product summary
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company name :
BioLegend
other brands :
Babco, Signet, Sternberger Monoclonals, Senetek, Covance
product type :
antibody
product name :
APC anti-human CD3
catalog :
317318
quantity :
100 tests
price :
77 USD
clonality :
monoclonal
host :
mouse
conjugate :
APC
clone name :
OKT3
reactivity :
human
application :
flow cytometry
more info or order :
citations: 27
Published Application/Species/Sample/DilutionReference
  • flow cytometry; human; 1:1000; loading ...
Zhang T, Xia W, Song X, Mao Q, Huang X, Chen B, et al. Super-enhancer hijacking LINC01977 promotes malignancy of early-stage lung adenocarcinoma addicted to the canonical TGF-β/SMAD3 pathway. J Hematol Oncol. 2022;15:114 pubmed publisher
Wartewig T, Daniels J, Schulz M, Hameister E, Joshi A, Park J, et al. PD-1 instructs a tumor-suppressive metabolic program that restricts glycolysis and restrains AP-1 activity in T cell lymphoma. Nat Cancer. 2023;4:1508-1525 pubmed publisher
Golubovskaya V, Sienkiewicz J, Sun J, Huang Y, Hu L, Zhou H, et al. mRNA-Lipid Nanoparticle (LNP) Delivery of Humanized EpCAM-CD3 Bispecific Antibody Significantly Blocks Colorectal Cancer Tumor Growth. Cancers (Basel). 2023;15: pubmed publisher
Pan Y, Shu G, Fu L, Huang K, Zhou X, Gui C, et al. EHBP1L1 Drives Immune Evasion in Renal Cell Carcinoma through Binding and Stabilizing JAK1. Adv Sci (Weinh). 2023;10:e2206792 pubmed publisher
Wu L, Brzostek J, Sakthi Vale P, Wei Q, Koh C, Ong J, et al. CD28-CAR-T cell activation through FYN kinase signaling rather than LCK enhances therapeutic performance. Cell Rep Med. 2023;4:100917 pubmed publisher
Witkowski M, Lee S, Wang E, Lee A, Talbot A, Ma C, et al. NUDT21 limits CD19 levels through alternative mRNA polyadenylation in B cell acute lymphoblastic leukemia. Nat Immunol. 2022;23:1424-1432 pubmed publisher
Potashnikova D, Saidova A, Tvorogova A, Anisimova A, Botsina A, Vasilieva E, et al. CTLs From Patients With Atherosclerosis Show Elevated Adhesiveness and Distinct Integrin Expression Patterns on 2D Substrates. Front Med (Lausanne). 2022;9:891916 pubmed publisher
Reustle A, Menig L, Leuthold P, Hofmann U, St xfc hler V, Schmees C, et al. Nicotinamide-N-methyltransferase is a promising metabolic drug target for primary and metastatic clear cell renal cell carcinoma. Clin Transl Med. 2022;12:e883 pubmed publisher
Jaiswal A, Verma A, Dannenfelser R, Melssen M, Tirosh I, Izar B, et al. An activation to memory differentiation trajectory of tumor-infiltrating lymphocytes informs metastatic melanoma outcomes. Cancer Cell. 2022;40:524-544.e5 pubmed publisher
Alam A, Levanduski E, Denz P, Villavicencio H, Bhatta M, Alhorebi L, et al. Fungal mycobiome drives IL-33 secretion and type 2 immunity in pancreatic cancer. Cancer Cell. 2022;40:153-167.e11 pubmed publisher
Song C, Wang L, Li Q, Liao B, Qiao W, Li Q, et al. Generation of individualized immunocompatible endothelial cells from HLA-I-matched human pluripotent stem cells. Stem Cell Res Ther. 2022;13:48 pubmed publisher
Beatson R, Parente Pereira A, Halim L, Cozzetto D, Hull C, Whilding L, et al. TGF-β1 potentiates Vγ9Vδ2 T cell adoptive immunotherapy of cancer. Cell Rep Med. 2021;2:100473 pubmed publisher
Billing F, Walter B, Fink S, Arefaine E, Pickarski L, Maier S, et al. Altered Proinflammatory Responses to Polyelectrolyte Multilayer Coatings Are Associated with Differences in Protein Adsorption and Wettability. ACS Appl Mater Interfaces. 2021;13:55534-55549 pubmed publisher
Chang M, Levescot A, Nelson Maney N, Blaustein R, Winden K, Morris A, et al. Arthritis flares mediated by tissue-resident memory T cells in the joint. Cell Rep. 2021;37:109902 pubmed publisher
Wu X, Sharma A, Oldenburg J, Weiher H, Essler M, Skowasch D, et al. NKG2D Engagement Alone Is Sufficient to Activate Cytokine-Induced Killer Cells While 2B4 Only Provides Limited Coactivation. Front Immunol. 2021;12:731767 pubmed publisher
