product summary
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company name :
BioLegend
other brands :
Babco, Signet, Sternberger Monoclonals, Senetek, Covance
product type :
antibody
product name :
Alexa Fluor® 488 anti-human CD326 (Ep-CAM)
catalog :
324210
quantity :
100 tests
price :
293 USD
clonality :
monoclonal
host :
mouse
conjugate :
AF488
clone name :
9C4
reactivity :
human
application :
immunohistochemistry, flow cytometry
more info or order :
citations: 44
Published Application/Species/Sample/DilutionReference
  • flow cytometry; human; 1:20; fig s3c
Calandrini C, Schutgens F, Oka R, Margaritis T, Candelli T, Mathijsen L, et al. An organoid biobank for childhood kidney cancers that captures disease and tissue heterogeneity. Nat Commun. 2020;11:1310 pubmed publisher
  • flow cytometry; human; loading ...; fig ex2a
Barkal A, Brewer R, Markovic M, Kowarsky M, Barkal S, Zaro B, et al. CD24 signalling through macrophage Siglec-10 is a target for cancer immunotherapy. Nature. 2019;572:392-396 pubmed publisher
  • flow cytometry; human; loading ...; fig 1b
Montel Hagen A, Seet C, Li S, Chick B, Zhu Y, Chang P, et al. Organoid-Induced Differentiation of Conventional T Cells from Human Pluripotent Stem Cells. Cell Stem Cell. 2019;24:376-389.e8 pubmed publisher
  • flow cytometry; human; loading ...; fig 9b
Casey A, Sinha A, Singhania R, Livingstone J, Waterhouse P, Tharmapalan P, et al. Mammary molecular portraits reveal lineage-specific features and progenitor cell vulnerabilities. J Cell Biol. 2018;217:2951-2974 pubmed publisher
  • immunohistochemistry; human; loading ...; fig 2c
Peranzoni E, Lemoine J, Vimeux L, Feuillet V, Barrin S, Kantari Mimoun C, et al. Macrophages impede CD8 T cells from reaching tumor cells and limit the efficacy of anti-PD-1 treatment. Proc Natl Acad Sci U S A. 2018;115:E4041-E4050 pubmed publisher
  • flow cytometry; human; fig 4
Cai X, Dai Z, Reeves R, Caballero Benítez A, Duran K, Delrow J, et al. Autonomous stimulation of cancer cell plasticity by the human NKG2D lymphocyte receptor coexpressed with its ligands on cancer cells. PLoS ONE. 2014;9:e108942 pubmed publisher
  • flow cytometry; human; fig 1c
Morris K, Khan H, Ahmad A, Weston L, Nofchissey R, Pinchuk I, et al. G-CSF and G-CSFR are highly expressed in human gastric and colon cancers and promote carcinoma cell proliferation and migration. Br J Cancer. 2014;110:1211-20 pubmed publisher
Qin X, Furutani Y, Yonezawa K, Shimizu N, Kato Murayama M, Shirouzu M, et al. Targeting transglutaminase 2 mediated exostosin glycosyltransferase 1 signaling in liver cancer stem cells with acyclic retinoid. Cell Death Dis. 2023;14:358 pubmed publisher
Jeong H, Lee H, Kim H, Jang J, Kim S, Hwang T, et al. Cellular plasticity and immune microenvironment of malignant pleural effusion are associated with EGFR-TKI resistance in non-small-cell lung carcinoma. iScience. 2022;25:105358 pubmed publisher
Pandolfi E, Hsu F, Duhon M, Zheng Y, Goldsmith S, Fu J, et al. In vitro germ cell induction from fertile and infertile monozygotic twin research participants. Cell Rep Med. 2022;3:100782 pubmed publisher
Vanslambrouck J, Wilson S, Tan K, Groenewegen E, Rudraraju R, Neil J, et al. Enhanced metanephric specification to functional proximal tubule enables toxicity screening and infectious disease modelling in kidney organoids. Nat Commun. 2022;13:5943 pubmed publisher
Sandlin C, Gu S, Xu J, Deshpande C, Feldman M, Good M. Epithelial cell size dysregulation in human lung adenocarcinoma. PLoS ONE. 2022;17:e0274091 pubmed publisher
Staudte S, Klinghammer K, Jurmeister P, Jank P, Blohmer J, Liebs S, et al. Multiparametric Phenotyping of Circulating Tumor Cells for Analysis of Therapeutic Targets, Oncogenic Signaling Pathways and DNA Repair Markers. Cancers (Basel). 2022;14: pubmed publisher
