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company name :
BioLegend
other brands :
Babco, Signet, Sternberger Monoclonals, Senetek, Covance
product type :
antibody
product name :
APC anti-human CD206 (MMR)
catalog :
321110
quantity :
100 tests
price :
314 USD
clonality :
monoclonal
host :
mouse
conjugate :
APC
clone name :
15-2
reactivity :
human
application :
flow cytometry
more info or order :
citations: 51
Published Application/Species/Sample/DilutionReference
  • flow cytometry; human; 1:100; loading ...; fig 4d, 7c
Beider K, Voevoda Dimenshtein V, Zoabi A, Rosenberg E, Magen H, Ostrovsky O, et al. CXCL13 chemokine is a novel player in multiple myeloma osteolytic microenvironment, M2 macrophage polarization, and tumor progression. J Hematol Oncol. 2022;15:144 pubmed publisher
  • flow cytometry; human; loading ...; fig 2a
Meng Y, Zhou W, Jin L, Liu L, Chang K, Mei J, et al. RANKL-mediated harmonious dialogue between fetus and mother guarantees smooth gestation by inducing decidual M2 macrophage polarization. Cell Death Dis. 2017;8:e3105 pubmed publisher
Yan J, Bai Y, Chen F, Zou X, Xu J, Huang A, et al. An invasive zone in human liver cancer identified by Stereo-seq promotes hepatocyte-tumor cell crosstalk, local immunosuppression and tumor progression. Cell Res. 2023;: pubmed publisher
Ji T, Shi Q, Mei S, Xu J, Liang H, Xie L, et al. Integrated analysis of single-cell and bulk RNA sequencing data reveals an immunostimulatory microenvironment in tumor thrombus of osteosarcoma. Oncogenesis. 2023;12:31 pubmed publisher
Xu J, Shi Q, Lou J, Wang B, Wang W, Niu J, et al. Chordoma recruits and polarizes tumor-associated macrophages via secreting CCL5 to promote malignant progression. J Immunother Cancer. 2023;11: pubmed publisher
Jiang Y, Yang J, Liang R, Zan X, Fan R, Shan B, et al. Single-cell RNA sequencing highlights intratumor heterogeneity and intercellular network featured in adamantinomatous craniopharyngioma. Sci Adv. 2023;9:eadc8933 pubmed publisher
He X, Chen H, Zhong X, Wang Y, Hu Z, Huang H, et al. BST2 induced macrophage M2 polarization to promote the progression of colorectal cancer. Int J Biol Sci. 2023;19:331-345 pubmed publisher
McEvoy C, Murphy J, Zhang L, Clotet Freixas S, Mathews J, An J, et al. Single-cell profiling of healthy human kidney reveals features of sex-based transcriptional programs and tissue-specific immunity. Nat Commun. 2022;13:7634 pubmed publisher
Wang X, Brea L, Lu X, Gritsina G, Park S, Xie W, et al. FOXA1 inhibits hypoxia programs through transcriptional repression of HIF1A. Oncogene. 2022;41:4259-4270 pubmed publisher
Wu T, Wang W, Shi G, Hao M, Wang Y, Yao M, et al. Targeting HIC1/TGF-β axis-shaped prostate cancer microenvironment restrains its progression. Cell Death Dis. 2022;13:624 pubmed publisher
Khan A, Zhang K, Singh V, Mishra A, Kachroo P, Bing T, et al. Human M1 macrophages express unique innate immune response genes after mycobacterial infection to defend against tuberculosis. Commun Biol. 2022;5:480 pubmed publisher
Sefik E, Qu R, Junqueira C, Kaffe E, Mirza H, Zhao J, et al. Inflammasome activation in infected macrophages drives COVID-19 pathology. Nature. 2022;606:585-593 pubmed publisher
