product summary
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company name :
BioLegend
other brands :
Babco, Signet, Sternberger Monoclonals, Senetek, Covance
product type :
antibody
product name :
APC anti-human CD137 (4-1BB)
catalog :
309810
quantity :
100 tests
price :
332 USD
clonality :
monoclonal
host :
mouse
conjugate :
APC
clone name :
4B4-1
reactivity :
human
application :
western blot, flow cytometry
more info or order :
citations: 48
Published Application/Species/Sample/DilutionReference
  • western blot; human; 1:50; loading ...; fig 2a
Mateus J, Grifoni A, Tarke A, Sidney J, Ramirez S, Dan J, et al. Selective and cross-reactive SARS-CoV-2 T cell epitopes in unexposed humans. Science. 2020;370:89-94 pubmed publisher
  • flow cytometry; human; loading ...; fig 2b
Grifoni A, Weiskopf D, Ramirez S, Mateus J, Dan J, Moderbacher C, et al. Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals. Cell. 2020;181:1489-1501.e15 pubmed publisher
  • flow cytometry; human; loading ...; fig 2i
Cirelli K, Carnathan D, Nogal B, Martin J, Rodriguez O, Upadhyay A, et al. Slow Delivery Immunization Enhances HIV Neutralizing Antibody and Germinal Center Responses via Modulation of Immunodominance. Cell. 2019;177:1153-1171.e28 pubmed publisher
Tarke A, Zhang Y, Methot N, Narowski T, Phillips E, Mallal S, et al. Targets and cross-reactivity of human T cell recognition of common cold coronaviruses. Cell Rep Med. 2023;4:101088 pubmed publisher
Zhang W, Kedzierski L, Chua B, Mayo M, Lonzi C, Rigas V, et al. Robust and prototypical immune responses toward COVID-19 vaccine in First Nations peoples are impacted by comorbidities. Nat Immunol. 2023;24:966-978 pubmed publisher
Xiao C, Ren Z, Zhang B, Mao L, Zhu G, Gao L, et al. Insufficient epitope-specific T cell clones are responsible for impaired cellular immunity to inactivated SARS-CoV-2 vaccine in older adults. Nat Aging. 2023;3:418-435 pubmed publisher
Nguyen T, Rowntree L, Allen L, Chua B, Kedzierski L, Lim C, et al. Robust SARS-CoV-2 T cell responses with common TCRαβ motifs toward COVID-19 vaccines in patients with hematological malignancy impacting B cells. Cell Rep Med. 2023;4:101017 pubmed publisher
Ryan F, Norton T, McCafferty C, Blake S, Stevens N, James J, et al. A systems immunology study comparing innate and adaptive immune responses in adults to COVID-19 mRNA and adenovirus vectored vaccines. Cell Rep Med. 2023;4:100971 pubmed publisher
Eschweiler S, Wang A, Ram xed rez Su xe1 stegui C, von Witzleben A, Li Y, Chee S, et al. JAML immunotherapy targets recently activated tumor-infiltrating CD8+ T cells. Cell Rep. 2023;42:112040 pubmed publisher
Yu E, Wang E, Garrigan E, Sutherland A, Khalil N, Kearns K, et al. Ex vivo assays show human gamma-delta T cells specific for common allergens are Th1-polarized in allergic donors. Cell Rep Methods. 2022;2:100350 pubmed publisher
Hong C, Pyo H, Baek I, Kim T. Rapid identification of CMV-specific TCRs via reverse TCR cloning system based on bulk TCR repertoire data. Front Immunol. 2022;13:1021067 pubmed publisher
Reitinger C, Ipsen Escobedo A, Hornung C, Heger L, Dudziak D, Lux A, et al. Modulation of urelumab glycosylation separates immune stimulatory activity from organ toxicity. Front Immunol. 2022;13:970290 pubmed publisher
Fendler A, Shepherd S, Au L, Wu M, Harvey R, Wilkinson K, et al. Functional immune responses against SARS-CoV-2 variants of concern after fourth COVID-19 vaccine dose or infection in patients with blood cancer. Cell Rep Med. 2022;3:100781 pubmed publisher
Sun P, Ramos I, Coelho C, Grifoni A, Balinsky C, Vangeti S, et al. Asymptomatic or symptomatic SARS-CoV-2 infection plus vaccination confers increased adaptive immunity to variants of concern. iScience. 2022;25:105202 pubmed publisher
Zhang J, Hu Y, Yang J, Li W, Zhang M, Wang Q, et al. Non-viral, specifically targeted CAR-T cells achieve high safety and efficacy in B-NHL. Nature. 2022;609:369-374 pubmed publisher
Terahara K, Sato T, Adachi Y, Tonouchi K, Onodera T, Moriyama S, et al. SARS-CoV-2-specific CD4+ T cell longevity correlates with Th17-like phenotype. iScience. 2022;25:104959 pubmed publisher
