product summary
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company name :
BioLegend
other brands :
Babco, Signet, Sternberger Monoclonals, Senetek, Covance
product type :
antibody
product name :
PE/Cyanine7 anti-human CD137 (4-1BB)
catalog :
309817
quantity :
25 tests
price :
153 USD
clonality :
monoclonal
host :
mouse
conjugate :
PE/Cy7
clone name :
4B4-1
reactivity :
human
application :
immunocytochemistry, flow cytometry
more info or order :
citations: 22
Published Application/Species/Sample/DilutionReference
  • flow cytometry; human; loading ...; fig 1a
Gabanti E, Bruno F, Scaramuzzi L, Mangione F, Zelini P, Gerna G, et al. Predictive value of human cytomegalovirus (HCMV) T-cell response in the control of HCMV infection by seropositive solid-organ transplant recipients according to different assays and stimuli. New Microbiol. 2016;39:247-258 pubmed
  • immunocytochemistry; human; fig 1
Chacon J, Sarnaik A, Chen J, Creasy C, Kale C, Robinson J, et al. Manipulating the tumor microenvironment ex vivo for enhanced expansion of tumor-infiltrating lymphocytes for adoptive cell therapy. Clin Cancer Res. 2015;21:611-21 pubmed publisher
  • flow cytometry; human
Jitschin R, Braun M, Büttner M, Dettmer Wilde K, Bricks J, Berger J, et al. CLL-cells induce IDOhi CD14+HLA-DRlo myeloid-derived suppressor cells that inhibit T-cell responses and promote TRegs. Blood. 2014;124:750-60 pubmed publisher
Adamo S, Gao Y, Sekine T, Mily A, Wu J, Storg xe4 rd E, et al. Memory profiles distinguish cross-reactive and virus-specific T cell immunity to mpox. Cell Host Microbe. 2023;31:928-936.e4 pubmed publisher
Lao L, Zeng W, Huang P, Chen H, Jia Z, Wang P, et al. CD8+ T cell-Dependent Remodeling of the Tumor Microenvironment Overcomes Chemoresistance. Cancer Immunol Res. 2023;11:320-338 pubmed publisher
Xu Q, Milanez Almeida P, Martins A, Radtke A, Hoehn K, Oguz C, et al. Adaptive immune responses to SARS-CoV-2 persist in the pharyngeal lymphoid tissue of children. Nat Immunol. 2023;24:186-199 pubmed publisher
Schnizer C, Andreas N, Vivas W, Kamradt T, Baier M, Kiehntopf M, et al. Persistent humoral and CD4+ TH cell immunity after mild SARS-COV-2 infection-The CoNAN long-term study. Front Immunol. 2022;13:1095129 pubmed publisher
Nogimori T, Suzuki K, Masuta Y, Washizaki A, Yagoto M, Ikeda M, et al. Functional changes in cytotoxic CD8+ T-cell cross-reactivity against the SARS-CoV-2 Omicron variant after mRNA vaccination. Front Immunol. 2022;13:1081047 pubmed publisher
Qiu C, Wang J, Zhu L, Cheng X, Xia B, Jin Y, et al. Improving the ex vivo expansion of human tumor-reactive CD8 + T cells by targeting toll-like receptors. Front Bioeng Biotechnol. 2022;10:1027619 pubmed publisher
Menges D, Zens K, Ballouz T, Caduff N, Llanas Cornejo D, Aschmann H, et al. Heterogenous humoral and cellular immune responses with distinct trajectories post-SARS-CoV-2 infection in a population-based cohort. Nat Commun. 2022;13:4855 pubmed publisher
Gao Y, Cai C, Wullimann D, Niessl J, Rivera Ballesteros O, Chen P, et al. Immunodeficiency syndromes differentially impact the functional profile of SARS-CoV-2-specific T cells elicited by mRNA vaccination. Immunity. 2022;55:1732-1746.e5 pubmed publisher
Kilpel xe4 inen A, Jimenez Moyano E, Blanch Lombarte O, Ouchi D, Pe xf1 a R, Quirant Sánchez B, et al. Skewed Cellular Distribution and Low Activation of Functional T-Cell Responses in SARS-CoV-2 Non-Seroconvertors. Front Immunol. 2022;13:815041 pubmed publisher
Eiva M, Omran D, Chacon J, Powell D. Systematic analysis of CD39, CD103, CD137, and PD-1 as biomarkers for naturally occurring tumor antigen-specific TILs. Eur J Immunol. 2022;52:96-108 pubmed publisher
