product summary
Loading...
company name :
BioLegend
other brands :
Babco, Signet, Sternberger Monoclonals, Senetek, Covance
product type :
antibody
product name :
Purified anti-human FOXP3
catalog :
320102
quantity :
100 μg
price :
265 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
206D
reactivity :
human
application :
western blot, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
citations: 60
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - paraffin section; human; loading ...; fig 3
Herrera Rios D, Mughal S, Teuber Hanselmann S, Pierscianek D, Sucker A, Jansen P, et al. Macrophages/Microglia Represent the Major Source of Indolamine 2,3-Dioxygenase Expression in Melanoma Metastases of the Brain. Front Immunol. 2020;11:120 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:50; loading ...; fig 2e
  • immunohistochemistry; human; 1:50; loading ...; fig 2f
Helmink B, Reddy S, Gao J, Zhang S, Basar R, Thakur R, et al. B cells and tertiary lymphoid structures promote immunotherapy response. Nature. 2020;577:549-555 pubmed publisher
  • immunohistochemistry; human; loading ...; fig 3c
Riquelme E, Zhang Y, Zhang L, Montiel M, Zoltan M, Dong W, et al. Tumor Microbiome Diversity and Composition Influence Pancreatic Cancer Outcomes. Cell. 2019;178:795-806.e12 pubmed publisher
  • immunohistochemistry - paraffin section; human
  • immunohistochemistry; human
Lin J, Izar B, Wang S, Yapp C, Mei S, Shah P, et al. Highly multiplexed immunofluorescence imaging of human tissues and tumors using t-CyCIF and conventional optical microscopes. elife. 2018;7: pubmed publisher
  • flow cytometry; human; loading ...; fig 1
Ondigo B, Ndombi E, Nicholson S, Oguso J, Carter J, Kittur N, et al. Functional Studies of T Regulatory Lymphocytes in Human Schistosomiasis in Western Kenya. Am J Trop Med Hyg. 2018;98:1770-1781 pubmed publisher
  • flow cytometry; human; loading ...; fig 3b
  • immunohistochemistry; human; loading ...; fig 3a
Amodio D, Cotugno N, Macchiarulo G, Rocca S, Dimopoulos Y, Castrucci M, et al. Quantitative Multiplexed Imaging Analysis Reveals a Strong Association between Immunogen-Specific B Cell Responses and Tonsillar Germinal Center Immune Dynamics in Children after Influenza Vaccination. J Immunol. 2018;200:538-550 pubmed publisher
  • flow cytometry; human; loading ...; fig 4d
Dias J, Leeansyah E, Sandberg J. Multiple layers of heterogeneity and subset diversity in human MAIT cell responses to distinct microorganisms and to innate cytokines. Proc Natl Acad Sci U S A. 2017;114:E5434-E5443 pubmed publisher
  • flow cytometry; human; loading ...; fig 1b
Wei C, Mei J, Tang L, Liu Y, Li D, Li M, et al. 1-Methyl-tryptophan attenuates regulatory T cells differentiation due to the inhibition of estrogen-IDO1-MRC2 axis in endometriosis. Cell Death Dis. 2016;7:e2489 pubmed publisher
  • flow cytometry; human; loading ...; fig 2b
Klarquist J, Tobin K, Farhangi Oskuei P, Henning S, Fernandez M, Dellacecca E, et al. Ccl22 Diverts T Regulatory Cells and Controls the Growth of Melanoma. Cancer Res. 2016;76:6230-6240 pubmed
  • flow cytometry; human; fig s2
Pachnio A, Ciáurriz M, Begum J, Lal N, Zuo J, Beggs A, et al. Cytomegalovirus Infection Leads to Development of High Frequencies of Cytotoxic Virus-Specific CD4+ T Cells Targeted to Vascular Endothelium. PLoS Pathog. 2016;12:e1005832 pubmed publisher
  • immunohistochemistry - paraffin section; human; 5 ug/ml; loading ...; tbl 2
Javvadi L, Parachuru V, Milne T, Seymour G, Rich A. Regulatory T-cells and IL17A(+) cells infiltrate oral lichen planus lesions. Pathology. 2016;48:564-73 pubmed publisher
  • flow cytometry; human; loading ...; fig 6b
Leitch C, Natafji E, Yu C, Abdul Ghaffar S, Madarasingha N, Venables Z, et al. Filaggrin-null mutations are associated with increased maturation markers on Langerhans cells. J Allergy Clin Immunol. 2016;138:482-490.e7 pubmed publisher
