PE/Cyanine7 anti-human CD172a/b (SIRPα/β) | BioLegend 323808 product information

product summary

company name :

BioLegend

other brands :

Babco, Signet, Sternberger Monoclonals, Senetek, Covance

product type :

antibody

product name :

PE/Cyanine7 anti-human CD172a/b (SIRPα/β)

catalog :

323808

quantity :

100 tests

price :

347 USD

clonality :

monoclonal

host :

mouse

conjugate :

PE/Cy7

clone name :

SE5A5

reactivity :

human

application :

flow cytometry

more info or order :

BioLegend product webpage

citations: 18

Published Application/Species/Sample/Dilution	Reference
flow cytometry; human; loading ...; fig 1e	Bujko A, Atlasy N, Landsverk O, Richter L, Yaqub S, Horneland R, et al. Transcriptional and functional profiling defines human small intestinal macrophage subsets. J Exp Med. 2018;215:441-458 pubmed publisher
	Ho B, Pang J, Chen Y, Loh Y, An O, Yang H, et al. Robust generation of human-chambered cardiac organoids from pluripotent stem cells for improved modelling of cardiovascular diseases. Stem Cell Res Ther. 2022;13:529 pubmed publisher
	Pezhouman A, Engel J, Nguyen N, Skelton R, Gilmore W, Qiao R, et al. Isolation and characterization of human embryonic stem cell-derived heart field-specific cardiomyocytes unravels new insights into their transcriptional and electrophysiological profiles. Cardiovasc Res. 2022;118:828-843 pubmed publisher
	Miki K, Deguchi K, Nakanishi Koakutsu M, Lucena Cacace A, Kondo S, Fujiwara Y, et al. ERRγ enhances cardiac maturation with T-tubule formation in human iPSC-derived cardiomyocytes. Nat Commun. 2021;12:3596 pubmed publisher
	Go Y, Kim J, Jeong H, Kim S, Kim Y, Park S, et al. Luteolin Induces Selective Cell Death of Human Pluripotent Stem Cells. Biomedicines. 2020;8: pubmed publisher
	Radice E, Ameti R, Melgrati S, Foglierini M, Antonello P, Stahl R, et al. Marginal Zone Formation Requires ACKR3 Expression on B Cells. Cell Rep. 2020;32:107951 pubmed publisher
	Durant L, Stentz R, Noble A, Brooks J, Gicheva N, Reddi D, et al. Bacteroides thetaiotaomicron-derived outer membrane vesicles promote regulatory dendritic cell responses in health but not in inflammatory bowel disease. Microbiome. 2020;8:88 pubmed publisher
	Lim C, Lee B, Geiger O, Passegger C, Beitzinger M, Romberger J, et al. miR-181a Modulation of ERK-MAPK Signaling Sustains DC-SIGN Expression and Limits Activation of Monocyte-Derived Dendritic Cells. Cell Rep. 2020;30:3793-3805.e5 pubmed publisher
	Xu H, Wang B, Ono M, Kagita A, Fujii K, Sasakawa N, et al. Targeted Disruption of HLA Genes via CRISPR-Cas9 Generates iPSCs with Enhanced Immune Compatibility. Cell Stem Cell. 2019;: pubmed publisher
	Lee J, Protze S, Laksman Z, Backx P, Keller G. Human Pluripotent Stem Cell-Derived Atrial and Ventricular Cardiomyocytes Develop from Distinct Mesoderm Populations. Cell Stem Cell. 2017;21:179-194.e4 pubmed publisher
	Protze S, Liu J, Nussinovitch U, Ohana L, Backx P, Gepstein L, et al. Sinoatrial node cardiomyocytes derived from human pluripotent cells function as a biological pacemaker. Nat Biotechnol. 2017;35:56-68 pubmed publisher
	Josowitz R, Mulero Navarro S, Rodriguez N, Falce C, Cohen N, Ullian E, et al. Autonomous and Non-autonomous Defects Underlie Hypertrophic Cardiomyopathy in BRAF-Mutant hiPSC-Derived Cardiomyocytes. Stem Cell Reports. 2016;7:355-369 pubmed publisher
	Schrøder M, Melum G, Landsverk O, Bujko A, Yaqub S, Gran E, et al. CD1c-Expression by Monocytes - Implications for the Use of Commercial CD1c+ Dendritic Cell Isolation Kits. PLoS ONE. 2016;11:e0157387 pubmed publisher
	Cashman T, Josowitz R, Johnson B, Gelb B, Costa K. Human Engineered Cardiac Tissues Created Using Induced Pluripotent Stem Cells Reveal Functional Characteristics of BRAF-Mediated Hypertrophic Cardiomyopathy. PLoS ONE. 2016;11:e0146697 pubmed publisher
	Bsat M, Chapuy L, Baba N, Rubio M, Panzini B, Wassef R, et al. Differential accumulation and function of proinflammatory 6-sulfo LacNAc dendritic cells in lymph node and colon of Crohn's versus ulcerative colitis patients. J Leukoc Biol. 2015;98:671-81 pubmed publisher
	Josowitz R, Lu J, Falce C, D Souza S, Wu M, Cohen N, et al. Identification and purification of human induced pluripotent stem cell-derived atrial-like cardiomyocytes based on sarcolipin expression. PLoS ONE. 2014;9:e101316 pubmed publisher
	Zhang D, Shadrin I, Lam J, Xian H, Snodgrass H, Bursac N. Tissue-engineered cardiac patch for advanced functional maturation of human ESC-derived cardiomyocytes. Biomaterials. 2013;34:5813-20 pubmed publisher
	Theocharides A, Jin L, Cheng P, Prasolava T, Malko A, Ho J, et al. Disruption of SIRP? signaling in macrophages eliminates human acute myeloid leukemia stem cells in xenografts. J Exp Med. 2012;209:1883-99 pubmed

product information

Antigen :

CD172a/b

Apps. Abbrev. :

Cat # :

323808

Clone :

SE5A5

Item :

PE/Cyanine7 anti-human CD172a/b (SIRPα/β)

Isotype :

Mouse IgG1, κ

Other Names :

SIRPa, SIRPb, SIRPalpha/beta, BIT, SHPS1, MFR, P84, PTPNS1, CD172 antigen-like family member A, CD172 antigen-like family member B

Size :

100 tests

Price (USD) :

347 USD

Reactivity :

Human

Clonality :

Monoclonal

Host :

Mouse

Conjugate/Tag/Label :

PE_CYANINE7

Immunogen :

NIH-3T3/hu-SIRPα cell line

Application Notes :

Clone SE5A5 recognizes a common epitope on SIRPa (90 kD) and SIRPß (50 kD)^3. A high degree of homology has been found between SIRP family isoforms alpha and beta at the level of extracellular domains. Consequently, many anti SIRP antibody clones, such as SE5A5, have been reported to cross react with several SIRP isoforms^1,4,5. It reacts with CD172a and has weak cross-reaction with CD172b. This antibody is able to block the binding of SIRPa (SIRPa1 and SIRPa2) to CD47^1,6.;

more info or order :

BioLegend product webpage