Purified anti-human MICA/MICB | BioLegend 320902 product information

product summary

company name :

BioLegend

other brands :

Babco, Signet, Sternberger Monoclonals, Senetek, Covance

product type :

antibody

product name :

Purified anti-human MICA/MICB

catalog :

320902

quantity :

100 μg

price :

118 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

6D4

reactivity :

human

application :

immunohistochemistry, immunocytochemistry, neutralization, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

more info or order :

BioLegend product webpage

citations: 11

Published Application/Species/Sample/Dilution	Reference
immunocytochemistry; human; loading ...; fig 1b immunohistochemistry; human; loading ...; fig 2a	Ghadially H, Brown L, Lloyd C, Lewis L, LEWIS A, Dillon J, et al. MHC class I chain-related protein A and B (MICA and MICB) are predominantly expressed intracellularly in tumour and normal tissue. Br J Cancer. 2017;116:1208-1217 pubmed publisher
flow cytometry; human; loading ...; fig s3g	Sauer M, Schuldner M, Hoffmann N, Cetintas A, Reiners K, Shatnyeva O, et al. CBP/p300 acetyltransferases regulate the expression of NKG2D ligands on tumor cells. Oncogene. 2017;36:933-941 pubmed publisher
flow cytometry; human; fig 4	Ritter C, Fan K, Paulson K, Nghiem P, Schrama D, Becker J. Reversal of epigenetic silencing of MHC class I chain-related protein A and B improves immune recognition of Merkel cell carcinoma. Sci Rep. 2016;6:21678 pubmed publisher
flow cytometry; human; fig 7	Yawata N, Selva K, Liu Y, Tan K, Lee A, Siak J, et al. Dynamic change in natural killer cell type in the human ocular mucosa in situ as means of immune evasion by adenovirus infection. Mucosal Immunol. 2016;9:159-70 pubmed publisher
flow cytometry; human	Vogel K, Thomann S, Vogel B, Schuster P, Schmidt B. Both plasmacytoid dendritic cells and monocytes stimulate natural killer cells early during human herpes simplex virus type 1 infections. Immunology. 2014;143:588-600 pubmed publisher
	Wang J, Liu K, Xiao T, Liu P, Prinz R, Xu X. Uric acid accumulation in DNA-damaged tumor cells induces NKG2D ligand expression and antitumor immunity by activating TGF-β-activated kinase 1. Oncoimmunology. 2022;11:2016159 pubmed publisher
	Suresh P, Long A, Dumont S. Microneedle manipulation of the mammalian spindle reveals specialized, short-lived reinforcement near chromosomes. elife. 2020;9: pubmed publisher
	Nakajima N, Niimi A, Isono M, Oike T, Sato H, Nakano T, et al. Inhibition of the HDAC/Suv39/G9a pathway restores the expression of DNA damage-dependent major histocompatibility complex classÂ I-related chainÂ AÂ andÂ B in cancer cells. Oncol Rep. 2017;38:693-702 pubmed publisher
	Nolan E, Savas P, Policheni A, Darcy P, Vaillant F, Mintoff C, et al. Combined immune checkpoint blockade as a therapeutic strategy for BRCA1-mutated breast cancer. Sci Transl Med. 2017;9: pubmed publisher
	Tjwa E, van Oord G, Biesta P, Boonstra A, Janssen H, Woltman A. Restoration of TLR3-activated myeloid dendritic cell activity leads to improved natural killer cell function in chronic hepatitis B virus infection. J Virol. 2012;86:4102-9 pubmed publisher
	Takahara M, Miyai M, Tomiyama M, Mutou M, Nicol A, Nieda M. Copulsing tumor antigen-pulsed dendritic cells with zoledronate efficiently enhance the expansion of tumor antigen-specific CD8+ T cells via Vgamma9gammadelta T cell activation. J Leukoc Biol. 2008;83:742-54 pubmed

product information

Antigen :

MICA MICB

Apps. Abbrev. :

FC, IHC-P, IHC-F, IP, Block

Cat # :

320902

Clone :

6D4

Item :

Purified anti-human MICA/MICB

Isotype :

Mouse IgG2a, κ

Other Names :

PERB11, MIC, MHC class I chain-related protein A, MICA, PERB11.1, MHC class I chain-related protein B, MICB, PERB11.2

Size :

100 μg

Price (USD) :

118 USD

Reactivity :

Human

Clonality :

Monoclonal

Host :

Mouse

Conjugate/Tag/Label :

PURE

Application Notes :

Additional reported (for the relevant formats) applications include: immunohistochemistry^2,3,5 of acetone-fixed frozen sections and formalin-fixed paraffin-embedded tissue sections, immunoprecipitation^7, and blocking^2,3 of MIC mediated cytotoxicity. The Ultra-LEAF™ Purified antibody (Endotoxin < 0.01 EU/µg, Azide-Free, 0.2 µm filtered) is recommended for functional assays (Cat. Nos. 320919 & 320120).;

more info or order :

BioLegend product webpage