Murugesan G, Davidson L, Jannetti L, Crocker P, Weigle B. Quantitative Proteomics of Polarised Macrophages Derived from Induced Pluripotent Stem Cells. Biomedicines. 2022;10: pubmed publisher
Liu Y, Wang X, Zhu Y, Cao Y, Wang L, Li F, et al. The CTCF/LncRNA-PACERR complex recruits E1A binding protein p300 to induce pro-tumour macrophages in pancreatic ductal adenocarcinoma via directly regulating PTGS2 expression. Clin Transl Med. 2022;12:e654 pubmed publisher
Vijayakumar B, Boustani K, Ogger P, Papadaki A, Tonkin J, Orton C, et al. Immuno-proteomic profiling reveals aberrant immune cell regulation in the airways of individuals with ongoing post-COVID-19 respiratory disease. Immunity. 2022;55:542-556.e5 pubmed publisher
Warmuth S, Gunde T, Snell D, Brock M, Weinert C, Simonin A, et al. Engineering of a trispecific tumor-targeted immunotherapy incorporating 4-1BB co-stimulation and PD-L1 blockade. Oncoimmunology. 2021;10:2004661 pubmed publisher
Sefik E, Israelow B, Mirza H, Zhao J, Qu R, Kaffe E, et al. A humanized mouse model of chronic COVID-19. Nat Biotechnol. 2021;: pubmed publisher
Cossarizza A, Chang H, Radbruch A, Abrignani S, Addo R, Akdis M, et al. Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition). Eur J Immunol. 2021;51:2708-3145 pubmed publisher
Bekere I, Huang J, Schnapp M, Rudolph M, Berneking L, Ruckdeschel K, et al. Yersinia remodels epigenetic histone modifications in human macrophages. PLoS Pathog. 2021;17:e1010074 pubmed publisher
Stempin C, Geysels R, Park S, Palacios L, Volpini X, Motrán C, et al. Secreted Factors by Anaplastic Thyroid Cancer Cells Induce Tumor-Promoting M2-like Macrophage Polarization through a TIM3-Dependent Mechanism. Cancers (Basel). 2021;13: pubmed publisher
Wang X, Zhang H, Ge Y, Cao L, He Y, Sun G, et al. AT1R Regulates Macrophage Polarization Through YAP and Regulates Aortic Dissection Incidence. Front Physiol. 2021;12:644903 pubmed publisher
Que Y, Li H, Lin L, Zhu X, Xiao M, Wang Y, et al. Study on the Immune Escape Mechanism of Acute Myeloid Leukemia With DNMT3A Mutation. Front Immunol. 2021;12:653030 pubmed publisher
Cui J, Shan K, Yang Q, Qi Y, Qu H, Li J, et al. Prostaglandin E3 attenuates macrophage-associated inflammation and prostate tumour growth by modulating polarization. J Cell Mol Med. 2021;25:5586-5601 pubmed publisher
Cui L, Jin X, Xu F, Wang S, Liu L, Li X, et al. Circadian rhythm-associated Rev-erbα modulates polarization of decidual macrophage via the PI3K/Akt signaling pathway. Am J Reprod Immunol. 2021;86:e13436 pubmed publisher
Song D, Wang W, Dong C, Ning Z, Liu X, Liu C, et al. Structure and function analysis of a potent human neutralizing antibody CA521FALA against SARS-CoV-2. Commun Biol. 2021;4:500 pubmed publisher
Wang Y, Monteagudo A, Downey M, Ashton Rickardt P, Elmaleh D. Cromolyn inhibits the secretion of inflammatory cytokines by human microglia (HMC3). Sci Rep. 2021;11:8054 pubmed publisher
Terenzi D, Bakbak E, Trac J, Al Omran M, Quan A, Teoh H, et al. Isolation and characterization of circulating pro-vascular progenitor cell subsets from human whole blood samples. STAR Protoc. 2021;2:100311 pubmed publisher
