product summary
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company name :
BioLegend
other brands :
Babco, Signet, Sternberger Monoclonals, Senetek, Covance
product type :
antibody
product name :
PE/Cyanine7 anti-human CD279 (PD-1)
catalog :
329917
quantity :
25 tests
price :
176 USD
clonality :
monoclonal
host :
mouse
conjugate :
PE/Cy7
clone name :
EH12.2H7
reactivity :
human, rhesus macaque
application :
flow cytometry
more info or order :
citations: 40
Published Application/Species/Sample/DilutionReference
  • flow cytometry; human; loading ...; fig s6d
Kuhny M, Forbes L, Çakan E, Vega Loza A, Kostiuk V, Dinesh R, et al. Disease-associated CTNNBL1 mutation impairs somatic hypermutation by decreasing nuclear AID. J Clin Invest. 2020;: pubmed publisher
  • flow cytometry; human; loading ...; fig s1a
Wang C, Edilova M, Wagar L, Mujib S, Singer M, Bernard N, et al. Effect of IL-7 Therapy on Phospho-Ribosomal Protein S6 and TRAF1 Expression in HIV-Specific CD8 T Cells in Patients Receiving Antiretroviral Therapy. J Immunol. 2018;200:558-564 pubmed publisher
  • flow cytometry; human; loading ...
Tauriainen J, Scharf L, Frederiksen J, Naji A, Ljunggren H, Sonnerborg A, et al. Perturbed CD8+ T cell TIGIT/CD226/PVR axis despite early initiation of antiretroviral treatment in HIV infected individuals. Sci Rep. 2017;7:40354 pubmed publisher
  • flow cytometry; rhesus macaque
Del Prete G, Shoemaker R, Oswald K, Lara A, Trubey C, Fast R, et al. Effect of suberoylanilide hydroxamic acid (SAHA) administration on the residual virus pool in a model of combination antiretroviral therapy-mediated suppression in SIVmac239-infected indian rhesus macaques. Antimicrob Agents Chemother. 2014;58:6790-806 pubmed publisher
Lederer K, Bettini E, Parvathaneni K, Painter M, Agarwal D, Lundgreen K, et al. Germinal center responses to SARS-CoV-2 mRNA vaccines in healthy and immunocompromised individuals. Cell. 2022;185:1008-1024.e15 pubmed publisher
Pušnik J, Richter E, Schulte B, Dolscheid Pommerich R, Bode C, Putensen C, et al. Memory B cells targeting SARS-CoV-2 spike protein and their dependence on CD4+ T cell help. Cell Rep. 2021;35:109320 pubmed publisher
McLane L, Ngiow S, Chen Z, Attanasio J, Manne S, Ruthel G, et al. Role of nuclear localization in the regulation and function of T-bet and Eomes in exhausted CD8 T cells. Cell Rep. 2021;35:109120 pubmed publisher
Wenthe J, Naseri S, Labani Motlagh A, Enblad G, Wikstrom K, Eriksson E, et al. Boosting CAR T-cell responses in lymphoma by simultaneous targeting of CD40/4-1BB using oncolytic viral gene therapy. Cancer Immunol Immunother. 2021;70:2851-2865 pubmed publisher
Lee J, Sheen J, Lim O, Lee Y, Ryu J, Shin D, et al. Abrogation of HLA surface expression using CRISPR/Cas9 genome editing: a step toward universal T cell therapy. Sci Rep. 2020;10:17753 pubmed publisher
Acharya N, Madi A, Zhang H, Klapholz M, Escobar G, Dulberg S, et al. Endogenous Glucocorticoid Signaling Regulates CD8+ T Cell Differentiation and Development of Dysfunction in the Tumor Microenvironment. Immunity. 2020;53:658-671.e6 pubmed publisher
Zhou J, Wang W, Liang Z, Ni B, He W, Wang D. Clinical significance of CD38 and CD101 expression in PD-1+CD8+ T cells in patients with epithelial ovarian cancer. Oncol Lett. 2020;20:724-732 pubmed publisher
Beltra J, Manne S, Abdel Hakeem M, Kurachi M, Giles J, Chen Z, et al. Developmental Relationships of Four Exhausted CD8+ T Cell Subsets Reveals Underlying Transcriptional and Epigenetic Landscape Control Mechanisms. Immunity. 2020;52:825-841.e8 pubmed publisher
Hu J, Lei B, Wen D, Ma B, Zhang T, Lu Z, et al. IL-2 enhanced MHC class I expression in papillary thyroid cancer with Hashimoto's thyroiditis overcomes immune escape in vitro. J Cancer. 2020;11:4250-4260 pubmed publisher