Stevenson E, Terry S, Copertino D, Leyre L, Danesh A, Weiler J, et al. SARS CoV-2 mRNA vaccination exposes latent HIV to Nef-specific CD8+ T-cells. Nat Commun. 2022;13:4888 pubmed publisher
Yu E, Narowski T, Wang E, Garrigan E, Mateus J, Frazier A, et al. Immunological memory to common cold coronaviruses assessed longitudinally over a three-year period pre-COVID19 pandemic. Cell Host Microbe. 2022;30:1269-1278.e4 pubmed publisher
Kishton R, Patel S, Decker A, Vodnala S, Cam M, Yamamoto T, et al. Cancer genes disfavoring T cell immunity identified via integrated systems approach. Cell Rep. 2022;40:111153 pubmed publisher
Nielsen M, Juul Madsen K, Stegmayr J, Gao C, Mehta A, Greisen S, et al. Galectin-3 Decreases 4-1BBL Bioactivity by Crosslinking Soluble and Membrane Expressed 4-1BB. Front Immunol. 2022;13:915890 pubmed publisher
Tarke A, Potestà M, Varchetta S, Fenoglio D, Iannetta M, Sarmati L, et al. Early and Polyantigenic CD4 T Cell Responses Correlate with Mild Disease in Acute COVID-19 Donors. Int J Mol Sci. 2022;23: pubmed publisher
van der Ploeg K, Kirosingh A, Mori D, Chakraborty S, Hu Z, Sievers B, et al. TNF-α+ CD4+ T cells dominate the SARS-CoV-2 specific T cell response in COVID-19 outpatients and are associated with durable antibodies. Cell Rep Med. 2022;3:100640 pubmed publisher
Lederer K, Bettini E, Parvathaneni K, Painter M, Agarwal D, Lundgreen K, et al. Germinal center responses to SARS-CoV-2 mRNA vaccines in healthy and immunocompromised individuals. Cell. 2022;185:1008-1024.e15 pubmed publisher
Yu E, Wang E, Garrigan E, Goodwin B, Sutherland A, Tarke A, et al. Development of a T cell-based immunodiagnostic system to effectively distinguish SARS-CoV-2 infection and COVID-19 vaccination status. Cell Host Microbe. 2022;30:388-399.e3 pubmed publisher
Tarke A, Coelho C, Zhang Z, Dan J, Yu E, Methot N, et al. SARS-CoV-2 vaccination induces immunological T cell memory able to cross-recognize variants from Alpha to Omicron. Cell. 2022;185:847-859.e11 pubmed publisher
Qiu C, Xiao C, Wang Z, Zhu G, Mao L, Chen X, et al. CD8+ T-Cell Epitope Variations Suggest a Potential Antigen HLA-A2 Binding Deficiency for Spike Protein of SARS-CoV-2. Front Immunol. 2021;12:764949 pubmed publisher
Kimura I, Kosugi Y, Wu J, Zahradník J, Yamasoba D, Butlertanaka E, et al. The SARS-CoV-2 Lambda variant exhibits enhanced infectivity and immune resistance. Cell Rep. 2021;:110218 pubmed publisher
Yarmarkovich M, Marshall Q, Warrington J, Premaratne R, Farrel A, Groff D, et al. Cross-HLA targeting of intracellular oncoproteins with peptide-centric CARs. Nature. 2021;599:477-484 pubmed publisher
Apostolidis S, Kakara M, Painter M, Goel R, Mathew D, Lenzi K, et al. Cellular and humoral immune responses following SARS-CoV-2 mRNA vaccination in patients with multiple sclerosis on anti-CD20 therapy. Nat Med. 2021;27:1990-2001 pubmed publisher
Painter M, Mathew D, Goel R, Apostolidis S, Pattekar A, Kuthuru O, et al. Rapid induction of antigen-specific CD4+ T cells is associated with coordinated humoral and cellular immunity to SARS-CoV-2 mRNA vaccination. Immunity. 2021;54:2133-2142.e3 pubmed publisher
Peluso M, Deitchman A, Torres L, Iyer N, Munter S, Nixon C, et al. Long-term SARS-CoV-2-specific immune and inflammatory responses in individuals recovering from COVID-19 with and without post-acute symptoms. Cell Rep. 2021;36:109518 pubmed publisher
Eriksen L, Nielsen M, Laursen T, Deleuran B, Vilstrup H, St xf8 y S. Early loss of T lymphocyte 4-1BB receptor expression is associated with higher short-term mortality in alcoholic hepatitis. PLoS ONE. 2021;16:e0255574 pubmed publisher
Tarke A, Sidney J, Methot N, Yu E, Zhang Y, Dan J, et al. Impact of SARS-CoV-2 variants on the total CD4+ and CD8+ T cell reactivity in infected or vaccinated individuals. Cell Rep Med. 2021;2:100355 pubmed publisher
Motozono C, Toyoda M, Zahradník J, Saito A, Nasser H, Tan T, et al. SARS-CoV-2 spike L452R variant evades cellular immunity and increases infectivity. Cell Host Microbe. 2021;29:1124-1136.e11 pubmed publisher
