product summary
Loading...
company name :
BioLegend
other brands :
Babco, Signet, Sternberger Monoclonals, Senetek, Covance
product type :
antibody
product name :
Purified anti-human CD337 (NKp30)
catalog :
325202
quantity :
100 μg
price :
121 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
P30-15
reactivity :
human, rhesus macaque
application :
ELISA, immunohistochemistry, neutralization, flow cytometry, blocking or activating experiments, mass cytometry
more info or order :
citations: 27
Published Application/Species/Sample/DilutionReference
  • flow cytometry; human; loading ...
Hood S, Cosma G, Foulds G, Johnson C, Reeder S, McArdle S, et al. Identifying prostate cancer and its clinical risk in asymptomatic men using machine learning of high dimensional peripheral blood flow cytometric natural killer cell subset phenotyping data. elife. 2020;9: pubmed publisher
  • blocking or activating experiments; human; 10 ug/ml; loading ...; fig 3a
Gunesch J, Dixon A, Ebrahim T, Berrien Elliott M, Tatineni S, Kumar T, et al. CD56 regulates human NK cell cytotoxicity through Pyk2. elife. 2020;9: pubmed publisher
  • flow cytometry; human; loading ...; fig s2a
van Erp E, Feyaerts D, Duijst M, Mulder H, Wicht O, Luytjes W, et al. Respiratory Syncytial Virus Infects Primary Neonatal and Adult Natural Killer Cells and Affects Their Antiviral Effector Function. J Infect Dis. 2019;219:723-733 pubmed publisher
  • blocking or activating experiments; human; 10 ug/ml; loading ...; fig s3e
Srpan K, Ambrose A, Karampatzakis A, Saeed M, Cartwright A, Guldevall K, et al. Shedding of CD16 disassembles the NK cell immune synapse and boosts serial engagement of target cells. J Cell Biol. 2018;217:3267-3283 pubmed publisher
  • immunohistochemistry; human; 5,000 ug/ml; loading ...; fig s1b
Carisey A, Mace E, Saeed M, Davis D, Orange J. Nanoscale Dynamism of Actin Enables Secretory Function in Cytolytic Cells. Curr Biol. 2018;28:489-502.e9 pubmed publisher
  • flow cytometry; human; loading ...; fig s3c
Cribbs A, Hookway E, Wells G, Lindow M, Obad S, Oerum H, et al. Inhibition of histone H3K27 demethylases selectively modulates inflammatory phenotypes of natural killer cells. J Biol Chem. 2018;293:2422-2437 pubmed publisher
  • mass cytometry; human; loading ...; fig 4f
Herndler Brandstetter D, Shan L, Yao Y, Stecher C, Plajer V, Lietzenmayer M, et al. Humanized mouse model supports development, function, and tissue residency of human natural killer cells. Proc Natl Acad Sci U S A. 2017;114:E9626-E9634 pubmed publisher
  • flow cytometry; human; fig 1a
Sadallah S, Schmied L, Eken C, Charoudeh H, Amicarella F, Schifferli J. Platelet-Derived Ectosomes Reduce NK Cell Function. J Immunol. 2016;197:1663-71 pubmed publisher
Correia M, Stojanovic A, Wels W, Cerwenka A. Innate-like NKp30+CD8+ T cells armed with TCR/CAR target tumor heterogeneity. Oncoimmunology. 2021;10:1973783 pubmed publisher
Ye W, Chew M, Hou J, Lai F, Leopold S, Loo H, et al. Microvesicles from malaria-infected red blood cells activate natural killer cells via MDA5 pathway. PLoS Pathog. 2018;14:e1007298 pubmed publisher
Walwyn Brown K, Guldevall K, Saeed M, Pende D, Önfelt B, MacDonald A, et al. Human NK Cells Lyse Th2-Polarizing Dendritic Cells via NKp30 and DNAM-1. J Immunol. 2018;201:2028-2041 pubmed publisher
Poznanski S, Nham T, Chew M, Lee A, Hammill J, Fan I, et al. Expanded CD56superbrightCD16+ NK Cells from Ovarian Cancer Patients Are Cytotoxic against Autologous Tumor in a Patient-Derived Xenograft Murine Model. Cancer Immunol Res. 2018;6:1174-1185 pubmed publisher
Desimio M, Giuliani E, Ferraro A, Adorno G, Doria M. In Vitro Exposure to Prostratin but Not Bryostatin-1 Improves Natural Killer Cell Functions Including Killing of CD4+ T Cells Harboring Reactivated Human Immunodeficiency Virus. Front Immunol. 2018;9:1514 pubmed publisher
Wang X, Liu W, Zhuang D, Hong S, Chen J. Sestrin2 and sestrin3 suppress NK-92 cell-mediated cytotoxic activity on ovarian cancer cells through AMPK and mTORC1 signaling. Oncotarget. 2017;8:90132-90143 pubmed publisher
