product summary
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company name :
BioLegend
other brands :
Babco, Signet, Sternberger Monoclonals, Senetek, Covance
product type :
antibody
product name :
PE anti-human CD137 (4-1BB)
catalog :
309804
quantity :
100 tests
price :
252 USD
clonality :
monoclonal
host :
mouse
conjugate :
PE
clone name :
4B4-1
reactivity :
human
application :
flow cytometry
more info or order :
citations: 20
Reference
Chow A, Uddin F, Liu M, Dobrin A, Nabet B, Mangarin L, et al. The ectonucleotidase CD39 identifies tumor-reactive CD8+ T cells predictive of immune checkpoint blockade efficacy in human lung cancer. Immunity. 2023;56:93-106.e6 pubmed publisher
Senger K, Akhmetzyanova I, Haley B, Rutz S, Oh S. Plasmid-Based Donor Templates for Nonviral CRISPR/Cas9-Mediated Gene Knock-In in Human T Cells. Curr Protoc. 2022;2:e538 pubmed publisher
Shin J, Par Young J, Unlu S, McNamara A, Park H, Shin M, et al. Defining Clinical and Immunological Predictors of Poor Immune Responses to COVID-19 mRNA Vaccines in Patients with Primary Antibody Deficiency. J Clin Immunol. 2022;42:1137-1150 pubmed publisher
Goncharov M, Bryushkova E, Sharaev N, Skatova V, Baryshnikova A, Sharonov G, et al. Pinpointing the tumor-specific T cells via TCR clusters. elife. 2022;11: pubmed publisher
Elias G, Meysman P, Bartholomeus E, De Neuter N, Keersmaekers N, Suls A, et al. Preexisting memory CD4 T cells in naïve individuals confer robust immunity upon hepatitis B vaccination. elife. 2022;11: pubmed publisher
Tian L, Xu B, Teng K, Song M, Zhu Z, Chen Y, et al. Targeting Fc Receptor-Mediated Effects and the "Don't Eat Me" Signal with an Oncolytic Virus Expressing an Anti-CD47 Antibody to Treat Metastatic Ovarian Cancer. Clin Cancer Res. 2022;28:201-214 pubmed publisher
Jung J, Rha M, Sa M, Choi H, Jeon J, Seok H, et al. SARS-CoV-2-specific T cell memory is sustained in COVID-19 convalescent patients for 10 months with successful development of stem cell-like memory T cells. Nat Commun. 2021;12:4043 pubmed publisher
Yamaguchi S, Hamana H, Shitaoka K, Sukegawa K, Nagata T, Hayee A, et al. TCR function analysis using a novel system reveals the multiple unconventional tumor-reactive T cells in human breast cancer-infiltrating lymphocytes. Eur J Immunol. 2021;51:2306-2316 pubmed publisher
Rajamanickam V, Ballesteros Merino C, Samson K, Ross D, Bernard B, Fox B, et al. Robust Antitumor Immunity in a Patient with Metastatic Colorectal Cancer Treated with Cytotoxic Regimens. Cancer Immunol Res. 2021;9:602-611 pubmed publisher
Liu T, Tan J, Wu M, Fan W, Wei J, Zhu B, et al. High-affinity neoantigens correlate with better prognosis and trigger potent antihepatocellular carcinoma (HCC) activity by activating CD39+CD8+ T cells. Gut. 2021;70:1965-1977 pubmed publisher
Correnti C, Hallinan J, Doyle L, Ruff R, Jaeger Ruckstuhl C, Xu Y, et al. Engineering and functionalization of large circular tandem repeat protein nanoparticles. Nat Struct Mol Biol. 2020;27:342-350 pubmed publisher
Lamichhane R, Galvin H, Hannaway R, de la Harpe S, Munro F, Tyndall J, et al. Type I interferons are important co-stimulatory signals during T cell receptor mediated human MAIT cell activation. Eur J Immunol. 2020;50:178-191 pubmed publisher
Lamichhane R, Schneider M, de la Harpe S, Harrop T, Hannaway R, Dearden P, et al. TCR- or Cytokine-Activated CD8+ Mucosal-Associated Invariant T Cells Are Rapid Polyfunctional Effectors That Can Coordinate Immune Responses. Cell Rep. 2019;28:3061-3076.e5 pubmed publisher
Gao R, Ma J, Wen Z, Yang P, Zhao J, Xue M, et al. Tumor cell-released autophagosomes (TRAP) enhance apoptosis and immunosuppressive functions of neutrophils. Oncoimmunology. 2018;7:e1438108 pubmed publisher
Arce Vargas F, Furness A, Litchfield K, Joshi K, Rosenthal R, Ghorani E, et al. Fc Effector Function Contributes to the Activity of Human Anti-CTLA-4 Antibodies. Cancer Cell. 2018;33:649-663.e4 pubmed publisher
Shitaoka K, Hamana H, Kishi H, Hayakawa Y, Kobayashi E, Sukegawa K, et al. Identification of Tumoricidal TCRs from Tumor-Infiltrating Lymphocytes by Single-Cell Analysis. Cancer Immunol Res. 2018;6:378-388 pubmed publisher
Pavlicek D, Krebs J, Capossela S, Bertolo A, Engelhardt B, Pannek J, et al. Immunosenescence in persons with spinal cord injury in relation to urinary tract infections -a cross-sectional study. Immun Ageing. 2017;14:22 pubmed publisher
Gordón Alonso M, Hirsch T, Wildmann C, van der Bruggen P. Galectin-3 captures interferon-gamma in the tumor matrix reducing chemokine gradient production and T-cell tumor infiltration. Nat Commun. 2017;8:793 pubmed publisher
Prado Garcia H, Romero Garcia S, Puerto Aquino A, Rumbo Nava U. The PD-L1/PD-1 pathway promotes dysfunction, but not "exhaustion", in tumor-responding T cells from pleural effusions in lung cancer patients. Cancer Immunol Immunother. 2017;66:765-776 pubmed publisher
Jutz S, Leitner J, Schmetterer K, Doel Perez I, Majdic O, Grabmeier Pfistershammer K, et al. Assessment of costimulation and coinhibition in a triple parameter T cell reporter line: Simultaneous measurement of NF-κB, NFAT and AP-1. J Immunol Methods. 2016;430:10-20 pubmed publisher
product information
Antigen :
CD137
Apps. Abbrev. :
FC
Cat # :
309804
Clone :
4B4-1
Item :
PE anti-human CD137 (4-1BB)
Isotype :
Mouse IgG1, κ
Other Names :
4-1BB, ILA, CD137, TNFRSF9
Size :
100 tests
Price (USD) :
252 USD
Reactivity :
Human
Clonality :
Monoclonal
Host :
Mouse
Conjugate/Tag/Label :
PE
Immunogen :
Ectodomain of recombinant human 4-1BB fusion protein
Application Notes :
Additional reported applications (for the relevant formats) include: immunoprecipitation^1,4, inhibition of cytokine production^2,3, and ELISA. For most successful immunofluorescent staining results, it may be important to maximize signal over background by using a relatively bright fluorochrome-antibody conjugate (Cat. No. 309804) or by using a high sensitivity, three-layer staining technique (e.g., including a biotinylated anti-mouse IgG second step (Cat. No. 405303), followed by Streptavidin-PE (Cat. No. 405204)).;
more info or order :
company information
BioLegend
8999 BioLegend Way
San Diego, CA 92121
customerserv@biolegend.com
https://www.biolegend.com
headquarters: USA