FITC anti-human TCR Vα7.2 | BioLegend 351703 product information

product summary

company name :

BioLegend

other brands :

Babco, Signet, Sternberger Monoclonals, Senetek, Covance

product type :

antibody

product name :

FITC anti-human TCR Vα7.2

catalog :

351703

quantity :

25 tests

price :

124 USD

clonality :

monoclonal

host :

mouse

conjugate :

FITC

clone name :

3C10

reactivity :

human

application :

flow cytometry

more info or order :

BioLegend product webpage

citations: 8

Reference
Hackstein C, Costigan D, Drexhage L, Pearson C, Bullers S, Ilott N, et al. A conserved population of MHC II-restricted, innate-like, commensal-reactive T cells in the gut of humans and mice. Nat Commun. 2022;13:7472 pubmed publisher
Leng T, Akther H, Hackstein C, Powell K, King T, Friedrich M, et al. TCR and Inflammatory Signals Tune Human MAIT Cells to Exert Specific Tissue Repair and Effector Functions. Cell Rep. 2019;28:3077-3091.e5 pubmed publisher
Lee C, Zhang H, Singh S, Koo L, Kabat J, Tsang H, et al. C/EBPδ drives interactions between human MAIT cells and endothelial cells that are important for extravasation. elife. 2018;7: pubmed publisher
Ben Youssef G, Tourret M, Salou M, Ghazarian L, Houdouin V, Mondot S, et al. Ontogeny of human mucosal-associated invariant T cells and related T cell subsets. J Exp Med. 2018;215:459-479 pubmed publisher
Jiang J, Chen X, An H, Yang B, Zhang F, Cheng X. Enhanced immune response of MAIT cells in tuberculous pleural effusions depends on cytokine signaling. Sci Rep. 2016;6:32320 pubmed publisher
van Wilgenburg B, Scherwitzl I, Hutchinson E, Leng T, Kurioka A, Kulicke C, et al. MAIT cells are activated during human viral infections. Nat Commun. 2016;7:11653 pubmed publisher
Leeansyah E, Loh L, Nixon D, Sandberg J. Acquisition of innate-like microbial reactivity in mucosal tissues during human fetal MAIT-cell development. Nat Commun. 2014;5:3143 pubmed publisher
Wakao H, Yoshikiyo K, Koshimizu U, Furukawa T, Enomoto K, Matsunaga T, et al. Expansion of functional human mucosal-associated invariant T cells via reprogramming to pluripotency and redifferentiation. Cell Stem Cell. 2013;12:546-58 pubmed publisher

product information

Antigen :

TCR Valpha7.2

Apps. Abbrev. :

Cat # :

351703

Clone :

3C10

Item :

FITC anti-human TCR Vα7.2

Isotype :

Mouse IgG1, κ

Other Names :

T cell antigen receptor Vα7.2

Size :

25 tests

Price (USD) :

124 USD

Reactivity :

Human

Clonality :

Monoclonal

Host :

Mouse

Conjugate/Tag/Label :

FITC

Immunogen :

Recombinant TCR

Application Notes :

Associated with an anti-CD161 or -IL18Ra staining, the 3C10 antibody allows unequivocal identification of MAIT cells. Importantly, the Va7.2 segment can also be used by conventional T cells. Therefore, the 3C10 also stains a subset of conventional CD4 and CD8 T cells. Additional reported applications (for the relevant formats) include: spatial biology (IBEX)^3,4.;

more info or order :

BioLegend product webpage