product summary
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company name :
BioLegend
other brands :
Babco, Signet, Sternberger Monoclonals, Senetek, Covance
product type :
antibody
product name :
Brilliant Violet 785™ anti-human CD4
catalog :
317441
quantity :
25 tests
price :
201 USD
clonality :
monoclonal
host :
mouse
conjugate :
Brilliant Violet 785
clone name :
OKT4
reactivity :
human, rhesus macaque
application :
flow cytometry
more info or order :
citations: 40
Published Application/Species/Sample/DilutionReference
  • flow cytometry; human; loading ...
Fierle J, Brioschi M, de Tiani M, Wetterwald L, Atsaves V, Abram Saliba J, et al. Soluble trivalent engagers redirect cytolytic T cell activity toward tumor endothelial marker 1. Cell Rep Med. 2021;2:100362 pubmed publisher
  • flow cytometry; human; loading ...; tbl s9
Mordmuller B, Surat G, Lagler H, Chakravarty S, Ishizuka A, Lalremruata A, et al. Sterile protection against human malaria by chemoattenuated PfSPZ vaccine. Nature. 2017;542:445-449 pubmed publisher
  • flow cytometry; human; loading ...
Tauriainen J, Scharf L, Frederiksen J, Naji A, Ljunggren H, Sonnerborg A, et al. Perturbed CD8+ T cell TIGIT/CD226/PVR axis despite early initiation of antiretroviral treatment in HIV infected individuals. Sci Rep. 2017;7:40354 pubmed publisher
Kerns J, Belgur C, Kanellias M, Manatakis D, Barrile R, Tien Street W, et al. Safety Profiling of Tumor-targeted T Cell-Bispecific Antibodies with Alveolus Lung- and Colon-on-Chip. Bio Protoc. 2023;13: pubmed publisher
Du Bruyn E, Stek C, Daroowala R, Said Hartley Q, Hsiao M, Schäfer G, et al. Effects of tuberculosis and/or HIV-1 infection on COVID-19 presentation and immune response in Africa. Nat Commun. 2023;14:188 pubmed publisher
Ezeonwumelu I, Garcia Vidal E, Riveira Mu xf1 oz E, Felip E, Guti xe9 rrez Chamorro L, Calba I, et al. Pharmacological Inhibition of IKK to Tackle Latency and Hyperinflammation in Chronic HIV-1 Infection. Int J Mol Sci. 2022;23: pubmed publisher
Jung I, Narayan V, McDonald S, Rech A, Bartoszek R, Hong G, et al. BLIMP1 and NR4A3 transcription factors reciprocally regulate antitumor CAR T cell stemness and exhaustion. Sci Transl Med. 2022;14:eabn7336 pubmed publisher
Baharlou H, Canete N, Vine E, Hu K, Yuan D, Sandgren K, et al. An in situ analysis pipeline for initial host-pathogen interactions reveals signatures of human colorectal HIV transmission. Cell Rep. 2022;40:111385 pubmed publisher
Wilson T, Kim H, Chou C, Langfitt D, Mettelman R, Minervina A, et al. Common trajectories of highly effective CD19-specific CAR T cells identified by endogenous T cell receptor lineages. Cancer Discov. 2022;: pubmed publisher
Kim S, Vale N, Zacharakis N, Krishna S, Yu Z, Gasmi B, et al. Adoptive Cellular Therapy with Autologous Tumor-Infiltrating Lymphocytes and T-cell Receptor-Engineered T Cells Targeting Common p53 Neoantigens in Human Solid Tumors. Cancer Immunol Res. 2022;10:932-946 pubmed publisher
Pathania A, Prathipati P, Olwenyi O, Chava S, Smith O, Gupta S, et al. miR-15a and miR-15b modulate natural killer and CD8+T-cell activation and anti-tumor immune response by targeting PD-L1 in neuroblastoma. Mol Ther Oncolytics. 2022;25:308-329 pubmed publisher
van Bruggen J, van der Windt G, Hoogendoorn M, Dubois J, Kater A, Peters F. Depletion of CLL cells by venetoclax treatment reverses oxidative stress and impaired glycolysis in CD4 T cells. Blood Adv. 2022;6:4185-4195 pubmed publisher
Sun C, Liu L, P xe9 rez L, Li X, Liu Y, Xu P, et al. Droplet-microfluidics-assisted sequencing of HIV proviruses and their integration sites in cells from people on antiretroviral therapy. Nat Biomed Eng. 2022;6:1004-1012 pubmed publisher