Nakasone H, Kusuda M, Terasako Saito K, Kawamura K, Akahoshi Y, Kawamura M, et al. Features of repertoire diversity and gene expression in human cytotoxic T cells following allogeneic hematopoietic cell transplantation. Commun Biol. 2021;4:1177 pubmed publisher
Khurana P, Burudpakdee C, Grupp S, Beier U, Barrett D, Bassiri H. Distinct Bioenergetic Features of Human Invariant Natural Killer T Cells Enable Retained Functions in Nutrient-Deprived States. Front Immunol. 2021;12:700374 pubmed publisher
Qian Y, Arellano G, Ifergan I, Lin J, Snowden C, Kim T, et al. ZEB1 promotes pathogenic Th1 and Th17 cell differentiation in multiple sclerosis. Cell Rep. 2021;36:109602 pubmed publisher
Mitsune A, Yamada M, Fujino N, Numakura T, Ichikawa T, Suzuki A, et al. Upregulation of leukocyte immunoglobulin-like receptor B4 on interstitial macrophages in COPD; their possible protective role against emphysema formation. Respir Res. 2021;22:232 pubmed publisher
Junker F, Gulati P, Wessels U, Seeber S, Stubenrauch K, Codarri Deak L, et al. A human receptor occupancy assay to measure anti-PD-1 binding in patients with prior anti-PD-1. Cytometry A. 2021;99:832-843 pubmed publisher
Bäcker Koduah P, Infante Duarte C, Ivaldi F, Uccelli A, Bellmann Strobl J, Wernecke K, et al. Effect of vitamin D supplementation on N-glycan branching and cellular immunophenotypes in MS. Ann Clin Transl Neurol. 2020;: pubmed publisher
Li Z, Deng M, Huang F, Jin C, Sun S, Chen H, et al. LILRB4 ITIMs mediate the T cell suppression and infiltration of acute myeloid leukemia cells. Cell Mol Immunol. 2020;17:272-282 pubmed publisher
Selich A, Ha T, Morgan M, Falk C, von Kaisenberg C, Schambach A, et al. Cytokine Selection of MSC Clones with Different Functionality. Stem Cell Reports. 2019;13:262-273 pubmed publisher
Chen J, Chernatynskaya A, Li J, Kimbrell M, Cassidy R, Perry D, et al. T cells display mitochondria hyperpolarization in human type 1 diabetes. Sci Rep. 2017;7:10835 pubmed publisher
Siedlik J, Deckert J, Benedict S, Bhatta A, Dunbar A, Vardiman J, et al. T cell activation and proliferation following acute exercise in human subjects is altered by storage conditions and mitogen selection. J Immunol Methods. 2017;446:7-14 pubmed publisher
Fisher J, Abramowski P, Wisidagamage Don N, Flutter B, Capsomidis A, Cheung G, et al. Avoidance of On-Target Off-Tumor Activation Using a Co-stimulation-Only Chimeric Antigen Receptor. Mol Ther. 2017;25:1234-1247 pubmed publisher
Sharei A, Trifonova R, Jhunjhunwala S, Hartoularos G, Eyerman A, Lytton Jean A, et al. Ex vivo cytosolic delivery of functional macromolecules to immune cells. PLoS ONE. 2015;10:e0118803 pubmed publisher
product information
Antigen :
CD3
Apps. Abbrev. :
FC
Cat # :
317318
Clone :
OKT3
Item :
APC anti-human CD3
Isotype :
Mouse IgG2a, κ
Other Names :
T3, CD3ε
Size :
100 tests
Price (USD) :
77 USD
Reactivity :
Human
Clonality :
Monoclonal
Host :
Mouse
Conjugate/Tag/Label :
APC
Application Notes :
The OKT3 monoclonal antibody reacts with an epitope on the epsilon-subunit within the human CD3 complex.Clone OKT3 can block the binding of clones SK7 and UCHT1.^4 The OKT3 antibody is able to induce T cell activation. Additional reported applications (for the relevant formats) include: immunohistochemical staining of acetone-fixed frozen sections and activation of T cells. The LEAF™ purified antibody (Endotoxin <0.1 EU/µg, Azide-Free, 0.2 µm filtered) is recommended for functional assays (Cat. No. 317304). For highly sensitive assays, we recommend Ultra-LEAF™ purified antibody (Cat. No. 317326) with a lower endotoxin limit than standard LEAF™ purified antibodies (Endotoxin <0.01 EU/µg).;
more info or order :
company information
BioLegend
8999 BioLegend Way
San Diego, CA 92121
customerserv@biolegend.com
https://www.biolegend.com
headquarters: USA