product summary
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company name :
BioLegend
other brands :
Babco, Signet, Sternberger Monoclonals, Senetek, Covance
product type :
antibody
product name :
Alexa Fluor® 647 anti-human CD56 (NCAM)
catalog :
318313
quantity :
25 tests
price :
124 USD
clonality :
monoclonal
host :
mouse
conjugate :
AF647
clone name :
HCD56
reactivity :
human, mouse, rhesus macaque
application :
flow cytometry, other
more info or order :
citations: 60
Published Application/Species/Sample/DilutionReference
  • flow cytometry; human; loading ...
Amaral E, Foreman T, Namasivayam S, Hilligan K, Kauffman K, Barbosa Bomfim C, et al. GPX4 regulates cellular necrosis and host resistance in Mycobacterium tuberculosis infection. J Exp Med. 2022;219: pubmed publisher
  • flow cytometry; human; fig 3e
Dalla Pietà A, Cappuzzello E, Palmerini P, Ventura A, Visentin A, Astori G, et al. Innovative therapeutic strategy for B-cell malignancies that combines obinutuzumab and cytokine-induced killer cells. J Immunother Cancer. 2021;9: pubmed publisher
  • flow cytometry; human; loading ...
Bohannon C, Ende Z, Cao W, Mboko W, Ranjan P, Kumar A, et al. Influenza Virus Infects and Depletes Activated Adaptive Immune Responders. Adv Sci (Weinh). 2021;8:e2100693 pubmed publisher
  • flow cytometry; human; loading ...; fig 3b
Ingelfinger F, Krishnarajah S, Kramer M, Utz S, Galli E, Lutz M, et al. Single-cell profiling of myasthenia gravis identifies a pathogenic T cell signature. Acta Neuropathol. 2021;141:901-915 pubmed publisher
  • flow cytometry; human; loading ...; fig s1
Katano I, Ito R, Kawai K, Takahashi T. Improved Detection of in vivo Human NK Cell-Mediated Antibody-Dependent Cellular Cytotoxicity Using a Novel NOG-FcγR-Deficient Human IL-15 Transgenic Mouse. Front Immunol. 2020;11:532684 pubmed publisher
  • other; mouse
Tseng H, Xiong W, Badeti S, Yang Y, Ma M, Liu T, et al. Efficacy of anti-CD147 chimeric antigen receptors targeting hepatocellular carcinoma. Nat Commun. 2020;11:4810 pubmed publisher
  • other; human; 1:100; loading ...
Leelatian N, Sinnaeve J, Mistry A, Barone S, Brockman A, Diggins K, et al. Unsupervised machine learning reveals risk stratifying glioblastoma tumor cells. elife. 2020;9: pubmed publisher
  • flow cytometry; human; loading ...; fig s1a
Martin E, Minet N, Boschat A, Sanquer S, Sobrino S, Lenoir C, et al. Impaired lymphocyte function and differentiation in CTPS1-deficient patients result from a hypomorphic homozygous mutation. JCI Insight. 2020;5: pubmed publisher
  • flow cytometry; human; loading ...; fig ex1
Ardain A, Domingo Gonzalez R, Das S, Kazer S, Howard N, Singh A, et al. Group 3 innate lymphoid cells mediate early protective immunity against tuberculosis. Nature. 2019;: pubmed publisher
  • flow cytometry; human; loading ...; fig 1a
Lim S, Kim J, Jeon S, Shin M, Kwon J, Kim T, et al. Defective Localization With Impaired Tumor Cytotoxicity Contributes to the Immune Escape of NK Cells in Pancreatic Cancer Patients. Front Immunol. 2019;10:496 pubmed publisher
  • flow cytometry; human; loading ...; fig s1a
