LEAF™ Purified anti-human CD282 (TLR2) | BioLegend 309710 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

BioLegend

other brands :

Babco, Signet, Sternberger Monoclonals, Senetek, Covance

product type :

antibody

product name :

LEAF™ Purified anti-human CD282 (TLR2)

catalog :

309710

quantity :

500 μg

price :

395 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

TL2.1

reactivity :

human

application :

western blot, neutralization, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, blocking or activating experiments

citations: 7

Published Application/Species/Sample/Dilution	Reference
blocking or activating experiments; human; loading ...; fig 3a	Cheng W, van Asten S, Burns L, Evans H, Walter G, Hashim A, et al. Periodontitis-associated pathogens P. gingivalis and A. actinomycetemcomitans activate human CD14(+) monocytes leading to enhanced Th17/IL-17 responses. Eur J Immunol. 2016;46:2211-21 pubmed publisher
	Miani M, Le Naour J, Waeckel Enée E, Verma S, Straube M, Emond P, et al. Gut Microbiota-Stimulated Innate Lymphoid Cells Support ?-Defensin 14 Expression in Pancreatic Endocrine Cells, Preventing Autoimmune Diabetes. Cell Metab. 2018;: pubmed publisher
	Shen Y, Guo D, Weng L, Wang S, Ma Z, Yang Y, et al. Tumor-derived exosomes educate dendritic cells to promote tumor metastasis via HSP72/HSP105-TLR2/TLR4 pathway. Oncoimmunology. 2017;6:e1362527 pubmed publisher
	Chu C, Yu Y, Kung Y, Liao P, Liu K, Tseng Y, et al. The immunomodulatory activity of meningococcal lipoprotein Ag473 depends on the conformation made up of the lipid and protein moieties. PLoS ONE. 2012;7:e40873 pubmed publisher
	Pagano S, Satta N, Werling D, Offord V, de Moerloose P, Charbonney E, et al. Anti-apolipoprotein A-1 IgG in patients with myocardial infarction promotes inflammation through TLR2/CD14 complex. J Intern Med. 2012;272:344-57 pubmed publisher
	West X, Malinin N, Merkulova A, Tischenko M, Kerr B, Borden E, et al. Oxidative stress induces angiogenesis by activating TLR2 with novel endogenous ligands. Nature. 2010;467:972-6 pubmed publisher
	Chambers M, Whelan A, Spallek R, Singh M, Coddeville B, Guerardel Y, et al. Non-acylated Mycobacterium bovis glycoprotein MPB83 binds to TLR1/2 and stimulates production of matrix metalloproteinase 9. Biochem Biophys Res Commun. 2010;400:403-8 pubmed publisher

product information

Antigen :

CD282

Apps. Abbrev. :

Flow Cytometry, Block, IHC-P, IHC-F, IP, Western Blotting

Cat # :

309710

Clone :

TL2.1

Item :

LEAF™ Purified anti-human CD282 (TLR2)

Isotype :

Mouse IgG2a, κ

Other Names :

Toll like receptor 2, TIL4, CD282

Size :

500 μg

Price (USD) :

395 USD

Reactivity :

Human

Clonality :

Monoclonal

Host :

Mouse

Conjugate/Tag/Label :

LEAF

Immunogen :

Human TLR2-transfected CHO cells

Application Notes :

The TL2.1 antibody is useful for blocking studies. It has been reported to block TLR2 agonist-induced cellular activation. Additional reported applications (for the relevant formats) include: inhibition of PGP activity and blocking of cytokine production 1,3,7 , immunoprecipitation 1 , immunohistochemistry of 4% paraformaldehyde-fixed frozen sections 2 and immunohistochemistry of HOPE-fixed (HEPES-glutamic acid buffer-mediated organic solvent protection effect) paraffin-embedded sections 4 , and Western blotting 2 . The LEAF™ purified antibody (Endotoxin 0.1 EU/μg, Azide-Free, 0.2 μm filtered) is recommended for functional assays (Cat. No. 309709). For highly sensitive assays, we recommend Ultra-LEAF™ purified antibody (Cat. No. 309716) with a lower endotoxin limit than standard LEAF™ purified antibodies (Endotoxin 0.01 EU/µg).