product summary
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company name :
BioLegend
other brands :
Babco, Signet, Sternberger Monoclonals, Senetek, Covance
product type :
antibody
product name :
Brilliant Violet 421™ anti-human CD137 (4-1BB)
catalog :
309820
quantity :
100 tests
price :
424 USD
clonality :
monoclonal
host :
mouse
conjugate :
BV421
clone name :
4B4-1
reactivity :
human
application :
flow cytometry
more info or order :
citations: 20
Reference
Babl N, Hofbauer J, Matos C, Voll F, Menevse A, Rechenmacher M, et al. Low-density lipoprotein balances T cell metabolism and enhances response to anti-PD-1 blockade in a HCT116 spheroid model. Front Oncol. 2023;13:1107484 pubmed publisher
Koutsakos M, Lee W, Reynaldi A, Tan H, Gare G, Kinsella P, et al. The magnitude and timing of recalled immunity after breakthrough infection is shaped by SARS-CoV-2 variants. Immunity. 2022;55:1316-1326.e4 pubmed publisher
Li Y, Wang X, Jin J, Ma Z, Liu Y, Zhang X, et al. T-cell responses to SARS-CoV-2 Omicron spike epitopes with mutations after the third booster dose of an inactivated vaccine. J Med Virol. 2022;94:3998-4004 pubmed publisher
Balachandran H, Phetsouphanh C, Agapiou D, Adhikari A, Rodrigo C, Hammoud M, et al. Maintenance of broad neutralizing antibodies and memory B cells 1 year post-infection is predicted by SARS-CoV-2-specific CD4+ T cell responses. Cell Rep. 2022;38:110345 pubmed publisher
Georg P, Astaburuaga García R, Bonaguro L, Brumhard S, Michalick L, Lippert L, et al. Complement activation induces excessive T cell cytotoxicity in severe COVID-19. Cell. 2022;185:493-512.e25 pubmed publisher
Smith A, Knochelmann H, Wyatt M, Rangel Rivera G, Rivera Reyes A, Dwyer C, et al. B cells imprint adoptively transferred CD8+ T cells with enhanced tumor immunity. J Immunother Cancer. 2022;10: pubmed publisher
Vanshylla K, Fan C, Wunsch M, Poopalasingam N, Meijers M, Kreer C, et al. Discovery of ultrapotent broadly neutralizing antibodies from SARS-CoV-2 elite neutralizers. Cell Host Microbe. 2022;30:69-82.e10 pubmed publisher
Sulejmani O, Grunewald L, Andersch L, Schwiebert S, Klaus A, Winkler A, et al. Inhibiting Lysine Demethylase 1A Improves L1CAM-Specific CAR T Cell Therapy by Unleashing Antigen-Independent Killing via the FAS-FASL Axis. Cancers (Basel). 2021;13: pubmed publisher
Duraiswamy J, Turrini R, Minasyan A, Barras D, Crespo I, Grimm A, et al. Myeloid antigen-presenting cell niches sustain antitumor T cells and license PD-1 blockade via CD28 costimulation. Cancer Cell. 2021;39:1623-1642.e20 pubmed publisher
Hu W, He M, Wang X, Sun Q, Kuang M. Specific CD8+ TCR Repertoire Recognizing Conserved Antigens of SARS-CoV-2 in Unexposed Population: A Prerequisite for Broad-Spectrum CD8+ T Cell Immunity. Vaccines (Basel). 2021;9: pubmed publisher
Vitanza N, Johnson A, Wilson A, Brown C, Yokoyama J, K xfc nkele A, et al. Locoregional infusion of HER2-specific CAR T cells in children and young adults with recurrent or refractory CNS tumors: an interim analysis. Nat Med. 2021;27:1544-1552 pubmed publisher
Harris M, Fuyal M, James J. Quantifying persistence in the T-cell signaling network using an optically controllable antigen receptor. Mol Syst Biol. 2021;17:e10091 pubmed publisher
Wenthe J, Naseri S, Labani Motlagh A, Enblad G, Wikstrom K, Eriksson E, et al. Boosting CAR T-cell responses in lymphoma by simultaneous targeting of CD40/4-1BB using oncolytic viral gene therapy. Cancer Immunol Immunother. 2021;70:2851-2865 pubmed publisher
Buggert M, Vella L, Nguyen S, Wu V, Chen Z, Sekine T, et al. The Identity of Human Tissue-Emigrant CD8+ T Cells. Cell. 2020;183:1946-1961.e15 pubmed publisher
Sekine T, Perez Potti A, Rivera Ballesteros O, Stralin K, Gorin J, Olsson A, et al. Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19. Cell. 2020;183:158-168.e14 pubmed publisher
Freeman Z, Nirschl T, Hovelson D, Johnston R, Engelhardt J, Selby M, et al. A conserved intratumoral regulatory T cell signature identifies 4-1BB as a pan-cancer target. J Clin Invest. 2020;130:1405-1416 pubmed publisher
Lamichhane R, Galvin H, Hannaway R, de la Harpe S, Munro F, Tyndall J, et al. Type I interferons are important co-stimulatory signals during T cell receptor mediated human MAIT cell activation. Eur J Immunol. 2020;50:178-191 pubmed publisher
Andersch L, Radke J, Klaus A, Schwiebert S, Winkler A, Schumann E, et al. CD171- and GD2-specific CAR-T cells potently target retinoblastoma cells in preclinical in vitro testing. BMC Cancer. 2019;19:895 pubmed publisher
Iwahori K, Shintani Y, Funaki S, Yamamoto Y, Matsumoto M, Yoshida T, et al. Peripheral T cell cytotoxicity predicts T cell function in the tumor microenvironment. Sci Rep. 2019;9:2636 pubmed publisher
Genoyer E, LOPEZ C. Defective Viral Genomes Alter How Sendai Virus Interacts with Cellular Trafficking Machinery, Leading to Heterogeneity in the Production of Viral Particles among Infected Cells. J Virol. 2019;93: pubmed publisher
product information
Antigen :
CD137
Apps. Abbrev. :
FC
Cat # :
309820
Clone :
4B4-1
Item :
Brilliant Violet 421™ anti-human CD137 (4-1BB)
Isotype :
Mouse IgG1, κ
Other Names :
4-1BB, ILA, CD137, TNFRSF9
Size :
100 tests
Price (USD) :
424 USD
Reactivity :
Human
Clonality :
Monoclonal
Host :
Mouse
Conjugate/Tag/Label :
BV421
Immunogen :
Ectodomain of recombinant human 4-1BB fusion protein
Application Notes :
Additional reported applications (for the relevant formats) include: immunoprecipitation^1,4, inhibition of cytokine production^2,3, and ELISA. For most successful immunofluorescent staining results, it may be important to maximize signal over background by using a relatively bright fluorochrome-antibody conjugate (Cat. No. 309804) or by using a high sensitivity, three-layer staining technique (e.g., including a biotinylated anti-mouse IgG second step (Cat. No. 405303), followed by Streptavidin-PE (Cat. No. 405204)).;
more info or order :
company information
BioLegend
8999 BioLegend Way
San Diego, CA 92121
customerserv@biolegend.com
https://www.biolegend.com
headquarters: USA