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company name :
BioLegend
other brands :
Babco, Signet, Sternberger Monoclonals, Senetek, Covance
product type :
antibody
product name :
PE anti-human CD206 (MMR)
catalog :
321106
quantity :
100 tests
price :
257 USD
clonality :
monoclonal
host :
mouse
conjugate :
PE
clone name :
15-2
reactivity :
human
application :
flow cytometry
more info or order :
citations: 37
Published Application/Species/Sample/DilutionReference
  • flow cytometry; human; loading ...; fig 5f
Rodriguez E, Boelaars K, Brown K, Eveline Li R, Kruijssen L, Bruijns S, et al. Sialic acids in pancreatic cancer cells drive tumour-associated macrophage differentiation via the Siglec receptors Siglec-7 and Siglec-9. Nat Commun. 2021;12:1270 pubmed publisher
  • flow cytometry; human; loading ...; fig s14b
Stewart B, Ferdinand J, Young M, Mitchell T, Loudon K, Riding A, et al. Spatiotemporal immune zonation of the human kidney. Science. 2019;365:1461-1466 pubmed publisher
Shen W, Li H, Zha A, Luo R, Zhang Y, Luo C, et al. Platelets reprogram monocyte functions by secreting MMP-9 to benefit postoperative outcomes following acute aortic dissection. iScience. 2023;26:106805 pubmed publisher
Wang X, Golino J, Hawk N, Xie C. Reciprocal Interaction of Cancer Stem Cells of Cholangiocarcinoma with Macrophage. Stem Cell Rev Rep. 2023;19:2013-2023 pubmed publisher
Garc xed a Garc xed a A, Pigeot S, Martin I. Engineering of immunoinstructive extracellular matrices for enhanced osteoinductivity. Bioact Mater. 2023;24:174-184 pubmed publisher
Huang L, Wang F, Wang X, Su C, Wu S, Yang C, et al. M2-like macrophage-derived exosomes facilitate metastasis in non-small-cell lung cancer by delivering integrin αVβ3. MedComm (2020). 2023;4:e191 pubmed publisher
Taffoni C, Marines J, Chamma H, Guha S, Saccas M, Bouzid A, et al. DNA damage repair kinase DNA-PK and cGAS synergize to induce cancer-related inflammation in glioblastoma. EMBO J. 2022;:e111961 pubmed publisher
Hao D, Liu J, Guo Z, Chen J, Li T, Li X, et al. Supercritical fluid extract of Angelica sinensis promotes the anti-colorectal cancer effect of oxaliplatin. Front Pharmacol. 2022;13:1007623 pubmed publisher
Rao X, Zhou X, Wang G, Jie X, Xing B, Xu Y, et al. NLRP6 is required for cancer-derived exosome-modified macrophage M2 polarization and promotes metastasis in small cell lung cancer. Cell Death Dis. 2022;13:891 pubmed publisher
Cao B, Liu M, Wang L, Zhu K, Cai M, Chen X, et al. Remodelling of tumour microenvironment by microwave ablation potentiates immunotherapy of AXL-specific CAR T cells against non-small cell lung cancer. Nat Commun. 2022;13:6203 pubmed publisher
Ja xe9 n R, Povo Retana A, Rosales Mendoza C, Capillas Herrero P, S xe1 nchez Garc xed a S, Mart xed n Sanz P, et al. Functional Crosstalk between PCSK9 Internalization and Pro-Inflammatory Activation in Human Macrophages: Role of Reactive Oxygen Species Release. Int J Mol Sci. 2022;23: pubmed publisher
Zhou W, Wang Y, Yan C, Du W, Al Aroomi M, Zheng L, et al. CC chemokine receptor 7 promotes macrophage recruitment and induces M2-polarization through CC chemokine ligand 19&21 in oral squamous cell carcinoma. Discov Oncol. 2022;13:67 pubmed publisher