  • flow cytometry; human; fig 6
Anandasabapathy N, Breton G, Hurley A, Caskey M, Trumpfheller C, Sarma P, et al. Efficacy and safety of CDX-301, recombinant human Flt3L, at expanding dendritic cells and hematopoietic stem cells in healthy human volunteers. Bone Marrow Transplant. 2015;50:924-30 pubmed publisher
  • flow cytometry; human; fig 6
Rochman Y, Yukawa M, Kartashov A, Barski A. Functional characterization of human T cell hyporesponsiveness induced by CTLA4-Ig. PLoS ONE. 2015;10:e0122198 pubmed publisher
  • immunohistochemistry; human; fig 2
Zsiros E, Duttagupta P, Dangaj D, Li H, Frank R, Garrabrant T, et al. The Ovarian Cancer Chemokine Landscape Is Conducive to Homing of Vaccine-Primed and CD3/CD28-Costimulated T Cells Prepared for Adoptive Therapy. Clin Cancer Res. 2015;21:2840-50 pubmed publisher
  • flow cytometry; human; loading ...; fig 1
Bhela S, Kempsell C, Manohar M, Dominguez Villar M, Griffin R, Bhatt P, et al. Nonapoptotic and extracellular activity of granzyme B mediates resistance to regulatory T cell (Treg) suppression by HLA-DR-CD25hiCD127lo Tregs in multiple sclerosis and in response to IL-6. J Immunol. 2015;194:2180-9 pubmed publisher
  • flow cytometry; human
Jin J, Zhang W, Wong K, Kwak M, van Driel I, Yu Q. Inhibition of breast cancer resistance protein (ABCG2) in human myeloid dendritic cells induces potent tolerogenic functions during LPS stimulation. PLoS ONE. 2014;9:e104753 pubmed publisher
Gregory S, Xu Y, Xie P, Fan J, Gao B, Mani N, et al. The ubiquitin-specific peptidase 22 is a deubiquitinase of CD73 in breast cancer cells. Am J Cancer Res. 2022;12:5564-5575 pubmed
Martini R, Delpe P, Chu T, Arora K, Lord B, Verma A, et al. African Ancestry-Associated Gene Expression Profiles in Triple-Negative Breast Cancer Underlie Altered Tumor Biology and Clinical Outcome in Women of African Descent. Cancer Discov. 2022;12:2530-2551 pubmed publisher
Liu X, Lv J, Wang H, Zheng Y, Su W. Functional analysis of human circulating immune cells based on high-dimensional mass cytometry. STAR Protoc. 2022;3:101310 pubmed publisher
Nugent J, Singh A, Wirth K, Oppler S, Hocum Stone L, Janecek J, et al. A nonhuman primate model of vertical sleeve gastrectomy facilitates mechanistic and translational research in human obesity. iScience. 2021;24:103421 pubmed publisher
Burlingame E, Eng J, Thibault G, Chin K, Gray J, Chang Y. Toward reproducible, scalable, and robust data analysis across multiplex tissue imaging platforms. Cell Rep Methods. 2021;1: pubmed publisher
Chen P, Zhao L, Wang H, Zhang L, Zhang W, Zhu J, et al. Human leukocyte antigen class II-based immune risk model for recurrence evaluation in stage I-III small cell lung cancer. J Immunother Cancer. 2021;9: pubmed publisher
Boucher Y, Kumar A, Posada J, Gjini E, PFAFF K, Lipschitz M, et al. Bevacizumab improves tumor infiltration of mature dendritic cells and effector T-cells in triple-negative breast cancer patients. NPJ Precis Oncol. 2021;5:62 pubmed publisher
Durgin J, Henderson F, Nasrallah M, Mohan S, Wang S, Lacey S, et al. Case Report: Prolonged Survival Following EGFRvIII CAR T Cell Treatment for Recurrent Glioblastoma. Front Oncol. 2021;11:669071 pubmed publisher
Jiang M, Wu C, Zhang L, Sun C, Wang H, Xu Y, et al. FOXP3-based immune risk model for recurrence prediction in small-cell lung cancer at stages I-III. J Immunother Cancer. 2021;9: pubmed publisher
Wang H, Chen S, Meng D, Wu C, Zhu J, Jiang M, et al. Tumor Mutation Burden and Differentially Mutated Genes Among Immune Phenotypes in Patients with Lung Adenocarcinoma. Onco Targets Ther. 2021;14:2953-2965 pubmed publisher
