product summary
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company name :
BioLegend
other brands :
Babco, Signet, Sternberger Monoclonals, Senetek, Covance
product type :
antibody
product name :
PerCP/Cyanine5.5 anti-human/mouse/rat CD278 (ICOS)
catalog :
313517
quantity :
25 μg
price :
118 USD
clonality :
monoclonal
host :
hamsters
conjugate :
PerCP/Cy5.5
clone name :
C398.4A
reactivity :
human, mouse, rat
application :
flow cytometry
more info or order :
citations: 22
Published Application/Species/Sample/DilutionReference
  • flow cytometry; mouse; loading ...; fig s4a
Lin X, Twelkmeyer T, Zhu D, Zhang L, Zhao Y, Zhang C, et al. Homeostatic regulation of T follicular helper and antibody response to particle antigens by IL-1Ra of medullary sinus macrophage origin. Proc Natl Acad Sci U S A. 2021;118: pubmed publisher
  • flow cytometry; mouse
Kawamoto S, Tran T, Maruya M, Suzuki K, Doi Y, Tsutsui Y, et al. The inhibitory receptor PD-1 regulates IgA selection and bacterial composition in the gut. Science. 2012;336:485-9 pubmed publisher
Mudd P, Minervina A, Pogorelyy M, Turner J, Kim W, Kalaidina E, et al. SARS-CoV-2 mRNA vaccination elicits a robust and persistent T follicular helper cell response in humans. Cell. 2022;185:603-613.e15 pubmed publisher
Stewart J, Posgai A, Leon J, Haller M, Keselowsky B. Combination Treatment with Antigen-Specific Dual-Sized Microparticle System Plus Anti-CD3 Immunotherapy Fails to Synergize to Improve Late-Stage Type 1 Diabetes Prevention in Nonobese Diabetic Mice. ACS Biomater Sci Eng. 2020;6:5941-5958 pubmed publisher
Vacca F, Chauch C, Jamwal A, Hinchy E, Heieis G, Webster H, et al. A helminth-derived suppressor of ST2 blocks allergic responses. elife. 2020;9: pubmed publisher
Wang L, Shen E, Luo L, Rabe H, Wang Q, Yin J, et al. Control of Germinal Center Localization and Lineage Stability of Follicular Regulatory T Cells by the Blimp1 Transcription Factor. Cell Rep. 2019;29:1848-1861.e6 pubmed publisher
Liu C, Chikina M, Deshpande R, Menk A, Wang T, Tabib T, et al. Treg Cells Promote the SREBP1-Dependent Metabolic Fitness of Tumor-Promoting Macrophages via Repression of CD8+ T Cell-Derived Interferon-γ. Immunity. 2019;51:381-397.e6 pubmed publisher
Vyas A, Negi P, Patra S, Maras J, Ramakrishna G, Sarin S, et al. Maternal Immunity Influences Vertical Transmission of Hepatitis B to Newborns. Hepatol Commun. 2019;3:795-811 pubmed publisher
Van Gool F, Nguyen M, Mumbach M, Satpathy A, Rosenthal W, Giacometti S, et al. A Mutation in the Transcription Factor Foxp3 Drives T Helper 2 Effector Function in Regulatory T Cells. Immunity. 2019;50:362-377.e6 pubmed publisher
Pauthner M, Nkolola J, Havenar Daughton C, Murrell B, Reiss S, Bastidas R, et al. Vaccine-Induced Protection from Homologous Tier 2 SHIV Challenge in Nonhuman Primates Depends on Serum-Neutralizing Antibody Titers. Immunity. 2019;50:241-252.e6 pubmed publisher
Knolle M, Chin S, Rana B, Englezakis A, Nakagawa R, Fallon P, et al. MicroRNA-155 Protects Group 2 Innate Lymphoid Cells From Apoptosis to Promote Type-2 Immunity. Front Immunol. 2018;9:2232 pubmed publisher
Trotta E, Bessette P, Silveria S, Ely L, Jude K, Le D, et al. A human anti-IL-2 antibody that potentiates regulatory T cells by a structure-based mechanism. Nat Med. 2018;24:1005-1014 pubmed publisher
