LEAF™ Purified anti-human CD158d (KIR2DL4) | BioLegend 347003 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

BioLegend

other brands :

Babco, Signet, Sternberger Monoclonals, Senetek, Covance

product type :

antibody

product name :

LEAF™ Purified anti-human CD158d (KIR2DL4)

catalog :

347003

quantity :

50 μg

price :

215 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

mAb 33 (33)

reactivity :

human

application :

flow cytometry

citations: 5

Reference
Ferrari de Andrade L, Kumar S, Luoma A, Ito Y, Alves da Silva P, Pan D, et al. Inhibition of MICA and MICB Shedding Elicits NK-Cell-Mediated Immunity against Tumors Resistant to Cytotoxic T Cells. Cancer Immunol Res. 2020;8:769-780 pubmed publisher
Zhai Y, Lin P, Feng Z, Lu H, Han Q, Chen J, et al. TNFAIP3-DEPTOR complex regulates inflammasome secretion through autophagy in ankylosing spondylitis monocytes. Autophagy. 2018;14:1629-1643 pubmed publisher
Fu B, Zhou Y, Ni X, Tong X, Xu X, Dong Z, et al. Natural Killer Cells Promote Fetal Development through the Secretion of Growth-Promoting Factors. Immunity. 2017;47:1100-1113.e6 pubmed publisher
Ueshima C, Kataoka T, Hirata M, Furuhata A, Suzuki E, Toi M, et al. The Killer Cell Ig-like Receptor 2DL4 Expression in Human Mast Cells and Its Potential Role in Breast Cancer Invasion. Cancer Immunol Res. 2015;3:871-80 pubmed publisher
Le Page M, Goodridge J, John E, Christiansen F, Witt C. Killer Ig-like receptor 2DL4 does not mediate NK cell IFN-? responses to soluble HLA-G preparations. J Immunol. 2014;192:732-40 pubmed publisher

product information

Antigen :

CD158d

Apps. Abbrev. :

Flow Cytometry, Activ

Cat # :

347003

Clone :

mAb 33 (33)

Item :

LEAF™ Purified anti-human CD158d (KIR2DL4)

Isotype :

Mouse IgG1, κ

Other Names :

KIR2DL4, 2DL4, p49, KIR103

Size :

50 μg

Price (USD) :

215 USD

Reactivity :

Human

Clonality :

Monoclonal

Host :

Mouse

Conjugate/Tag/Label :

LEAF

Immunogen :

NK3.3 cells and KIR2DL4-Ig fusion protein

Application Notes :

KIR2DL4 expression in NK cells is highly localized to the endosomes 3 . mAb 33 can be internalized by NK cells by endocytosis at 37 C 3 , and induces NK cell cytotoxicity 1,2 . Based on in-house observations, we suggest incubating for 45 - 60 minutes at room temperature with clone mAb 33 to observe better CD158d staining. This clone has been tested in-house and determined to not be suitable for applications in immunohistochemistry of paraffin-embedded tissue sections (IHC-P).