Chen M, Li Y, Wu Y, Xie S, Ma J, Yue J, et al. Anti-Tumor Activity of Expanded PBMC-Derived NK Cells by Feeder-Free Protocol in Ovarian Cancer. Cancers (Basel). 2021;13: pubmed publisher
Duhen R, Ballesteros Merino C, Frye A, Tran E, Rajamanickam V, Chang S, et al. Neoadjuvant anti-OX40 (MEDI6469) therapy in patients with head and neck squamous cell carcinoma activates and expands antigen-specific tumor-infiltrating T cells. Nat Commun. 2021;12:1047 pubmed publisher
Thieme C, Anft M, Paniskaki K, Blazquez Navarro A, Doevelaar A, Seibert F, et al. Robust T Cell Response Toward Spike, Membrane, and Nucleocapsid SARS-CoV-2 Proteins Is Not Associated with Recovery in Critical COVID-19 Patients. Cell Rep Med. 2020;1:100092 pubmed publisher
Rodriguez Garcia A, Sharma P, Poussin M, Boesteanu A, Minutolo N, Gitto S, et al. CAR T Cells Targeting MISIIR for the Treatment of Ovarian Cancer and Other Gynecologic Malignancies. Mol Ther. 2020;28:548-560 pubmed publisher
Lecciso M, Ocadlikova D, Sangaletti S, Trabanelli S, De Marchi E, Orioli E, et al. ATP Release from Chemotherapy-Treated Dying Leukemia Cells Elicits an Immune Suppressive Effect by Increasing Regulatory T Cells and Tolerogenic Dendritic Cells. Front Immunol. 2017;8:1918 pubmed publisher
van de Sandt C, Kreijtz J, Geelhoed Mieras M, Nieuwkoop N, Spronken M, van de Vijver D, et al. Differential Recognition of Influenza A Viruses by M158-66 Epitope-Specific CD8+ T Cells Is Determined by Extraepitopic Amino Acid Residues. J Virol. 2016;90:1009-22 pubmed publisher
Hodge G, Hodge S, Reynolds P, Holmes M. Targeting peripheral blood pro-inflammatory CD28null T cells and natural killer T-like cells by inhibiting CD137 expression: possible relevance to treatment of bronchiolitis obliterans syndrome. J Heart Lung Transplant. 2013;32:1081-9 pubmed publisher
Afanasiev O, Yelistratova L, Miller N, Nagase K, Paulson K, Iyer J, et al. Merkel polyomavirus-specific T cells fluctuate with merkel cell carcinoma burden and express therapeutically targetable PD-1 and Tim-3 exhaustion markers. Clin Cancer Res. 2013;19:5351-60 pubmed publisher
Tischer S, Kaireit T, Figueiredo C, Hiller O, Maecker Kolhoff B, Geyeregger R, et al. Establishment of the reversible peptide-major histocompatibility complex (pMHC) class I Histamer technology: tool for visualization and selection of functionally active antigen-specific CD8(+) T lymphocytes. Int Immunol. 2012;24:561-72 pubmed publisher
product information
Antigen :
CD137
Apps. Abbrev. :
FC
Cat # :
309817
Clone :
4B4-1
Item :
PE/Cyanine7 anti-human CD137 (4-1BB)
Isotype :
Mouse IgG1, κ
Other Names :
4-1BB, ILA, CD137, TNFRSF9
Size :
25 tests
Price (USD) :
153 USD
Reactivity :
Human
Clonality :
Monoclonal
Host :
Mouse
Conjugate/Tag/Label :
PE_CYANINE7
Immunogen :
Ectodomain of recombinant human 4-1BB fusion protein
Application Notes :
Additional reported applications (for the relevant formats) include: immunoprecipitation^1,4, inhibition of cytokine production^2,3, and ELISA. For most successful immunofluorescent staining results, it may be important to maximize signal over background by using a relatively bright fluorochrome-antibody conjugate (Cat. No. 309804) or by using a high sensitivity, three-layer staining technique (e.g., including a biotinylated anti-mouse IgG second step (Cat. No. 405303), followed by Streptavidin-PE (Cat. No. 405204)).;
more info or order :
company information
BioLegend
8999 BioLegend Way
San Diego, CA 92121
customerserv@biolegend.com
https://www.biolegend.com
headquarters: USA