product summary
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company name :
BioLegend
other brands :
Babco, Signet, Sternberger Monoclonals, Senetek, Covance
product type :
antibody
product name :
Purified anti-human/mouse CLA
catalog :
321302
quantity :
100 μg
price :
119 USD
clonality :
monoclonal
host :
rat
conjugate :
nonconjugated
clone name :
HECA-452
reactivity :
human, mouse
application :
flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
citations: 21
Published Application/Species/Sample/DilutionReference
  • flow cytometry; human; fig 2a
Tyler C, McCarthy N, Lindsay J, Stagg A, Moser B, Eberl M. Antigen-Presenting Human γδ T Cells Promote Intestinal CD4+ T Cell Expression of IL-22 and Mucosal Release of Calprotectin. J Immunol. 2017;198:3417-3425 pubmed publisher
  • flow cytometry; human; loading ...; fig s1g
Cheuk S, Schlums H, Gallais Sérézal I, Martini E, Chiang S, Marquardt N, et al. CD49a Expression Defines Tissue-Resident CD8+ T Cells Poised for Cytotoxic Function in Human Skin. Immunity. 2017;46:287-300 pubmed publisher
  • flow cytometry; human; fig 6b
Szilagyi B, Triebus J, Kressler C, De Almeida M, Tierling S, Durek P, et al. Gut memories do not fade: epigenetic regulation of lasting gut homing receptor expression in CD4+ memory T cells. Mucosal Immunol. 2017;10:1443-1454 pubmed publisher
  • flow cytometry; human; fig 6b
Fu N, Rios A, Pal B, Law C, Jamieson P, Liu R, et al. Identification of quiescent and spatially restricted mammary stem cells that are hormone responsive. Nat Cell Biol. 2017;19:164-176 pubmed publisher
  • flow cytometry; human; loading ...; fig 2f
Boardman D, Philippeos C, Fruhwirth G, Ibrahim M, Hannen R, Cooper D, et al. Expression of a Chimeric Antigen Receptor Specific for Donor HLA Class I Enhances the Potency of Human Regulatory T Cells in Preventing Human Skin Transplant Rejection. Am J Transplant. 2017;17:931-943 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:100; fig 1
Liu J, Akanuma N, Liu C, Naji A, Halff G, Washburn W, et al. TGF-?1 promotes acinar to ductal metaplasia of human pancreatic acinar cells. Sci Rep. 2016;6:30904 pubmed publisher
  • flow cytometry; human; loading ...; fig 4a
Roan F, Stoklasek T, Whalen E, Molitor J, Bluestone J, Buckner J, et al. CD4+ Group 1 Innate Lymphoid Cells (ILC) Form a Functionally Distinct ILC Subset That Is Increased in Systemic Sclerosis. J Immunol. 2016;196:2051-2062 pubmed publisher
  • flow cytometry; mouse; fig 7
Scottà C, Fanelli G, Hoong S, Romano M, Lamperti E, Sukthankar M, et al. Impact of immunosuppressive drugs on the therapeutic efficacy of ex vivo expanded human regulatory T cells. Haematologica. 2016;101:91-100 pubmed publisher
  • flow cytometry; human; loading ...; fig 8a
Mitson Salazar A, Yin Y, Wansley D, Young M, Bolan H, Arceo S, et al. Hematopoietic prostaglandin D synthase defines a proeosinophilic pathogenic effector human T(H)2 cell subpopulation with enhanced function. J Allergy Clin Immunol. 2016;137:907-18.e9 pubmed publisher
Ma T, McGregor M, Giron L, Xie G, George A, Abdel Mohsen M, et al. Single-cell glycomics analysis by CyTOF-Lec reveals glycan features defining cells differentially susceptible to HIV. elife. 2022;11: pubmed publisher
