product summary
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company name :
BioLegend
other brands :
Babco, Signet, Sternberger Monoclonals, Senetek, Covance
product type :
antibody
product name :
PE anti-human CD4
catalog :
317410
quantity :
100 tests
price :
66 USD
clonality :
monoclonal
host :
mouse
conjugate :
PE
clone name :
OKT4
reactivity :
human, rhesus macaque
application :
flow cytometry
more info or order :
citations: 29
Published Application/Species/Sample/DilutionReference
  • flow cytometry; human; 1:200; loading ...; fig 2s1b
Zumaquero E, Stone S, Scharer C, Jenks S, Nellore A, Mousseau B, et al. IFNγ induces epigenetic programming of human T-bethi B cells and promotes TLR7/8 and IL-21 induced differentiation. elife. 2019;8: pubmed publisher
  • flow cytometry; human; loading ...; fig 3c
Ye C, Wang W, Cheng L, Li G, Wen M, Wang Q, et al. Glycosylphosphatidylinositol-Anchored Anti-HIV scFv Efficiently Protects CD4 T Cells from HIV-1 Infection and Deletion in hu-PBL Mice. J Virol. 2017;91: pubmed publisher
Sitlinger A, Deal M, Garcia E, Thompson D, Stewart T, MacDonald G, et al. Physiological Fitness and the Pathophysiology of Chronic Lymphocytic Leukemia (CLL). Cells. 2021;10: pubmed publisher
Xie G, Luo X, Ma T, Frouard J, Neidleman J, Hoh R, et al. Characterization of HIV-induced remodeling reveals differences in infection susceptibility of memory CD4+ T cell subsets in vivo. Cell Rep. 2021;35:109038 pubmed publisher
Perelman S, James D, Boguslawski K, Nelson C, Ilmain J, Zwack E, et al. Genetic variation of staphylococcal LukAB toxin determines receptor tropism. Nat Microbiol. 2021;6:731-745 pubmed publisher
Delacher M, Simon M, Sanderink L, Hotz Wagenblatt A, Wuttke M, Schambeck K, et al. Single-cell chromatin accessibility landscape identifies tissue repair program in human regulatory T cells. Immunity. 2021;54:702-720.e17 pubmed publisher
Wallace J, Alosaimi M, Khayat C, Jaber F, Almutairi A, Beaussant Cohen S, et al. ITK deficiency presenting as autoimmune lymphoproliferative syndrome. J Allergy Clin Immunol. 2021;147:743-745.e1 pubmed publisher
Dyson M, Masters E, Pazeraitis D, Perera R, Syrjänen J, Surade S, et al. Beyond affinity: selection of antibody variants with optimal biophysical properties and reduced immunogenicity from mammalian display libraries. MAbs. 2020;12:1829335 pubmed publisher
Landgraf K, Williams S, Steiger D, Gebhart D, Lok S, Martin D, et al. convertibleCARs: A chimeric antigen receptor system for flexible control of activity and antigen targeting. Commun Biol. 2020;3:296 pubmed publisher
Zhang D, Jiang F, Zaynagetdinov R, Huang H, Sood V, Wang H, et al. Identification and characterization of M6903, an antagonistic anti-TIM-3 monoclonal antibody. Oncoimmunology. 2020;9:1744921 pubmed publisher
Nixon C, Mavigner M, Sampey G, Brooks A, Spagnuolo R, Irlbeck D, et al. Systemic HIV and SIV latency reversal via non-canonical NF-κB signalling in vivo. Nature. 2020;578:160-165 pubmed publisher
Mozhgani S, Piran M, Zarei Ghobadi M, Jafari M, Jazayeri S, Mokhtari Azad T, et al. An insight to HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) pathogenesis; evidence from high-throughput data integration and meta-analysis. Retrovirology. 2019;16:46 pubmed publisher
Bhargava R, Lopezcolorado F, Tsai L, Stark J. The canonical non-homologous end joining factor XLF promotes chromosomal deletion rearrangements in human cells. J Biol Chem. 2019;: pubmed publisher
Del Alcazar D, Wang Y, He C, Wendel B, Del Rio Estrada P, Lin J, et al. Mapping the Lineage Relationship between CXCR5+ and CXCR5- CD4+ T Cells in HIV-Infected Human Lymph Nodes. Cell Rep. 2019;28:3047-3060.e7 pubmed publisher
Chang H, Ho C, Tomita B, Silva A, Sparks J, Karlson E, et al. Utilizing a PTPN22 gene signature to predict response to targeted therapies in rheumatoid arthritis. J Autoimmun. 2019;101:121-130 pubmed publisher
Dawson N, Lamarche C, Hoeppli R, Bergqvist P, Fung V, McIver E, et al. Systematic testing and specificity mapping of alloantigen-specific chimeric antigen receptors in regulatory T cells. JCI Insight. 2019;4: pubmed publisher