Li L, Muftuoglu M, Liang S, Basyal M, Lv J, Akdogan M, et al. In-depth analysis of SARS-CoV-2-specific T cells reveals diverse differentiation hierarchies in vaccinated individuals. JCI Insight. 2022;7: pubmed publisher
Lee P, Macdonald K, Massi E, Chew P, Bee C, Perkins P, et al. Improved therapeutic index of an acidic pH-selective antibody. MAbs. 2022;14:2024642 pubmed publisher
Schlicher L, Kulig P, von M xfc nchow A, Murphy M, Keller M. In Vitro Characterization of Sphingosine 1-Phosphate Receptor 1 (S1P1) Expression and Mediated Migration of Primary Human T and B Cells in the Context of Cenerimod, a Novel, Selective S1P1 Receptor Modulator. Int J Mol Sci. 2022;23: pubmed publisher
Zhang Q, Hresko M, Picton L, Su L, Hollander M, Nunez Cruz S, et al. A human orthogonal IL-2 and IL-2Rβ system enhances CAR T cell expansion and antitumor activity in a murine model of leukemia. Sci Transl Med. 2021;13:eabg6986 pubmed publisher
Zebley C, Brown C, Mi T, Fan Y, Alli S, Boi S, et al. CD19-CAR T cells undergo exhaustion DNA methylation programming in patients with acute lymphoblastic leukemia. Cell Rep. 2021;37:110079 pubmed publisher
Rivero Hinojosa S, Grant M, Panigrahi A, Zhang H, Caisová V, Bollard C, et al. Proteogenomic discovery of neoantigens facilitates personalized multi-antigen targeted T cell immunotherapy for brain tumors. Nat Commun. 2021;12:6689 pubmed publisher
Lutter L, Roosenboom B, Brand E, Ter Linde J, Oldenburg B, Van Lochem E, et al. Homeostatic Function and Inflammatory Activation of Ileal CD8+ Tissue-Resident T Cells Is Dependent on Mucosal Location. Cell Mol Gastroenterol Hepatol. 2021;12:1567-1581 pubmed publisher
Rajamanickam V, Ballesteros Merino C, Samson K, Ross D, Bernard B, Fox B, et al. Robust Antitumor Immunity in a Patient with Metastatic Colorectal Cancer Treated with Cytotoxic Regimens. Cancer Immunol Res. 2021;9:602-611 pubmed publisher
Rubio Perez C, Planas Rigol E, Trincado J, Bonfill Teixidor E, Arias A, Marchese D, et al. Immune cell profiling of the cerebrospinal fluid enables the characterization of the brain metastasis microenvironment. Nat Commun. 2021;12:1503 pubmed publisher
Duhen R, Ballesteros Merino C, Frye A, Tran E, Rajamanickam V, Chang S, et al. Neoadjuvant anti-OX40 (MEDI6469) therapy in patients with head and neck squamous cell carcinoma activates and expands antigen-specific tumor-infiltrating T cells. Nat Commun. 2021;12:1047 pubmed publisher
Tebas P, Jadlowsky J, Shaw P, Tian L, Esparza E, Brennan A, et al. CCR5-edited CD4+ T cells augment HIV-specific immunity to enable post-rebound control of HIV replication. J Clin Invest. 2021;131: pubmed publisher
Wang F, Trier A, Li F, Kim S, Chen Z, Chai J, et al. A basophil-neuronal axis promotes itch. Cell. 2021;184:422-440.e17 pubmed publisher
Riberdy J, Zhou S, Zheng F, Kim Y, Moore J, Vaidya A, et al. The Art and Science of Selecting a CD123-Specific Chimeric Antigen Receptor for Clinical Testing. Mol Ther Methods Clin Dev. 2020;18:571-581 pubmed publisher
Gurusamy D, Henning A, Yamamoto T, Yu Z, Zacharakis N, Krishna S, et al. Multi-phenotype CRISPR-Cas9 Screen Identifies p38 Kinase as a Target for Adoptive Immunotherapies. Cancer Cell. 2020;37:818-833.e9 pubmed publisher
Mineo M, Lyons S, Zdioruk M, von Spreckelsen N, Ferrer Luna R, Ito H, et al. Tumor Interferon Signaling Is Regulated by a lncRNA INCR1 Transcribed from the PD-L1 Locus. Mol Cell. 2020;78:1207-1223.e8 pubmed publisher
Leylek R, Alcántara Hernández M, Lanzar Z, Lüdtke A, Perez O, Reizis B, et al. Integrated Cross-Species Analysis Identifies a Conserved Transitional Dendritic Cell Population. Cell Rep. 2019;29:3736-3750.e8 pubmed publisher