You M, Chen L, Zhang D, Zhao P, Chen Z, Qin E, et al. Single-cell epigenomic landscape of peripheral immune cells reveals establishment of trained immunity in individuals convalescing from COVID-19. Nat Cell Biol. 2021;23:620-630 pubmed publisher
Valenzuela N. IFNγ, and to a Lesser Extent TNFα, Provokes a Sustained Endothelial Costimulatory Phenotype. Front Immunol. 2021;12:648946 pubmed publisher
Schouest B, Grifoni A, Pham J, Mateus J, Sydney J, Brien J, et al. Pre-existing T Cell Memory against Zika Virus. J Virol. 2021;95: pubmed publisher
Tarke A, Sidney J, Kidd C, Dan J, Ramirez S, Yu E, et al. Comprehensive analysis of T cell immunodominance and immunoprevalence of SARS-CoV-2 epitopes in COVID-19 cases. Cell Rep Med. 2021;2:100204 pubmed publisher
Nesterenko P, McLaughlin J, Cheng D, Bangayan N, Burton Sojo G, Seet C, et al. Droplet-based mRNA sequencing of fixed and permeabilized cells by CLInt-seq allows for antigen-specific TCR cloning. Proc Natl Acad Sci U S A. 2021;118: pubmed publisher
Voic H, de Vries R, Sidney J, Rubiro P, Moore E, Phillips E, et al. Identification and Characterization of CD4+ T Cell Epitopes after Shingrix Vaccination. J Virol. 2020;94: pubmed publisher
Mo F, Watanabe N, McKenna M, Hicks M, Srinivasan M, Gomes Silva D, et al. Engineered off-the-shelf therapeutic T cells resist host immune rejection. Nat Biotechnol. 2021;39:56-63 pubmed publisher
Luo X, Cui H, Cai L, Zhu W, Yang W, PATRICK M, et al. Selection of a Clinical Lead TCR Targeting Alpha-Fetoprotein-Positive Liver Cancer Based on a Balance of Risk and Benefit. Front Immunol. 2020;11:623 pubmed publisher
Grifoni A, Voic H, Dhanda S, Kidd C, Brien J, Buus S, et al. T Cell Responses Induced by Attenuated Flavivirus Vaccination Are Specific and Show Limited Cross-Reactivity with Other Flavivirus Species. J Virol. 2020;94: pubmed publisher
Pahl J, Koch J, Götz J, Arnold A, Reusch U, Gantke T, et al. CD16A Activation of NK Cells Promotes NK Cell Proliferation and Memory-Like Cytotoxicity against Cancer Cells. Cancer Immunol Res. 2018;6:517-527 pubmed publisher
Martin S, Wick D, Nielsen J, Little N, Holt R, Nelson B. A library-based screening method identifies neoantigen-reactive T cells in peripheral blood prior to relapse of ovarian cancer. Oncoimmunology. 2017;7:e1371895 pubmed publisher
Zaldivar Fujigaki J, Arroyo Valerio A, Lopez Alvarenga J, Gutiérrez Reyes E, Kershenobich D, Hernández Ruiz J. Alterations in Activation, Cytotoxic Capacity and Trafficking Profile of Peripheral CD8 T Cells in Young Adult Binge Drinkers. PLoS ONE. 2015;10:e0132521 pubmed publisher
Ohue Y, Kurose K, Mizote Y, Matsumoto H, Nishio Y, Isobe M, et al. Prolongation of overall survival in advanced lung adenocarcinoma patients with the XAGE1 (GAGED2a) antibody. Clin Cancer Res. 2014;20:5052-63 pubmed publisher
Van Nuffel A, Tuyaerts S, Benteyn D, Wilgenhof S, Corthals J, Heirman C, et al. Epitope and HLA-type independent monitoring of antigen-specific T-cells after treatment with dendritic cells presenting full-length tumor antigens. J Immunol Methods. 2012;377:23-36 pubmed publisher
product information
Antigen :
CD137
Apps. Abbrev. :
FC
Cat # :
309810
Clone :
4B4-1
Item :
APC anti-human CD137 (4-1BB)
Isotype :
Mouse IgG1, κ
Other Names :
4-1BB, ILA, CD137, TNFRSF9
Size :
100 tests
Price (USD) :
332 USD
Reactivity :
Human
Clonality :
Monoclonal
Host :
Mouse
Conjugate/Tag/Label :
APC
Immunogen :
Ectodomain of recombinant human 4-1BB fusion protein
Application Notes :
Additional reported applications (for the relevant formats) include: immunoprecipitation^1,4, inhibition of cytokine production^2,3, and ELISA. For most successful immunofluorescent staining results, it may be important to maximize signal over background by using a relatively bright fluorochrome-antibody conjugate (Cat. No. 309804) or by using a high sensitivity, three-layer staining technique (e.g., including a biotinylated anti-mouse IgG second step (Cat. No. 405303), followed by Streptavidin-PE (Cat. No. 405204)).;
more info or order :
company information
BioLegend
8999 BioLegend Way
San Diego, CA 92121
customerserv@biolegend.com
https://www.biolegend.com
headquarters: USA