product summary
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company name :
BioLegend
other brands :
Babco, Signet, Sternberger Monoclonals, Senetek, Covance
product type :
antibody
product name :
Brilliant Violet 421™ anti-human CD8
catalog :
344748
quantity :
100 tests
price :
396 USD
clonality :
monoclonal
host :
mouse
conjugate :
BV421
clone name :
SK1
reactivity :
human, rhesus macaque
application :
flow cytometry
more info or order :
citations: 18
Published Application/Species/Sample/DilutionReference
  • flow cytometry; human; loading ...; fig 8i
Wang Y, Mohseni M, Grauel A, Diez J, Guan W, Liang S, et al. SHP2 blockade enhances anti-tumor immunity via tumor cell intrinsic and extrinsic mechanisms. Sci Rep. 2021;11:1399 pubmed publisher
Melo V, Nelemans L, Vlaming M, Lourens H, Wiersma V, Bilemjian V, et al. EGFR-selective activation of CD27 co-stimulatory signaling by a bispecific antibody enhances anti-tumor activity of T cells. Front Immunol. 2023;14:1191866 pubmed publisher
Deng G, He J, Huang Q, Li T, Huang Z, Gao S, et al. Ibrutinib Inhibits BTK Signaling in Tumor-Infiltrated B Cells and Amplifies Antitumor Immunity by PD-1 Checkpoint Blockade for Metastatic Prostate Cancer. Cancers (Basel). 2023;15: pubmed publisher
Yin Z, Chen J, Lu Y, Wang B, Godfrey L, Mentzer A, et al. Evaluation of T cell responses to naturally processed variant SARS-CoV-2 spike antigens in individuals following infection or vaccination. Cell Rep. 2023;42:112470 pubmed publisher
Xiong H, Cui M, Kong N, Jing J, Xu Y, Liu X, et al. Cytotoxic CD161-CD8+ TEMRA cells contribute to the pathogenesis of systemic lupus erythematosus. EBioMedicine. 2023;90:104507 pubmed publisher
Gravina A, Tediashvili G, Rajalingam R, Quandt Z, Deisenroth C, Schrepfer S, et al. Protection of cell therapeutics from antibody-mediated killing by CD64 overexpression. Nat Biotechnol. 2023;41:717-727 pubmed publisher
Yuan X, Sun L, Jeske R, Nkosi D, York S, Liu Y, et al. Engineering extracellular vesicles by three-dimensional dynamic culture of human mesenchymal stem cells. J Extracell Vesicles. 2022;11:e12235 pubmed publisher
Tu J, Tan X, Chen Y, Li Z, Zhang Y, Chen X, et al. Growth arrest-specific transcript 5 represses endometrial cancer development by promoting antitumor function of tumor-associated macrophages. Cancer Sci. 2022;113:2496-2512 pubmed publisher
Sefik E, Qu R, Junqueira C, Kaffe E, Mirza H, Zhao J, et al. Inflammasome activation in infected macrophages drives COVID-19 pathology. Nature. 2022;606:585-593 pubmed publisher
Goncharov M, Bryushkova E, Sharaev N, Skatova V, Baryshnikova A, Sharonov G, et al. Pinpointing the tumor-specific T cells via TCR clusters. elife. 2022;11: pubmed publisher
Sefik E, Israelow B, Mirza H, Zhao J, Qu R, Kaffe E, et al. A humanized mouse model of chronic COVID-19. Nat Biotechnol. 2021;: pubmed publisher
Yamada E, Martin C, Moreno Huizar N, Fouquier J, Neff C, Coleman S, et al. Intestinal microbial communities and Holdemanella isolated from HIV+/- men who have sex with men increase frequencies of lamina propria CCR5+ CD4+ T cells. Gut Microbes. 2021;13:1997292 pubmed publisher
Ma K, Schonnesen A, He C, Xia A, Sun E, Chen E, et al. High-throughput and high-dimensional single-cell analysis of antigen-specific CD8+ T cells. Nat Immunol. 2021;22:1590-1598 pubmed publisher
O Connor R, Chauhan V, Mathieson L, Titmarsh H, Koppensteiner L, Young I, et al. T cells drive negative feedback mechanisms in cancer associated fibroblasts, promoting expression of co-inhibitory ligands, CD73 and IL-27 in non-small cell lung cancer. Oncoimmunology. 2021;10:1940675 pubmed publisher
Derada Troletti C, Enzmann G, Chiurchiù V, Kamermans A, Tietz S, Norris P, et al. Pro-resolving lipid mediator lipoxin A4 attenuates neuro-inflammation by modulating T cell responses and modifies the spinal cord lipidome. Cell Rep. 2021;35:109201 pubmed publisher
Zamarin D, Hamid O, Nayak Kapoor A, Sahebjam S, Sznol M, Collaku A, et al. Mogamulizumab in Combination with Durvalumab or Tremelimumab in Patients with Advanced Solid Tumors: A Phase I Study. Clin Cancer Res. 2020;26:4531-4541 pubmed publisher
Kim N, Kim H, Lee K, Hong Y, Cho J, Choi J, et al. Single-cell RNA sequencing demonstrates the molecular and cellular reprogramming of metastatic lung adenocarcinoma. Nat Commun. 2020;11:2285 pubmed publisher
Klichinsky M, Ruella M, Shestova O, Lu X, Best A, Zeeman M, et al. Human chimeric antigen receptor macrophages for cancer immunotherapy. Nat Biotechnol. 2020;38:947-953 pubmed publisher
product information
Antigen :
CD8
Apps. Abbrev. :
FC
Cat # :
344748
Clone :
SK1
Item :
Brilliant Violet 421™ anti-human CD8
Isotype :
Mouse IgG1, κ
Other Names :
T8, Leu2
Size :
100 tests
Price (USD) :
396 USD
Reactivity :
Human, Cynomolgus, Rhesus
Clonality :
Monoclonal
Host :
Mouse
Conjugate/Tag/Label :
BV421
Application Notes :
Clone SK1 recognizes the a chain of CD8. Additional reported applications (for the relevant formats) include: proteogenomics^8, immunohistochemistry of acetone-fixed frozen tissue sections, and spatial biology (IBEX)^9,10. This clone was tested in-house and does not demonstrate utility for formalin-fixed paraffin-embedded (FFPE) human tonsil sections.;
more info or order :
company information
BioLegend
8999 BioLegend Way
San Diego, CA 92121
customerserv@biolegend.com
https://www.biolegend.com
headquarters: USA