Muller Durovic B, Grählert J, Devine O, Akbar A, Hess C. CD56-negative NK cells with impaired effector function expand in CMV and EBV co-infected healthy donors with age. Aging (Albany NY). 2019;11:724-740 pubmed publisher
  • flow cytometry; human; loading ...; fig 1b
Montel Hagen A, Seet C, Li S, Chick B, Zhu Y, Chang P, et al. Organoid-Induced Differentiation of Conventional T Cells from Human Pluripotent Stem Cells. Cell Stem Cell. 2019;24:376-389.e8 pubmed publisher
  • flow cytometry; human; loading ...; fig s3
Ye W, Chew M, Hou J, Lai F, Leopold S, Loo H, et al. Microvesicles from malaria-infected red blood cells activate natural killer cells via MDA5 pathway. PLoS Pathog. 2018;14:e1007298 pubmed publisher
  • flow cytometry; human; loading ...; fig s3
van Erp E, Feyaerts D, Duijst M, Mulder H, Wicht O, Luytjes W, et al. Respiratory Syncytial Virus Infects Primary Neonatal and Adult Natural Killer Cells and Affects Their Antiviral Effector Function. J Infect Dis. 2019;219:723-733 pubmed publisher
  • flow cytometry; human; loading ...; fig 4a
Walwyn Brown K, Guldevall K, Saeed M, Pende D, Önfelt B, MacDonald A, et al. Human NK Cells Lyse Th2-Polarizing Dendritic Cells via NKp30 and DNAM-1. J Immunol. 2018;201:2028-2041 pubmed publisher
  • flow cytometry; human; loading ...; fig 1a, 5b
Cooper G, Ostridge K, Khakoo S, Wilkinson T, Staples K. Human CD49a+ Lung Natural Killer Cell Cytotoxicity in Response to Influenza A Virus. Front Immunol. 2018;9:1671 pubmed publisher
  • flow cytometry; human; loading ...; fig 2a
Srpan K, Ambrose A, Karampatzakis A, Saeed M, Cartwright A, Guldevall K, et al. Shedding of CD16 disassembles the NK cell immune synapse and boosts serial engagement of target cells. J Cell Biol. 2018;217:3267-3283 pubmed publisher
  • flow cytometry; mouse; 1:60; loading ...; fig 7a
Kiener R, Fleischmann M, Wiegand M, Lemmermann N, Schwegler C, Kaufmann C, et al. Efficient Delivery of Human Cytomegalovirus T Cell Antigens by Attenuated Sendai Virus Vectors. J Virol. 2018;92: pubmed publisher
  • flow cytometry; rhesus macaque; loading ...; fig 1b
Manickam C, Nwanze C, Ram D, Shah S, Smith S, Jones R, et al. Progressive lentivirus infection induces natural killer cell receptor-expressing B cells in the gastrointestinal tract. AIDS. 2018;32:1571-1578 pubmed publisher
  • flow cytometry; human; fig e1b
Maric J, Ravindran A, Mazzurana L, Björklund Ã, Van Acker A, Rao A, et al. Prostaglandin E2 suppresses human group 2 innate lymphoid cell function. J Allergy Clin Immunol. 2018;141:1761-1773.e6 pubmed publisher
  • flow cytometry; human; loading ...; fig 5j
Herndler Brandstetter D, Shan L, Yao Y, Stecher C, Plajer V, Lietzenmayer M, et al. Humanized mouse model supports development, function, and tissue residency of human natural killer cells. Proc Natl Acad Sci U S A. 2017;114:E9626-E9634 pubmed publisher
  • flow cytometry; human; loading ...; fig s1
Chan Y, Zuo J, Inman C, Croft W, Begum J, Croudace J, et al. NK cells produce high levels of IL-10 early after allogeneic stem cell transplantation and suppress development of acute GVHD. Eur J Immunol. 2018;48:316-329 pubmed publisher
