product summary
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company name :
BioLegend
other brands :
Babco, Signet, Sternberger Monoclonals, Senetek, Covance
product type :
antibody
product name :
PE/Cyanine7 anti-human CD8
catalog :
344750
quantity :
100 μg
price :
229 USD
clonality :
monoclonal
host :
mouse
conjugate :
PE/Cy7
clone name :
SK1
reactivity :
human, mouse, rhesus macaque
application :
flow cytometry
more info or order :
citations: 51
Published Application/Species/Sample/DilutionReference
  • flow cytometry; mouse; loading ...; fig 2b
Trapecar M, Khan S, Cohn B, Wu F, Sanjabi S. B cells are the predominant mediators of early systemic viral dissemination during rectal LCMV infection. Mucosal Immunol. 2018;11:1158-1167 pubmed publisher
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Xiao Q, Su X. Anti-tumor Efficacy of CD19 CAR-T in a Raji B Cell Xenografted Mouse Model. Bio Protoc. 2023;13:e4655 pubmed publisher
Boucher L, Prinslow E, Feldkamp M, Yi F, Nanjunda R, Wu S, et al. "Stapling" scFv for multispecific biotherapeutics of superior properties. MAbs. 2023;15:2195517 pubmed publisher
van Os B, Vos W, Bosmans L, Van Tiel C, Lith S, den Toom M, et al. Hyperlipidaemia elicits an atypical, T helper 1-like CD4+ T-cell response: a key role for very low-density lipoprotein. Eur Heart J Open. 2023;3:oead013 pubmed publisher
Saeland E, van der Fits L, Bolder R, Heemskerk van der Meer M, Drijver J, van Polanen Y, et al. Combination Ad26.RSV.preF/preF protein vaccine induces superior protective immunity compared with individual vaccine components in preclinical models. NPJ Vaccines. 2023;8:45 pubmed publisher
Battistello E, Hixon K, Comstock D, Collings C, Chen X, Rodriguez Hernaez J, et al. Stepwise activities of mSWI/SNF family chromatin remodeling complexes direct T cell activation and exhaustion. Mol Cell. 2023;83:1216-1236.e12 pubmed publisher
Ritacco C, K xf6 se M, Courtois J, Canti L, Beguin C, Dubois S, et al. Post-transplant cyclophosphamide prevents xenogeneic graft-versus-host disease while depleting proliferating regulatory T cells. iScience. 2023;26:106085 pubmed publisher
Mart xed nez Sabadell A, Ovejero Romero P, Arribas J, Arenas E. Protocol to generate a patient derived xenograft model of acquired resistance to immunotherapy in humanized mice. STAR Protoc. 2022;3:101712 pubmed publisher
Mart xed nez Sabadell A, Morancho B, Rius Ruiz I, Rom xe1 n Alonso M, Ovejero Romero P, Escorihuela M, et al. The target antigen determines the mechanism of acquired resistance to T cell-based therapies. Cell Rep. 2022;41:111430 pubmed publisher
Reitinger C, Ipsen Escobedo A, Hornung C, Heger L, Dudziak D, Lux A, et al. Modulation of urelumab glycosylation separates immune stimulatory activity from organ toxicity. Front Immunol. 2022;13:970290 pubmed publisher
Song M, Xie H, Liu W, Zhao M, Deng Z, Zhang L, et al. Characterization of the evolution trajectory and immune profiling of new histologic patterns in lung adenocarcinoma. J Gene Med. 2022;24:e3455 pubmed publisher
Castellano E, Samba C, Esteso G, Simpson L, Vendrame E, Garc xed a Cuesta E, et al. CyTOF analysis identifies unusual immune cells in urine of BCG-treated bladder cancer patients. Front Immunol. 2022;13:970931 pubmed publisher
Wang H, Liu H, Zhou L, Wang D, Wang S, Liu Q, et al. Cytomegalovirus-specific neutralizing antibodies effectively prevent uncontrolled infection after allogeneic hematopoietic stem cell transplantation. iScience. 2022;25:105065 pubmed publisher
Su x161 ac L, Vuong M, Thomas C, von B xfc low S, O Brien Ball C, Santos A, et al. Structure of a fully assembled tumor-specific T cell receptor ligated by pMHC. Cell. 2022;185:3201-3213.e19 pubmed publisher
Batikan O, Sevinc M, Tekin O, Sonmez D, Dogan S, Kegin M. Flowcytometric Ratios of Immune Cells in the Prognosis and Staging of Acute Biliary Pancreatitis. J Coll Physicians Surg Pak. 2022;32:1004-1008 pubmed publisher