Chen X, Yang M, Yin J, Li P, Zeng S, Zheng G, et al. Tumor-associated macrophages promote epithelial-mesenchymal transition and the cancer stem cell properties in triple-negative breast cancer through CCL2/AKT/β-catenin signaling. Cell Commun Signal. 2022;20:92 pubmed publisher
Zangeneh Z, Khamisipour G, Andalib A. Induced overexpression of MARCH-1 in human macrophages altered to M2 phenotype for suppressing inflammation process. Iran J Basic Med Sci. 2022;25:474-482 pubmed publisher
Sefik E, Qu R, Junqueira C, Kaffe E, Mirza H, Zhao J, et al. Inflammasome activation in infected macrophages drives COVID-19 pathology. Nature. 2022;606:585-593 pubmed publisher
Sefik E, Israelow B, Mirza H, Zhao J, Qu R, Kaffe E, et al. A humanized mouse model of chronic COVID-19. Nat Biotechnol. 2021;: pubmed publisher
Shen Y, Wang Y, Fu Z, Ma Q, Song Y, Fang L, et al. UPR attenuates the proinflammatory effect of HPDLF on macrophage polarization. Cell Stress Chaperones. 2021;26:937-944 pubmed publisher
Madsen N, Nielsen B, Nhat S, Skov S, Gad M, Larsen J. Monocyte Infiltration and Differentiation in 3D Multicellular Spheroid Cancer Models. Pathogens. 2021;10: pubmed publisher
Forsberg M, Kink J, Thickens A, Lewis B, Childs C, Hematti P, et al. Exosomes from primed MSCs can educate monocytes as a cellular therapy for hematopoietic acute radiation syndrome. Stem Cell Res Ther. 2021;12:459 pubmed publisher
Lv J, Liu C, Chen F, Feng Z, Jia L, Liu P, et al. M2‑like tumour‑associated macrophage‑secreted IGF promotes thyroid cancer stemness and metastasis by activating the PI3K/AKT/mTOR pathway. Mol Med Rep. 2021;24: pubmed publisher
Xun X, Zhang C, Wang S, Hu S, Xiang X, Cheng Q, et al. Cyclooxygenase-2 expressed hepatocellular carcinoma induces cytotoxic T lymphocytes exhaustion through M2 macrophage polarization. Am J Transl Res. 2021;13:4360-4375 pubmed
Rodriguez Garcia A, Lynn R, Poussin M, Eiva M, Shaw L, O Connor R, et al. CAR-T cell-mediated depletion of immunosuppressive tumor-associated macrophages promotes endogenous antitumor immunity and augments adoptive immunotherapy. Nat Commun. 2021;12:877 pubmed publisher
Cho J, Okuma A, Sofjan K, Lee S, Collins J, Wong W. Engineering advanced logic and distributed computing in human CAR immune cells. Nat Commun. 2021;12:792 pubmed publisher
Bourdely P, Anselmi G, Vaivode K, Ramos R, Missolo Koussou Y, Hidalgo S, et al. Transcriptional and Functional Analysis of CD1c+ Human Dendritic Cells Identifies a CD163+ Subset Priming CD8+CD103+ T Cells. Immunity. 2020;53:335-352.e8 pubmed publisher
Malekghasemi S, Majidi J, Baradaran B, Aghebati Maleki L. Prostate cancer cells modulate the differentiation of THP-1 cells in response to etoposide and TLR agonists treatments. Cell Biol Int. 2020;44:2031-2041 pubmed publisher
Friebel E, Kapolou K, Unger S, Núñez N, Utz S, Rushing E, et al. Single-Cell Mapping of Human Brain Cancer Reveals Tumor-Specific Instruction of Tissue-Invading Leukocytes. Cell. 2020;181:1626-1642.e20 pubmed publisher
Dan H, Liu S, Liu J, Liu D, Yin F, Wei Z, et al. RACK1 promotes cancer progression by increasing the M2/M1 macrophage ratio via the NF-κB pathway in oral squamous cell carcinoma. Mol Oncol. 2020;14:795-807 pubmed publisher
Wilcz Villega E, Carter E, Ironside A, Xu R, Mataloni I, Holdsworth J, et al. Macrophages induce malignant traits in mammary epithelium via IKKε/TBK1 kinases and the serine biosynthesis pathway. EMBO Mol Med. 2020;12:e10491 pubmed publisher
