaping in human volunteers challenged with Salmonella Paratyphi A. Nat Commun. 2018;9:253 pubmed publisher
Wakao H, Yoshikiyo K, Koshimizu U, Furukawa T, Enomoto K, Matsunaga T, et al. Expansion of functional human mucosal-associated invariant T cells via reprogramming to pluripotency and redifferentiation. Cell Stem Cell. 2013;12:546-58 pubmed publisher

product information

Antigen :

TCR Valpha7.2

Apps. Abbrev. :

Cat # :

351709

Clone :

3C10

Item :

PerCP/Cyanine5.5 anti-human TCR Vα7.2

Isotype :

Mouse IgG1, κ

Other Names :

T cell antigen receptor Vα7.2

Size :

25 tests

Price (USD) :

176 USD

Reactivity :

Human

Clonality :

Monoclonal

Host :

Mouse

Conjugate/Tag/Label :

PERCP_CYANINE5.5

Immunogen :

Recombinant TCR

Application Notes :

Associated with an anti-CD161 or -IL18Ra staining, the 3C10 antibody allows unequivocal identification of MAIT cells. Importantly, the Va7.2 segment can also be used by conventional T cells. Therefore, the 3C10 also stains a subset of conventional CD4 and CD8 T cells. Additional reported applications (for the relevant formats) include: spatial biology (IBEX)^3,4.;

more info or order :

BioLegend product webpage