. A blood atlas of COVID-19 defines hallmarks of disease severity and specificity. Cell. 2022;185:916-938.e58 pubmed publisher
Rouers A, Chng M, Lee B, Rajapakse M, Kaur K, Toh Y, et al. Immune cell phenotypes associated with disease severity and long-term neutralizing antibody titers after natural dengue virus infection. Cell Rep Med. 2021;2:100278 pubmed publisher
Bang C, Song J, Song Y, Lee J, Park Y, Lee J. Production of IL-31 in CD45RO+CLA+H4R+ T Cells in Atopic Dermatitis. J Clin Med. 2021;10: pubmed publisher
Eccles J, Turner R, Kirk N, Muehling L, Borish L, Steinke J, et al. T-bet+ Memory B Cells Link to Local Cross-Reactive IgG upon Human Rhinovirus Infection. Cell Rep. 2020;30:351-366.e7 pubmed publisher
Chng M, Lim M, Rouers A, Becht E, Lee B, Macary P, et al. Large-Scale HLA Tetramer Tracking of T Cells during Dengue Infection Reveals Broad Acute Activation and Differentiation into Two Memory Cell Fates. Immunity. 2019;51:1119-1135.e5 pubmed publisher
Carrascal M, Talina C, Borralho P, Gonçalo Mineiro A, Henriques A, Pen C, et al. Staining of E-selectin ligands on paraffin-embedded sections of tumor tissue. BMC Cancer. 2018;18:495 pubmed publisher
Sander J, Schmidt S, Cirovic B, McGovern N, Papantonopoulou O, Hardt A, et al. Cellular Differentiation of Human Monocytes Is Regulated by Time-Dependent Interleukin-4 Signaling and the Transcriptional Regulator NCOR2. Immunity. 2017;47:1051-1066.e12 pubmed publisher
Hensel M, Peng T, Cheng A, De Rosa S, Wald A, Laing K, et al. Selective Expression of CCR10 and CXCR3 by Circulating Human Herpes Simplex Virus-Specific CD8 T Cells. J Virol. 2017;91: pubmed publisher
Betts R, Perkovic A, Mahapatra S, Del Bufalo A, Camara K, Howell A, et al. Contact sensitizers trigger human CD1-autoreactive T-cell responses. Eur J Immunol. 2017;47:1171-1180 pubmed publisher
Silva M, Fung R, Donnelly C, Videira P, Sackstein R. Cell-Specific Variation in E-Selectin Ligand Expression among Human Peripheral Blood Mononuclear Cells: Implications for Immunosurveillance and Pathobiology. J Immunol. 2017;198:3576-3587 pubmed publisher
Ren Y, Nong L, Zhang S, Zhao J, Zhang X, Li T. Analysis of 142 Northern Chinese patients with peripheral T/NK-Cell lymphomas: subtype distribution, clinicopathologic features, and prognosis. Am J Clin Pathol. 2012;138:435-47 pubmed publisher
product information
Antigen :
CLA
Apps. Abbrev. :
FC, IHC-P, IHC-F
Cat # :
321302
Clone :
HECA-452
Item :
Purified anti-human/mouse CLA
Isotype :
Rat IgM, κ
Other Names :
Cutaneous Lymphocyte-associated Antigen (CLA)
Size :
100 μg
Price (USD) :
119 USD
Reactivity :
Human, Mouse
Clonality :
Monoclonal
Host :
Rat
Conjugate/Tag/Label :
PURE
Application Notes :
The HECA-452 antibody cross-reacts with mouse skin homing lymphocytes^4. Treatment of activated HUVEC cells with HECA-452 antibody inhibits lymphocyte adhesion. Additional reported applications (for the relevant formats) include: blocking of lymphocyte binding to E-selectin^3, and immunohistochemistry^1,2 of acetone-fixed frozen sections and formalin-fixed paraffin-embedded sections.;
more info or order :
company information
BioLegend
8999 BioLegend Way
San Diego, CA 92121
customerserv@biolegend.com
https://www.biolegend.com
headquarters: USA