Alexa Fluor® 700 anti-human CD172a/b (SIRPα/β) | BioLegend 323816 product information

product summary

company name :

BioLegend

other brands :

Babco, Signet, Sternberger Monoclonals, Senetek, Covance

product type :

antibody

product name :

Alexa Fluor® 700 anti-human CD172a/b (SIRPα/β)

catalog :

323816

quantity :

100 tests

price :

335 USD

clonality :

monoclonal

host :

mouse

conjugate :

AF700

clone name :

SE5A5

reactivity :

human

application :

flow cytometry

more info or order :

BioLegend product webpage

citations: 4

Published Application/Species/Sample/Dilution	Reference
flow cytometry; human; loading ...; fig 1e	Bujko A, Atlasy N, Landsverk O, Richter L, Yaqub S, Horneland R, et al. Transcriptional and functional profiling defines human small intestinal macrophage subsets. J Exp Med. 2018;215:441-458 pubmed publisher
	Cytlak U, Resteu A, Pagan S, Green K, Milne P, Maisuria S, et al. Differential IRF8 Transcription Factor Requirement Defines Two Pathways of Dendritic Cell Development in Humans. Immunity. 2020;53:353-370.e8 pubmed publisher
	Pilling D, Galvis Carvajal E, Karhadkar T, Cox N, Gomer R. Monocyte differentiation and macrophage priming are regulated differentially by pentraxins and their ligands. BMC Immunol. 2017;18:30 pubmed publisher
	Lopes F, BÃ¡lint Å, Valvo S, Felce J, Hessel E, Dustin M, et al. Membrane nanoclusters of FcÎ³RI segregate from inhibitory SIRPÎ± upon activation of human macrophages. J Cell Biol. 2017;216:1123-1141 pubmed publisher

product information

Antigen :

CD172a/b

Apps. Abbrev. :

Cat # :

323816

Clone :

SE5A5

Item :

Alexa Fluor® 700 anti-human CD172a/b (SIRPα/β)

Isotype :

Mouse IgG1, κ

Other Names :

SIRPa, SIRPb, SIRPalpha/beta, BIT, SHPS1, MFR, P84, PTPNS1, CD172 antigen-like family member A, CD172 antigen-like family member B

Size :

100 tests

Price (USD) :

335 USD

Reactivity :

Human

Clonality :

Monoclonal

Host :

Mouse

Conjugate/Tag/Label :

A700

Immunogen :

NIH-3T3/hu-SIRPα cell line

Application Notes :

Clone SE5A5 recognizes a common epitope on SIRPa (90 kD) and SIRPß (50 kD)^3. A high degree of homology has been found between SIRP family isoforms alpha and beta at the level of extracellular domains. Consequently, many anti SIRP antibody clones, such as SE5A5, have been reported to cross react with several SIRP isoforms^1,4,5. It reacts with CD172a and has weak cross-reaction with CD172b. This antibody is able to block the binding of SIRPa (SIRPa1 and SIRPa2) to CD47^1,6.;

more info or order :

BioLegend product webpage