Vojtech L, Zhang M, Davé V, Levy C, Hughes S, Wang R, et al. Extracellular vesicles in human semen modulate antigen-presenting cell function and decrease downstream antiviral T cell responses. PLoS ONE. 2019;14:e0223901 pubmed publisher
Serwas N, Hoeger B, Ardy R, Stulz S, Sui Z, Memaran N, et al. Human DEF6 deficiency underlies an immunodeficiency syndrome with systemic autoimmunity and aberrant CTLA-4 homeostasis. Nat Commun. 2019;10:3106 pubmed publisher
Kacherovsky N, Cardle I, Cheng E, Yu J, Baldwin M, Salipante S, et al. Traceless aptamer-mediated isolation of CD8+ T cells for chimeric antigen receptor T-cell therapy. Nat Biomed Eng. 2019;: pubmed publisher
Darrah P, Difazio R, Maiello P, Gideon H, Myers A, Rodgers M, et al. Boosting BCG with proteins or rAd5 does not enhance protection against tuberculosis in rhesus macaques. NPJ Vaccines. 2019;4:21 pubmed publisher
Adel Patient K, Lezmi G, Castelli F, Blanc S, Bernard H, Soulaines P, et al. Deep analysis of immune response and metabolic signature in children with food protein induced enterocolitis to cow's milk. Clin Transl Allergy. 2018;8:38 pubmed publisher
Ruella M, Xu J, Barrett D, Fraietta J, Reich T, Ambrose D, et al. Induction of resistance to chimeric antigen receptor T cell therapy by transduction of a single leukemic B cell. Nat Med. 2018;24:1499-1503 pubmed publisher
Moravcikova E, Meyer E, Corselli M, Donnenberg V, Donnenberg A. Proteomic Profiling of Native Unpassaged and Culture-Expanded Mesenchymal Stromal Cells (MSC). Cytometry A. 2018;93:894-904 pubmed publisher
Alcántara Hernández M, Leylek R, Wagar L, Engleman E, Keler T, Marinkovich M, et al. High-Dimensional Phenotypic Mapping of Human Dendritic Cells Reveals Interindividual Variation and Tissue Specialization. Immunity. 2017;47:1037-1050.e6 pubmed publisher
Biajoux V, Bignon A, Freitas C, Martinez V, Thelen M, Lima G, et al. Expression of CXCL12 receptors in B cells from Mexican Mestizos patients with systemic Lupus erythematosus. J Transl Med. 2012;10:251 pubmed publisher
Cicin Sain L, Smyk Pearson S, Smyk Paerson S, Currier N, Byrd L, Koudelka C, et al. Loss of naive T cells and repertoire constriction predict poor response to vaccination in old primates. J Immunol. 2010;184:6739-45 pubmed publisher
Kmieciak M, Gowda M, Graham L, Godder K, Bear H, Marincola F, et al. Human T cells express CD25 and Foxp3 upon activation and exhibit effector/memory phenotypes without any regulatory/suppressor function. J Transl Med. 2009;7:89 pubmed publisher
product information
Antigen :
CD4
Apps. Abbrev. :
FC
Cat # :
317441
Clone :
OKT4
Item :
Brilliant Violet 785™ anti-human CD4
Isotype :
Mouse IgG2b, κ
Other Names :
T4
Size :
25 tests
Price (USD) :
201 USD
Reactivity :
Human, Cynomolgus, Rhesus
Clonality :
Monoclonal
Host :
Mouse
Conjugate/Tag/Label :
BV785
Immunogen :
Human peripheral T cells
Application Notes :
The OKT4 antibody binds to the D3 domain of CD4 and does not block HIV binding. Additional reported applications (for the relevant formats) include: immunohistochemistry of frozen sections and blocking of T cell activation. This clone was tested in-house and does not work on formalin fixed paraffin-embedded (FFPE) tissue. The Ultra-LEAF™ purified antibody (Endotoxin < 0.01 EU/µg, Azide-Free, 0.2 µm filtered) is recommended for functional assays (Cat. No. 317453 and 317454).In a small subset of individuals, the OKT4 clone does not bind to CD4 due to polymorphisms in CD4.^9;
more info or order :
company information
BioLegend
8999 BioLegend Way
San Diego, CA 92121
customerserv@biolegend.com
https://www.biolegend.com
headquarters: USA