product summary
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company name :
BioLegend
other brands :
Babco, Signet, Sternberger Monoclonals, Senetek, Covance
product type :
antibody
product name :
Purified anti-human CD335 (NKp46)
catalog :
331902
quantity :
100 μg
price :
129 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
9.00E+02
reactivity :
human, mouse
application :
flow cytometry, blocking or activating experiments, other, mass cytometry
more info or order :
citations: 33
Published Application/Species/Sample/DilutionReference
  • blocking or activating experiments; human; 10 ug/ml; loading ...; fig 2e
Zhu Y, Xie J, Shi J. Rac1/ROCK-driven membrane dynamics promote natural killer cell cytotoxicity via granzyme-induced necroptosis. BMC Biol. 2021;19:140 pubmed publisher
  • flow cytometry; human; loading ...; fig s1
Katano I, Ito R, Kawai K, Takahashi T. Improved Detection of in vivo Human NK Cell-Mediated Antibody-Dependent Cellular Cytotoxicity Using a Novel NOG-FcγR-Deficient Human IL-15 Transgenic Mouse. Front Immunol. 2020;11:532684 pubmed publisher
  • other; mouse
Tseng H, Xiong W, Badeti S, Yang Y, Ma M, Liu T, et al. Efficacy of anti-CD147 chimeric antigen receptors targeting hepatocellular carcinoma. Nat Commun. 2020;11:4810 pubmed publisher
  • flow cytometry; human; loading ...
Hood S, Cosma G, Foulds G, Johnson C, Reeder S, McArdle S, et al. Identifying prostate cancer and its clinical risk in asymptomatic men using machine learning of high dimensional peripheral blood flow cytometric natural killer cell subset phenotyping data. elife. 2020;9: pubmed publisher
  • mass cytometry; human; loading ...; fig 1b, 1d, s2
Leylek R, Alcántara Hernández M, Lanzar Z, Lüdtke A, Perez O, Reizis B, et al. Integrated Cross-Species Analysis Identifies a Conserved Transitional Dendritic Cell Population. Cell Rep. 2019;29:3736-3750.e8 pubmed publisher
  • flow cytometry; human; loading ...
Sanz Ortega L, Rojas J, Portilla Y, Pérez Yagüe S, Barber D. Magnetic Nanoparticles Attached to the NK Cell Surface for Tumor Targeting in Adoptive Transfer Therapies Does Not Affect Cellular Effector Functions. Front Immunol. 2019;10:2073 pubmed publisher
  • flow cytometry; human; fig 1b
Kyoizumi S, Kubo Y, Kajimura J, Yoshida K, Hayashi T, Nakachi K, et al. Fate Decision Between Group 3 Innate Lymphoid and Conventional NK Cell Lineages by Notch Signaling in Human Circulating Hematopoietic Progenitors. J Immunol. 2017;199:2777-2793 pubmed publisher
  • flow cytometry; human; loading ...; fig s4a
See P, Dutertre C, Chen J, Günther P, McGovern N, Irac S, et al. Mapping the human DC lineage through the integration of high-dimensional techniques. Science. 2017;356: pubmed publisher
  • flow cytometry; human; 1:50; loading ...; fig 2a
Siegers G, Barreira C, Postovit L, Dekaban G. CD11d ?2 integrin expression on human NK, B, and ?? T cells. J Leukoc Biol. 2017;101:1029-1035 pubmed publisher
  • flow cytometry; human; loading ...; fig 1b
Rölle A, Halenius A, Ewen E, Cerwenka A, Hengel H, Momburg F. CD2-CD58 interactions are pivotal for the activation and function of adaptive natural killer cells in human cytomegalovirus infection. Eur J Immunol. 2016;46:2420-2425 pubmed publisher
  • flow cytometry; human; fig 1a
Sadallah S, Schmied L, Eken C, Charoudeh H, Amicarella F, Schifferli J. Platelet-Derived Ectosomes Reduce NK Cell Function. J Immunol. 2016;197:1663-71 pubmed publisher
  • flow cytometry; human; loading ...; fig 5b
Zanetti S, Ziblat A, Torres N, Zwirner N, Bouzat C. Expression and Functional Role of ?7 Nicotinic Receptor in Human Cytokine-stimulated Natural Killer (NK) Cells. J Biol Chem. 2016;291:16541-52 pubmed publisher
  • flow cytometry; human; fig s2
Anandasabapathy N, Breton G, Hurley A, Caskey M, Trumpfheller C, Sarma P, et al. Efficacy and safety of CDX-301, recombinant human Flt3L, at expanding dendritic cells and hematopoietic stem cells in healthy human volunteers. Bone Marrow Transplant. 2015;50:924-30 pubmed publisher
  • flow cytometry; human
Zhou J, Amran F, Kramski M, Angelovich T, Elliott J, Hearps A, et al. An NK Cell Population Lacking FcRγ Is Expanded in Chronically Infected HIV Patients. J Immunol. 2015;194:4688-97 pubmed publisher
  • flow cytometry; human; fig 1
Marquardt N, Béziat V, Nyström S, Hengst J, Ivarsson M, Kekäläinen E, et al. Cutting edge: identification and characterization of human intrahepatic CD49a+ NK cells. J Immunol. 2015;194:2467-71 pubmed publisher
  • flow cytometry; human; fig 2