Weisberg S, Carpenter D, Chait M, Dogra P, Gartrell Corrado R, Chen A, et al. Tissue-Resident Memory T Cells Mediate Immune Homeostasis in the Human Pancreas through the PD-1/PD-L1 Pathway. Cell Rep. 2019;29:3916-3932.e5 pubmed publisher
Georgouli M, Herraiz C, Crosas Molist E, Fanshawe B, Maiques O, Perdrix A, et al. Regional Activation of Myosin II in Cancer Cells Drives Tumor Progression via a Secretory Cross-Talk with the Immune Microenvironment. Cell. 2019;176:757-774.e23 pubmed publisher
Widdrington J, Gómez Durán A, Pyle A, Ruchaud Sparagano M, Scott J, Baudouin S, et al. Exposure of Monocytic Cells to Lipopolysaccharide Induces Coordinated Endotoxin Tolerance, Mitochondrial Biogenesis, Mitophagy, and Antioxidant Defenses. Front Immunol. 2018;9:2217 pubmed publisher
Soberanes S, Misharin A, Jairaman A, Morales Nebreda L, McQuattie Pimentel A, Cho T, et al. Metformin Targets Mitochondrial Electron Transport to Reduce Air-Pollution-Induced Thrombosis. Cell Metab. 2019;29:335-347.e5 pubmed publisher
Qin X, Senturk B, Valentin J, Malheiro V, Fortunato G, Ren Q, et al. Cell-Membrane-Inspired Silicone Interfaces that Mitigate Proinflammatory Macrophage Activation and Bacterial Adhesion. Langmuir. 2019;35:1882-1894 pubmed publisher
Yang M, Xu J, Wang Q, Zhang A, Wang K. An obligatory anaerobic Salmonella typhimurium strain redirects M2 macrophages to the M1 phenotype. Oncol Lett. 2018;15:3918-3922 pubmed publisher
Barman S, Kayama H, Okuzaki D, Ogino T, Osawa H, Matsuno H, et al. Identification of a human intestinal myeloid cell subset that regulates gut homeostasis. Int Immunol. 2016;28:533-545 pubmed
Zhan X, Jia L, Niu Y, Qi H, Chen X, Zhang Q, et al. Targeted depletion of tumour-associated macrophages by an alendronate-glucomannan conjugate for cancer immunotherapy. Biomaterials. 2014;35:10046-57 pubmed publisher
Kleinnijenhuis J, Quintin J, Preijers F, Joosten L, Ifrim D, Saeed S, et al. Bacille Calmette-Guerin induces NOD2-dependent nonspecific protection from reinfection via epigenetic reprogramming of monocytes. Proc Natl Acad Sci U S A. 2012;109:17537-42 pubmed publisher
product information
Antigen :
CD206
Apps. Abbrev. :
FC
Cat # :
321106
Clone :
15-2
Item :
PE anti-human CD206 (MMR)
Isotype :
Mouse IgG1, κ
Other Names :
MMR (macrophage mannose receptor), MR (mannose receptor), CD206, MRC1
Size :
100 tests
Price (USD) :
257 USD
Reactivity :
Human
Clonality :
Monoclonal
Host :
Mouse
Conjugate/Tag/Label :
PE
Immunogen :
Purified human mannose receptor
Application Notes :
The 15-2 antibody blocks the interaction of MMR with its ligand, and inhibits mannose receptor-mediated degradation of t-PA by macrophages. Additional reported applications of this antibody (for the relevant formats) include: Western blotting^1, blocking of ligand binding^1,2, immunofluorescence^3, and immunohistochemical staining of acetone-fixed frozen tissue sections^1. The Utra-LEAF™ purified antibody (Endotoxin < 0.01 EU/µg, Azide-Free, 0.2 µm filtered) is recommended for functional assays (Cat. No. 321149 and 321150).;
more info or order :
company information
BioLegend
8999 BioLegend Way
San Diego, CA 92121
customerserv@biolegend.com
https://www.biolegend.com
headquarters: USA