Zhang B, Miao T, Shen X, Bao L, Zhang C, Yan C, et al. EB virus-induced ATR activation accelerates nasopharyngeal carcinoma growth via M2-type macrophages polarization. Cell Death Dis. 2020;11:742 pubmed publisher
Yang L, Han Y, Nilsson Payant B, Gupta V, Wang P, Duan X, et al. A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids. Cell Stem Cell. 2020;27:125-136.e7 pubmed publisher
Yang H, Wang C, Lai Z, Yang S, Zheng Z, Shi J, et al. Decidual stromal cells maintain decidual macrophage homeostasis by secreting IL-24 in early pregnancy. Am J Reprod Immunol. 2020;84:e13261 pubmed publisher
Sohrabi Y, Sonntag G, Braun L, Lagache S, Liebmann M, Klotz L, et al. LXR Activation Induces a Proinflammatory Trained Innate Immunity-Phenotype in Human Monocytes. Front Immunol. 2020;11:353 pubmed publisher
Li Z, Wang J, Zhang X, Liu P, Zhang X, Wang J, et al. Proinflammatory S100A8 Induces PD-L1 Expression in Macrophages, Mediating Tumor Immune Escape. J Immunol. 2020;204:2589-2599 pubmed publisher
Arlt A, von Bonin F, Rehberg T, Perez Rubio P, Engelmann J, Limm K, et al. High CD206 levels in Hodgkin lymphoma-educated macrophages are linked to matrix-remodeling and lymphoma dissemination. Mol Oncol. 2020;14:571-589 pubmed publisher
Hou Z, Xu X, Fu X, Zhou L, Liu S, Tan D. Long non-coding RNA MALAT1 promotes angiogenesis and immunosuppressive properties of HCC cells by sponging miR-140. Am J Physiol Cell Physiol. 2020;318:C649-C663 pubmed publisher
Wang X, Sun G, Feng T, Zhang J, Huang X, Wang T, et al. Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer's disease progression. Cell Res. 2019;29:787-803 pubmed publisher
de Tymowski C, Heming N, Correia M, Abbad L, Chavarot N, Le Stang M, et al. CD89 Is a Potent Innate Receptor for Bacteria and Mediates Host Protection from Sepsis. Cell Rep. 2019;27:762-775.e5 pubmed publisher
Li B, SONG T, Wang F, Yin C, Li Z, Lin J, et al. Tumor-derived exosomal HMGB1 promotes esophageal squamous cell carcinoma progression through inducing PD1+ TAM expansion. Oncogenesis. 2019;8:17 pubmed publisher
Sohrabi Y, Lagache S, Schnack L, Godfrey R, Kahles F, Bruemmer D, et al. mTOR-Dependent Oxidative Stress Regulates oxLDL-Induced Trained Innate Immunity in Human Monocytes. Front Immunol. 2018;9:3155 pubmed publisher
Blaszczak A, Jalilvand A, Liu J, Wright V, Suzo A, Needleman B, et al. Human Visceral Adipose Tissue Macrophages Are Not Adequately Defined by Standard Methods of Characterization. J Diabetes Res. 2019;2019:8124563 pubmed publisher
Unger A, Finkernagel F, Hoffmann N, Neuhaus F, Joos B, Nist A, et al. Chromatin Binding of c-REL and p65 Is Not Limiting for Macrophage IL12B Transcription During Immediate Suppression by Ovarian Carcinoma Ascites. Front Immunol. 2018;9:1425 pubmed publisher
Wang F, Li B, Wei Y, Zhao Y, Wang L, Zhang P, et al. Tumor-derived exosomes induce PD1+ macrophage population in human gastric cancer that promotes disease progression. Oncogenesis. 2018;7:41 pubmed publisher
Ray S, Baban B, Tucker M, Seaton A, Chang K, Mannon E, et al. Oral NaHCO3 Activates a Splenic Anti-Inflammatory Pathway: Evidence That Cholinergic Signals Are Transmitted via Mesothelial Cells. J Immunol. 2018;200:3568-3586 pubmed publisher