  • flow cytometry; human; loading ...; fig 4a
Jackson E, Zhang C, Kiani Z, Lisovsky I, Tallon B, Del Corpo A, et al. HIV exposed seronegative (HESN) compared to HIV infected individuals have higher frequencies of telomeric Killer Immunoglobulin-like Receptor (KIR) B motifs; Contribution of KIR B motif encoded genes to NK cell responsiveness. PLoS ONE. 2017;12:e0185160 pubmed publisher
  • flow cytometry; human; loading ...; fig s1
Djaoud Z, Guethlein L, Horowitz A, Azzi T, Nemat Gorgani N, Olive D, et al. Two alternate strategies for innate immunity to Epstein-Barr virus: One using NK cells and the other NK cells and ?? T cells. J Exp Med. 2017;214:1827-1841 pubmed publisher
  • flow cytometry; human; loading ...; fig s2a
Jensen H, Chen S, Folkersen L, Nolan G, Lanier L. EBI3 regulates the NK cell response to mouse cytomegalovirus infection. Proc Natl Acad Sci U S A. 2017;114:1625-1630 pubmed publisher
  • flow cytometry; human; loading ...; fig 6a
Suliman S, Geldenhuys H, Johnson J, Hughes J, Smit E, Murphy M, et al. Bacillus Calmette-Guérin (BCG) Revaccination of Adults with Latent Mycobacterium tuberculosis Infection Induces Long-Lived BCG-Reactive NK Cell Responses. J Immunol. 2016;197:1100-1110 pubmed publisher
Crespo A, Mulik S, Dotiwala F, Ansara J, Sen Santara S, Ingersoll K, et al. Decidual NK Cells Transfer Granulysin to Selectively Kill Bacteria in Trophoblasts. Cell. 2020;182:1125-1139.e18 pubmed publisher
Pham T, Meziane O, Miah M, Volodina O, Colas C, Beland K, et al. Flt3L-Mediated Expansion of Plasmacytoid Dendritic Cells Suppresses HIV Infection in Humanized Mice. Cell Rep. 2019;29:2770-2782.e5 pubmed publisher
Pandori W, Lima T, Mallya S, Kao T, Gov L, Lodoen M. Toxoplasma gondii activates a Syk-CARD9-NF-κB signaling axis and gasdermin D-independent release of IL-1β during infection of primary human monocytes. PLoS Pathog. 2019;15:e1007923 pubmed publisher
Kuang Y, Muñoz A, Nalula G, Santostefano K, Sanghez V, Sanchez G, et al. Evaluation of commonly used ectoderm markers in iPSC trilineage differentiation. Stem Cell Res. 2019;37:101434 pubmed publisher
Furie R, Werth V, Merola J, Stevenson L, Reynolds T, Naik H, et al. Monoclonal antibody targeting BDCA2 ameliorates skin lesions in systemic lupus erythematosus. J Clin Invest. 2019;129:1359-1371 pubmed publisher
Kwaa A, Talana C, Blankson J. Interferon Alpha Enhances NK Cell Function and the Suppressive Capacity of HIV-Specific CD8+ T Cells. J Virol. 2019;93: pubmed publisher
Bradley T, Peppa D, Pedroza Pacheco I, Li D, Cain D, Henao R, et al. RAB11FIP5 Expression and Altered Natural Killer Cell Function Are Associated with Induction of HIV Broadly Neutralizing Antibody Responses. Cell. 2018;175:387-399.e17 pubmed publisher
Al Absi A, Wurzer H, Guérin C, Hoffmann C, Moreau F, Mao X, et al. Actin Cytoskeleton Remodeling Drives Breast Cancer Cell Escape from Natural Killer-Mediated Cytotoxicity. Cancer Res. 2018;78:5631-5643 pubmed publisher
Achita P, Dervović D, Ly D, Lee J, Haug T, Joe B, et al. Infusion of ex-vivo expanded human TCR-αβ+ double-negative regulatory T cells delays onset of xenogeneic graft-versus-host disease. Clin Exp Immunol. 2018;193:386-399 pubmed publisher