Sullivan N, Cooke M. Protocol for fluorescence-activated cell sorting of human EpCAM+ lung cancer cells for gene expression analysis of Rac guanine-nucleotide exchange factors. STAR Protoc. 2022;3:101367 pubmed publisher
Inde Z, Croker B, Yapp C, Joshi G, Spetz J, Fraser C, et al. Age-dependent regulation of SARS-CoV-2 cell entry genes and cell death programs correlates with COVID-19 severity. Sci Adv. 2021;7: pubmed publisher
Hancock G, Liu W, Peretz L, Chen D, Gell J, Collier A, et al. Divergent roles for KLF4 and TFCP2L1 in naive ground state pluripotency and human primordial germ cell development. Stem Cell Res. 2021;55:102493 pubmed publisher
Safaric Tepes P, Pal D, Lindsted T, Ibarra I, Lujambio A, Jimenez Sabinina V, et al. An epigenetic switch regulates the ontogeny of AXL-positive/EGFR-TKi-resistant cells by modulating miR-335 expression. elife. 2021;10: pubmed publisher
Mourcin F, Verdière L, Roulois D, Amin R, Lamaison C, Sibut V, et al. Follicular lymphoma triggers phenotypic and functional remodeling of the human lymphoid stromal cell landscape. Immunity. 2021;54:1788-1806.e7 pubmed publisher
Carraro G, Langerman J, Sabri S, Lorenzana Z, Purkayastha A, Zhang G, et al. Transcriptional analysis of cystic fibrosis airways at single-cell resolution reveals altered epithelial cell states and composition. Nat Med. 2021;27:806-814 pubmed publisher
Palkowitz A, Tuna T, Bishti S, B xf6 ke F, Steinke N, M xfc ller Newen G, et al. Biofunctionalization of Dental Abutment Surfaces by Crosslinked ECM Proteins Strongly Enhances Adhesion and Proliferation of Gingival Fibroblasts. Adv Healthc Mater. 2021;10:e2100132 pubmed publisher
Howden S, Wilson S, Groenewegen E, Starks L, Forbes T, Tan K, et al. Plasticity of distal nephron epithelia from human kidney organoids enables the induction of ureteric tip and stalk. Cell Stem Cell. 2020;: pubmed publisher
Yu L, Wei Y, Sun H, Mahdi A, Pinzon Arteaga C, Sakurai M, et al. Derivation of Intermediate Pluripotent Stem Cells Amenable to Primordial Germ Cell Specification. Cell Stem Cell. 2020;: pubmed publisher
Chitiashvili T, Dror I, Kim R, Hsu F, Chaudhari R, Pandolfi E, et al. Female human primordial germ cells display X-chromosome dosage compensation despite the absence of X-inactivation. Nat Cell Biol. 2020;22:1436-1446 pubmed publisher
Morsing M, Kim J, Villadsen R, Goldhammer N, Jafari A, Kassem M, et al. Fibroblasts direct differentiation of human breast epithelial progenitors. Breast Cancer Res. 2020;22:102 pubmed publisher
Zabala M, Lobo N, Antony J, Heitink L, Gulati G, Lam J, et al. LEFTY1 Is a Dual-SMAD Inhibitor that Promotes Mammary Progenitor Growth and Tumorigenesis. Cell Stem Cell. 2020;27:284-299.e8 pubmed publisher
Pyo D, Hong H, Lee W, Cho Y. Patient-derived cancer modeling for precision medicine in colorectal cancer: beyond the cancer cell line. Cancer Biol Ther. 2020;21:495-502 pubmed publisher
Cardenas J, Robles Oteiza C, Politi K. Assessment of IFNγ responsiveness in patient-derived xenografts. Methods Enzymol. 2020;631:415-427 pubmed publisher
Chen D, Sun N, Hou L, Kim R, Faith J, Aslanyan M, et al. Human Primordial Germ Cells Are Specified from Lineage-Primed Progenitors. Cell Rep. 2019;29:4568-4582.e5 pubmed publisher
Ísberg Ó, Kim J, Fridriksdottir A, Morsing M, Timmermans Wielenga V, Rønnov Jessen L, et al. A CD146 FACS Protocol Enriches for Luminal Keratin 14/19 Double Positive Human Breast Progenitors. Sci Rep. 2019;9:14843 pubmed publisher
Koyama M, Mukhopadhyay P, Schuster I, Henden A, Hülsdünker J, Varelias A, et al. MHC Class II Antigen Presentation by the Intestinal Epithelium Initiates Graft-versus-Host Disease and Is Influenced by the Microbiota. Immunity. 2019;51:885-898.e7 pubmed publisher
Vanslambrouck J, Wilson S, Tan K, Soo J, Scurr M, Spijker H, et al. A Toolbox to Characterize Human Induced Pluripotent Stem Cell-Derived Kidney Cell Types and Organoids. J Am Soc Nephrol. 2019;30:1811-1823 pubmed publisher
