product summary
Loading...
company name :
BioLegend
other brands :
Babco, Signet, Sternberger Monoclonals, Senetek, Covance
product type :
antibody
product name :
Purified anti-human HLA-E
catalog :
342602
quantity :
100 μg
price :
159 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
3D12
reactivity :
human
application :
immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
citations: 15
Published Application/Species/Sample/DilutionReference
  • flow cytometry; human; loading ...; fig 2b
Zhu Y, Xie J, Shi J. Rac1/ROCK-driven membrane dynamics promote natural killer cell cytotoxicity via granzyme-induced necroptosis. BMC Biol. 2021;19:140 pubmed publisher
  • flow cytometry; human; loading ...; fig 5a
Altvater B, Kailayangiri S, Pérez Lanuza L, Urban K, Greune L, Flügge M, et al. HLA-G and HLA-E Immune Checkpoints Are Widely Expressed in Ewing Sarcoma but Have Limited Functional Impact on the Effector Functions of Antigen-Specific CAR T Cells. Cancers (Basel). 2021;13: pubmed publisher
  • immunocytochemistry; human; loading ...; fig 7
Yang Y, Sun M, Yu Z, Liu J, Yan W, Liu Z, et al. Designing high affinity target-binding peptides to HLA-E: a key membrane antigen of multiple myeloma. Aging (Albany NY). 2020;12:20457-20470 pubmed publisher
  • immunocytochemistry; human; loading ...; fig 7
Culbertson M, Bennett K, Kelly C, Sharp L, Cahir C. The psychosocial determinants of quality of life in breast cancer survivors: a scoping review. BMC Cancer. 2020;20:948 pubmed publisher
  • immunocytochemistry; human; loading ...; fig 7
Chen S, Li K. HOXD-AS1 facilitates cell migration and invasion as an oncogenic lncRNA by competitively binding to miR-877-3p and upregulating FGF2 in human cervical cancer. BMC Cancer. 2020;20:924 pubmed publisher
  • flow cytometry; human; loading ...; fig 1d
Tremblay McLean A, Coenraads S, Kiani Z, Dupuy F, Bernard N. Expression of ligands for activating natural killer cell receptors on cell lines commonly used to assess natural killer cell function. BMC Immunol. 2019;20:8 pubmed publisher
  • flow cytometry; human; loading ...; fig 2c
Hallner A, Bernson E, Hussein B, Sander F, Brune M, Aurelius J, et al. The HLA-B -21 dimorphism impacts on NK cell education and clinical outcome of immunotherapy in acute myeloid leukemia. Blood. 2019;: pubmed publisher
  • immunohistochemistry - frozen section; human; loading ...; fig 4a, 4c
  • immunohistochemistry - paraffin section; human; loading ...; fig 4a, 4c
Andre P, Denis C, Soulas C, Bourbon Caillet C, Lopez J, Arnoux T, et al. Anti-NKG2A mAb Is a Checkpoint Inhibitor that Promotes Anti-tumor Immunity by Unleashing Both T and NK Cells. Cell. 2018;175:1731-1743.e13 pubmed publisher
  • flow cytometry; human; fig 6
Yawata N, Selva K, Liu Y, Tan K, Lee A, Siak J, et al. Dynamic change in natural killer cell type in the human ocular mucosa in situ as means of immune evasion by adenovirus infection. Mucosal Immunol. 2016;9:159-70 pubmed publisher
Ruibal P, Franken K, van Meijgaarden K, van Loon J, van der Steen D, Heemskerk M, et al. Peptide Binding to HLA-E Molecules in Humans, Nonhuman Primates, and Mice Reveals Unique Binding Peptides but Remarkably Conserved Anchor Residues. J Immunol. 2020;205:2861-2872 pubmed publisher
Carlsten M, Namazi A, Reger R, Levy E, Berg M, St Hilaire C, et al. Bortezomib sensitizes multiple myeloma to NK cells via ER-stress-induced suppression of HLA-E and upregulation of DR5. Oncoimmunology. 2019;8:e1534664 pubmed publisher
Villa Álvarez M, Sordo Bahamonde C, Lorenzo Herrero S, Gonzalez Rodriguez A, Payer A, González García E, et al. Ig-Like Transcript 2 (ILT2) Blockade and Lenalidomide Restore NK Cell Function in Chronic Lymphocytic Leukemia. Front Immunol. 2018;9:2917 pubmed publisher
Miles B, Miller S, Folkvord J, Levy D, Rakasz E, Skinner P, et al. Follicular Regulatory CD8 T Cells Impair the Germinal Center Response in SIV and Ex Vivo HIV Infection. PLoS Pathog. 2016;12:e1005924 pubmed publisher
Laroni A, Armentani E, Kerlero de Rosbo N, Ivaldi F, Marcenaro E, Sivori S, et al. Dysregulation of regulatory CD56(bright) NK cells/T cells interactions in multiple sclerosis. J Autoimmun. 2016;72:8-18 pubmed publisher
Corrah T, Goonetilleke N, Kopycinski J, Deeks S, Cohen M, Borrow P, et al. Reappraisal of the relationship between the HIV-1-protective single-nucleotide polymorphism 35 kilobases upstream of the HLA-C gene and surface HLA-C expression. J Virol. 2011;85:3367-74 pubmed publisher
product information
Antigen :
HLA-E
Apps. Abbrev. :
FC, IP
Cat # :
342602
Clone :
3D12
Item :
Purified anti-human HLA-E
Isotype :
Mouse IgG1, κ
Other Names :
HLA class I histocompatibility antigen, alpha chain E, HLAE
Size :
100 μg
Price (USD) :
159 USD
Reactivity :
Human
Clonality :
Monoclonal
Host :
Mouse
Conjugate/Tag/Label :
PURE
more info or order :
company information
BioLegend
8999 BioLegend Way
San Diego, CA 92121
customerserv@biolegend.com
https://www.biolegend.com
headquarters: USA