Ziblat A, Domaica C, Spallanzani R, Iraolagoitia X, Rossi L, Avila D, et al. IL-27 stimulates human NK-cell effector functions and primes NK cells for IL-18 responsiveness. Eur J Immunol. 2015;45:192-202 pubmed publisher
  • flow cytometry; human
Kobayashi E, Motoi S, Sugiura M, Kajikawa M, Kojima S, Kohroki J, et al. Antibody-dependent cellular cytotoxicity and cytokine/chemokine secretion by KHYG-1 cells stably expressing Fc?RIIIA. Immunol Lett. 2014;161:59-64 pubmed publisher
Gadalla R, Boukhaled G, Brooks D, Wang B. Mass cytometry immunostaining protocol for multiplexing clinical samples. STAR Protoc. 2022;3:101643 pubmed publisher
Aarsund M, Segers F, Wu Y, Inngjerdingen M. Comparison of characteristics and tumor targeting properties of extracellular vesicles derived from primary NK cells or NK-cell lines stimulated with IL-15 or IL-12/15/18. Cancer Immunol Immunother. 2022;71:2227-2238 pubmed publisher
Alcántara Hernández M, Idoyaga J. Mass cytometry profiling of human dendritic cells in blood and tissues. Nat Protoc. 2021;16:4855-4877 pubmed publisher
Gao H, Ozantürk A, Wang Q, Harlan G, Schmitz A, Presti R, et al. Evaluation of HIV-1 latency reversal and antibody-dependent viral clearance by quantification of singly spliced HIV-1 vpu/env mRNA. J Virol. 2021;: pubmed publisher
Damele L, Amaro A, Serio A, Luchetti S, Pfeffer U, Mingari M, et al. EZH1/2 Inhibitors Favor ILC3 Development from Human HSPC-CD34+ Cells. Cancers (Basel). 2021;13: pubmed publisher
Li J, Whelan S, Kotturi M, Meyran D, D Souza C, Hansen K, et al. PVRIG is a novel natural killer cell immune checkpoint receptor in acute myeloid leukemia. Haematologica. 2021;106:3115-3124 pubmed publisher
Leylek R, Alcántara Hernández M, Granja J, Chavez M, Perez K, Diaz O, et al. Chromatin Landscape Underpinning Human Dendritic Cell Heterogeneity. Cell Rep. 2020;32:108180 pubmed publisher
Nguyen R, Patel A, Griffiths L, Dapper J, Stewart E, Houston J, et al. Next-generation humanized patient-derived xenograft mouse model for pre-clinical antibody studies in neuroblastoma. Cancer Immunol Immunother. 2021;70:721-732 pubmed publisher
Dorsch M, Urlaub D, B xf6 nnemann V, Br xf6 de P, Sandusky M, Watzl C. Quantitative analysis of human NK cell reactivity using latex beads coated with defined amounts of antibodies. Eur J Immunol. 2020;50:656-665 pubmed publisher
Capuano C, Pighi C, Maggio R, Battella S, Morrone S, Palmieri G, et al. CD16 pre-ligation by defucosylated tumor-targeting mAb sensitizes human NK cells to γc cytokine stimulation via PI3K/mTOR axis. Cancer Immunol Immunother. 2020;69:501-512 pubmed publisher
van Montfoort N, Borst L, Korrer M, Sluijter M, Marijt K, Santegoets S, et al. NKG2A Blockade Potentiates CD8 T Cell Immunity Induced by Cancer Vaccines. Cell. 2018;175:1744-1755.e15 pubmed publisher
Alcántara Hernández M, Leylek R, Wagar L, Engleman E, Keler T, Marinkovich M, et al. High-Dimensional Phenotypic Mapping of Human Dendritic Cells Reveals Interindividual Variation and Tissue Specialization. Immunity. 2017;47:1037-1050.e6 pubmed publisher
Fasbender F, Claus M, Wingert S, Sandusky M, Watzl C. Differential Requirements for Src-Family Kinases in SYK or ZAP70-Mediated SLP-76 Phosphorylation in Lymphocytes. Front Immunol. 2017;8:789 pubmed publisher
Rother S, Hundrieser J, Pokoyski C, Kollrich S, Borns K, Blasczyk R, et al. The c.503T>C Polymorphism in the Human KLRB1 Gene Alters Ligand Binding and Inhibitory Potential of CD161 Molecules. PLoS ONE. 2015;10:e0135682 pubmed publisher
Correia D, Fogli M, Hudspeth K, da Silva M, Mavilio D, Silva Santos B. Differentiation of human peripheral blood V?1+ T cells expressing the natural cytotoxicity receptor NKp30 for recognition of lymphoid leukemia cells. Blood. 2011;118:992-1001 pubmed publisher
Jarahian M, Watzl C, Fournier P, Arnold A, Djandji D, Zahedi S, et al. Activation of natural killer cells by newcastle disease virus hemagglutinin-neuraminidase. J Virol. 2009;83:8108-21 pubmed publisher
product information
Antigen :
CD335
Apps. Abbrev. :
FC
Cat # :
331902
Clone :
9.00E+02
Item :
Purified anti-human CD335 (NKp46)
Isotype :
Mouse IgG1, κ
Other Names :
NKp46, NCR1
Size :
100 μg
Price (USD) :
129 USD
Reactivity :
Human
Clonality :
Monoclonal
Host :
Mouse
Conjugate/Tag/Label :
PURE
Immunogen :
NKp46-Fc fusion protein
Application Notes :
Clone 9E2 has been shown to block NK activation through NKp46.^6;
more info or order :
company information
BioLegend
8999 BioLegend Way
San Diego, CA 92121
customerserv@biolegend.com
https://www.biolegend.com
headquarters: USA