Yang X, Zhou J, He J, Liu J, Wang H, Liu Y, et al. An Immune System-Modified Rat Model for Human Stem Cell Transplantation Research. Stem Cell Reports. 2018;11:514-521 pubmed publisher
Jegaskanda S, Mason R, Andrews S, Wheatley A, Zhang R, Reynoso G, et al. Intranasal Live Influenza Vaccine Priming Elicits Localized B Cell Responses in Mediastinal Lymph Nodes. J Virol. 2018;92: pubmed publisher
Patel K, Roberts J, Subedi G, Barb A. Restricted processing of CD16a/Fc γ receptor IIIa N-glycans from primary human NK cells impacts structure and function. J Biol Chem. 2018;293:3477-3489 pubmed publisher
Ruiz García R, Vargas Hernandez A, Chinn I, Angelo L, Cao T, Coban Akdemir Z, et al. Mutations in PI3K110? cause impaired natural killer cell function partially rescued by rapamycin treatment. J Allergy Clin Immunol. 2018;142:605-617.e7 pubmed publisher
Vargas Hernandez A, Mace E, Zimmerman O, Zerbe C, Freeman A, Rosenzweig S, et al. Ruxolitinib partially reverses functional natural killer cell deficiency in patients with signal transducer and activator of transcription 1 (STAT1) gain-of-function mutations. J Allergy Clin Immunol. 2018;141:2142-2155.e5 pubmed publisher
Lee B, Mace E. Acquisition of cell migration defines NK cell differentiation from hematopoietic stem cell precursors. Mol Biol Cell. 2017;28:3573-3581 pubmed publisher
Gov L, Schneider C, Lima T, Pandori W, Lodoen M. NLRP3 and Potassium Efflux Drive Rapid IL-1β Release from Primary Human Monocytes during Toxoplasma gondii Infection. J Immunol. 2017;199:2855-2864 pubmed publisher
Kyoizumi S, Kubo Y, Kajimura J, Yoshida K, Hayashi T, Nakachi K, et al. Fate Decision Between Group 3 Innate Lymphoid and Conventional NK Cell Lineages by Notch Signaling in Human Circulating Hematopoietic Progenitors. J Immunol. 2017;199:2777-2793 pubmed publisher
Cichocki F, Valamehr B, Bjordahl R, Zhang B, Rezner B, Rogers P, et al. GSK3 Inhibition Drives Maturation of NK Cells and Enhances Their Antitumor Activity. Cancer Res. 2017;77:5664-5675 pubmed publisher
Gorvel L, Korenfeld D, Tung T, Klechevsky E. Dendritic Cell-Derived IL-32?: A Novel Inhibitory Cytokine of NK Cell Function. J Immunol. 2017;199:1290-1300 pubmed publisher
Madhavi V, Wines B, Amin J, Emery S, Lopez E, Kelleher A, et al. HIV-1 Env- and Vpu-Specific Antibody-Dependent Cellular Cytotoxicity Responses Associated with Elite Control of HIV. J Virol. 2017;91: pubmed publisher
Nirschl C, Suárez Fariñas M, Izar B, Prakadan S, Dannenfelser R, Tirosh I, et al. IFNγ-Dependent Tissue-Immune Homeostasis Is Co-opted in the Tumor Microenvironment. Cell. 2017;170:127-141.e15 pubmed publisher
McDonnell A, Cook A, Robinson B, Lake R, Nowak A. Serial immunomonitoring of cancer patients receiving combined antagonistic anti-CD40 and chemotherapy reveals consistent and cyclical modulation of T cell and dendritic cell parameters. BMC Cancer. 2017;17:417 pubmed publisher
Lu X, Horner J, Paul E, Shang X, Troncoso P, Deng P, et al. Effective combinatorial immunotherapy for castration-resistant prostate cancer. Nature. 2017;543:728-732 pubmed publisher
