PE anti-human CD210 (IL-10 R) | BioLegend 308804 product information

product summary

company name :

BioLegend

other brands :

Babco, Signet, Sternberger Monoclonals, Senetek, Covance

product type :

antibody

product name :

PE anti-human CD210 (IL-10 R)

catalog :

308804

quantity :

100 tests

price :

262 USD

clonality :

monoclonal

host :

rat

conjugate :

clone name :

3F9

reactivity :

human, rhesus macaque

application :

flow cytometry

more info or order :

BioLegend product webpage

citations: 7

Reference
Ni G, Chen S, Yuan J, Cavezza S, Wei M, Li H, et al. Comparative proteomic study reveals the enhanced immune response with the blockade of interleukin 10 with anti-IL-10 and anti-IL-10 receptor antibodies in human U937 cells. PLoS ONE. 2019;14:e0213813 pubmed publisher
Eriksson E, Milenova I, Wenthe J, Moreno R, Alemany R, Loskog A. IL-6 Signaling Blockade during CD40-Mediated Immune Activation Favors Antitumor Factors by Reducing TGF-β, Collagen Type I, and PD-L1/PD-1. J Immunol. 2019;: pubmed publisher
Vahl J, Friedrich J, Mittler S, Trump S, Heim L, Kachler K, et al. Interleukin-10-regulated tumour tolerance in non-small cell lung cancer. Br J Cancer. 2017;117:1644-1655 pubmed publisher
Eriksson E, Moreno R, Milenova I, Liljenfeldt L, Dieterich L, Christiansson L, et al. Activation of myeloid and endothelial cells by CD40L gene therapy supports T-cell expansion and migration into the tumor microenvironment. Gene Ther. 2017;24:92-103 pubmed publisher
Barry J, Shakibakho S, Durrer C, Simtchouk S, Jawanda K, Cheung S, et al. Hyporesponsiveness to the anti-inflammatory action of interleukin-10 in type 2 diabetes. Sci Rep. 2016;6:21244 pubmed publisher
Sun Z, Fourcade J, Pagliano O, Chauvin J, Sander C, Kirkwood J, et al. IL10 and PD-1 Cooperate to Limit the Activity of Tumor-Specific CD8+ T Cells. Cancer Res. 2015;75:1635-44 pubmed publisher
Zizzo G, Hilliard B, Monestier M, Cohen P. Efficient clearance of early apoptotic cells by human macrophages requires M2c polarization and MerTK induction. J Immunol. 2012;189:3508-20 pubmed

product information

Antigen :

CD210

Apps. Abbrev. :

Cat # :

308804

Clone :

3F9

Item :

PE anti-human CD210 (IL-10 R)

Isotype :

Rat IgG2a, κ

Other Names :

IL-10 Receptor, IL-10R

Size :

100 tests

Price (USD) :

262 USD

Reactivity :

Human, Cynomolgus, Rhesus

Clonality :

Monoclonal

Host :

Rat

Conjugate/Tag/Label :

Immunogen :

shIL-10R

Application Notes :

Clone 3F9 recognizes the IL-10-binding epitope of IL-10R1.^8 Additional reported applications (for the relevant formats) include: immunoprecipitation^1, in vitro blocking^1-3 of human IL-10 binding to IL-10R. For most successful immunofluorescent staining results, it may be important to maximize signal over background by using a relatively bright fluorochrome-antibody conjugate (Cat. No. 308804) or by using a high sensitivity, three-layer staining technique (e.g., including a biotinylated anti-rat IgG second step), followed by SAv-PE (Cat. No. 405204). The Ultra-LEAF™ purified antibody (Endotoxin < 0.01 EU/µg, Azide-Free, 0.2 µm filtered) is recommended for highly sensitive assays (Cat. No. 308817 and 308818).;

more info or order :

BioLegend product webpage