Tang X, Zhang S, Peng Q, Ling L, Shi H, Liu Y, et al. Sustained IFN-I stimulation impairs MAIT cell responses to bacteria by inducing IL-10 during chronic HIV-1 infection. Sci Adv. 2020;6:eaaz0374 pubmed publisher
Barili V, Fisicaro P, Montanini B, Acerbi G, Filippi A, Forleo G, et al. Targeting p53 and histone methyltransferases restores exhausted CD8+ T cells in HCV infection. Nat Commun. 2020;11:604 pubmed publisher
Tardif V, Muir R, Cubas R, Chakhtoura M, Wilkinson P, Metcalf T, et al. Adenosine deaminase-1 delineates human follicular helper T cell function and is altered with HIV. Nat Commun. 2019;10:823 pubmed publisher
Chellappa S, Kushekhar K, Munthe L, Tjønnfjord G, Aandahl E, Okkenhaug K, et al. The PI3K p110δ Isoform Inhibitor Idelalisib Preferentially Inhibits Human Regulatory T Cell Function. J Immunol. 2019;202:1397-1405 pubmed publisher
van Montfoort N, Borst L, Korrer M, Sluijter M, Marijt K, Santegoets S, et al. NKG2A Blockade Potentiates CD8 T Cell Immunity Induced by Cancer Vaccines. Cell. 2018;175:1744-1755.e15 pubmed publisher
Yoshitomi H, Kobayashi S, Miyagawa Hayashino A, Okahata A, Doi K, Nishitani K, et al. Human Sox4 facilitates the development of CXCL13-producing helper T cells in inflammatory environments. Nat Commun. 2018;9:3762 pubmed publisher
Kuo H, Ahmad R, Lee G, Gao C, Chen H, Ouyang Z, et al. Anti-apoptotic Protein BIRC5 Maintains Survival of HIV-1-Infected CD4+ T Cells. Immunity. 2018;48:1183-1194.e5 pubmed publisher
McGary C, Deléage C, Harper J, Micci L, Ribeiro S, Paganini S, et al. CTLA-4+PD-1- Memory CD4+ T Cells Critically Contribute to Viral Persistence in Antiretroviral Therapy-Suppressed, SIV-Infected Rhesus Macaques. Immunity. 2017;47:776-788.e5 pubmed publisher
Gordón Alonso M, Hirsch T, Wildmann C, van der Bruggen P. Galectin-3 captures interferon-gamma in the tumor matrix reducing chemokine gradient production and T-cell tumor infiltration. Nat Commun. 2017;8:793 pubmed publisher
Horn L, Ciavattone N, Atkinson R, Woldergerima N, Wolf J, Clements V, et al. CD3xPDL1 bi-specific T cell engager (BiTE) simultaneously activates T cells and NKT cells, kills PDL1+ tumor cells, and extends the survival of tumor-bearing humanized mice. Oncotarget. 2017;8:57964-57980 pubmed publisher
Zhang Y, Kurupati R, Liu L, Zhou X, Zhang G, Hudaihed A, et al. Enhancing CD8+ T Cell Fatty Acid Catabolism within a Metabolically Challenging Tumor Microenvironment Increases the Efficacy of Melanoma Immunotherapy. Cancer Cell. 2017;32:377-391.e9 pubmed publisher
Parsons E, Otieno J, Ong Echa J, Nixon C, Vulule J, MUNZ C, et al. Regulatory T Cells in Endemic Burkitt Lymphoma Patients Are Associated with Poor Outcomes: A Prospective, Longitudinal Study. PLoS ONE. 2016;11:e0167841 pubmed publisher
Policicchio B, Xu C, Brocca Cofano E, Raehtz K, He T, Ma D, et al. Multi-dose Romidepsin Reactivates Replication Competent SIV in Post-antiretroviral Rhesus Macaque Controllers. PLoS Pathog. 2016;12:e1005879 pubmed publisher
Hsu H, Boudová S, Mvula G, Divala T, Mungwira R, Harman C, et al. Prolonged PD1 Expression on Neonatal V?2 Lymphocytes Dampens Proinflammatory Responses: Role of Epigenetic Regulation. J Immunol. 2016;197:1884-92 pubmed publisher
Beyer M, Abdullah Z, Chemnitz J, Maisel D, Sander J, Lehmann C, et al. Tumor-necrosis factor impairs CD4(+) T cell-mediated immunological control in chronic viral infection. Nat Immunol. 2016;17:593-603 pubmed publisher
Mylvaganam G, Velu V, Hong J, Sadagopal S, Kwa S, Basu R, et al. Diminished viral control during simian immunodeficiency virus infection is associated with aberrant PD-1hi CD4 T cell enrichment in the lymphoid follicles of the rectal mucosa. J Immunol. 2014;193:4527-36 pubmed publisher
