product summary
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company name :
BioLegend
other brands :
Babco, Signet, Sternberger Monoclonals, Senetek, Covance
product type :
antibody
product name :
Brilliant Violet 421™ anti-human CD366 (Tim-3)
catalog :
345008
quantity :
100 tests
price :
407 USD
clonality :
monoclonal
host :
mouse
conjugate :
BV421
clone name :
F38-2E2
reactivity :
human
application :
flow cytometry
more info or order :
citations: 13
Published Application/Species/Sample/DilutionReference
  • flow cytometry; human; fig 3g
Dalla Pietà A, Cappuzzello E, Palmerini P, Ventura A, Visentin A, Astori G, et al. Innovative therapeutic strategy for B-cell malignancies that combines obinutuzumab and cytokine-induced killer cells. J Immunother Cancer. 2021;9: pubmed publisher
Junker F, Gulati P, Wessels U, Seeber S, Stubenrauch K, Codarri Deak L, et al. A human receptor occupancy assay to measure anti-PD-1 binding in patients with prior anti-PD-1. Cytometry A. 2021;99:832-843 pubmed publisher
Wenthe J, Naseri S, Labani Motlagh A, Enblad G, Wikstrom K, Eriksson E, et al. Boosting CAR T-cell responses in lymphoma by simultaneous targeting of CD40/4-1BB using oncolytic viral gene therapy. Cancer Immunol Immunother. 2021;70:2851-2865 pubmed publisher
Bonifacius A, Tischer Zimmermann S, Dragon A, Gussarow D, Vogel A, Krettek U, et al. COVID-19 immune signatures reveal stable antiviral T cell function despite declining humoral responses. Immunity. 2021;54:340-354.e6 pubmed publisher
Trivedi S, Labuz D, Anderson C, Araújo C, Blair A, Middleton E, et al. Mucosal-associated invariant T (MAIT) cells mediate protective host responses in sepsis. elife. 2020;9: pubmed publisher
Acharya N, Madi A, Zhang H, Klapholz M, Escobar G, Dulberg S, et al. Endogenous Glucocorticoid Signaling Regulates CD8+ T Cell Differentiation and Development of Dysfunction in the Tumor Microenvironment. Immunity. 2020;53:658-671.e6 pubmed publisher
Li X, Wang R, Fan P, Yao X, Qin L, Peng Y, et al. A Comprehensive Analysis of Key Immune Checkpoint Receptors on Tumor-Infiltrating T Cells From Multiple Types of Cancer. Front Oncol. 2019;9:1066 pubmed publisher
Cunningham R, Holland M, McWilliams E, Hodi F, Severgnini M. Detection of clinically relevant immune checkpoint markers by multicolor flow cytometry. J Biol Methods. 2019;6:e114 pubmed publisher
Li J, Byrne K, Yan F, Yamazoe T, Chen Z, Baslan T, et al. Tumor Cell-Intrinsic Factors Underlie Heterogeneity of Immune Cell Infiltration and Response to Immunotherapy. Immunity. 2018;49:178-193.e7 pubmed publisher
Linedale R, Schmidt C, King B, Ganko A, Simpson F, Panizza B, et al. Elevated frequencies of CD8 T cells expressing PD-1, CTLA-4 and Tim-3 within tumour from perineural squamous cell carcinoma patients. PLoS ONE. 2017;12:e0175755 pubmed publisher
Karlsson H, Svensson E, Gigg C, Jarvius M, Olsson Strömberg U, Savoldo B, et al. Evaluation of Intracellular Signaling Downstream Chimeric Antigen Receptors. PLoS ONE. 2015;10:e0144787 pubmed publisher
Thommen D, Schreiner J, Müller P, Herzig P, Roller A, Belousov A, et al. Progression of Lung Cancer Is Associated with Increased Dysfunction of T Cells Defined by Coexpression of Multiple Inhibitory Receptors. Cancer Immunol Res. 2015;3:1344-55 pubmed publisher
de Kivit S, Lempsink L, Plants J, Martinson J, Keshavarzian A, Landay A. Modulation of TIM-3 expression on NK and T cell subsets in HIV immunological non-responders. Clin Immunol. 2015;156:28-35 pubmed publisher
product information
Antigen :
CD366
Apps. Abbrev. :
Flow Cytometry
Cat # :
345008
Clone :
F38-2E2
Item :
Brilliant Violet 421™ anti-human CD366 (Tim-3)
Isotype :
Mouse IgG1, κ
Other Names :
T cell immunoglobulin and mucin domain containing protein 3, hepatitis virus cellular receptor 2, CD366
Size :
100 tests
Price (USD) :
407 USD
Reactivity :
Human
Clonality :
Monoclonal
Host :
Mouse
Conjugate/Tag/Label :
BV421
Immunogen :
Human Tim-3 fusion protein
Application Notes :
Additional reported applications (for relevant formats of this clone) include: costimulation 1 (clone 2E2 has been shown to enhance T-cell receptor mediated activation and cytokine secretion) and blocking 2,3 .
more info or order :
company information
BioLegend
8999 BioLegend Way
San Diego, CA 92121
customerserv@biolegend.com
https://www.biolegend.com
headquarters: USA