product summary
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company name :
BioLegend
other brands :
Babco, Signet, Sternberger Monoclonals, Senetek, Covance
product type :
antibody
product name :
Brilliant Violet 605™ anti-human CD4
catalog :
317438
quantity :
100 tests
price :
424 USD
clonality :
monoclonal
host :
mouse
conjugate :
BV605
clone name :
OKT4
reactivity :
human, rhesus macaque
application :
flow cytometry
more info or order :
citations: 16
Reference
Rossignol E, Dugast A, Compere H, Cottrell C, Copps J, Lin S, et al. Mining HIV controllers for broad and functional antibodies to recognize and eliminate HIV-infected cells. Cell Rep. 2021;35:109167 pubmed publisher
Caduff N, McHugh D, Rieble L, Forconi C, Ong echa J, Oluoch P, et al. KSHV infection drives poorly cytotoxic CD56-negative natural killer cell differentiation in vivo upon KSHV/EBV dual infection. Cell Rep. 2021;35:109056 pubmed publisher
Iwabuchi R, Ide K, Terahara K, Wagatsuma R, Iwaki R, Matsunaga H, et al. Development of an Inflammatory CD14+ Dendritic Cell Subset in Humanized Mice. Front Immunol. 2021;12:643040 pubmed publisher
Gannon P, Harari A, Auger A, Murgues C, Zangiacomi V, Rubin O, et al. Development of an optimized closed and semi-automatic protocol for Good Manufacturing Practice manufacturing of tumor-infiltrating lymphocytes in a hospital environment. Cytotherapy. 2020;22:780-791 pubmed publisher
Stone D, Kenkel E, Loprieno M, Tanaka M, De Silva Feelixge H, Kumar A, et al. Gene Transfer in Adeno-Associated Virus Seropositive Rhesus Macaques Following Rapamycin Treatment and Subcutaneous Delivery of AAV6, but Not Retargeted AAV6 Vectors. Hum Gene Ther. 2020;: pubmed publisher
Om K, Paquin Proulx D, Montero M, Peachman K, Shen X, Wieczorek L, et al. Adjuvanted HIV-1 vaccine promotes antibody-dependent phagocytic responses and protects against heterologous SHIV challenge. PLoS Pathog. 2020;16:e1008764 pubmed publisher
Serra E, Schwerd T, Moutsianas L, Cavounidis A, Fachal L, Pandey S, et al. Somatic mosaicism and common genetic variation contribute to the risk of very-early-onset inflammatory bowel disease. Nat Commun. 2020;11:995 pubmed publisher
Freeman Z, Nirschl T, Hovelson D, Johnston R, Engelhardt J, Selby M, et al. A conserved intratumoral regulatory T cell signature identifies 4-1BB as a pan-cancer target. J Clin Invest. 2020;130:1405-1416 pubmed publisher
Monel B, McKeon A, Lamothe Molina P, Jani P, Boucau J, Pacheco Y, et al. HIV Controllers Exhibit Effective CD8+ T Cell Recognition of HIV-1-Infected Non-activated CD4+ T Cells. Cell Rep. 2019;27:142-153.e4 pubmed publisher
Zhang H, Pandey S, Travers M, Sun H, Morton G, Madzo J, et al. Targeting CDK9 Reactivates Epigenetically Silenced Genes in Cancer. Cell. 2018;175:1244-1258.e26 pubmed publisher
Waight J, Chand D, Dietrich S, Gombos R, Horn T, Gonzalez A, et al. Selective FcγR Co-engagement on APCs Modulates the Activity of Therapeutic Antibodies Targeting T Cell Antigens. Cancer Cell. 2018;33:1033-1047.e5 pubmed publisher
McGary C, Deléage C, Harper J, Micci L, Ribeiro S, Paganini S, et al. CTLA-4+PD-1- Memory CD4+ T Cells Critically Contribute to Viral Persistence in Antiretroviral Therapy-Suppressed, SIV-Infected Rhesus Macaques. Immunity. 2017;47:776-788.e5 pubmed publisher
Walker Sperling V, Pohlmeyer C, Veenhuis R, May M, Luna K, Kirkpatrick A, et al. Factors Associated With the Control of Viral Replication and Virologic Breakthrough in a Recently Infected HIV-1 Controller. EBioMedicine. 2017;16:141-149 pubmed publisher
Smedley J, Macalister R, Wangari S, Gathuka M, Ahrens J, Iwayama N, et al. Laparoscopic Technique for Serial Collection of Para-Colonic, Left Colic, and Inferior Mesenteric Lymph Nodes in Macaques. PLoS ONE. 2016;11:e0157535 pubmed publisher
Hensley McBain T, Zevin A, Manuzak J, Smith E, Gile J, Miller C, et al. Effects of Fecal Microbial Transplantation on Microbiome and Immunity in Simian Immunodeficiency Virus-Infected Macaques. J Virol. 2016;90:4981-4989 pubmed publisher
Bialas K, Tanaka T, Tran D, Varner V, Cisneros De La Rosa E, Chiuppesi F, et al. Maternal CD4+ T cells protect against severe congenital cytomegalovirus disease in a novel nonhuman primate model of placental cytomegalovirus transmission. Proc Natl Acad Sci U S A. 2015;112:13645-50 pubmed publisher
product information
Antigen :
CD4
Apps. Abbrev. :
FC
Cat # :
317438
Clone :
OKT4
Item :
Brilliant Violet 605™ anti-human CD4
Isotype :
Mouse IgG2b, κ
Other Names :
T4
Size :
100 tests
Price (USD) :
424 USD
Reactivity :
Human, Cynomolgus, Rhesus
Clonality :
Monoclonal
Host :
Mouse
Conjugate/Tag/Label :
BV605
Immunogen :
Human peripheral T cells
Application Notes :
The OKT4 antibody binds to the D3 domain of CD4 and does not block HIV binding. Additional reported applications (for the relevant formats) include: immunohistochemistry of frozen sections and blocking of T cell activation. This clone was tested in-house and does not work on formalin fixed paraffin-embedded (FFPE) tissue. The Ultra-LEAF™ purified antibody (Endotoxin < 0.01 EU/µg, Azide-Free, 0.2 µm filtered) is recommended for functional assays (Cat. No. 317453 and 317454).In a small subset of individuals, the OKT4 clone does not bind to CD4 due to polymorphisms in CD4.^9;
more info or order :
company information
BioLegend
8999 BioLegend Way
San Diego, CA 92121
customerserv@biolegend.com
https://www.biolegend.com
headquarters: USA