Ohue Y, Kurose K, Mizote Y, Matsumoto H, Nishio Y, Isobe M, et al. Prolongation of overall survival in advanced lung adenocarcinoma patients with the XAGE1 (GAGED2a) antibody. Clin Cancer Res. 2014;20:5052-63 pubmed publisher
Hong J, Amancha P, Rogers K, Courtney C, Havenar Daughton C, Crotty S, et al. Early lymphoid responses and germinal center formation correlate with lower viral load set points and better prognosis of simian immunodeficiency virus infection. J Immunol. 2014;193:797-806 pubmed publisher
Amancha P, Hong J, Rogers K, Ansari A, Villinger F. In vivo blockade of the programmed cell death-1 pathway using soluble recombinant PD-1-Fc enhances CD4+ and CD8+ T cell responses but has limited clinical benefit. J Immunol. 2013;191:6060-70 pubmed publisher
Hong J, Amancha P, Rogers K, Ansari A, Villinger F. Spatial alterations between CD4(+) T follicular helper, B, and CD8(+) T cells during simian immunodeficiency virus infection: T/B cell homeostasis, activation, and potential mechanism for viral escape. J Immunol. 2012;188:3247-56 pubmed publisher
Conrad J, Ramalingam R, Smith R, Barnett L, Lorey S, Wei J, et al. Dominant clonotypes within HIV-specific T cell responses are programmed death-1high and CD127low and display reduced variant cross-reactivity. J Immunol. 2011;186:6871-85 pubmed publisher
Monteiro P, Gosselin A, Wacleche V, El Far M, Said E, Kared H, et al. Memory CCR6+CD4+ T cells are preferential targets for productive HIV type 1 infection regardless of their expression of integrin ?7. J Immunol. 2011;186:4618-30 pubmed publisher
Radziewicz H, Ibegbu C, Hon H, Bedard N, Bruneau J, Workowski K, et al. Transient CD86 expression on hepatitis C virus-specific CD8+ T cells in acute infection is linked to sufficient IL-2 signaling. J Immunol. 2010;184:2410-22 pubmed publisher
Vojnov L, Reed J, Weisgrau K, Rakasz E, Loffredo J, Piaskowski S, et al. Effective simian immunodeficiency virus-specific CD8+ T cells lack an easily detectable, shared characteristic. J Virol. 2010;84:753-64 pubmed publisher
Jones R, Yue F, Gu X, Hunter D, Mujib S, Gyenes G, et al. Human immunodeficiency virus type 1 escapes from interleukin-2-producing CD4+ T-cell responses without high-frequency fixation of mutations. J Virol. 2009;83:8722-32 pubmed publisher
Chang W, Kim J, Kim Y, Kim Y, Lee J, Azuma M, et al. Cutting edge: Programmed death-1/programmed death ligand 1 interaction regulates the induction and maintenance of invariant NKT cell anergy. J Immunol. 2008;181:6707-10 pubmed
Zahn R, Rett M, Korioth Schmitz B, Sun Y, Buzby A, Goldstein S, et al. Simian immunodeficiency virus (SIV)-specific CD8+ T-cell responses in vervet African green monkeys chronically infected with SIVagm. J Virol. 2008;82:11577-88 pubmed publisher
product information
Antigen :
CD279
Apps. Abbrev. :
Flow Cytometry
Cat # :
329917
Clone :
EH12.2H7
Item :
PE/Cyanine7 anti-human CD279 (PD-1)
Isotype :
Mouse IgG1, κ
Other Names :
PD-1, PDCD1
Size :
25 tests
Price (USD) :
176 USD
Reactivity :
Human
Clonality :
Monoclonal
Host :
Mouse
Conjugate/Tag/Label :
PE_CYANINE7
Application Notes :
Additional reported applications (for the relevant formats) include: blocking of ligand binding 1-3 , immunohistochemical staining of paraformaldehyde fixed frozen sections 13 , and spatial biology (IBEX) 15,16 . The LEAF purified antibody (Endotoxin 0.1 EU/ug, Azide-Free, 0.2 um filtered) is recommended for functional assays (Cat. No. 329911 and 329912). For highly sensitive assays, we recommend Ultra-LEAF purified antibody (Cat. No. 329926) with a lower endotoxin limit than standard LEAF purified antibodies (Endotoxin 0.01 EU/ug).
more info or order :
company information
BioLegend
8999 BioLegend Way
San Diego, CA 92121
customerserv@biolegend.com
https://www.biolegend.com
headquarters: USA