APC anti-human CD152 (CTLA-4) | BioLegend 349908 product information

product summary

company name :

BioLegend

other brands :

Babco, Signet, Sternberger Monoclonals, Senetek, Covance

product type :

antibody

product name :

APC anti-human CD152 (CTLA-4)

catalog :

349908

quantity :

100 tests

price :

284 USD

clonality :

monoclonal

host :

mouse

conjugate :

APC

clone name :

L3D10

reactivity :

human

application :

immunocytochemistry, flow cytometry

more info or order :

BioLegend product webpage

citations: 11

Published Application/Species/Sample/Dilution	Reference
flow cytometry; human; loading ...; fig 6c	Kim G, Kim W, Lim S, Lee H, Koo J, Nam K, et al. In Vivo Induction of Regulatory T Cells Via CTLA-4 Signaling Peptide to Control Autoimmune Encephalomyelitis and Prevent Disease Relapse. Adv Sci (Weinh). 2021;8:2004973 pubmed publisher
flow cytometry; human; fig 5	NouÃ«l A, Pochard P, Simon Q, SÃ©galen I, Le Meur Y, Pers J, et al. B-Cells induce regulatory T cells through TGF-Î²/IDO production in A CTLA-4 dependent manner. J Autoimmun. 2015;59:53-60 pubmed publisher
	Theodoraki M, Laban S, Jackson E, Lotfi R, Schuler P, Brunner C, et al. Changes in circulating exosome molecular profiles following surgery/(chemo)radiotherapy: early detection of response in head and neck cancer patients. Br J Cancer. 2021;125:1677-1686 pubmed publisher
	Kumagai S, Togashi Y, Sakai C, Kawazoe A, Kawazu M, Ueno T, et al. An Oncogenic Alteration Creates a Microenvironment that Promotes Tumor Progression by Conferring a Metabolic Advantage to Regulatory T Cells. Immunity. 2020;53:187-203.e8 pubmed publisher
	Brummer G, Fang W, Smart C, Zinda B, Alissa N, Berkland C, et al. CCR2 signaling in breast carcinoma cells promotes tumor growth and invasion by promoting CCL2 and suppressing CD154 effects on the angiogenic and immune microenvironments. Oncogene. 2020;39:2275-2289 pubmed publisher
	Garcia Perez J, Baxter R, Kong D, Tobin R, McCarter M, Routes J, et al. CTLA4 Message Reflects Pathway Disruption in Monogenic Disorders and Under Therapeutic Blockade. Front Immunol. 2019;10:998 pubmed publisher
	Theodoraki M, Yerneni S, Gooding W, Ohr J, Clump D, Bauman J, et al. Circulating exosomes measure responses to therapy in head and neck cancer patients treated with cetuximab, ipilimumab, and IMRT. Oncoimmunology. 2019;8:1593805 pubmed publisher
	Chellappa S, Kushekhar K, Munthe L, Tjønnfjord G, Aandahl E, Okkenhaug K, et al. The PI3K p110δ Isoform Inhibitor Idelalisib Preferentially Inhibits Human Regulatory T Cell Function. J Immunol. 2019;202:1397-1405 pubmed publisher
	Levin M, Kroehl M, Johnson M, Hammes A, Reinhold D, Lang N, et al. Th1 memory differentiates recombinant from live herpes zoster vaccines. J Clin Invest. 2018;128:4429-4440 pubmed publisher
	Arce Vargas F, Furness A, Litchfield K, Joshi K, Rosenthal R, Ghorani E, et al. Fc Effector Function Contributes to the Activity of Human Anti-CTLA-4 Antibodies. Cancer Cell. 2018;33:649-663.e4 pubmed publisher
	Linedale R, Schmidt C, King B, Ganko A, Simpson F, Panizza B, et al. Elevated frequencies of CD8 T cells expressing PD-1, CTLA-4 and Tim-3 within tumour from perineural squamous cell carcinoma patients. PLoS ONE. 2017;12:e0175755 pubmed publisher

product information

Antigen :

CD152

Apps. Abbrev. :

ICFC

Cat # :

349908

Clone :

L3D10

Item :

APC anti-human CD152 (CTLA-4)

Isotype :

Mouse IgG1, κ

Other Names :

Cytotoxic T-Lymphocyte Antigen 4

Size :

100 tests

Price (USD) :

284 USD

Reactivity :

Human

Clonality :

Monoclonal

Host :

Mouse

Conjugate/Tag/Label :

APC

Immunogen :

Extracellular domain of human CTLA-4 and human IgG1 Fc fusion protein

Application Notes :

ELISA Detection: The biotinylated L3D10 antibody is useful as the detection antibody in a sandwich ELISA assay, when used in conjunction with the purified A3.6B10.G1 antibody (Cat. No. 525401) as the capture antibody and recombinant human CTLA-4 (Cat. No. 591909) as the standard.Flow Cytometry: The fluorochrome-labeled L3D10 antibody is useful for immunofluorescent staining and flow cytometric analysis to identify CTLA-4-producing cells within mixed cell populations.Note: For testing human soluble CTLA-4 in serum, plasma or cell culture supernatant, LEGEND MAX™ Human Soluble CTLA-4 ELISA Kit with Pre-coated Plates (Cat. No. 437407) are specially developed and recommended.Additional reported applications (for the relevant formats) include: Blocking of CTLA-4/B7-1 interaction and blocking of CTLA-4-mediated inhibitory function to promote T cell expansion^1^,^2.This clone has been tested in-house and determined to not be suitable for applications in immunohistochemistry of frozen or paraffin-embedded tissue sections (IHC-F or IHC-P).;

more info or order :

BioLegend product webpage