PE anti-human CD3 | BioLegend 317308 product information

product summary

company name :

BioLegend

other brands :

Babco, Signet, Sternberger Monoclonals, Senetek, Covance

product type :

antibody

product name :

PE anti-human CD3

catalog :

317308

quantity :

100 tests

price :

66 USD

clonality :

monoclonal

host :

mouse

conjugate :

clone name :

OKT3

reactivity :

human

application :

flow cytometry

more info or order :

BioLegend product webpage

citations: 19

Reference
Parajuli P, Rosati R, Mamdani H, Wright R, Hussain Z, Naeem A, et al. Senescence-associated secretory proteins induced in lung adenocarcinoma by extended treatment with dexamethasone enhance migration and activation of lymphocytes. Cancer Immunol Immunother. 2023;72:1273-1284 pubmed publisher
Ogura H, Gohda J, Lu X, Yamamoto M, Takesue Y, Son A, et al. Dysfunctional Sars-CoV-2-M protein-specific cytotoxic T lymphocytes in patients recovering from severe COVID-19. Nat Commun. 2022;13:7063 pubmed publisher
Campisi L, Chizari S, Ho J, Gromova A, Arnold F, Mosca L, et al. Clonally expanded CD8 T cells characterize amyotrophic lateral sclerosis-4. Nature. 2022;606:945-952 pubmed publisher
Mirchandani A, Jenkins S, Bain C, Sánchez García M, Lawson H, Coelho P, et al. Hypoxia shapes the immune landscape in lung injury and promotes the persistence of inflammation. Nat Immunol. 2022;23:927-939 pubmed publisher
Huanosta Murillo E, Alc xe1 ntara Hern xe1 ndez M, Hern xe1 ndez Rico B, Victoria Acosta G, Miranda Cruz P, Dom xed nguez G xf3 mez M, et al. NLRP3 Regulates IL-4 Expression in TOX+ CD4+ T Cells of Cutaneous T Cell Lymphoma to Potentially Promote Disease Progression. Front Immunol. 2021;12:668369 pubmed publisher
Loo Yau H, De Carvalho D. Measuring the effect of drug treatments on primary human CD8+ T cell activation and cytolytic potential. STAR Protoc. 2021;2:100549 pubmed publisher
Lugo Reyes S, Pastor N, Gonzalez Serrano E, Yamazaki Nakashimada M, Scheffler Mendoza S, Berrón Ruiz L, et al. Clinical Manifestations, Mutational Analysis, and Immunological Phenotype in Patients with RAG1/2 Mutations: First Cases Series from Mexico and Description of Two Novel Mutations. J Clin Immunol. 2021;41:1291-1302 pubmed publisher
Rau A, Kocher K, Rommel M, Kühl L, Albrecht M, Gotthard H, et al. A bivalent, bispecific Dab-Fc antibody molecule for dual targeting of HER2 and HER3. MAbs. 2021;13:1902034 pubmed publisher
Loo Yau H, Bell E, Ettayebi I, de Almeida F, Boukhaled G, Shen S, et al. DNA hypomethylating agents increase activation and cytolytic activity of CD8+ T cells. Mol Cell. 2021;81:1469-1483.e8 pubmed publisher
Dam T, Junghans V, Humphrey J, Chouliara M, J xf6 nsson P. Calcium Signaling in T Cells Is Induced by Binding to Nickel-Chelating Lipids in Supported Lipid Bilayers. Front Physiol. 2020;11:613367 pubmed publisher
Wang L, Wang H, Chiang H, Huang L, Chiu S, Siu L, et al. Human Placental MSC-Secreted IL-1β Enhances Neutrophil Bactericidal Functions during Hypervirulent Klebsiella Infection. Cell Rep. 2020;32:108188 pubmed publisher
Zhao Y, Lee C, Lin C, Gassen R, Xu X, Huang Z, et al. PD-L1:CD80 Cis-Heterodimer Triggers the Co-stimulatory Receptor CD28 While Repressing the Inhibitory PD-1 and CTLA-4 Pathways. Immunity. 2019;51:1059-1073.e9 pubmed publisher
Peng S, Zaretsky J, Ng A, Chour W, Bethune M, Choi J, et al. Sensitive Detection and Analysis of Neoantigen-Specific T Cell Populations from Tumors and Blood. Cell Rep. 2019;28:2728-2738.e7 pubmed publisher
Imle A, Kumberger P, Schnellbächer N, Fehr J, Carrillo Bustamante P, Ales J, et al. Experimental and computational analyses reveal that environmental restrictions shape HIV-1 spread in 3D cultures. Nat Commun. 2019;10:2144 pubmed publisher
Trinklein N, Pham D, Schellenberger U, Buelow B, Boudreau A, Choudhry P, et al. Efficient tumor killing and minimal cytokine release with novel T-cell agonist bispecific antibodies. MAbs. 2019;11:639-652 pubmed publisher
Man F, Lim L, Volpe A, Gabizon A, Shmeeda H, Draper B, et al. In Vivo PET Tracking of 89Zr-Labeled Vγ9Vδ2 T Cells to Mouse Xenograft Breast Tumors Activated with Liposomal Alendronate. Mol Ther. 2019;27:219-229 pubmed publisher
Kelly D, Li X, Kilday C, Feldman S, Clark S, Liu F, et al. Increased circulating regulatory T cells in medicated people with schizophrenia. Psychiatry Res. 2018;269:517-523 pubmed publisher
Giesecke C, Feher K, von Volkmann K, Kirsch J, Radbruch A, Kaiser T. Determination of background, signal-to-noise, and dynamic range of a flow cytometer: A novel practical method for instrument characterization and standardization. Cytometry A. 2017;91:1104-1114 pubmed publisher
O Neill A, Dearling J, Wang Y, Tupper T, Sun Y, Aster J, et al. Targeted imaging of Ewing sarcoma in preclinical models using a 64Cu-labeled anti-CD99 antibody. Clin Cancer Res. 2014;20:678-87 pubmed publisher

product information

Antigen :

CD3

Apps. Abbrev. :

Cat # :

317308

Clone :

OKT3

Item :

PE anti-human CD3

Isotype :

Mouse IgG2a, κ

Other Names :

T3, CD3ε

Size :

100 tests

Price (USD) :

66 USD

Reactivity :

Human

Clonality :

Monoclonal

Host :

Mouse

Conjugate/Tag/Label :

Application Notes :

The OKT3 monoclonal antibody reacts with an epitope on the epsilon-subunit within the human CD3 complex.Clone OKT3 can block the binding of clones SK7 and UCHT1.^4 The OKT3 antibody is able to induce T cell activation. Additional reported applications (for the relevant formats) include: immunohistochemical staining of acetone-fixed frozen sections and activation of T cells. The LEAF™ purified antibody (Endotoxin <0.1 EU/µg, Azide-Free, 0.2 µm filtered) is recommended for functional assays (Cat. No. 317304). For highly sensitive assays, we recommend Ultra-LEAF™ purified antibody (Cat. No. 317326) with a lower endotoxin limit than standard LEAF™ purified antibodies (Endotoxin <0.01 EU/µg).;

more info or order :

BioLegend product webpage