Haymaker C, Johnson D, Murthy R, Bentebibel S, Uemura M, Hudgens C, et al. Tilsotolimod with Ipilimumab Drives Tumor Responses in Anti-PD-1 Refractory Melanoma. Cancer Discov. 2021;11:1996-2013 pubmed publisher
Xie S, Shan X, Yau V, Zhang J, Zhang X, Yan Y, et al. Hyperion imaging system reveals heterogeneous tumor microenvironment of oral squamous cell carcinoma patients at T1N0M0 stage. Ann Transl Med. 2020;8:1513 pubmed publisher
Chen S, Wu S, Zhang L, Zhang W, Liu Y, Chen B, et al. CD39: the potential target in small cell lung cancer. Transl Lung Cancer Res. 2020;9:1483-1495 pubmed publisher
Richardson L, Nieman L, Stemmer Rachamimov A, Zheng X, Stafford K, Nagashima H, et al. IDH-mutant gliomas harbor fewer regulatory T cells in humans and mice. Oncoimmunology. 2020;9:1806662 pubmed publisher
Luoma A, Suo S, Williams H, Sharova T, Sullivan K, Manos M, et al. Molecular Pathways of Colon Inflammation Induced by Cancer Immunotherapy. Cell. 2020;: pubmed publisher
Derks S, de Klerk L, Xu X, Fleitas T, Liu K, Liu Y, et al. Characterizing diversity in the tumor-immune microenvironment of distinct subclasses of gastroesophageal adenocarcinomas. Ann Oncol. 2020;31:1011-1020 pubmed publisher
Msaouel P, Malouf G, Su X, Yao H, Tripathi D, Soeung M, et al. Comprehensive Molecular Characterization Identifies Distinct Genomic and Immune Hallmarks of Renal Medullary Carcinoma. Cancer Cell. 2020;37:720-734.e13 pubmed publisher
Mitra A, Andrews M, Roh W, De Macedo M, Hudgens C, Carapeto F, et al. Spatially resolved analyses link genomic and immune diversity and reveal unfavorable neutrophil activation in melanoma. Nat Commun. 2020;11:1839 pubmed publisher
Werneburg S, Jung J, Kunjamma R, Ha S, Luciano N, Willis C, et al. Targeted Complement Inhibition at Synapses Prevents Microglial Synaptic Engulfment and Synapse Loss in Demyelinating Disease. Immunity. 2020;52:167-182.e7 pubmed publisher
Sadigh S, Farahani S, Shah A, Vaughn D, Lal P. Differences in PD-L1-Expressing Macrophages and Immune Microenvironment in Testicular Germ Cell Tumors. Am J Clin Pathol. 2020;153:387-395 pubmed publisher
de Groot J, Penas Prado M, Alfaro Munoz K, Hunter K, Pei B, O BRIEN B, et al. Window-of-opportunity clinical trial of pembrolizumab in patients with recurrent glioblastoma reveals predominance of immune-suppressive macrophages. Neuro Oncol. 2020;22:539-549 pubmed publisher
Vence L, Bucktrout S, Fernandez Curbelo I, Blando J, Smith B, Mahne A, et al. Characterization and Comparison of GITR Expression in Solid Tumors. Clin Cancer Res. 2019;25:6501-6510 pubmed publisher
Li Y, Teteloshvili N, Tan S, Rao S, Han A, Yang Y, et al. Humanized Mice Reveal New Insights Into the Thymic Selection of Human Autoreactive CD8+ T Cells. Front Immunol. 2019;10:63 pubmed publisher
Blessin N, Simon R, Kluth M, Fischer K, Hube Magg C, Li W, et al. Patterns of TIGIT Expression in Lymphatic Tissue, Inflammation, and Cancer. Dis Markers. 2019;2019:5160565 pubmed publisher
Li W, Blessin N, Simon R, Kluth M, Fischer K, Hube Magg C, et al. Expression of the immune checkpoint receptor TIGIT in Hodgkin's lymphoma. BMC Cancer. 2018;18:1209 pubmed publisher
Amaria R, Reddy S, Tawbi H, Davies M, Ross M, Glitza I, et al. Neoadjuvant immune checkpoint blockade in high-risk resectable melanoma. Nat Med. 2018;24:1649-1654 pubmed publisher
Donnelly C, Dykstra B, Mondal N, Huang J, Kaskow B, Griffin R, et al. Optimizing human Treg immunotherapy by Treg subset selection and E-selectin ligand expression. Sci Rep. 2018;8:420 pubmed publisher
Parra E, Uraoka N, Jiang M, Cook P, Gibbons D, Forget M, et al. Validation of multiplex immunofluorescence panels using multispectral microscopy for immune-profiling of formalin-fixed and paraffin-embedded human tumor tissues. Sci Rep. 2017;7:13380 pubmed publisher