Hong H, Pyo D, Kim T, Yun N, Lee Y, Song S, et al. Efficient primary culture model of patient‑derived tumor cells from colorectal cancer using a Rho‑associated protein kinase inhibitor and feeder cells. Oncol Rep. 2019;42:2029-2038 pubmed publisher
Chen D, Liu W, Zimmerman J, Pastor W, Kim R, Hosohama L, et al. The TFAP2C-Regulated OCT4 Naive Enhancer Is Involved in Human Germline Formation. Cell Rep. 2018;25:3591-3602.e5 pubmed publisher
Hu H, Gehart H, Artegiani B, Lopez Iglesias C, Dekkers F, Basak O, et al. Long-Term Expansion of Functional Mouse and Human Hepatocytes as 3D Organoids. Cell. 2018;175:1591-1606.e19 pubmed publisher
Forbes T, Howden S, Lawlor K, Phipson B, Maksimovic J, Hale L, et al. Patient-iPSC-Derived Kidney Organoids Show Functional Validation of a Ciliopathic Renal Phenotype and Reveal Underlying Pathogenetic Mechanisms. Am J Hum Genet. 2018;102:816-831 pubmed publisher
Gell J, Zhao J, Chen D, Hunt T, Clark A. PRDM14 is expressed in germ cell tumors with constitutive overexpression altering human germline differentiation and proliferation. Stem Cell Res. 2018;27:46-56 pubmed publisher
Chen D, Liu W, Lukianchikov A, Hancock G, Zimmerman J, Lowe M, et al. Germline competency of human embryonic stem cells depends on EOMESODERMIN. Biol Reprod. 2017;: pubmed publisher
Cai X, Caballero Benítez A, Gewe M, Jenkins I, Drescher C, Strong R, et al. Control of Tumor Initiation by NKG2D Naturally Expressed on Ovarian Cancer Cells. Neoplasia. 2017;19:471-482 pubmed publisher
Pal D, Pertot A, Shirole N, Yao Z, Anaparthy N, Garvin T, et al. TGF-β reduces DNA ds-break repair mechanisms to heighten genetic diversity and adaptability of CD44+/CD24- cancer cells. elife. 2017;6: pubmed publisher
Catenacci D, Chapman C, Xu P, Koons A, Konda V, Siddiqui U, et al. Acquisition of Portal Venous Circulating Tumor Cells From Patients With Pancreaticobiliary Cancers by Endoscopic Ultrasound. Gastroenterology. 2015;149:1794-1803.e4 pubmed publisher
van Noort V, Schölch S, Iskar M, Zeller G, Ostertag K, Schweitzer C, et al. Novel drug candidates for the treatment of metastatic colorectal cancer through global inverse gene-expression profiling. Cancer Res. 2014;74:5690-9 pubmed publisher
Morris K, Nofchissey R, Pinchuk I, Beswick E. Chronic macrophage migration inhibitory factor exposure induces mesenchymal epithelial transition and promotes gastric and colon cancers. PLoS ONE. 2014;9:e98656 pubmed publisher
Shultz L, Saito Y, Najima Y, Tanaka S, Ochi T, Tomizawa M, et al. Generation of functional human T-cell subsets with HLA-restricted immune responses in HLA class I expressing NOD/SCID/IL2r gamma(null) humanized mice. Proc Natl Acad Sci U S A. 2010;107:13022-7 pubmed publisher
Horwitz K, Dye W, Harrell J, Kabos P, Sartorius C. Rare steroid receptor-negative basal-like tumorigenic cells in luminal subtype human breast cancer xenografts. Proc Natl Acad Sci U S A. 2008;105:5774-9 pubmed publisher
product information
Antigen :
CD326
Apps. Abbrev. :
FC, SB
Cat # :
324210
Clone :
9C4
Item :
Alexa Fluor® 488 anti-human CD326 (Ep-CAM)
Isotype :
Mouse IgG2b, κ
Other Names :
Ep-CAM, tumor associated calcium signal transducer 1, epithelial cell surface antigen, epithelial glycoprotein 2, EGP2, adenocarcinoma associated antigen, TROP1
Size :
100 tests
Price (USD) :
293 USD
Reactivity :
Human
Clonality :
Monoclonal
Host :
Mouse
Conjugate/Tag/Label :
A488
Immunogen :
DU.4475 breast carcinoma
Application Notes :
Additional reported applications (for the revelant formats) include: immunofluorescence, immunohistochemistry^3, and spatial biology (IBEX)^4,5.;
more info or order :
company information
BioLegend
8999 BioLegend Way
San Diego, CA 92121
customerserv@biolegend.com
https://www.biolegend.com
headquarters: USA