Lai Y, Zhao S, Chen B, Huang Y, Guo C, Li M, et al. Iron controls T helper cell pathogenicity by promoting glucose metabolism in autoimmune myopathy. Clin Transl Med. 2022;12:e999 pubmed publisher
Idiz U, Yurttas T, Degirmencioglu S, Orhan B, Erdoğan E, Sevik H, et al. Immunophenotyping of lymphocytes and monocytes and the status of cytokines in the clinical course of Covid-19 patients. J Med Virol. 2022;94:4744-4753 pubmed publisher
Chen Y, Tong P, WHITEMAN N, Moghaddam A, Zarghami M, Zuiani A, et al. Immune recall improves antibody durability and breadth to SARS-CoV-2 variants. Sci Immunol. 2022;:eabp8328 pubmed publisher
Zhang T, Zhao Y, Cheung W, Gan Y, Huang L, Li M, et al. Serial changes in two immune checkpoint receptors and ligands, Tim-3/Gal-9 and PD-1/PD-L1 in peripheral blood prior to miscarriage: Comparison with pregnancies resulting in a live birth. Am J Reprod Immunol. 2022;87:e13524 pubmed publisher
Hu J, Yang Q, Zhang W, Du H, Chen Y, Zhao Q, et al. Cell membrane-anchored and tumor-targeted IL-12 (attIL12)-T cell therapy for eliminating large and heterogeneous solid tumors. J Immunother Cancer. 2022;10: pubmed publisher
Stunnenberg M, van Hamme J, Zijlstra Willems E, Gringhuis S, Geijtenbeek T. Crosstalk between R848 and abortive HIV-1 RNA-induced signaling enhances antiviral immunity. J Leukoc Biol. 2022;112:289-298 pubmed publisher
Yuan H, Nishikori M, Ueda C, Fujimoto M, Yasumi T, Otsuka Y, et al. A sporadic case of CTLA4 haploinsufficiency manifesting as Epstein-Barr virus-positive diffuse large B-cell lymphoma. J Clin Exp Hematop. 2022;62:52-57 pubmed publisher
Mo Y, To K, Zhou R, Liu L, Cao T, Huang H, et al. Mitochondrial Dysfunction Associates With Acute T Lymphocytopenia and Impaired Functionality in COVID-19 Patients. Front Immunol. 2021;12:799896 pubmed publisher
Beatson R, Parente Pereira A, Halim L, Cozzetto D, Hull C, Whilding L, et al. TGF-β1 potentiates Vγ9Vδ2 T cell adoptive immunotherapy of cancer. Cell Rep Med. 2021;2:100473 pubmed publisher
Muliaditan T, Halim L, Whilding L, Draper B, Achkova D, Kausar F, et al. Synergistic T cell signaling by 41BB and CD28 is optimally achieved by membrane proximal positioning within parallel chimeric antigen receptors. Cell Rep Med. 2021;2:100457 pubmed publisher
Cossarizza A, Chang H, Radbruch A, Abrignani S, Addo R, Akdis M, et al. Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition). Eur J Immunol. 2021;51:2708-3145 pubmed publisher
Gussarow D, Bonifacius A, Cossmann A, Stankov M, Mausberg P, Tischer Zimmermann S, et al. Long-Lasting Immunity Against SARS-CoV-2: Dream or Reality?. Front Med (Lausanne). 2021;8:770381 pubmed publisher
Ma C, Ma X, Jiang B, Pan H, Liao X, Zhang L, et al. A novel inactivated whole-cell Pseudomonas aeruginosa vaccine that acts through the cGAS-STING pathway. Signal Transduct Target Ther. 2021;6:353 pubmed publisher
Ho C, Silva A, Tomita B, Weng H, Ho I. Differential impacts of TNFα inhibitors on the transcriptome of Th cells. Arthritis Res Ther. 2021;23:199 pubmed publisher
Liu R, Ma R, Liu Z, Hu H, Shu J, Hu P, et al. HTNV infection of CD8+ T cells is associated with disease progression in HFRS patients. Commun Biol. 2021;4:652 pubmed publisher
Hohmann M, Habiel D, Espíndola M, Huang G, Jones I, Narayanan R, et al. Antibody-mediated depletion of CCR10+EphA3+ cells ameliorates fibrosis in IPF. JCI Insight. 2021;6: pubmed publisher
Arenas E, Martínez Sabadell A, Rius Ruiz I, Román Alonso M, Escorihuela M, Luque A, et al. Acquired cancer cell resistance to T cell bispecific antibodies and CAR T targeting HER2 through JAK2 down-modulation. Nat Commun. 2021;12:1237 pubmed publisher
Bonifacius A, Tischer Zimmermann S, Dragon A, Gussarow D, Vogel A, Krettek U, et al. COVID-19 immune signatures reveal stable antiviral T cell function despite declining humoral responses. Immunity. 2021;54:340-354.e6 pubmed publisher
Dai G, Wanek A, Eddens T, Volden P, Kolls J. Toward a humanized mouse model of Pneumocystis pneumonia. JCI Insight. 2021;6: pubmed publisher