Vargas Hernandez A, Mace E, Zimmerman O, Zerbe C, Freeman A, Rosenzweig S, et al. Ruxolitinib partially reverses functional natural killer cell deficiency in patients with signal transducer and activator of transcription 1 (STAT1) gain-of-function mutations. J Allergy Clin Immunol. 2018;141:2142-2155.e5 pubmed publisher
Cruz González D, Gómez Martín D, Layseca Espinosa E, Baranda L, Abud Mendoza C, Alcocer Varela J, et al. Analysis of the regulatory function of natural killer cells from patients with systemic lupus erythematosus. Clin Exp Immunol. 2017;: pubmed publisher
Streltsova M, Barsov E, Erokhina S, Kovalenko E. Retroviral gene transfer into primary human NK cells activated by IL-2 and K562 feeder cells expressing membrane-bound IL-21. J Immunol Methods. 2017;450:90-94 pubmed publisher
Cichocki F, Valamehr B, Bjordahl R, Zhang B, Rezner B, Rogers P, et al. GSK3 Inhibition Drives Maturation of NK Cells and Enhances Their Antitumor Activity. Cancer Res. 2017;77:5664-5675 pubmed publisher
Crome S, Nguyen L, Lopez Verges S, Yang S, Martin B, Yam J, et al. A distinct innate lymphoid cell population regulates tumor-associated T cells. Nat Med. 2017;23:368-375 pubmed publisher
Urlaub D, Höfer K, Müller M, Watzl C. LFA-1 Activation in NK Cells and Their Subsets: Influence of Receptors, Maturation, and Cytokine Stimulation. J Immunol. 2017;198:1944-1951 pubmed publisher
Mace E, Orange J. Visualization of the immunological synapse by dual color time-gated stimulated emission depletion (STED) nanoscopy. J Vis Exp. 2014;: pubmed publisher
Wang H, Zheng X, Wei H, Tian Z, Sun R. Preparation and functional identification of a monoclonal antibody against the recombinant soluble human NKp30 receptor. Int Immunopharmacol. 2011;11:1732-9 pubmed publisher
Van Elssen C, Vanderlocht J, Oth T, Senden Gijsbers B, Germeraad W, Bos G. Inflammation-restraining effects of prostaglandin E2 on natural killer-dendritic cell (NK-DC) interaction are imprinted during DC maturation. Blood. 2011;118:2473-82 pubmed publisher
Correia D, Fogli M, Hudspeth K, da Silva M, Mavilio D, Silva Santos B. Differentiation of human peripheral blood V?1+ T cells expressing the natural cytotoxicity receptor NKp30 for recognition of lymphoid leukemia cells. Blood. 2011;118:992-1001 pubmed publisher
Joyce M, Tran P, Zhuravleva M, Jaw J, Colonna M, Sun P. Crystal structure of human natural cytotoxicity receptor NKp30 and identification of its ligand binding site. Proc Natl Acad Sci U S A. 2011;108:6223-8 pubmed publisher
Mao H, Tu W, Liu Y, Qin G, Zheng J, Chan P, et al. Inhibition of human natural killer cell activity by influenza virions and hemagglutinin. J Virol. 2010;84:4148-57 pubmed publisher
Manaster I, Mizrahi S, Goldman Wohl D, Sela H, Stern Ginossar N, Lankry D, et al. Endometrial NK cells are special immature cells that await pregnancy. J Immunol. 2008;181:1869-76 pubmed
product information
Antigen :
CD337
Apps. Abbrev. :
Flow Cytometry, ELISA, Block
Cat # :
325202
Clone :
P30-15
Item :
Purified anti-human CD337 (NKp30)
Isotype :
Mouse IgG1, κ
Other Names :
NKp30, NCR3, Activating NK receptor NKp30, natural cytotoxicity triggering receptor 3
Size :
100 μg
Price (USD) :
121 USD
Reactivity :
Human, African Green, Baboon, Cynomolgus, Rhesus
Clonality :
Monoclonal
Host :
Mouse
Conjugate/Tag/Label :
PURE
Immunogen :
Recombinant human NKp30
Application Notes :
Additional reported applications (for the relevant formats) include: ELISA, stimulation of human NK cells via NKp30 in a redirected lysis assay, and blocking of NKp30 function in solution 1,3,5 . The Ultra-LEAF purified antibody (Endotoxin 0.1 EU/ug, Azide-Free, 0.2 um filtered) is recommended for functional assays (Cat. Nos. 325223 325224).
more info or order :
company information
BioLegend
8999 BioLegend Way
San Diego, CA 92121
customerserv@biolegend.com
https://www.biolegend.com
headquarters: USA