Purified anti-human CD210 (IL-10 R) | BioLegend 308802 product information

product summary

company name :

BioLegend

other brands :

Babco, Signet, Sternberger Monoclonals, Senetek, Covance

product type :

antibody

product name :

Purified anti-human CD210 (IL-10 R)

catalog :

308802

quantity :

100 μg

price :

114 USD

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

3F9

reactivity :

human, rhesus macaque

application :

neutralization, immunoprecipitation, flow cytometry, blocking or activating experiments

more info or order :

BioLegend product webpage

citations: 11

Published Application/Species/Sample/Dilution	Reference
blocking or activating experiments; human; fig 4	Rancan C, Schirrmann L, Hüls C, Zeidler R, Moosmann A. Latent Membrane Protein LMP2A Impairs Recognition of EBV-Infected Cells by CD8+ T Cells. PLoS Pathog. 2015;11:e1004906 pubmed publisher
blocking or activating experiments; human	Hatano R, Ohnuma K, Otsuka H, Komiya E, Taki I, Iwata S, et al. CD26-mediated induction of EGR2 and IL-10 as potential regulatory mechanism for CD26 costimulatory pathway. J Immunol. 2015;194:960-72 pubmed publisher
	Jenkins B, Blaseg N, Grifka Walk H, Deuling B, Swain S, Campbell E, et al. Loss of interleukin-10 receptor disrupts intestinal epithelial cell proliferation and skews differentiation towards the goblet cell fate. FASEB J. 2021;35:e21551 pubmed publisher
	Lu Y, Zhao Q, Liao J, Song E, Xia Q, Pan J, et al. Complement Signals Determine Opposite Effects of B Cells in Chemotherapy-Induced Immunity. Cell. 2020;180:1081-1097.e24 pubmed publisher
	Tang X, Zhang S, Peng Q, Ling L, Shi H, Liu Y, et al. Sustained IFN-I stimulation impairs MAIT cell responses to bacteria by inducing IL-10 during chronic HIV-1 infection. Sci Adv. 2020;6:eaaz0374 pubmed publisher
	Svajger U, Rožman P. Synergistic Effects of Interferon-γ and Vitamin D3 Signaling in Induction of ILT-3highPDL-1high Tolerogenic Dendritic Cells. Front Immunol. 2019;10:2627 pubmed publisher
	Ni G, Chen S, Yuan J, Cavezza S, Wei M, Li H, et al. Comparative proteomic study reveals the enhanced immune response with the blockade of interleukin 10 with anti-IL-10 and anti-IL-10 receptor antibodies in human U937 cells. PLoS ONE. 2019;14:e0213813 pubmed publisher
	Claassen M, de Knegt R, Turgut D, Groothuismink Z, Janssen H, Boonstra A. Negative regulation of hepatitis C virus specific immunity is highly heterogeneous and modulated by pegylated interferon-alpha/ribavirin therapy. PLoS ONE. 2012;7:e49389 pubmed publisher
	Joffe M, Necula A, Chand R, McWhinney B, Krishnamurthy B, Loudovaris T, et al. Residual methylprednisolone suppresses human T-cell responses to spleen, but not islet, extracts from deceased organ donors. Int Immunol. 2012;24:447-53 pubmed publisher
	Liu B, Groothuismink Z, Janssen H, Boonstra A. Role for IL-10 in inducing functional impairment of monocytes upon TLR4 ligation in patients with chronic HCV infections. J Leukoc Biol. 2011;89:981-8 pubmed publisher
	Huang Y, Zozulya A, Weidenfeller C, Schwab N, Wiendl H. T cell suppression by naturally occurring HLA-G-expressing regulatory CD4+ T cells is IL-10-dependent and reversible. J Leukoc Biol. 2009;86:273-81 pubmed publisher

product information

Antigen :

CD210

Apps. Abbrev. :

FC, IP, Block

Cat # :

308802

Clone :

3F9

Item :

Purified anti-human CD210 (IL-10 R)

Isotype :

Rat IgG2a, κ

Other Names :

IL-10 Receptor, IL-10R

Size :

100 μg

Price (USD) :

114 USD

Reactivity :

Human, Cynomolgus, Rhesus

Clonality :

Monoclonal

Host :

Rat

Conjugate/Tag/Label :

PURE

Immunogen :

shIL-10R

Application Notes :

Clone 3F9 recognizes the IL-10-binding epitope of IL-10R1.^8 Additional reported applications (for the relevant formats) include: immunoprecipitation^1, in vitro blocking^1-3 of human IL-10 binding to IL-10R. For most successful immunofluorescent staining results, it may be important to maximize signal over background by using a relatively bright fluorochrome-antibody conjugate (Cat. No. 308804) or by using a high sensitivity, three-layer staining technique (e.g., including a biotinylated anti-rat IgG second step), followed by SAv-PE (Cat. No. 405204). The Ultra-LEAF™ purified antibody (Endotoxin < 0.01 EU/µg, Azide-Free, 0.2 µm filtered) is recommended for highly sensitive assays (Cat. No. 308817 and 308818).;

more info or order :

BioLegend product webpage