Zeigler Johnson C, Morales K, Lal P, Feldman M. The Relationship between Obesity, Prostate Tumor Infiltrating Lymphocytes and Macrophages, and Biochemical Failure. PLoS ONE. 2016;11:e0159109 pubmed publisher
Hodi F, Lawrence D, Lezcano C, Wu X, Zhou J, Sasada T, et al. Bevacizumab plus ipilimumab in patients with metastatic melanoma. Cancer Immunol Res. 2014;2:632-42 pubmed publisher
Nigam P, Velu V, Kannanganat S, Chennareddi L, Kwa S, Siddiqui M, et al. Expansion of FOXP3+ CD8 T cells with suppressive potential in colorectal mucosa following a pathogenic simian immunodeficiency virus infection correlates with diminished antiviral T cell response and viral control. J Immunol. 2010;184:1690-701 pubmed publisher
Kmieciak M, Gowda M, Graham L, Godder K, Bear H, Marincola F, et al. Human T cells express CD25 and Foxp3 upon activation and exhibit effector/memory phenotypes without any regulatory/suppressor function. J Transl Med. 2009;7:89 pubmed publisher
Nevala W, Vachon C, Leontovich A, Scott C, Thompson M, Markovic S. Evidence of systemic Th2-driven chronic inflammation in patients with metastatic melanoma. Clin Cancer Res. 2009;15:1931-9 pubmed publisher
Raghavan S, Cao D, Widhe M, Roth K, Herrath J, Engstrom M, et al. FOXP3 expression in blood, synovial fluid and synovial tissue during inflammatory arthritis and intra-articular corticosteroid treatment. Ann Rheum Dis. 2009;68:1908-15 pubmed publisher
Grant J, Bourcier K, Wallace S, Pan D, Conway A, Seyfert Margolis V, et al. Validated protocol for FoxP3 reveals increased expression in type 1 diabetes patients. Cytometry B Clin Cytom. 2009;76:69-78 pubmed publisher
Zheng Y, Manzotti C, Burke F, Dussably L, Qureshi O, Walker L, et al. Acquisition of suppressive function by activated human CD4+ CD25- T cells is associated with the expression of CTLA-4 not FoxP3. J Immunol. 2008;181:1683-91 pubmed
Kavanagh B, O Brien S, Lee D, Hou Y, Weinberg V, Rini B, et al. CTLA4 blockade expands FoxP3+ regulatory and activated effector CD4+ T cells in a dose-dependent fashion. Blood. 2008;112:1175-83 pubmed publisher
Zonios D, Falloon J, Bennett J, Shaw P, Chaitt D, Baseler M, et al. Idiopathic CD4+ lymphocytopenia: natural history and prognostic factors. Blood. 2008;112:287-94 pubmed publisher
Pillai V, Karandikar N. Attack on the clones? Human FOXP3 detection by PCH101, 236A/E7, 206D, and 259D reveals 259D as the outlier with lower sensitivity. Blood. 2008;111:463-4; author reply 464-6 pubmed
Hartigan O Connor D, Abel K, McCune J. Suppression of SIV-specific CD4+ T cells by infant but not adult macaque regulatory T cells: implications for SIV disease progression. J Exp Med. 2007;204:2679-92 pubmed
Tran D, Ramsey H, Shevach E. Induction of FOXP3 expression in naive human CD4+FOXP3 T cells by T-cell receptor stimulation is transforming growth factor-beta dependent but does not confer a regulatory phenotype. Blood. 2007;110:2983-90 pubmed
Gao Q, Qiu S, Fan J, Zhou J, Wang X, Xiao Y, et al. Intratumoral balance of regulatory and cytotoxic T cells is associated with prognosis of hepatocellular carcinoma after resection. J Clin Oncol. 2007;25:2586-93 pubmed
Liu W, Putnam A, Xu Yu Z, Szot G, Lee M, Zhu S, et al. CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells. J Exp Med. 2006;203:1701-11 pubmed
product information
Antigen :
FOXP3
Apps. Abbrev. :
WB, ICFC, IHC-F, IHC-P
Cat # :
320102
Clone :
206D
Item :
Purified anti-human FOXP3
Isotype :
Mouse IgG1, κ
Other Names :
Forkhead box protein P3, Scurfin, JM2, IPEX, Zinc finger protein JM2
Size :
100 μg
Price (USD) :
265 USD
Reactivity :
Human
Clonality :
Monoclonal
Host :
Mouse
Conjugate/Tag/Label :
PURE
Immunogen :
Full-length FOXP3 protein
more info or order :
company information
BioLegend
8999 BioLegend Way
San Diego, CA 92121
customerserv@biolegend.com
https://www.biolegend.com
headquarters: USA