Bravo Flores E, Mancilla Herrera I, Espino y Sosa S, Ortiz Ramirez M, Flores Rueda V, Ibargüengoitia Ochoa F, et al. Macrophage Populations in Visceral Adipose Tissue from Pregnant Women: Potential Role of Obesity in Maternal Inflammation. Int J Mol Sci. 2018;19: pubmed publisher
Alcántara Hernández M, Leylek R, Wagar L, Engleman E, Keler T, Marinkovich M, et al. High-Dimensional Phenotypic Mapping of Human Dendritic Cells Reveals Interindividual Variation and Tissue Specialization. Immunity. 2017;47:1037-1050.e6 pubmed publisher
Shinohara H, Kuranaga Y, Kumazaki M, Sugito N, Yoshikawa Y, Takai T, et al. Regulated Polarization of Tumor-Associated Macrophages by miR-145 via Colorectal Cancer-Derived Extracellular Vesicles. J Immunol. 2017;199:1505-1515 pubmed publisher
Lundholm M, Hägglöf C, Wikberg M, Stattin P, Egevad L, Bergh A, et al. Secreted Factors from Colorectal and Prostate Cancer Cells Skew the Immune Response in Opposite Directions. Sci Rep. 2015;5:15651 pubmed publisher
Deng W, Chen W, Zhang Z, Huang S, Kong W, Sun Y, et al. Mesenchymal stem cells promote CD206 expression and phagocytic activity of macrophages through IL-6 in systemic lupus erythematosus. Clin Immunol. 2015;161:209-16 pubmed publisher
O Regan N, Steinfelder S, Venugopal G, Rao G, Lucius R, Srikantam A, et al. Brugia malayi microfilariae induce a regulatory monocyte/macrophage phenotype that suppresses innate and adaptive immune responses. PLoS Negl Trop Dis. 2014;8:e3206 pubmed publisher
Nguyen A, Tao H, Metrione M, Hajri T. Very low density lipoprotein receptor (VLDLR) expression is a determinant factor in adipose tissue inflammation and adipocyte-macrophage interaction. J Biol Chem. 2014;289:1688-703 pubmed publisher
Edin S, Wikberg M, Rutegård J, Oldenborg P, Palmqvist R. Phenotypic skewing of macrophages in vitro by secreted factors from colorectal cancer cells. PLoS ONE. 2013;8:e74982 pubmed publisher
Yoshimura T, Howard O, Ito T, Kuwabara M, Matsukawa A, Chen K, et al. Monocyte chemoattractant protein-1/CCL2 produced by stromal cells promotes lung metastasis of 4T1 murine breast cancer cells. PLoS ONE. 2013;8:e58791 pubmed publisher
product information
Antigen :
CD206
Apps. Abbrev. :
FC
Cat # :
321110
Clone :
15-2
Item :
APC anti-human CD206 (MMR)
Isotype :
Mouse IgG1, κ
Other Names :
MMR (macrophage mannose receptor), MR (mannose receptor), CD206, MRC1
Size :
100 tests
Price (USD) :
314 USD
Reactivity :
Human
Clonality :
Monoclonal
Host :
Mouse
Conjugate/Tag/Label :
APC
Immunogen :
Purified human mannose receptor
Application Notes :
The 15-2 antibody blocks the interaction of MMR with its ligand, and inhibits mannose receptor-mediated degradation of t-PA by macrophages. Additional reported applications of this antibody (for the relevant formats) include: Western blotting^1, blocking of ligand binding^1,2, immunofluorescence^3, and immunohistochemical staining of acetone-fixed frozen tissue sections^1. The Utra-LEAF™ purified antibody (Endotoxin < 0.01 EU/µg, Azide-Free, 0.2 µm filtered) is recommended for functional assays (Cat. No. 321149 and 321150).;
more info or order :
company information
BioLegend
8999 BioLegend Way
San Diego, CA 92121
customerserv@biolegend.com
https://www.biolegend.com
headquarters: USA