Lopes F, Bálint Å, Valvo S, Felce J, Hessel E, Dustin M, et al. Membrane nanoclusters of FcγRI segregate from inhibitory SIRPα upon activation of human macrophages. J Cell Biol. 2017;216:1123-1141 pubmed publisher
Kailayangiri S, Altvater B, Spurny C, Jamitzky S, Schelhaas S, Jacobs A, et al. Targeting Ewing sarcoma with activated and GD2-specific chimeric antigen receptor-engineered human NK cells induces upregulation of immune-inhibitory HLA-G. Oncoimmunology. 2017;6:e1250050 pubmed publisher
Jeffery H, Jeffery L, Lutz P, Corrigan M, Webb G, Hirschfield G, et al. Low-dose interleukin-2 promotes STAT-5 phosphorylation, Treg survival and CTLA-4-dependent function in autoimmune liver diseases. Clin Exp Immunol. 2017;188:394-411 pubmed publisher
Hasan M, Ryan P, Bergmeier L, Fortune F. Circulating NK cells and their subsets in Behçet's disease. Clin Exp Immunol. 2017;188:311-322 pubmed publisher
Riether C, Schürch C, Bührer E, Hinterbrandner M, Huguenin A, Hoepner S, et al. CD70/CD27 signaling promotes blast stemness and is a viable therapeutic target in acute myeloid leukemia. J Exp Med. 2017;214:359-380 pubmed publisher
Mace E, Gunesch J, Dixon A, Orange J. Human NK cell development requires CD56-mediated motility and formation of the developmental synapse. Nat Commun. 2016;7:12171 pubmed publisher
Sekine T, Marin D, Cao K, Li L, Mehta P, Shaim H, et al. Specific combinations of donor and recipient KIR-HLA genotypes predict for large differences in outcome after cord blood transplantation. Blood. 2016;128:297-312 pubmed publisher
O Connor G, Vivian J, Widjaja J, Bridgeman J, Gostick E, Lafont B, et al. Mutational and structural analysis of KIR3DL1 reveals a lineage-defining allotypic dimorphism that impacts both HLA and peptide sensitivity. J Immunol. 2014;192:2875-84 pubmed publisher
Perros F, Cohen Kaminsky S, Gambaryan N, Girerd B, Raymond N, Klingelschmitt I, et al. Cytotoxic cells and granulysin in pulmonary arterial hypertension and pulmonary veno-occlusive disease. Am J Respir Crit Care Med. 2013;187:189-96 pubmed publisher
Foley B, Cooley S, Verneris M, Curtsinger J, Luo X, Waller E, et al. Human cytomegalovirus (CMV)-induced memory-like NKG2C(+) NK cells are transplantable and expand in vivo in response to recipient CMV antigen. J Immunol. 2012;189:5082-8 pubmed publisher
Correia D, Fogli M, Hudspeth K, da Silva M, Mavilio D, Silva Santos B. Differentiation of human peripheral blood V?1+ T cells expressing the natural cytotoxicity receptor NKp30 for recognition of lymphoid leukemia cells. Blood. 2011;118:992-1001 pubmed publisher
product information
Antigen :
CD56
Apps. Abbrev. :
FC
Cat # :
318313
Clone :
HCD56
Item :
Alexa Fluor® 647 anti-human CD56 (NCAM)
Isotype :
Mouse IgG1, κ
Other Names :
Leu-19, NKH1
Size :
25 tests
Price (USD) :
124 USD
Reactivity :
Human
Clonality :
Monoclonal
Host :
Mouse
Conjugate/Tag/Label :
A647
Application Notes :
Clone HCD56 is not recommended for immunohistochemistry formalin-fixed paraffin-embedded tissue.;
more info or order :
company information
BioLegend
8999 BioLegend Way
San Diego, CA 92121
customerserv@biolegend.com
https://www.biolegend.com
headquarters: USA