PE/Cyanine7 anti-human CD152 (CTLA-4) | BioLegend 349913 product information

product summary

company name :

BioLegend

other brands :

Babco, Signet, Sternberger Monoclonals, Senetek, Covance

product type :

antibody

product name :

PE/Cyanine7 anti-human CD152 (CTLA-4)

catalog :

349913

quantity :

25 tests

price :

176 USD

clonality :

monoclonal

host :

mouse

conjugate :

PE/Cy7

clone name :

L3D10

reactivity :

human

application :

immunocytochemistry, flow cytometry

more info or order :

BioLegend product webpage

citations: 10

Published Application/Species/Sample/Dilution	Reference
flow cytometry; human; loading ...; fig 2b,2c	Huang R, Francois A, McGray A, Miliotto A, Odunsi K. Compensatory upregulation of PD-1, LAG-3, and CTLA-4 limits the efficacy of single-agent checkpoint blockade in metastatic ovarian cancer. Oncoimmunology. 2017;6:e1249561 pubmed publisher
	Hao Y, Miraghazadeh B, Chand R, Davies A, Cardinez C, Kwong K, et al. CTLA4 protects against maladaptive cytotoxicity during the differentiation of effector and follicular CD4+ T cells. Cell Mol Immunol. 2023;20:777-793 pubmed publisher
	Mathewson N, Ashenberg O, Tirosh I, Gritsch S, Perez E, Marx S, et al. Inhibitory CD161 receptor identified in glioma-infiltrating T cells by single-cell analysis. Cell. 2021;184:1281-1298.e26 pubmed publisher
	Shevyrev D, Tereshchenko V, Kozlov V, Sizikov A, Chumasova O, Koksharova V. T-regulatory cells from patients with rheumatoid arthritis retain suppressor functions in vitro. Exp Ther Med. 2021;21:209 pubmed publisher
	Berezhnoy A, Sumrow B, Stahl K, Shah K, Liu D, Li J, et al. Development and Preliminary Clinical Activity of PD-1-Guided CTLA-4 Blocking Bispecific DART Molecule. Cell Rep Med. 2020;1:100163 pubmed publisher
	Wang A, Yang M, Liang R, Zhu F, Zhu F, Liu X, et al. Mouse Double Minute 2 Homolog-Mediated Ubiquitination Facilitates Forkhead Box P3 Stability and Positively Modulates Human Regulatory T Cell Function. Front Immunol. 2020;11:1087 pubmed publisher
	Luoma A, Suo S, Williams H, Sharova T, Sullivan K, Manos M, et al. Molecular Pathways of Colon Inflammation Induced by Cancer Immunotherapy. Cell. 2020;: pubmed publisher
	Li X, Wang R, Fan P, Yao X, Qin L, Peng Y, et al. A Comprehensive Analysis of Key Immune Checkpoint Receptors on Tumor-Infiltrating T Cells From Multiple Types of Cancer. Front Oncol. 2019;9:1066 pubmed publisher
	Zheng Z, Sze C, Keng C, Al Haddawi M, Liu M, Tan S, et al. Hepatitis C virus mediated chronic inflammation and tumorigenesis in the humanised immune system and liver mouse model. PLoS ONE. 2017;12:e0184127 pubmed publisher
	Sander F, Nilsson M, Rydström A, Aurelius J, Riise R, Movitz C, et al. Role of regulatory T cells in acute myeloid leukemia patients undergoing relapse-preventive immunotherapy. Cancer Immunol Immunother. 2017;66:1473-1484 pubmed publisher

product information

Antigen :

CD152

Apps. Abbrev. :

ICFC, FC

Cat # :

349913

Clone :

L3D10

Item :

PE/Cyanine7 anti-human CD152 (CTLA-4)

Isotype :

Mouse IgG1, κ

Other Names :

Cytotoxic T-Lymphocyte Antigen 4

Size :

25 tests

Price (USD) :

176 USD

Reactivity :

Human

Clonality :

Monoclonal

Host :

Mouse

Conjugate/Tag/Label :

PE_CYANINE7

Immunogen :

Extracellular domain of human CTLA-4 and human IgG1 Fc fusion protein

Application Notes :

ELISA Detection: The biotinylated L3D10 antibody is useful as the detection antibody in a sandwich ELISA assay, when used in conjunction with the purified A3.6B10.G1 antibody (Cat. No. 525401) as the capture antibody and recombinant human CTLA-4 (Cat. No. 591909) as the standard.Flow Cytometry: The fluorochrome-labeled L3D10 antibody is useful for immunofluorescent staining and flow cytometric analysis to identify CTLA-4-producing cells within mixed cell populations.Note: For testing human soluble CTLA-4 in serum, plasma or cell culture supernatant, LEGEND MAX™ Human Soluble CTLA-4 ELISA Kit with Pre-coated Plates (Cat. No. 437407) are specially developed and recommended.Additional reported applications (for the relevant formats) include: Blocking of CTLA-4/B7-1 interaction and blocking of CTLA-4-mediated inhibitory function to promote T cell expansion^1^,^2.This clone has been tested in-house and determined to not be suitable for applications in immunohistochemistry of frozen or paraffin-embedded tissue sections (IHC-F or IHC-P).;

more info or order :

BioLegend product webpage