Alsaleh G, Panse I, Swadling L, Zhang H, Richter F, Meyer A, et al. Autophagy in T cells from aged donors is maintained by spermidine and correlates with function and vaccine responses. elife. 2020;9: pubmed publisher
Bhatt R, Berjis A, Konge J, Mahoney K, Klee A, Freeman S, et al. KIR3DL3 Is an Inhibitory Receptor for HHLA2 that Mediates an Alternative Immunoinhibitory Pathway to PD1. Cancer Immunol Res. 2021;9:156-169 pubmed publisher
Chen Y, Zuiani A, Fischinger S, Mullur J, Atyeo C, Travers M, et al. Quick COVID-19 Healers Sustain Anti-SARS-CoV-2 Antibody Production. Cell. 2020;183:1496-1507.e16 pubmed publisher
Pierce C, Preston Hurlburt P, Dai Y, Aschner C, Cheshenko N, Galen B, et al. Immune responses to SARS-CoV-2 infection in hospitalized pediatric and adult patients. Sci Transl Med. 2020;12: pubmed publisher
Lickliter J, Gan H, Voskoboynik M, Arulananda S, Gao B, Nagrial A, et al. A First-in-Human Dose Finding Study of Camrelizumab in Patients with Advanced or Metastatic Cancer in Australia. Drug Des Devel Ther. 2020;14:1177-1189 pubmed publisher
Arif S, Gomez Tourino I, Kamra Y, Pujol Autonell I, Hanton E, Tree T, et al. GAD-alum immunotherapy in type 1 diabetes expands bifunctional Th1/Th2 autoreactive CD4 T cells. Diabetologia. 2020;63:1186-1198 pubmed publisher
Manukyan G, Martirosyan A, Slavik L, Margaryan S, Ulehlova J, Mikulkova Z, et al. Anti-domain 1 β2 glycoprotein antibodies increase expression of tissue factor on monocytes and activate NK Cells and CD8+ cells in vitro. Auto Immun Highlights. 2020;11:5 pubmed publisher
James K, Gomes T, Elmentaite R, Kumar N, Gulliver E, King H, et al. Distinct microbial and immune niches of the human colon. Nat Immunol. 2020;21:343-353 pubmed publisher
van Beek J, Flórez Grau G, Gorris M, Mathan T, Schreibelt G, Bol K, et al. Human pDCs Are Superior to cDC2s in Attracting Cytolytic Lymphocytes in Melanoma Patients Receiving DC Vaccination. Cell Rep. 2020;30:1027-1038.e4 pubmed publisher
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Franco L, Gadkari M, Howe K, Sun J, Kardava L, Kumar P, et al. Immune regulation by glucocorticoids can be linked to cell type-dependent transcriptional responses. J Exp Med. 2019;216:384-406 pubmed publisher
Neal J, Li X, Zhu J, Giangarrà V, Grzeskowiak C, Ju J, et al. Organoid Modeling of the Tumor Immune Microenvironment. Cell. 2018;175:1972-1988.e16 pubmed publisher
Buchan S, Dou L, Remer M, Booth S, Dunn S, Lai C, et al. Antibodies to Costimulatory Receptor 4-1BB Enhance Anti-tumor Immunity via T Regulatory Cell Depletion and Promotion of CD8 T Cell Effector Function. Immunity. 2018;49:958-970.e7 pubmed publisher
Iannetta M, Zingaropoli M, Bellizzi A, Morreale M, Pontecorvo S, D Abramo A, et al. Natalizumab Affects T-Cell Phenotype in Multiple Sclerosis: Implications for JCV Reactivation. PLoS ONE. 2016;11:e0160277 pubmed publisher
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Ch en I, Tsau J, Molkentin J, Komatsu M, Hedrick S. Mechanisms of necroptosis in T cells. J Exp Med. 2011;208:633-41 pubmed publisher
product information
Antigen :
CD8
Apps. Abbrev. :
FC
Cat # :
344750
Clone :
SK1
Item :
PE/Cyanine7 anti-human CD8
Isotype :
Mouse IgG1, κ
Other Names :
T8, Leu2
Size :
100 μg
Price (USD) :
229 USD
Reactivity :
Human, Cynomolgus, Rhesus
Clonality :
Monoclonal
Host :
Mouse
Conjugate/Tag/Label :
PE_CYANINE7
Application Notes :
Clone SK1 recognizes the a chain of CD8. Additional reported applications (for the relevant formats) include: proteogenomics^8, immunohistochemistry of acetone-fixed frozen tissue sections, and spatial biology (IBEX)^9,10. This clone was tested in-house and does not demonstrate utility for formalin-fixed paraffin-embedded (FFPE) human tonsil sections.;
more info or order :
company information
BioLegend
8999 BioLegend Way
San Diego, CA 92121
customerserv@biolegend.com
https://www.biolegend.com
headquarters: USA