Pauthner M, Havenar Daughton C, Sok D, Nkolola J, Bastidas R, Boopathy A, et al. Elicitation of Robust Tier 2 Neutralizing Antibody Responses in Nonhuman Primates by HIV Envelope Trimer Immunization Using Optimized Approaches. Immunity. 2017;46:1073-1088.e6 pubmed publisher
Overacre Delgoffe A, Chikina M, Dadey R, Yano H, Brunazzi E, Shayan G, et al. Interferon-? Drives Treg Fragility to Promote Anti-tumor Immunity. Cell. 2017;169:1130-1141.e11 pubmed publisher
Ma W, Jia Y, Liu Q, Yang Y, Yang J, Zhao Z, et al. Modulation of liver regeneration via myeloid PTEN deficiency. Cell Death Dis. 2017;8:e2827 pubmed publisher
Pilkinton M, Nicholas K, Warren C, Smith R, Yoder S, Talbot H, et al. Greater activation of peripheral T follicular helper cells following high dose influenza vaccine in older adults forecasts seroconversion. Vaccine. 2017;35:329-336 pubmed publisher
GORDON E, Simpson L, Rios C, Ringel L, Lachowicz Scroggins M, Peters M, et al. Alternative splicing of interleukin-33 and type 2 inflammation in asthma. Proc Natl Acad Sci U S A. 2016;113:8765-70 pubmed publisher
Engel I, Seumois G, Chavez L, Samaniego Castruita D, White B, Chawla A, et al. Innate-like functions of natural killer T cell subsets result from highly divergent gene programs. Nat Immunol. 2016;17:728-39 pubmed publisher
Gomez Rodriguez J, Meylan F, Handon R, Hayes E, Anderson S, Kirby M, et al. Itk is required for Th9 differentiation via TCR-mediated induction of IL-2 and IRF4. Nat Commun. 2016;7:10857 pubmed publisher
Colineau L, Rouers A, Yamamoto T, Xu Y, Urrutia A, Pham H, et al. HIV-Infected Spleens Present Altered Follicular Helper T Cell (Tfh) Subsets and Skewed B Cell Maturation. PLoS ONE. 2015;10:e0140978 pubmed publisher
Jie Z, Liang Y, Hou L, Dong C, Iwakura Y, Soong L, et al. Intrahepatic innate lymphoid cells secrete IL-17A and IL-17F that are crucial for T cell priming in viral infection. J Immunol. 2014;192:3289-300 pubmed publisher
Hasegawa M, Fujimoto M, Matsushita T, Hamaguchi Y, Takehara K. Augmented ICOS expression in patients with early diffuse cutaneous systemic sclerosis. Rheumatology (Oxford). 2013;52:242-51 pubmed publisher
product information
Antigen :
CD278
Apps. Abbrev. :
FC
Cat # :
313517
Clone :
C398.4A
Item :
PerCP/Cyanine5.5 anti-human/mouse/rat CD278 (ICOS)
Isotype :
Armenian Hamster IgG
Other Names :
Inducible COStimulatory molecule, H4
Size :
25 μg
Price (USD) :
118 USD
Reactivity :
Human, Mouse, Rat
Clonality :
Monoclonal
Host :
Armenian Hamster
Conjugate/Tag/Label :
PERCP_CYANINE5.5
Immunogen :
Mouse T cell clone D10.G4.1
Application Notes :
The C398.4A antibody is useful for flow cytometric analysis and is able to costimulate T cell activation and proliferation. Additional reported applications (for the relevant formats) include: immunoprecipitation^1, in vitro costimulation of T cell activation^1,3,4, and spatial biology (IBEX)^5,6. The LEAF™ purified antibody (Endotoxin < 0.1 EU/µg, Azide-Free, 0.2 µm filtered) is recommended for functional assays (Cat. No. 313512).;
more info or order :
company information
BioLegend
8999 BioLegend Way
San Diego, CA 92121
customerserv@biolegend.com
https://www.biolegend.com
headquarters: USA