Li Z, Wu J, Chavez L, Hoh R, Deeks S, Pillai S, et al. Reiterative Enrichment and Authentication of CRISPRi Targets (REACT) identifies the proteasome as a key contributor to HIV-1 latency. PLoS Pathog. 2019;15:e1007498 pubmed publisher
Zimmerman K, Gonzalez N, Chumley P, Chacana T, Harrington L, Yoder B, et al. Urinary T cells correlate with rate of renal function loss in autosomal dominant polycystic kidney disease. Physiol Rep. 2019;7:e13951 pubmed publisher
Zhou Y, Du J, Hou H, Lu Y, Yu J, Mao L, et al. Application of ImmunoScore Model for the Differentiation between Active Tuberculosis and Latent Tuberculosis Infection as Well as Monitoring Anti-tuberculosis Therapy. Front Cell Infect Microbiol. 2017;7:457 pubmed publisher
Albayati Z, Alyami A, Alomar S, Middleton D, Bonnett L, Aleem S, et al. The Influence of Cytomegalovirus on Expression of HLA-G and its Ligand KIR2DL4 by Human Peripheral Blood Leucocyte Subsets. Scand J Immunol. 2017;86:396-407 pubmed publisher
Watanabe R, Shirai T, Namkoong H, Zhang H, Berry G, Wallis B, et al. Pyruvate controls the checkpoint inhibitor PD-L1 and suppresses T cell immunity. J Clin Invest. 2017;127:2725-2738 pubmed publisher
Tuero I, Venzon D, Robert Guroff M. Mucosal and Systemic γδ+ T Cells Associated with Control of Simian Immunodeficiency Virus Infection. J Immunol. 2016;197:4686-4695 pubmed
Rosskopf S, Jutz S, Neunkirchner A, Candia M, Jahn Schmid B, Bohle B, et al. Creation of an engineered APC system to explore and optimize the presentation of immunodominant peptides of major allergens. Sci Rep. 2016;6:31580 pubmed publisher
Estes J, Reilly C, Trubey C, Fletcher C, Cory T, Piatak M, et al. Antifibrotic therapy in simian immunodeficiency virus infection preserves CD4+ T-cell populations and improves immune reconstitution with antiretroviral therapy. J Infect Dis. 2015;211:744-54 pubmed publisher
Guo H, Ma O, Friedman A. The Cebpa +37-kb enhancer directs transgene expression to myeloid progenitors and to long-term hematopoietic stem cells. J Leukoc Biol. 2014;96:419-26 pubmed publisher
Liu Y, Lan Q, Lu L, Chen M, Xia Z, Ma J, et al. Phenotypic and functional characteristic of a newly identified CD8+ Foxp3- CD103+ regulatory T cells. J Mol Cell Biol. 2014;6:81-92 pubmed publisher
Hewitt R, Pele L, Tremelling M, Metz A, Parkes M, Powell J. Immuno-inhibitory PD-L1 can be induced by a peptidoglycan/NOD2 mediated pathway in primary monocytic cells and is deficient in Crohn's patients with homozygous NOD2 mutations. Clin Immunol. 2012;143:162-9 pubmed publisher
Cicin Sain L, Smyk Pearson S, Smyk Paerson S, Currier N, Byrd L, Koudelka C, et al. Loss of naive T cells and repertoire constriction predict poor response to vaccination in old primates. J Immunol. 2010;184:6739-45 pubmed publisher
Kmieciak M, Gowda M, Graham L, Godder K, Bear H, Marincola F, et al. Human T cells express CD25 and Foxp3 upon activation and exhibit effector/memory phenotypes without any regulatory/suppressor function. J Transl Med. 2009;7:89 pubmed publisher
product information
Antigen :
CD4
Apps. Abbrev. :
FC
Cat # :
317410
Clone :
OKT4
Item :
PE anti-human CD4
Isotype :
Mouse IgG2b, κ
Other Names :
T4
Size :
100 tests
Price (USD) :
66 USD
Reactivity :
Human, Cynomolgus, Rhesus
Clonality :
Monoclonal
Host :
Mouse
Conjugate/Tag/Label :
PE
Immunogen :
Human peripheral T cells
Application Notes :
The OKT4 antibody binds to the D3 domain of CD4 and does not block HIV binding. Additional reported applications (for the relevant formats) include: immunohistochemistry of frozen sections and blocking of T cell activation. This clone was tested in-house and does not work on formalin fixed paraffin-embedded (FFPE) tissue. The Ultra-LEAF™ purified antibody (Endotoxin < 0.01 EU/µg, Azide-Free, 0.2 µm filtered) is recommended for functional assays (Cat. No. 317453 and 317454).In a small subset of individuals, the OKT4 clone does not bind to CD4 due to polymorphisms in CD4.^9;
more info or order :
company information
BioLegend
8999 BioLegend Way
San Diego, CA 92121
customerserv@biolegend.com
https://www.biolegend.com
headquarters: USA