product summary
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company name :
BioLegend
other brands :
Babco, Signet, Sternberger Monoclonals, Senetek, Covance
product type :
antibody
product name :
APC anti-human/mouse/rat CD278 (ICOS)
catalog :
313510
quantity :
100 μg
price :
237 USD
clonality :
monoclonal
host :
hamsters
conjugate :
APC
clone name :
C398.4A
reactivity :
human, mouse, rat
application :
flow cytometry
more info or order :
citations: 18
Published Application/Species/Sample/DilutionReference
  • flow cytometry; mouse; 200 ug/ml; loading ...; fig 2e
Patial S, Lewis B, Vo T, Choudhary I, Paudel K, Mao Y, et al. Myeloid-IL4Rα is an indispensable link in IL-33-ILCs-IL-13-IL4Rα axis of eosinophil recruitment in murine lungs. Sci Rep. 2021;11:15465 pubmed publisher
  • flow cytometry; mouse; loading ...; fig s5l
Binnewies M, Mujal A, Pollack J, Combes A, Hardison E, Barry K, et al. Unleashing Type-2 Dendritic Cells to Drive Protective Antitumor CD4+ T Cell Immunity. Cell. 2019;177:556-571.e16 pubmed publisher
  • flow cytometry; mouse; loading ...
Ramirez Carrozzi V, Sambandam A, Zhou M, Yan D, Kang J, Wu X, et al. Combined blockade of the IL-13 and IL-33 pathways leads to a greater inhibition of type 2 inflammation over inhibition of either pathway alone. J Allergy Clin Immunol. 2017;139:705-708.e6 pubmed publisher
  • flow cytometry; human
Llibre A, López Macías C, Marafioti T, Mehta H, Partridge A, Kanzig C, et al. LLT1 and CD161 Expression in Human Germinal Centers Promotes B Cell Activation and CXCR4 Downregulation. J Immunol. 2016;196:2085-94 pubmed publisher
  • flow cytometry; mouse
Kawamoto S, Tran T, Maruya M, Suzuki K, Doi Y, Tsutsui Y, et al. The inhibitory receptor PD-1 regulates IgA selection and bacterial composition in the gut. Science. 2012;336:485-9 pubmed publisher
Zhang Y, Qin Y, Chen Z. Neuromedin U Suppresses Collagen-Induced Arthritis through ILC2-Th2 Activation. J Immunol Res. 2021;2021:5599439 pubmed publisher
Cassotta A, Paparoditis P, Geiger R, Mettu R, Landry S, Donati A, et al. Deciphering and predicting CD4+ T cell immunodominance of influenza virus hemagglutinin. J Exp Med. 2020;217: pubmed publisher
Wijesinghe A, Gamage J, Goonewardena H, Gomes L, Jayathilaka D, Wijeratne D, et al. Phenotype and functionality of follicular helper T cells in patients with acute dengue infection. J Biomed Sci. 2020;27:50 pubmed publisher
Court A, Le Gatt A, Luz Crawford P, Parra E, Aliaga Tobar V, Batiz L, et al. Mitochondrial transfer from MSCs to T cells induces Treg differentiation and restricts inflammatory response. EMBO Rep. 2020;21:e48052 pubmed publisher
Jain A, Irizarry Caro R, McDaniel M, Chawla A, Carroll K, Overcast G, et al. T cells instruct myeloid cells to produce inflammasome-independent IL-1β and cause autoimmunity. Nat Immunol. 2020;21:65-74 pubmed publisher
Del Alcazar D, Wang Y, He C, Wendel B, Del Rio Estrada P, Lin J, et al. Mapping the Lineage Relationship between CXCR5+ and CXCR5- CD4+ T Cells in HIV-Infected Human Lymph Nodes. Cell Rep. 2019;28:3047-3060.e7 pubmed publisher
Arce Vargas F, Furness A, Litchfield K, Joshi K, Rosenthal R, Ghorani E, et al. Fc Effector Function Contributes to the Activity of Human Anti-CTLA-4 Antibodies. Cancer Cell. 2018;33:649-663.e4 pubmed publisher
Xu L, Huang Q, Wang H, Hao Y, Bai Q, Hu J, et al. The Kinase mTORC1 Promotes the Generation and Suppressive Function of Follicular Regulatory T Cells. Immunity. 2017;47:538-551.e5 pubmed publisher
Lim S, Kwon M, Lee J, Oh Y, Jang J, Lee J, et al. Weissella cibaria WIKIM28 ameliorates atopic dermatitis-like skin lesions by inducing tolerogenic dendritic cells and regulatory T cells in BALB/c mice. Sci Rep. 2017;7:40040 pubmed publisher
Sebina I, James K, Soon M, Fogg L, Best S, Labastida Rivera F, et al. IFNAR1-Signalling Obstructs ICOS-mediated Humoral Immunity during Non-lethal Blood-Stage Plasmodium Infection. PLoS Pathog. 2016;12:e1005999 pubmed publisher
Bonnet B, Vigneron J, Levacher B, Vazquez T, Pitoiset F, Brimaud F, et al. Low-Dose IL-2 Induces Regulatory T Cell-Mediated Control of Experimental Food Allergy. J Immunol. 2016;197:188-98 pubmed publisher
Miles B, Miller S, Folkvord J, Kimball A, Chamanian M, Meditz A, et al. Follicular regulatory T cells impair follicular T helper cells in HIV and SIV infection. Nat Commun. 2015;6:8608 pubmed publisher
Deakin A, Duddy G, Wilson S, Harrison S, Latcham J, Fulleylove M, et al. Characterisation of a K390R ITK kinase dead transgenic mouse--implications for ITK as a therapeutic target. PLoS ONE. 2014;9:e107490 pubmed publisher
product information
Antigen :
CD278
Apps. Abbrev. :
FC
Cat # :
313510
Clone :
C398.4A
Item :
APC anti-human/mouse/rat CD278 (ICOS)
Isotype :
Armenian Hamster IgG
Other Names :
Inducible COStimulatory molecule, H4
Size :
100 μg
Price (USD) :
237 USD
Reactivity :
Human, Mouse, Rat
Clonality :
Monoclonal
Host :
Armenian Hamster
Conjugate/Tag/Label :
APC
Immunogen :
Mouse T cell clone D10.G4.1
Application Notes :
The C398.4A antibody is useful for flow cytometric analysis and is able to costimulate T cell activation and proliferation. Additional reported applications (for the relevant formats) include: immunoprecipitation^1, in vitro costimulation of T cell activation^1,3,4, and spatial biology (IBEX)^5,6. The LEAF™ purified antibody (Endotoxin < 0.1 EU/µg, Azide-Free, 0.2 µm filtered) is recommended for functional assays (Cat. No. 313512).;
more info or order :
company information
BioLegend
8999 BioLegend Way
San Diego, CA 92121
customerserv@biolegend.com
https://www.biolegend.com
headquarters: USA